JP2023085476A5 - - Google Patents
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- JP2023085476A5 JP2023085476A5 JP2023061823A JP2023061823A JP2023085476A5 JP 2023085476 A5 JP2023085476 A5 JP 2023085476A5 JP 2023061823 A JP2023061823 A JP 2023061823A JP 2023061823 A JP2023061823 A JP 2023061823A JP 2023085476 A5 JP2023085476 A5 JP 2023085476A5
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- Prior art keywords
- seq
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- cdr
- binding protein
- amino acid
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Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562246113P | 2015-10-25 | 2015-10-25 | |
| US62/246,113 | 2015-10-25 | ||
| EP16305211 | 2016-02-24 | ||
| EP16305211.1 | 2016-02-24 | ||
| US201662322029P | 2016-04-13 | 2016-04-13 | |
| US62/322,029 | 2016-04-13 | ||
| US201662331169P | 2016-05-03 | 2016-05-03 | |
| US62/331,169 | 2016-05-03 | ||
| JP2018521308A JP7169190B2 (ja) | 2015-10-25 | 2016-10-24 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
| JP2021016190A JP7328267B2 (ja) | 2015-10-25 | 2021-02-04 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021016190A Division JP7328267B2 (ja) | 2015-10-25 | 2021-02-04 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023085476A JP2023085476A (ja) | 2023-06-20 |
| JP2023085476A5 true JP2023085476A5 (cg-RX-API-DMAC7.html) | 2024-03-22 |
| JP7724814B2 JP7724814B2 (ja) | 2025-08-18 |
Family
ID=55588187
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521308A Active JP7169190B2 (ja) | 2015-10-25 | 2016-10-24 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
| JP2021016190A Active JP7328267B2 (ja) | 2015-10-25 | 2021-02-04 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
| JP2023061823A Active JP7724814B2 (ja) | 2015-10-25 | 2023-04-06 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521308A Active JP7169190B2 (ja) | 2015-10-25 | 2016-10-24 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
| JP2021016190A Active JP7328267B2 (ja) | 2015-10-25 | 2021-02-04 | Ｈｉｖ感染症の予防または処置のための三重特異性および／または三価結合タンパク質 |
Country Status (31)
Families Citing this family (32)
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| US10308707B2 (en) | 2013-12-02 | 2019-06-04 | Aaron Diamond Aids Research Center | Bispecific HIV-1-neutralizing antibodies |
| WO2015128846A1 (en) * | 2014-02-28 | 2015-09-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Broadly neutralizing monoclonal antibodies against hiv-1 v1v2 env region |
| HRP20211528T1 (hr) * | 2015-10-25 | 2021-12-24 | Sanofi | Trispecifični i/ili trovalentni vezujući proteini za prevenciju ili liječenje hiv infekcije |
| AU2016349392B2 (en) * | 2015-11-03 | 2023-07-13 | The Trustees Of Columbia University In The City Of New York | Neutralizing antibodies to HIV-1 gp41 and their use |
| SG11201808911SA (en) * | 2016-04-13 | 2018-11-29 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
| DK3443006T5 (da) | 2016-04-13 | 2024-09-16 | Sanofi Sa | Trispecifikke og/eller trivalente bindingsproteiner |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2018151841A1 (en) | 2017-02-17 | 2018-08-23 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| JP7304288B2 (ja) | 2017-02-17 | 2023-07-06 | サノフイ | ジストログリカンおよびラミニン２に対する特異性を有する多特異性結合性分子 |
| WO2018183294A1 (en) * | 2017-03-27 | 2018-10-04 | David Weiner | Dna antibody constructs for use against hiv |
| CA3065328C (en) | 2017-06-21 | 2023-08-15 | Gilead Sciences, Inc. | Multispecific antibodies that target hiv gp120 and cd3 |
| CN111788225B (zh) * | 2017-10-10 | 2025-02-18 | 赛诺菲 | 抗cd38抗体及与抗cd3和抗cd28抗体的组合 |
| JP2021507717A (ja) * | 2017-12-18 | 2021-02-25 | ビーブ、ヘルスケア、ユーケー、（ナンバー５）、リミテッドＶｉｉｖ Ｈｅａｌｔｈｃａｒｅ Ｕｋ （Ｎｏ．５） Ｌｉｍｉｔｅｄ | 抗原結合性ポリペプチド |
| JP7345861B2 (ja) * | 2017-12-21 | 2023-09-19 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 二重特異性ｈｉｖ－１中和抗体 |
| CN111801580B (zh) | 2018-01-12 | 2024-08-23 | 建新公司 | 用于定量多肽的方法 |
| US11845788B2 (en) | 2018-05-22 | 2023-12-19 | Beth Israel Deaconess Medical Center, Inc. | Antibody therapies for human immunodeficiency virus (HIV) |
| WO2020076853A1 (en) * | 2018-10-09 | 2020-04-16 | Sanofi | Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infection |
| WO2020106713A1 (en) * | 2018-11-21 | 2020-05-28 | Beth Israel Deaconess Medical Center, Inc. | Antibody therapies for human immunodeficiency virus (hiv) |
| TW202104274A (zh) | 2019-04-09 | 2021-02-01 | 法商賽諾菲公司 | 用於治療ｈｉｖ感染之三特異性及／或三價結合蛋白 |
| MY208876A (en) * | 2019-04-09 | 2025-06-05 | Sanofi Sa | Trispecific binding proteins, methods, and uses thereof |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| BR112022007664A2 (pt) | 2019-10-25 | 2022-08-09 | Sanofi Sa | Métodos para analisar o pareamento incorreto de cadeias em proteínas de ligação multiespecíficas |
| US20230203466A1 (en) * | 2020-04-03 | 2023-06-29 | Medgenome Inc. | Ace2 receptor polymorphisms and varying susceptibility to sars-cov-2, methods for diagnosis and treatment |
| BR112023003366A2 (pt) | 2020-08-25 | 2023-05-09 | Gilead Sciences Inc | Moléculas multiespecíficas de ligação ao antígeno que têm como alvo hiv e métodos de uso |
| IL311762A (en) * | 2021-09-29 | 2024-05-01 | Modex Therapeutics Inc | Antigen-binding polypeptides, antigen-binding peptide complexes and methods for their use in HIV |
| AU2022356387A1 (en) * | 2021-09-29 | 2024-04-18 | Modex Therapeutics, Inc. | Antigen binding polypeptides, antigen binding polypeptide complexes and methods of use thereof |
| CN118317979A (zh) * | 2021-09-29 | 2024-07-09 | 摩德斯医疗股份有限公司 | 抗原结合多肽、抗原结合多肽复合物及其使用方法 |
| WO2025109206A1 (en) | 2023-11-22 | 2025-05-30 | Mabylon Ag | Multispecific anti-allergen antibodies and uses thereof |
| WO2025108551A1 (en) | 2023-11-23 | 2025-05-30 | Mabylon Ag | Multispecific anti-allergen antibodies and uses thereof |
| WO2025238419A1 (en) | 2024-05-17 | 2025-11-20 | Sanofi | Methods of treating cancer using trispecific binding proteins targeting her2-expressing tumors |
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| ATE108068T1 (de) | 1987-09-23 | 1994-07-15 | Bristol Myers Squibb Co | Antikörper-heterokonjugate zur töting von hiv- infizierten zellen. |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| IL138608A0 (en) | 1998-04-02 | 2001-10-31 | Genentech Inc | Antibody variants and fragments thereof |
| EP2316951A1 (en) | 2001-01-17 | 2011-05-04 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| CN1294148C (zh) | 2001-04-11 | 2007-01-10 | 中国科学院遗传与发育生物学研究所 | 环状单链三特异抗体 |
| JP5091476B2 (ja) | 2003-06-27 | 2012-12-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 均質な抗体溶液の生成のための疎水性相互作用クロマトグラフィーまたはヒンジ領域改変の使用 |
| US9200061B2 (en) | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
| CN100376599C (zh) | 2004-04-01 | 2008-03-26 | 北京安波特基因工程技术有限公司 | 基因工程重组抗cea抗cd3抗cd28线性单链三特异抗体 |
| EP2014680A1 (en) * | 2007-07-10 | 2009-01-14 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Recombinant, single-chain, trivalent tri-specific or bi-specific antibody derivatives |
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| AU2010298025B2 (en) | 2009-09-25 | 2016-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to HIV-1 and their use |
| SI2580243T1 (sl) | 2010-06-09 | 2020-02-28 | Genmab A/S | Protitelesa proti humanemu CD38 |
| WO2012065055A2 (en) | 2010-11-12 | 2012-05-18 | The Rockefeller University | Fusion proteins for hiv therapy |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| TWI743461B (zh) | 2011-03-28 | 2021-10-21 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
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| EA201990685A1 (ru) * | 2011-05-17 | 2019-12-30 | Дзе Рокфеллер Юниверсити | Нейтрализующие вирус иммунодефицита человека антитела и способы их применения |
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| BR112014010823B1 (pt) | 2011-11-07 | 2021-02-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | anticorpos que se ligam a gp41 e neutralizam o vírus da imunodeficiência humana tipo 1 (hiv-1), seus usos, molécula de ácido nucleico, vetor de expressão, composição, kit, bem como métodos de detecção de infecção pelo hiv-1 e de teste de imunógeno potencial |
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| US9951106B2 (en) | 2012-12-04 | 2018-04-24 | University Of Maryland, Baltimore | Recombinant fusion protein comprising HIV gp120 linked to an enhancing CD4 binding site mAb |
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| WO2016187580A1 (en) | 2015-05-20 | 2016-11-24 | Quantum-Si Incorporated | Method of determining the sequence of a nuclear acid using time resolved luminescence |
| US10654943B2 (en) | 2015-06-02 | 2020-05-19 | The Rockefeller University | Tri-specific antibodies for HIV therapy |
| KR20180050413A (ko) | 2015-09-22 | 2018-05-14 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Hiv 감염을 치료하기 위해 t 세포를 리디렉션시키는 방법 |
| HRP20211528T1 (hr) | 2015-10-25 | 2021-12-24 | Sanofi | Trispecifični i/ili trovalentni vezujući proteini za prevenciju ili liječenje hiv infekcije |
| CN105837688B (zh) | 2015-11-20 | 2019-02-26 | 北京大学深圳研究生院 | 单域抗体及其编码基因，免疫毒素及其编码基因、制备方法、表达载体、应用，及宿主细胞 |
| MY196200A (en) | 2015-12-15 | 2023-03-22 | Gilead Sciences Inc | Human Immunodeficiency Virus Neutralizing Antibodies |
| SG11201808911SA (en) | 2016-04-13 | 2018-11-29 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
| DK3443006T5 (da) | 2016-04-13 | 2024-09-16 | Sanofi Sa | Trispecifikke og/eller trivalente bindingsproteiner |
| EP3575319A4 (en) | 2016-12-30 | 2021-03-10 | Shanghai Sinobio Biotech Co., Ltd. | BIFUNCTIONAL MOLECULE AND USE OF IT |
| JP7304288B2 (ja) | 2017-02-17 | 2023-07-06 | サノフイ | ジストログリカンおよびラミニン２に対する特異性を有する多特異性結合性分子 |
| WO2018151841A1 (en) | 2017-02-17 | 2018-08-23 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| WO2018183294A1 (en) | 2017-03-27 | 2018-10-04 | David Weiner | Dna antibody constructs for use against hiv |
| CN111788225B (zh) | 2017-10-10 | 2025-02-18 | 赛诺菲 | 抗cd38抗体及与抗cd3和抗cd28抗体的组合 |
| WO2020076853A1 (en) | 2018-10-09 | 2020-04-16 | Sanofi | Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infection |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
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2016
- 2016-10-24 HR HRP20211528TT patent/HRP20211528T1/hr unknown
- 2016-10-24 SG SG11201803324VA patent/SG11201803324VA/en unknown
- 2016-10-24 BR BR112018008011-0A patent/BR112018008011A2/en not_active Application Discontinuation
- 2016-10-24 CA CA3002664A patent/CA3002664A1/en active Pending
- 2016-10-24 CN CN202310185803.8A patent/CN117069855A/zh active Pending
- 2016-10-24 EP EP20197556.2A patent/EP3819310A1/en active Pending
- 2016-10-24 US US15/770,471 patent/US20190054182A1/en not_active Abandoned
- 2016-10-24 NZ NZ781602A patent/NZ781602A/en unknown
- 2016-10-24 PL PL16794472T patent/PL3365366T3/pl unknown
- 2016-10-24 EA EA201891028A patent/EA201891028A1/ru unknown
- 2016-10-24 ES ES16794472T patent/ES2894304T3/es active Active
- 2016-10-24 JP JP2018521308A patent/JP7169190B2/ja active Active
- 2016-10-24 CN CN202310186776.6A patent/CN116789841A/zh active Pending
- 2016-10-24 CN CN202310147287.XA patent/CN116675776A/zh active Pending
- 2016-10-24 SI SI201631358T patent/SI3365366T1/sl unknown
- 2016-10-24 IL IL301140A patent/IL301140A/en unknown
- 2016-10-24 EP EP16794472.7A patent/EP3365366B1/en active Active
- 2016-10-24 HU HUE16794472A patent/HUE056608T2/hu unknown
- 2016-10-24 PE PE2018000603A patent/PE20181167A1/es unknown
- 2016-10-24 CR CR20180288A patent/CR20180288A/es unknown
- 2016-10-24 AU AU2016347058A patent/AU2016347058B2/en active Active
- 2016-10-24 MA MA42641A patent/MA42641A1/fr unknown
- 2016-10-24 CN CN201680075852.4A patent/CN109311966B/zh active Active
- 2016-10-24 KR KR1020187014534A patent/KR102687212B1/ko active Active
- 2016-10-24 MY MYPI2018701634A patent/MY192278A/en unknown
- 2016-10-24 RS RS20211266A patent/RS62437B1/sr unknown
- 2016-10-24 WO PCT/US2016/058540 patent/WO2017074878A1/en not_active Ceased
- 2016-10-24 MX MX2018005048A patent/MX2018005048A/es unknown
- 2016-10-25 UY UY0001036965A patent/UY36965A/es not_active Application Discontinuation
- 2016-10-25 TW TW113100534A patent/TW202442675A/zh unknown
- 2016-10-25 TW TW110126977A patent/TW202219064A/zh unknown
- 2016-10-25 TW TW105134405A patent/TWI750139B/zh active
- 2016-10-25 AR ARP160103249A patent/AR106466A1/es unknown
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2018
- 2018-04-20 DO DO2018000102A patent/DOP2018000102A/es unknown
- 2018-04-22 IL IL258822A patent/IL258822B2/en unknown
- 2018-04-23 PH PH12018500873A patent/PH12018500873A1/en unknown
- 2018-04-23 CL CL2018001065A patent/CL2018001065A1/es unknown
- 2018-04-24 MX MX2022014631A patent/MX2022014631A/es unknown
- 2018-05-22 CO CONC2018/0005337A patent/CO2018005337A2/es unknown
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2019
- 2019-10-21 US US16/659,426 patent/US11129905B2/en active Active
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2021
- 2021-02-04 JP JP2021016190A patent/JP7328267B2/ja active Active
- 2021-08-17 US US17/404,908 patent/US11779651B2/en active Active
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2023
- 2023-04-06 JP JP2023061823A patent/JP7724814B2/ja active Active
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2024
- 2024-01-22 AU AU2024200395A patent/AU2024200395A1/en active Pending
- 2024-11-26 US US18/960,890 patent/US20250312475A1/en active Pending