JP2021094022A5 - - Google Patents

Info

Publication number

JP2021094022A5

JP2021094022A5 JP2020206866A JP2020206866A JP2021094022A5 JP 2021094022 A5 JP2021094022 A5 JP 2021094022A5 JP 2020206866 A JP2020206866 A JP 2020206866A JP 2020206866 A JP2020206866 A JP 2020206866A JP 2021094022 A5 JP2021094022 A5 JP 2021094022A5

Authority

JP

Japan

Prior art keywords

amino acid

bispecific antibody

seq

acid sequence

mutation

Prior art date

2020-12-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 52
• 230000035772 mutation Effects 0.000 claims 35
• 238000006467 substitution reaction Methods 0.000 claims 22
• 101000958332 Homo sapiens Lymphocyte antigen 6 complex locus protein G6d Proteins 0.000 claims 15
• 101000958312 Homo sapiens Lymphocyte antigen 6 complex locus protein G6f Proteins 0.000 claims 15
• 102100038210 Lymphocyte antigen 6 complex locus protein G6d Human genes 0.000 claims 15
• 206010009944 Colon cancer Diseases 0.000 claims 6
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 6
• 208000032818 Microsatellite Instability Diseases 0.000 claims 6
• 206010028980 Neoplasm Diseases 0.000 claims 6
• 201000011510 cancer Diseases 0.000 claims 6
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 4
• 229920001184 polypeptide Polymers 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 108090000765 processed proteins & peptides Proteins 0.000 claims 4
• 125000000539 amino acid group Chemical group 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 102220534532 Protein quaking_Q38K_mutation Human genes 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 102220138687 rs201607115 Human genes 0.000 claims 2
• 102220044848 rs377730553 Human genes 0.000 claims 2
• 102220321637 rs377730553 Human genes 0.000 claims 2
• 239000013598 vector Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108091092878 Microsatellite Proteins 0.000 claims 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 230000000781 anti-lymphocytic effect Effects 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 230000004069 differentiation Effects 0.000 claims 1
• 230000009977 dual effect Effects 0.000 claims 1
• 239000012636 effector Substances 0.000 claims 1
• 230000013595 glycosylation Effects 0.000 claims 1
• 238000006206 glycosylation reaction Methods 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1