JP2022105108A5 - - Google Patents
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- JP2022105108A5 JP2022105108A5 JP2022073522A JP2022073522A JP2022105108A5 JP 2022105108 A5 JP2022105108 A5 JP 2022105108A5 JP 2022073522 A JP2022073522 A JP 2022073522A JP 2022073522 A JP2022073522 A JP 2022073522A JP 2022105108 A5 JP2022105108 A5 JP 2022105108A5
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- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 6
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 229960002621 pembrolizumab Drugs 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 3
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 3
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 102000049823 human TIGIT Human genes 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 241000235648 Pichia Species 0.000 claims 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
Claims (26)
- ２つの重鎖免疫グロブリンおよび２つの軽鎖免疫グロブリンを含む、ヒトＴＩＧＩＴに結合するモノクローナル抗体であって、前記重鎖免疫グロブリンは（ｉ）配列番号１２８を含む重鎖可変領域、および（ｉｉ）配列番号８６を含むＩｇＧ１定常ドメインを含み、前記軽鎖免疫グロブリンは（ｉ）配列番号１３２を含む軽鎖可変領域、および（ｉｉ）配列番号５６を含むヒトκ定常ドメインを含む、前記モノクローナル抗体。
- ２つの重鎖免疫グロブリンおよび２つの軽鎖免疫グロブリンを含む、ヒトＴＩＧＩＴに結合するモノクローナル抗体であって、前記重鎖免疫グロブリンは（ｉ）配列番号１２８を含む重鎖可変領域、および（ｉｉ）配列番号８６を含むＩｇＧ１定常ドメインを含み、前記軽鎖免疫グロブリンは（ｉ）配列番号１３３を含む軽鎖可変領域、および（ｉｉ）配列番号５６を含むヒトκ定常ドメインを含む、前記モノクローナル抗体。
- ２つの重鎖免疫グロブリンおよび２つの軽鎖免疫グロブリンを含む、ヒトＴＩＧＩＴに結合するモノクローナル抗体であって、前記重鎖免疫グロブリンは（ｉ）配列番号１２７を含む重鎖可変領域、および（ｉｉ）配列番号８６を含むＩｇＧ１定常ドメインを含み、前記軽鎖免疫グロブリンは（ｉ）配列番号１３０を含む軽鎖可変領域、および（ｉｉ）配列番号５６を含むヒトκ定常ドメインを含む、前記抗体。
- カニクイザルおよびアカゲザルＴＩＧＩＴと交差反応する、請求項１～３のいずれか一項に記載のモノクローナル抗体。
- 重鎖可変領域のフレームワーク領域内に、１、２、３、４、５、６、７、８、９、１０、１１、１２、１３、１４、１５、１６、１７、１８、１９、２０、２１、２２、２３、２４、２５、２６、２７、２８、２９または３０個のアミノ酸置換を含む、請求項１～３のいずれか一項に記載のモノクローナル抗体。
- 軽鎖可変領域のフレームワーク領域内に、１、２、３、４、５、６、７、８、９、１０、１１、１２、１３、１４、１５、１６、１７、１８、１９、２０、２１、２２、２３、２４、２５、２６、２７、２８、２９または３０個のアミノ酸置換を含む、請求項１～４のいずれか一項に記載のモノクローナル抗体。
- チャイニーズハムスター卵巣細胞（ＣＨＯ）細胞において産生される、請求項１～３のいずれか一項に記載のモノクローナル抗体。
- 請求項１～７のいずれか一項に記載の抗体の重鎖可変領域および軽鎖可変領域を含む、単離されたポリペプチド。
- 配列番号１２４～１２９のいずれかのアミノ酸配列を備える重鎖可変領域を含む、請求項８に記載の単離されたポリペプチド。
- 配列番号１３０～１３３のいずれかのアミノ酸配列を備える軽鎖可変領域を含む、請求項８に記載の単離されたポリペプチド。
- 請求項１～７のいずれか一項に記載の抗体、または請求項８～１０のいずれか一項に記載の単離されたポリペプチドをコードする単離された核酸。
- 請求項１１記載の単離された核酸を含む発現ベクター。
- 請求項１２記載の発現ベクターを含む宿主細胞。
- ピチア（Ｐｉｃｈｉａ）細胞またはチャイニーズハムスター卵巣（ＣＨＯ）細胞である、請求項１３記載の宿主細胞。
- 請求項１～７のいずれか１項記載の抗体、または請求項８～１０のいずれか一項に記載の単離されたポリペプチドと、医薬上許容される担体または希釈剤とを含む組成物。
- 抗ＰＤ１抗体をさらに含む、請求項１５に記載の組成物。
- 前記抗ＰＤ１抗体がペンブロリズマブまたはその抗原結合性フラグメントおよびニボルマブまたはその抗原結合性フラグメントである、請求項１６に記載の組成物。
- 前記抗ＰＤ１抗体がペンブロリズマブである、請求項１７に記載の組成物。
- 抗ＰＤＬ１抗体をさらに含む、請求項１５に記載の組成物。
- 請求項１～７のいずれか一項記載の抗体のいずれかの重鎖可変領域および／または軽鎖可変領域をコードするポリヌクレオチドを含む宿主細胞を、該ポリヌクレオチドの発現に好ましい条件下で培養することを含む、抗体の製造方法。
- 前記抗体を前記宿主細胞および／または培地から回収することを含む、請求項２０に記載の抗体の製造方法。
- 請求項１～７のいずれか一項記載の抗体を含む、ヒト対象における癌を治療するための組成物。
- ヒト対象における癌を治療するための医薬の製造における、抗体の使用であって、請求項１～７のいずれか一項に記載の抗体の有効量を含み、さらなる治療剤または治療方法と組み合わせて使用されてもよい、前記使用。
- 前記さらなる治療剤は、甲ＰＤ１抗体または抗ＰＤＬ－１抗体である、請求項２２に記載の方法。
- 前記ＰＤ－１抗体はペンブロリズマブまたはニボルマブである、請求項２４に記載の方法。
- 前記ＰＤ－１抗体はペンブロリズマブである、請求項２４に記載の方法。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462038912P | 2014-08-19 | 2014-08-19 | |
| US62/038,912 | 2014-08-19 | ||
| US201562126733P | 2015-03-02 | 2015-03-02 | |
| US62/126,733 | 2015-03-02 | ||
| JP2020101881A JP7066777B2 (ja) | 2014-08-19 | 2020-06-11 | 抗ｔｉｇｉｔ抗体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020101881A Division JP7066777B2 (ja) | 2014-08-19 | 2020-06-11 | 抗ｔｉｇｉｔ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022105108A JP2022105108A (ja) | 2022-07-12 |
| JP2022105108A5 true JP2022105108A5 (ja) | 2022-11-10 |
| JP7487256B2 JP7487256B2 (ja) | 2024-05-20 |
Family
ID=53938463
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017509009A Active JP6920194B2 (ja) | 2014-08-19 | 2015-08-17 | 抗ｔｉｇｉｔ抗体 |
| JP2020101881A Active JP7066777B2 (ja) | 2014-08-19 | 2020-06-11 | 抗ｔｉｇｉｔ抗体 |
| JP2022073522A Active JP7487256B2 (ja) | 2014-08-19 | 2022-04-27 | 抗ｔｉｇｉｔ抗体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017509009A Active JP6920194B2 (ja) | 2014-08-19 | 2015-08-17 | 抗ｔｉｇｉｔ抗体 |
| JP2020101881A Active JP7066777B2 (ja) | 2014-08-19 | 2020-06-11 | 抗ｔｉｇｉｔ抗体 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US20160355589A1 (ja) |
| EP (1) | EP3183267A1 (ja) |
| JP (3) | JP6920194B2 (ja) |
| KR (2) | KR102321168B1 (ja) |
| CN (2) | CN113583131A (ja) |
| AP (1) | AP2017009765A0 (ja) |
| AU (3) | AU2015305754B2 (ja) |
| BR (1) | BR112017003108A8 (ja) |
| CA (1) | CA2957722C (ja) |
| CL (2) | CL2017000310A1 (ja) |
| CO (1) | CO2017001561A2 (ja) |
| CR (1) | CR20170060A (ja) |
| DO (1) | DOP2017000046A (ja) |
| EA (1) | EA036311B1 (ja) |
| GE (1) | GEP20217331B (ja) |
| GT (1) | GT201700033A (ja) |
| IL (1) | IL250583B (ja) |
| JO (2) | JO3664B1 (ja) |
| MA (1) | MA40475A (ja) |
| MD (1) | MD4733C1 (ja) |
| MX (2) | MX2017002229A (ja) |
| MY (2) | MY198017A (ja) |
| NI (1) | NI201700019A (ja) |
| PE (1) | PE20170289A1 (ja) |
| PH (1) | PH12017500296B1 (ja) |
| SG (1) | SG11201701161QA (ja) |
| TN (1) | TN2017000024A1 (ja) |
| TW (2) | TWI790593B (ja) |
| UA (1) | UA122395C2 (ja) |
| WO (1) | WO2016028656A1 (ja) |
| ZA (1) | ZA201700955B (ja) |
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