|
US5565215A
(en)
|
1993-07-23 |
1996-10-15 |
Massachusettes Institute Of Technology |
Biodegradable injectable particles for imaging
|
|
GB9322014D0
(en)
|
1993-10-26 |
1993-12-15 |
Co Ordinated Drug Dev |
Improvements in and relating to carrier particles for use in dry powder inhalers
|
|
SE9401108D0
(sv)
|
1994-03-31 |
1994-03-31 |
Leiras Oy |
Ophthalmic composition I
|
|
SE9401109D0
(sv)
|
1994-03-31 |
1994-03-31 |
Leiras Oy |
Opthalmic composition II
|
|
GB9412273D0
(en)
|
1994-06-18 |
1994-08-10 |
Univ Nottingham |
Administration means
|
|
US6007845A
(en)
|
1994-07-22 |
1999-12-28 |
Massachusetts Institute Of Technology |
Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
|
|
GB9501841D0
(en)
|
1995-01-31 |
1995-03-22 |
Co Ordinated Drug Dev |
Improvements in and relating to carrier particles for use in dry powder inhalers
|
|
US6413539B1
(en)
|
1996-10-31 |
2002-07-02 |
Poly-Med, Inc. |
Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
|
|
GB9515182D0
(en)
|
1995-07-24 |
1995-09-20 |
Co Ordinated Drug Dev |
Improvements in and relating to powders for use in dry powder inhalers
|
|
US5635517B1
(en)
|
1996-07-24 |
1999-06-29 |
Celgene Corp |
Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
|
|
HU228769B1
(en)
|
1996-07-24 |
2013-05-28 |
Celgene Corp |
Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
|
|
CN1109037C
(zh)
|
1996-09-13 |
2003-05-21 |
三菱制药株式会社 |
噻吩并－三唑并二氮杂䓬化合物及其医药用途
|
|
TR200101502T2
(tr)
*
|
1998-03-16 |
2002-06-21 |
Celgene Corporation |
2-(2,6-dioksopiperidin-3-il) izoindolin türevleri, bunların hazırlanması ve enflamatuar sitokinlerin inhibitörleri olarak kullanımı
|
|
US6045501A
(en)
|
1998-08-28 |
2000-04-04 |
Celgene Corporation |
Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug
|
|
GB9827145D0
(en)
|
1998-12-09 |
1999-02-03 |
Co Ordinated Drug Dev |
Improvements in or relating to powders
|
|
US6306663B1
(en)
|
1999-02-12 |
2001-10-23 |
Proteinex, Inc. |
Controlling protein levels in eucaryotic organisms
|
|
US6287588B1
(en)
|
1999-04-29 |
2001-09-11 |
Macromed, Inc. |
Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
|
|
WO2001074400A1
(en)
|
2000-04-03 |
2001-10-11 |
Santen Pharmaceutical Co., Ltd. |
Transporters and drug delivery system by using the same
|
|
GB0009469D0
(en)
|
2000-04-17 |
2000-06-07 |
Vectura Ltd |
Improvements in or relating to formalities for use in inhaler devices
|
|
GB0009468D0
(en)
|
2000-04-17 |
2000-06-07 |
Vectura Ltd |
Improvements in or relating to formulations for use in inhaler devices
|
|
US6589549B2
(en)
|
2000-04-27 |
2003-07-08 |
Macromed, Incorporated |
Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
|
|
US6495164B1
(en)
|
2000-05-25 |
2002-12-17 |
Alkermes Controlled Therapeutics, Inc. I |
Preparation of injectable suspensions having improved injectability
|
|
JP5698423B2
(ja)
|
2000-06-27 |
2015-04-08 |
ベクトゥラ・リミテッド |
医薬組成物で使用するための粒子の製造法
|
|
GB2364919A
(en)
|
2000-07-21 |
2002-02-13 |
Cambridge Consultants |
Inhalers
|
|
US7208157B2
(en)
|
2000-09-08 |
2007-04-24 |
California Institute Of Technology |
Proteolysis targeting chimeric pharmaceutical
|
|
WO2002020740A2
(en)
|
2000-09-08 |
2002-03-14 |
California Institute Of Technology |
Proteolysis targeting chimeric pharmaceutical
|
|
US6315720B1
(en)
|
2000-10-23 |
2001-11-13 |
Celgene Corporation |
Methods for delivering a drug to a patient while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug
|
|
CN1507357A
(zh)
|
2000-10-31 |
2004-06-23 |
PRҩƷ����˾ |
提高生物活性分子传递的方法和组合物
|
|
DE60140268D1
(de)
|
2000-11-30 |
2009-12-03 |
Vectura Ltd |
Partikel zur verwendung in einer pharmazeutischen zusammensetzung
|
|
US20030045552A1
(en)
|
2000-12-27 |
2003-03-06 |
Robarge Michael J. |
Isoindole-imide compounds, compositions, and uses thereof
|
|
GB0122318D0
(en)
|
2001-09-14 |
2001-11-07 |
Novartis Ag |
Organic compounds
|
|
US7968569B2
(en)
|
2002-05-17 |
2011-06-28 |
Celgene Corporation |
Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
|
DE60309887T2
(de)
|
2002-07-30 |
2007-05-16 |
Novartis Ag |
Kombination von einem aromatasehemmer mit einem bisphosphonat
|
|
US7189740B2
(en)
*
|
2002-10-15 |
2007-03-13 |
Celgene Corporation |
Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
|
|
US8404716B2
(en)
|
2002-10-15 |
2013-03-26 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
|
US7230012B2
(en)
|
2002-11-14 |
2007-06-12 |
Celgene Corporation |
Pharmaceutical compositions and dosage forms of thalidomide
|
|
US20050009910A1
(en)
|
2003-07-10 |
2005-01-13 |
Allergan, Inc. |
Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
|
|
JP2007505831A
(ja)
|
2003-09-15 |
2007-03-15 |
ベクトゥラ・リミテッド |
肺吸入による、早漏を治療するための医薬品組成物
|
|
KR20060085246A
(ko)
|
2003-09-18 |
2006-07-26 |
마커사이트, 인코포레이티드 |
경공막 전달
|
|
GB0407627D0
(en)
|
2004-04-02 |
2004-05-05 |
Vectura Ltd |
Corkscrew pump
|
|
ES2246694B1
(es)
|
2004-04-29 |
2007-05-01 |
Instituto Cientifico Y Tecnologico De Navarra, S.A. |
Nanoparticulas pegiladas.
|
|
US7771742B2
(en)
|
2004-04-30 |
2010-08-10 |
Allergan, Inc. |
Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
|
|
WO2005107708A1
(en)
|
2004-04-30 |
2005-11-17 |
Allergan, Inc. |
Biodegradable intravitreal tyrosine kinase inhibitors implants
|
|
US20050244469A1
(en)
|
2004-04-30 |
2005-11-03 |
Allergan, Inc. |
Extended therapeutic effect ocular implant treatments
|
|
DK1848431T3
(en)
|
2005-02-09 |
2016-04-18 |
Santen Pharmaceutical Co Ltd |
LIQUID FORMULATIONS FOR TREATMENT OF DISEASES OR CONDITIONS
|
|
US8663639B2
(en)
|
2005-02-09 |
2014-03-04 |
Santen Pharmaceutical Co., Ltd. |
Formulations for treating ocular diseases and conditions
|
|
US8999289B2
(en)
|
2005-03-22 |
2015-04-07 |
President And Fellows Of Harvard College |
Treatment of protein degradation disorders
|
|
CN102016814B
(zh)
|
2005-06-17 |
2013-10-23 |
北卡罗来纳大学查珀尔希尔分校 |
纳米粒子制备方法、系统及材料
|
|
US20070071756A1
(en)
|
2005-09-26 |
2007-03-29 |
Peyman Gholam A |
Delivery of an agent to ameliorate inflammation
|
|
WO2007056561A2
(en)
|
2005-11-09 |
2007-05-18 |
Liquidia Technologies, Inc. |
Medical device, materials, and methods
|
|
WO2007081876A2
(en)
|
2006-01-04 |
2007-07-19 |
Liquidia Technologies, Inc. |
Nanostructured surfaces for biomedical/biomaterial applications and processes thereof
|
|
JP5819579B2
(ja)
|
2006-01-13 |
2015-11-24 |
サーモディクス，インコーポレイティド |
薬物送達のためのマトリックスを含む微粒子
|
|
ES2563288T3
(es)
|
2006-03-23 |
2016-03-14 |
Santen Pharmaceutical Co., Ltd |
Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular
|
|
US20080166411A1
(en)
|
2006-04-10 |
2008-07-10 |
Pfizer Inc |
Injectable Depot Formulations And Methods For Providing Sustained Release Of Poorly Soluble Drugs Comprising Nanoparticles
|
|
WO2007133808A2
(en)
|
2006-05-15 |
2007-11-22 |
Liquidia Technologies, Inc. |
Nano-particles for cosmetic applications
|
|
CL2007002218A1
(es)
|
2006-08-03 |
2008-03-14 |
Celgene Corp Soc Organizada Ba |
Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa.
|
|
US8877780B2
(en)
|
2006-08-30 |
2014-11-04 |
Celgene Corporation |
5-substituted isoindoline compounds
|
|
CL2007002513A1
(es)
|
2006-08-30 |
2008-04-04 |
Celgene Corp Soc Organizada Ba |
Compuestos derivados de isoindolina sustituidos, compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento y prevencion de enfermedades tales como cancer, dolor, degeneracion macular, entre otras.
|
|
CL2007002670A1
(es)
|
2006-09-15 |
2008-05-16 |
Celgene Corp Soc Organizada Ba |
Compuestos derivados de n-metilaminometil-isoindolina; composicion farmaceutica; forma de dosificacion, util para tratar o prevenir enfermedades tales como cancer, dolor, trastorno pulmonar, trastorno del snc y aterosclerosis.
|
|
ME02420B
(me)
|
2006-09-26 |
2016-09-20 |
Celgene Corp |
5-supstituirani derivati kinazolinona kao sredstva protiv raka
|
|
US20100216928A1
(en)
|
2006-11-15 |
2010-08-26 |
The University of North Carolona at Chapel Hill |
Polymer particle composite having high fidelity order, size, and shape particles
|
|
MX2009010082A
(es)
|
2007-03-20 |
2009-10-19 |
Celgene Corp |
Derivados y composiciones que comprenden isoindolina 4'-o-sustituida y metodos para utilizar la misma.
|
|
WO2008122038A1
(en)
|
2007-04-02 |
2008-10-09 |
President And Fellows Of Harvard College |
Regulating autophagy
|
|
CA2704710C
(en)
|
2007-09-26 |
2016-02-02 |
Celgene Corporation |
6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising the same
|
|
KR101600634B1
(ko)
|
2007-12-28 |
2016-03-07 |
미쓰비시 타나베 파마 코퍼레이션 |
항암제
|
|
WO2009100176A2
(en)
|
2008-02-07 |
2009-08-13 |
Abbott Laboratories |
Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor
|
|
US9943401B2
(en)
|
2008-04-04 |
2018-04-17 |
Eugene de Juan, Jr. |
Therapeutic device for pain management and vision
|
|
WO2009132206A1
(en)
|
2008-04-25 |
2009-10-29 |
Liquidia Technologies, Inc. |
Compositions and methods for intracellular delivery and release of cargo
|
|
WO2009132265A2
(en)
|
2008-04-25 |
2009-10-29 |
The University Of North Carolina At Chapel Hill |
Degradable compounds and methods of use thereof, particularly with particle replication in non-wetting templates
|
|
US20090298882A1
(en)
|
2008-05-13 |
2009-12-03 |
Muller George W |
Thioxoisoindoline compounds and compositions comprising and methods of using the same
|
|
WO2010009087A1
(en)
|
2008-07-15 |
2010-01-21 |
Eyegate Pharmaceuticals, Inc. |
Iontophoretic delivery of a controlled-release formulation in the eye
|
|
PT2358697E
(pt)
|
2008-10-29 |
2016-02-03 |
Celgene Corp |
Compostos de isoindolina para utilização no tratamento do cancro
|
|
KR101690643B1
(ko)
|
2008-12-05 |
2016-12-28 |
리퀴디아 테크놀로지스 인코포레이티드 |
패턴 재료 제조 방법
|
|
US8623395B2
(en)
|
2010-01-29 |
2014-01-07 |
Forsight Vision4, Inc. |
Implantable therapeutic device
|
|
AU2010208046B2
(en)
|
2009-01-29 |
2014-10-02 |
Forsight Vision4, Inc. |
Posterior segment drug delivery
|
|
WO2010091187A2
(en)
|
2009-02-04 |
2010-08-12 |
The Brigham And Women's Hospital, Inc. |
Polymeric nanoparticles with enhanced drug-loading and methods of use thereof
|
|
WO2010093662A2
(en)
|
2009-02-10 |
2010-08-19 |
Psivida Us, Inc. |
Ocular trocar assembly
|
|
KR101674904B1
(ko)
|
2009-02-26 |
2016-11-10 |
더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 |
중재형 약물전달 시스템과 그 방법
|
|
WO2010107485A1
(en)
|
2009-03-17 |
2010-09-23 |
The Trustees Of Columbia University In The City Of New York |
E3 ligase inhibitors
|
|
US10952965B2
(en)
|
2009-05-15 |
2021-03-23 |
Baxter International Inc. |
Compositions and methods for drug delivery
|
|
BRPI1007855B1
(pt)
|
2009-05-19 |
2020-03-10 |
Celgene Corporation |
Formas de dosagem oral compreendendo 4-amino-2-(2,6-dioxopiperidina-3-il)isoindolina-1,3-diona
|
|
EP2437684B1
(en)
|
2009-06-03 |
2022-06-15 |
ForSight Vision5, Inc. |
Anterior segment drug delivery
|
|
JP5656996B2
(ja)
|
2009-07-13 |
2015-01-21 |
ザ ユニバーシティ オブ ノース キャロライナ アット チャペル ヒル |
工学的に作製されたエアロゾル粒子、およびそれに関連した方法
|
|
US9556426B2
(en)
|
2009-09-16 |
2017-01-31 |
Celgene Avilomics Research, Inc. |
Protein kinase conjugates and inhibitors
|
|
US20130066283A1
(en)
|
2009-10-23 |
2013-03-14 |
Nexisvision, Inc. |
Corneal Denervation for Treatment of Ocular Pain
|
|
EP2490620A4
(en)
|
2009-10-23 |
2017-03-22 |
Forsight Labs, Llc |
Conformable therapeutic shield for vision and pain
|
|
KR20120117905A
(ko)
|
2010-01-28 |
2012-10-24 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
프로테아좀 활성을 향상시키는 조성물 및 방법
|
|
WO2013022801A1
(en)
|
2011-08-05 |
2013-02-14 |
Forsight Vision4, Inc. |
Small molecule delivery with implantable therapeutic device
|
|
WO2011097218A1
(en)
|
2010-02-02 |
2011-08-11 |
Wayne State University |
Anti-cancer therapeutic agents
|
|
WO2011109384A2
(en)
|
2010-03-02 |
2011-09-09 |
Allergan, Inc. |
Biodegradable polymers for lowering intraocular pressure
|
|
PL2902030T3
(pl)
|
2010-05-14 |
2017-07-31 |
Dana-Farber Cancer Institute, Inc. |
Związki tienotriazolodiazepinowe do leczenia nowotworu
|
|
RS56042B1
(sr)
|
2010-06-10 |
2017-09-29 |
Seragon Pharmaceuticals Inc |
Modulatori estrogenih receptora i njihove upotrebe
|
|
CN103153335A
(zh)
|
2010-06-30 |
2013-06-12 |
布兰代斯大学 |
小分子靶定的蛋白质降解
|
|
EP3861969A1
(en)
|
2010-08-05 |
2021-08-11 |
ForSight Vision4, Inc. |
Injector apparatus for drug delivery
|
|
AU2011285548B2
(en)
|
2010-08-05 |
2014-02-06 |
Forsight Vision4, Inc. |
Combined drug delivery methods and apparatus
|
|
CN103209664A
(zh)
|
2010-08-05 |
2013-07-17 |
弗赛特影像4股份有限公司 |
可植入的治疗装置
|
|
CA2807508A1
(en)
|
2010-08-05 |
2012-02-09 |
Forsight Vision4, Inc. |
Subconjunctival implant for posterior segment drug delivery
|
|
GB2483736B
(en)
|
2010-09-16 |
2012-08-29 |
Aragon Pharmaceuticals Inc |
Estrogen receptor modulators and uses thereof
|
|
US20140033800A1
(en)
|
2010-11-11 |
2014-02-06 |
Forsight Vision4, Inc. |
Methods and apparatus to determine diffusion properties of porous structures for drug delivery
|
|
TW201304822A
(zh)
|
2010-11-15 |
2013-02-01 |
Vectura Ltd |
組成物及用途
|
|
WO2012068549A2
(en)
|
2010-11-19 |
2012-05-24 |
Forsight Vision4, Inc. |
Therapeutic agent formulations for implanted devices
|
|
WO2012075456A1
(en)
|
2010-12-02 |
2012-06-07 |
Constellation Pharmaceuticals |
Bromodomain inhibitors and uses thereof
|
|
CA2823837A1
(en)
|
2010-12-07 |
2012-06-14 |
Yale University |
Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same
|
|
WO2012079022A1
(en)
|
2010-12-10 |
2012-06-14 |
Concert Pharmaceuticals, Inc. |
Substituted dioxopiperidinyl phthalimide derivatives
|
|
BRPI1100318A2
(pt)
|
2011-02-18 |
2013-05-21 |
Univ Estadual Paulista Jelio De Mesquita Filho |
processo de obtenÇço de compostos derivados derivados de anti-inflamatàrios esteràides (aies), composiÇÕes farmacÊuticas contendo tais compostos e seus usos no tratamento de doenÇas de carÁter inflamatàrio.
|
|
US20150197497A1
(en)
|
2011-06-24 |
2015-07-16 |
Dana-Farber Cancer Institute, Inc. |
Selective inhibitors of histone deacetylase isoform 6 and methods thereof
|
|
JP5989780B2
(ja)
|
2011-09-14 |
2016-09-07 |
フォーサイト・ビジョン５・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ５，Ｉｎｃ． |
眼挿入装置および方法
|
|
PT2755600T
(pt)
|
2011-09-16 |
2021-04-19 |
Forsight Vision4 Inc |
Aparelhos de troca de fluidos
|
|
AU2012326361B2
(en)
|
2011-10-17 |
2017-08-03 |
Biotheryx, Inc. |
Substituted biaryl alkyl amides
|
|
WO2013082111A2
(en)
|
2011-11-29 |
2013-06-06 |
The University Of North Carolina At Chapel Hill |
Geometrically engineered particles and methods for modulating macrophage or immune responses
|
|
EP2724741B1
(en)
|
2012-10-26 |
2017-06-14 |
Vectura GmbH |
Inhalation device for use in aerosol therapy
|
|
PT2797652T
(pt)
|
2011-12-27 |
2019-02-19 |
Vectura Gmbh |
Dispositivo para inalação com sistema de feedback
|
|
WO2013106646A2
(en)
|
2012-01-12 |
2013-07-18 |
Yale University |
Compounds and methods for the inhibition of vcb e3 ubiquitin ligase
|
|
KR102668696B1
(ko)
|
2012-01-12 |
2024-05-29 |
예일 유니버시티 |
E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법
|
|
WO2013116061A1
(en)
|
2012-02-03 |
2013-08-08 |
Forsight Vision4, Inc. |
Insertion and removal methods and apparatus for therapeutic devices
|
|
EP2846859B1
(en)
|
2012-03-09 |
2017-01-04 |
Vectura GmbH |
Mixing channel for an inhalation device and inhalation device
|
|
US20140107025A1
(en)
|
2012-04-16 |
2014-04-17 |
Jade Therapeutics, Llc |
Ocular drug delivery system
|
|
WO2013170147A1
(en)
|
2012-05-11 |
2013-11-14 |
Yale University |
Compounds useful for promoting protein degradation and methods using same
|
|
EP2895146A1
(en)
|
2012-09-17 |
2015-07-22 |
BIND Therapeutics, Inc. |
Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
|
|
KR20150090038A
(ko)
|
2012-09-20 |
2015-08-05 |
아키나, 인크. |
충전재를 함유한 생분해성 미세캡슐
|
|
USRE48175E1
(en)
|
2012-10-19 |
2020-08-25 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
RU2652063C2
(ru)
|
2012-10-26 |
2018-04-24 |
Форсайт Вижн5, Инк. |
Офтальмологическая система для замедленного высвобождения лекарственного средства в глазу
|
|
AU2013337717B2
(en)
|
2012-11-01 |
2018-10-25 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using PI3 kinase isoform modulators
|
|
JP2016512846A
(ja)
|
2013-03-13 |
2016-05-09 |
ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド |
Ｒａｓ阻害剤およびその使用
|
|
WO2014152959A1
(en)
|
2013-03-14 |
2014-09-25 |
Forsight Vision4, Inc. |
Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
|
|
US9670221B2
(en)
|
2013-03-14 |
2017-06-06 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Furopyridines as bromodomain inhibitors
|
|
HK1220325A1
(zh)
|
2013-03-15 |
2017-05-05 |
Whitehead Institute For Biomedical Research |
苯并咪唑衍生物及其用途
|
|
CN105246438B
(zh)
|
2013-03-28 |
2018-01-26 |
弗赛特影像4股份有限公司 |
用于输送治疗物质的眼科植入物
|
|
AU2014248460B2
(en)
|
2013-04-01 |
2019-04-11 |
Allergan, Inc. |
Microsphere drug delivery system for sustained intraocular release
|
|
CN103421061A
(zh)
|
2013-08-14 |
2013-12-04 |
中国药科大学 |
来那度胺衍生物、其制法及其医药用途
|
|
EP3057514A4
(en)
|
2013-10-15 |
2017-08-02 |
Forsight Vision5, Inc. |
Formulations and methods for increasing or reducing mucus
|
|
US20160296627A1
(en)
|
2013-12-06 |
2016-10-13 |
Envisia Therapeutics Inc. |
Intracameral implant for treatment of an ocular condition
|
|
WO2015085234A1
(en)
|
2013-12-06 |
2015-06-11 |
Forsight Vision4, Inc. |
Implantable therapeutic devices
|
|
WO2015085172A2
(en)
*
|
2013-12-06 |
2015-06-11 |
Celgene Corporation |
Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers
|
|
US20160058872A1
(en)
|
2014-04-14 |
2016-03-03 |
Arvinas, Inc. |
Imide-based modulators of proteolysis and associated methods of use
|
|
RU2738833C9
(ru)
|
2014-04-14 |
2022-02-28 |
Арвинас, Оперэйшнз, Инк. |
Имидные модуляторы протеолиза и способы их применения
|
|
US20160022642A1
(en)
|
2014-07-25 |
2016-01-28 |
Yale University |
Compounds Useful for Promoting Protein Degradation and Methods Using Same
|
|
US10071164B2
(en)
|
2014-08-11 |
2018-09-11 |
Yale University |
Estrogen-related receptor alpha based protac compounds and associated methods of use
|
|
WO2016065139A1
(en)
|
2014-10-24 |
2016-04-28 |
Fl Therapeutics Llc |
3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin
|
|
WO2016105518A1
(en)
|
2014-12-23 |
2016-06-30 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
JP6817962B2
(ja)
|
2015-01-20 |
2021-01-20 |
アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． |
ターゲティングされたアンドロゲン受容体分解のための化合物および方法
|
|
GB201504314D0
(en)
|
2015-03-13 |
2015-04-29 |
Univ Dundee |
Small molecules
|
|
EP3270917A4
(en)
|
2015-03-18 |
2018-08-08 |
Arvinas, Inc. |
Compounds and methods for the enhanced degradation of targeted proteins
|
|
GB201506871D0
(en)
|
2015-04-22 |
2015-06-03 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
SG11201708303XA
(en)
|
2015-05-22 |
2017-11-29 |
Biotheryx Inc |
Compounds targeting proteins, compositions, methods, and uses thereof
|
|
CA2988414C
(en)
|
2015-06-04 |
2023-09-26 |
Arvinas, Inc. |
Imide-based modulators of proteolysis and associated methods of use
|
|
WO2016197114A1
(en)
|
2015-06-05 |
2016-12-08 |
Arvinas, Inc. |
Tank-binding kinase-1 protacs and associated methods of use
|
|
WO2017007612A1
(en)
|
2015-07-07 |
2017-01-12 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
EP3319944A4
(en)
|
2015-07-10 |
2019-04-24 |
Arvinas, Inc. |
MDM2-BASED MODULATORS OF PROTEOLYSIS AND RELATED USE METHODS
|
|
BR112017028269A2
(pt)
|
2015-07-13 |
2018-09-04 |
Arvinas Inc |
composto, composição farmacêutica, uso de uma quantidade efetiva de um composto, estado ou condição de doença, e, método para identificar um composto.
|
|
WO2017024317A2
(en)
|
2015-08-06 |
2017-02-09 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
WO2017024318A1
(en)
|
2015-08-06 |
2017-02-09 |
Dana-Farber Cancer Institute, Inc. |
Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses
|
|
US10772962B2
(en)
|
2015-08-19 |
2020-09-15 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of bromodomain-containing proteins
|
|
BR112018008918A8
(pt)
|
2015-11-02 |
2019-02-26 |
Univ Yale |
compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos
|
|
BR112018068906A2
(pt)
|
2016-03-16 |
2019-01-22 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
composição, método, método de redução de risco, prevenção ou tratamento de um indivíduo que tem uma doença ou distúrbio autoimune, método de indução de degradação de uma proteína-alvo numa célula, método para reduzir o risco, prevenir ou tratar um estado da doença ou afecção num paciente em que a atividade proteica desregulada é responsável pelo referido estado da doença ou afecção, método para reduzir o risco, prevenir ou tratar câncer num indivíduo e método de tratamento de uma doença ou distúrbio genético num indivíduo
|
|
US20170281784A1
(en)
|
2016-04-05 |
2017-10-05 |
Arvinas, Inc. |
Protein-protein interaction inducing technology
|
|
SG11201808728QA
(en)
|
2016-04-06 |
2018-11-29 |
Univ Michigan Regents |
Mdm2 protein degraders
|
|
US10759808B2
(en)
|
2016-04-06 |
2020-09-01 |
The Regents Of The University Of Michigan |
Monofunctional intermediates for ligand-dependent target protein degradation
|
|
KR20180132861A
(ko)
|
2016-04-12 |
2018-12-12 |
더 리젠츠 오브 더 유니버시티 오브 미시간 |
Bet 단백질 분해제
|
|
ES2990061T3
(es)
|
2016-05-10 |
2024-11-28 |
C4 Therapeutics Inc |
Degronímeros espirocíclicos para la degradación de proteínas diana
|
|
EP3454856B1
(en)
|
2016-05-10 |
2024-09-11 |
C4 Therapeutics, Inc. |
Heterocyclic degronimers for target protein degradation
|
|
CN109641874A
(zh)
|
2016-05-10 |
2019-04-16 |
C4医药公司 |
用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
|
|
CN109790143A
(zh)
*
|
2016-05-10 |
2019-05-21 |
C4医药公司 |
用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
|
|
WO2017197056A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Bromodomain targeting degronimers for target protein degradation
|
|
ES2910787T3
(es)
|
2016-05-12 |
2022-05-13 |
Univ Michigan Regents |
Inhibidores de ASH1L y métodos de tratamiento con los mismos
|
|
WO2017201069A1
(en)
|
2016-05-18 |
2017-11-23 |
Biotheryx, Inc. |
Oxoindoline derivatives as protein function modulators
|
|
CN118436801A
(zh)
|
2016-05-20 |
2024-08-06 |
豪夫迈·罗氏有限公司 |
Protac抗体缀合物及其使用方法
|
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
|
US11401255B2
(en)
|
2016-07-28 |
2022-08-02 |
Mayo Foundation For Medical Education And Research |
Small molecule activators of Parkin enzyme function
|
|
CA3036841A1
(en)
|
2016-09-13 |
2018-03-22 |
The Regents Of The University Of Michigan |
Fused 1,4-diazepines as bet protein degraders
|
|
CA3036834A1
(en)
|
2016-09-13 |
2018-03-22 |
The Regents Of The University Of Michigan |
Fused 1,4-oxazepines as bet protein degraders
|
|
GB2554071A
(en)
|
2016-09-14 |
2018-03-28 |
Univ Dundee |
Small molecules
|
|
US20180072711A1
(en)
|
2016-09-15 |
2018-03-15 |
Arvinas, Inc. |
Indole derivatives as estrogen receptor degraders
|
|
CN110506039A
(zh)
|
2016-10-11 |
2019-11-26 |
阿尔维纳斯股份有限公司 |
用于雄激素受体靶向降解的化合物和方法
|
|
US10689366B2
(en)
|
2016-11-01 |
2020-06-23 |
Cornell University |
Compounds for MALT1 degredation
|
|
MX2019005007A
(es)
|
2016-11-01 |
2019-07-18 |
Arvinas Inc |
Protac dirigidos a la proteína tau y métodos asociados de uso.
|
|
BR112019011200B1
(pt)
|
2016-12-01 |
2021-12-28 |
Arvinas Operations, Inc |
Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio
|
|
US10040804B2
(en)
|
2016-12-21 |
2018-08-07 |
Biotheryx, Inc. |
Compounds targeting proteins, compositions, methods, and uses thereof
|
|
KR20250117470A
(ko)
|
2016-12-23 |
2025-08-04 |
아비나스 오퍼레이션스, 인코포레이티드 |
급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법
|
|
US10806737B2
(en)
|
2016-12-23 |
2020-10-20 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
|
|
JP2020505327A
(ja)
|
2016-12-23 |
2020-02-20 |
アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． |
Ｅｇｆｒタンパク質分解標的化キメラ分子およびその関連する使用方法
|
|
US11191741B2
(en)
|
2016-12-24 |
2021-12-07 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
|
|
BR112019015312A2
(pt)
|
2017-01-26 |
2020-03-10 |
Arvinas Operations, Inc. |
Moduladores da proteólise pelo receptor de estrogênio e métodos de uso associados
|
|
IL312367A
(en)
|
2017-01-31 |
2024-06-01 |
Arvinas Operations Inc |
Cereblon ligands and bifunctional compounds comprising the same
|
|
US10406165B2
(en)
|
2017-03-14 |
2019-09-10 |
Biotheryx, Inc. |
Compounds targeting proteins, compositions, methods, and uses thereof
|
|
WO2018183411A1
(en)
|
2017-03-28 |
2018-10-04 |
The Regents Of The University Of Michigan |
Small molecule dcn1 inhibitors and therapeutic methods using the same
|
|
JP7086171B2
(ja)
|
2017-04-10 |
2022-06-17 |
ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン |
共有結合性小分子ｄｃｎ１阻害物質およびそれを使用する治療方法
|
|
CN110573507B
(zh)
|
2017-04-14 |
2023-11-14 |
邓迪大学 |
小分子
|
|
EP4467143B1
(en)
|
2017-07-10 |
2026-03-11 |
Celgene Corporation |
Method for preparing 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-l-yl)-3-fluorobenzonitrile
|
|
WO2019060742A1
(en)
|
2017-09-22 |
2019-03-28 |
Kymera Therapeutics, Inc |
AGENTS FOR DEGRADING PROTEINS AND USES THEREOF
|
|
US11358948B2
(en)
|
2017-09-22 |
2022-06-14 |
Kymera Therapeutics, Inc. |
CRBN ligands and uses thereof
|
|
WO2019140387A1
(en)
|
2018-01-12 |
2019-07-18 |
Kymera Therapeutics, Inc. |
Crbn ligands and uses thereof
|
|
EP3746135A4
(en)
|
2018-01-30 |
2022-03-09 |
Foghorn Therapeutics Inc. |
METHODS AND COMPOUNDS FOR TREATMENT OF DISEASE
|
|
CA3090417A1
(en)
|
2018-02-23 |
2019-08-29 |
Dana-Farber Cancer Institute, Inc. |
Small molecules for inducing selective protein degradation and uses thereof
|
|
IL302595A
(en)
|
2018-04-13 |
2023-07-01 |
Arvinas Operations Inc |
Servalon ligands and bifunctional compounds containing them
|
|
US11771697B2
(en)
|
2018-04-30 |
2023-10-03 |
Dana-Farber Cancer Institute, Inc. |
Small molecule degraders of polybromo-1 (PBRM1)
|
|
AU2019294835B2
(en)
|
2018-06-29 |
2025-04-17 |
Dana-Farber Cancer Institute, Inc. |
Ligands to cereblon (CRBN)
|
|
US12030892B2
(en)
|
2018-06-29 |
2024-07-09 |
Dana-Farber Cancer Institute, Inc. |
CRBN modulators
|
|
US12060366B2
(en)
|
2018-06-29 |
2024-08-13 |
Dana-Farber Cancer Institute, Inc. |
Bispecific degraders
|
|
WO2020010227A1
(en)
|
2018-07-06 |
2020-01-09 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
|
WO2020023851A1
(en)
|
2018-07-26 |
2020-01-30 |
Yale University |
Bifunctional substitued pyrimidines as modulators of fak proteolyse
|
|
JP7297053B2
(ja)
|
2018-08-20 |
2023-06-23 |
アルビナス・オペレーションズ・インコーポレイテッド |
神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ－シヌクレインタンパク質を標的とするタンパク質分解
|
|
IL281188B2
(en)
|
2018-09-07 |
2025-08-01 |
Arvinas Operations Inc |
Polycyclic compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
|
|
MX2021004191A
(es)
|
2018-10-15 |
2021-05-27 |
Nurix Therapeutics Inc |
Compuestos bifuncionales para degradar la tirosina cinasa de bruton (btk) mediante la trayectoria de ubiquitina proteosoma.
|