JP2021519337A - Ｉｋａｒｏｓの分解のためのセレブロン結合剤 - Google Patents
Ｉｋａｒｏｓの分解のためのセレブロン結合剤 Download PDFInfo
- Publication number
- JP2021519337A JP2021519337A JP2020552829A JP2020552829A JP2021519337A JP 2021519337 A JP2021519337 A JP 2021519337A JP 2020552829 A JP2020552829 A JP 2020552829A JP 2020552829 A JP2020552829 A JP 2020552829A JP 2021519337 A JP2021519337 A JP 2021519337A
- Authority
- JP
- Japan
- Prior art keywords
- cycloalkyl
- alkyl
- aryl
- heteroaryl
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 C*C(CC1)CCN1C(CC1N(C)CCC1)=O Chemical compound C*C(CC1)CCN1C(CC1N(C)CCC1)=O 0.000 description 32
- SKRSBROYZONEMK-UHFFFAOYSA-N CC(C(CC1)CCN1C(C1CCC(CNC(C)=O)CC1)=C)=C Chemical compound CC(C(CC1)CCN1C(C1CCC(CNC(C)=O)CC1)=C)=C SKRSBROYZONEMK-UHFFFAOYSA-N 0.000 description 1
- XDNCLZHJPPOMQP-UHFFFAOYSA-N CC(C(CC1)CCN1C(OCc1ccccc1)=O)=C Chemical compound CC(C(CC1)CCN1C(OCc1ccccc1)=O)=C XDNCLZHJPPOMQP-UHFFFAOYSA-N 0.000 description 1
- UQGXHNDRCRTZAC-UHFFFAOYSA-N CC(C)(C)CNC Chemical compound CC(C)(C)CNC UQGXHNDRCRTZAC-UHFFFAOYSA-N 0.000 description 1
- IFGAJZCPWYEVJP-UHFFFAOYSA-N CC(C)C(CC1)CCN1C(CC1CCN(C)CC1)=N Chemical compound CC(C)C(CC1)CCN1C(CC1CCN(C)CC1)=N IFGAJZCPWYEVJP-UHFFFAOYSA-N 0.000 description 1
- KZEIPCUNNHLBJE-UHFFFAOYSA-N CC(C)C(CC1)CCN1C(CC1CCOCC1)=O Chemical compound CC(C)C(CC1)CCN1C(CC1CCOCC1)=O KZEIPCUNNHLBJE-UHFFFAOYSA-N 0.000 description 1
- CMPURDVCPZGUNA-UHFFFAOYSA-N CC(C)C(CC1)CCN1C(CC1CN(C)C1)=O Chemical compound CC(C)C(CC1)CCN1C(CC1CN(C)C1)=O CMPURDVCPZGUNA-UHFFFAOYSA-N 0.000 description 1
- MGMNXYCBARBPMH-UHFFFAOYSA-N CC(C)C(CC1)CCN1C(CC1COC1)=O Chemical compound CC(C)C(CC1)CCN1C(CC1COC1)=O MGMNXYCBARBPMH-UHFFFAOYSA-N 0.000 description 1
- FFEZTXAEQLCIGY-UHFFFAOYSA-N CC(C)C(CC1)CCN1C(Cc1ccc2OCCCOc2c1Cl)=O Chemical compound CC(C)C(CC1)CCN1C(Cc1ccc2OCCCOc2c1Cl)=O FFEZTXAEQLCIGY-UHFFFAOYSA-N 0.000 description 1
- JRIDIIXZVUIYGZ-UHFFFAOYSA-N CC(CCC(CC(C(c1c2c(NCc3c[n](C(CC4)CC[N]4(CC45C6=C7C4C4C7C6C54)C=O)nc3[I]3CC3)ccc1)=C)=CC2=C)C(N)=O)=O Chemical compound CC(CCC(CC(C(c1c2c(NCc3c[n](C(CC4)CC[N]4(CC45C6=C7C4C4C7C6C54)C=O)nc3[I]3CC3)ccc1)=C)=CC2=C)C(N)=O)=O JRIDIIXZVUIYGZ-UHFFFAOYSA-N 0.000 description 1
- BKRULAOSIKJLRB-UHFFFAOYSA-N CC(CCCCC(N)(N)N)=C Chemical compound CC(CCCCC(N)(N)N)=C BKRULAOSIKJLRB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862648238P | 2018-03-26 | 2018-03-26 | |
| US62/648,238 | 2018-03-26 | ||
| PCT/US2019/024094 WO2019191112A1 (en) | 2018-03-26 | 2019-03-26 | Cereblon binders for the degradation of ikaros |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021519337A true JP2021519337A (ja) | 2021-08-10 |
| JPWO2019191112A5 JPWO2019191112A5 (https=) | 2022-03-29 |
| JP2021519337A5 JP2021519337A5 (https=) | 2022-03-29 |
Family
ID=68060453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020552829A Ceased JP2021519337A (ja) | 2018-03-26 | 2019-03-26 | Ｉｋａｒｏｓの分解のためのセレブロン結合剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11753397B2 (https=) |
| EP (1) | EP3773576A4 (https=) |
| JP (1) | JP2021519337A (https=) |
| KR (1) | KR20210018199A (https=) |
| CN (1) | CN111902141A (https=) |
| WO (1) | WO2019191112A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022527216A (ja) * | 2019-04-12 | 2022-05-31 | シー４ セラピューティクス， インコーポレイテッド | Ｉｋａｒｏｓ及びＡｉｏｌｏｓの三環式分解誘導薬 |
| JP2025509610A (ja) * | 2022-03-17 | 2025-04-11 | ギリアード サイエンシーズ， インコーポレイテッド | Ｉｋａｒｏｓジンクフィンガーファミリー分解剤及びその使用 |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| EP4717317A2 (en) | 2017-06-20 | 2026-04-01 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| CN111278816B (zh) | 2017-09-04 | 2024-03-15 | C4医药公司 | 二氢喹啉酮 |
| CN118108706A (zh) | 2017-09-04 | 2024-05-31 | C4医药公司 | 戊二酰亚胺 |
| EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | DEGRADER AND DEGRONE FOR TARGETED PROTEIN DEGRADATION |
| CN119751456A (zh) | 2018-04-16 | 2025-04-04 | C4医药公司 | 螺环化合物 |
| DK3820573T3 (da) * | 2018-07-10 | 2023-10-23 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidin-2,6-dion-derivativer og anvendelse deraf ved behandling af ikaros family zinc finger 2 (ikzf2)-afhængige sygdomme |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| KR102672549B1 (ko) | 2018-09-30 | 2024-06-10 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | 이소인돌린계 화합물, 이의 제조 방법, 약학 조성물 및 용도 |
| EP3896062A4 (en) * | 2018-12-06 | 2022-06-15 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences | ISOINDOLINE COMPOUND, METHOD FOR PREPARATION, PHARMACEUTICAL COMPOSITION AND USE OF ISOINDOLINE COMPOUND |
| KR20210106437A (ko) * | 2018-12-20 | 2021-08-30 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물 |
| CN120698983A (zh) | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
| WO2020181232A1 (en) | 2019-03-06 | 2020-09-10 | C4 Therapeutics, Inc. | Heterocyclic compounds for medical treatment |
| AU2020387392B2 (en) | 2019-11-19 | 2025-09-11 | Bristol-Myers Squibb Company | Compounds useful as inhibitors of Helios protein |
| JP7682181B2 (ja) * | 2019-12-18 | 2025-05-23 | ノバルティス アーゲー | ３－（５－メトキシ－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用 |
| BR112022011827A2 (pt) | 2019-12-20 | 2022-08-30 | C4 Therapeutics Inc | Composto, composição farmacêutica, uso de um composto, métodos para tratamento ou profilaxia de câncer e para tratar um paciente com um distúrbio mediado por receptor do fator de crescimento epidérmico, e, invenção |
| AU2021231898A1 (en) | 2020-03-05 | 2022-10-27 | C4 Therapeutics, Inc. | Compounds for targeted degradation of BRD9 |
| TW202140441A (zh) | 2020-03-23 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 經取代之側氧基異吲哚啉化合物 |
| WO2021222542A1 (en) * | 2020-04-30 | 2021-11-04 | President And Fellows Of Harvard College | 5-amino-2-piperidinon-3-yl-1-oxoisoindoline derivatives for degradation of ikzf2 degraders |
| WO2021255212A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Braf degraders |
| EP4192458A4 (en) | 2020-08-05 | 2024-09-04 | C4 Therapeutics, Inc. | COMPOUNDS FOR TARGETED DEGRADATION OF RET |
| MX2023001545A (es) * | 2020-08-07 | 2023-05-03 | C4 Therapeutics Inc | Terapias ventajosas para trastornos mediados por ikaros o aiolos. |
| BR112023020410A2 (pt) * | 2021-04-05 | 2023-11-28 | Bristol Myers Squibb Co | Compostos de oxoisoindolina substituída por piridinila para tratamento de câncer |
| BR112023020077A2 (pt) * | 2021-04-06 | 2023-11-14 | Bristol Myers Squibb Co | Compostos de oxoisoindolina substituída por piridinila |
| CA3219597A1 (en) * | 2021-06-23 | 2022-12-29 | F. Hoffmann-La Roche Ag | Novel process |
| US20250129047A1 (en) | 2021-07-04 | 2025-04-24 | Newave Pharmaceutical Inc. | Isoquinoline derivatives as mutant egfr modulators and uses thereof |
| CN113603630B (zh) * | 2021-08-10 | 2023-06-27 | 苏州小栗医药科技有限公司 | 一种4-苯基哌啶盐酸盐的合成方法 |
| CN117088864B (zh) * | 2022-05-13 | 2026-03-03 | 广州智药生物科技有限公司 | 一种苯并[d]异恶唑类化合物及其应用 |
| JP2025523393A (ja) | 2022-06-06 | 2025-07-23 | シーフォー セラピューティクス， インコーポレイテッド | 二環式置換グルタルイミドセレブロンバインダー |
| CA3259017A1 (en) * | 2022-06-16 | 2023-12-21 | Prelude Therapeutics Incorporated | KAT6 Targeting Compounds with Ubiquitin Ligasis Bonding Fraction |
| WO2023246944A1 (zh) * | 2022-06-24 | 2023-12-28 | 中国科学院上海药物研究所 | 一类取代的4-氨基异吲哚啉类化合物、其制备方法、药物组合物及应用 |
| CN120303264A (zh) | 2022-09-09 | 2025-07-11 | 医诺康治疗公司 | CK1α和双重CK1α/GSPT1降解化合物 |
| WO2024073507A1 (en) | 2022-09-28 | 2024-04-04 | Theseus Pharmaceuticals, Inc. | Macrocyclic compounds and uses thereof |
| CN118556047A (zh) * | 2022-12-27 | 2024-08-27 | 标新生物医药科技(上海)有限公司 | 氧代异吲哚啉基取代哌啶二酮衍生物及其应用 |
| WO2025006753A2 (en) | 2023-06-30 | 2025-01-02 | Merck Patent Gmbh | Heterobifunctional compounds for the degradation of kras protein |
| WO2025006783A2 (en) | 2023-06-30 | 2025-01-02 | Merck Patent Gmbh | Heterobifunctional compounds for the degradation of kras |
| WO2025063888A1 (en) | 2023-09-19 | 2025-03-27 | Kancure Pte. Ltd. | Survivin-targeted compounds |
| WO2025179161A1 (en) | 2024-02-21 | 2025-08-28 | Innovo Therapeutics, Inc. | Protein degrading compounds |
| US20250333407A1 (en) * | 2024-04-29 | 2025-10-30 | Bristol-Myers Squibb Company | Compounds and Their Use for Treatment of Hemoglobinopathies |
| WO2026035974A1 (en) * | 2024-08-09 | 2026-02-12 | Triana Biomedicines, Inc. | Anaplastic lymphoma kinase (alk) degraders and uses thereof |
Citations (5)
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| JP2017501400A (ja) * | 2013-12-06 | 2017-01-12 | セルジーン コーポレイション | びまん性大細胞型ｂ細胞リンパ腫、多発性骨髄腫、及び骨髄癌の治療の薬効を決定するための方法 |
| WO2017176958A1 (en) * | 2016-04-06 | 2017-10-12 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| WO2017197051A1 (en) * | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Amine-linked c3-glutarimide degronimers for target protein degradation |
| WO2017197056A1 (en) * | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Bromodomain targeting degronimers for target protein degradation |
| JP2018502097A (ja) * | 2014-12-23 | 2018-01-25 | ダナ ファーバー キャンサー インスティテュート，インコーポレイテッド | 二官能性分子によって標的化タンパク質分解を誘導する方法 |
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- 2019-03-26 EP EP19777205.6A patent/EP3773576A4/en not_active Withdrawn
- 2019-03-26 WO PCT/US2019/024094 patent/WO2019191112A1/en not_active Ceased
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| JP7692362B2 (ja) | 2019-04-12 | 2025-06-13 | シーフォー セラピューティクス， インコーポレイテッド | Ｉｋａｒｏｓ及びＡｉｏｌｏｓの三環式分解誘導薬 |
| JP2025131678A (ja) * | 2019-04-12 | 2025-09-09 | シーフォー セラピューティクス， インコーポレイテッド | Ｉｋａｒｏｓ及びＡｉｏｌｏｓの三環式分解誘導薬 |
| JP7846819B2 (ja) | 2019-04-12 | 2026-04-15 | シーフォー セラピューティクス， インコーポレイテッド | Ｉｋａｒｏｓ及びＡｉｏｌｏｓの三環式分解誘導薬 |
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Also Published As
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|---|---|
| US20210009559A1 (en) | 2021-01-14 |
| KR20210018199A (ko) | 2021-02-17 |
| EP3773576A4 (en) | 2021-12-29 |
| CN111902141A (zh) | 2020-11-06 |
| EP3773576A1 (en) | 2021-02-17 |
| US11753397B2 (en) | 2023-09-12 |
| WO2019191112A1 (en) | 2019-10-03 |
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