JP2021098732A5 - - Google Patents
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- JP2021098732A5 JP2021098732A5 JP2021037440A JP2021037440A JP2021098732A5 JP 2021098732 A5 JP2021098732 A5 JP 2021098732A5 JP 2021037440 A JP2021037440 A JP 2021037440A JP 2021037440 A JP2021037440 A JP 2021037440A JP 2021098732 A5 JP2021098732 A5 JP 2021098732A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 166
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 38
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 37
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 37
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 37
- 102000004169 proteins and genes Human genes 0.000 claims 32
- 108090000623 proteins and genes Proteins 0.000 claims 32
- 239000000427 antigen Substances 0.000 claims 24
- 102000036639 antigens Human genes 0.000 claims 24
- 108091007433 antigens Proteins 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 8
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 6
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 6
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 6
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 6
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 6
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 6
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 5
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 5
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 5
- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 3
- HKZAAJSTFUZYTO-LURJTMIESA-N (2s)-2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoic acid Chemical compound NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(O)=O HKZAAJSTFUZYTO-LURJTMIESA-N 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 208000003200 Adenoma Diseases 0.000 claims 1
- 206010001233 Adenoma benign Diseases 0.000 claims 1
- 206010001413 Adult T-cell lymphoma/leukaemia Diseases 0.000 claims 1
- IPWKGIFRRBGCJO-IMJSIDKUSA-N Ala-Ser Chemical compound C[C@H]([NH3+])C(=O)N[C@@H](CO)C([O-])=O IPWKGIFRRBGCJO-IMJSIDKUSA-N 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000027190 Peripheral T-cell lymphomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 1
- 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000020968 mature T-cell and NK-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 230000009826 neoplastic cell growth Effects 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 239000001608 potassium adipate Substances 0.000 claims 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 201000006845 reticulosarcoma Diseases 0.000 claims 1
- 208000029922 reticulum cell sarcoma Diseases 0.000 claims 1
- 239000001601 sodium adipate Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000000115 thoracic cavity Anatomy 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762546300P | 2017-08-16 | 2017-08-16 | |
| US201762546297P | 2017-08-16 | 2017-08-16 | |
| US62/546,300 | 2017-08-16 | ||
| US62/546,297 | 2017-08-16 | ||
| US201762552152P | 2017-08-30 | 2017-08-30 | |
| US62/552,152 | 2017-08-30 | ||
| US201762555114P | 2017-09-07 | 2017-09-07 | |
| US62/555,114 | 2017-09-07 | ||
| JP2020508477A JP2020531438A (ja) | 2017-08-16 | 2018-08-16 | Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｈｌａ−ｅ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020508477A Division JP2020531438A (ja) | 2017-08-16 | 2018-08-16 | Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｈｌａ−ｅ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021098732A JP2021098732A (ja) | 2021-07-01 |
| JP2021098732A5 true JP2021098732A5 (cg-RX-API-DMAC7.html) | 2021-09-24 |
Family
ID=65362495
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020508477A Pending JP2020531438A (ja) | 2017-08-16 | 2018-08-16 | Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｈｌａ−ｅ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質 |
| JP2021037440A Pending JP2021098732A (ja) | 2017-08-16 | 2021-03-09 | Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020508477A Pending JP2020531438A (ja) | 2017-08-16 | 2018-08-16 | Ｎｋｇ２ｄ、ｃｄ１６、およびｅｇｆｒ、ｈｌａ−ｅ、ｃｃｒ４、またはｐｄ−ｌ１に結合するタンパク質 |
Country Status (12)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250089564A (ko) | 2017-02-08 | 2025-06-18 | 드래곤플라이 쎄라퓨틱스, 인크. | 천연 킬러 세포의 활성화를 위한 다중-특이적 결합 단백질 및 암 치료에서의 그의 치료적 용도 |
| KR20190120782A (ko) | 2017-02-20 | 2019-10-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Her2, nkg2d 및 cd16에 결합하는 단백질 |
| CA3090244A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the nkg2d receptor |
| PE20210375A1 (es) | 2018-02-08 | 2021-03-02 | Dragonfly Therapeutics Inc | Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales |
| CN112119093A (zh) | 2018-02-20 | 2020-12-22 | 蜻蜓治疗公司 | 结合cd33、nkg2d和cd16的多特异性结合蛋白和使用方法 |
| WO2019222449A1 (en) * | 2018-05-16 | 2019-11-21 | Dragonfly Therapeutics, Inc. | Protein binding nkg2d, cd16 and a fibroblast activation protein |
| EA202091977A1 (ru) * | 2018-05-28 | 2021-02-09 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения |
| CA3108427A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| BR112021002276A2 (pt) | 2018-08-08 | 2021-05-04 | Dragonfly Therapeutics, Inc. | proteínas de ligação a nkg2d, cd16 e um antígeno associado ao tumor |
| US20230067182A1 (en) * | 2019-11-29 | 2023-03-02 | Boe Technology Group Co., Ltd. | Data Processing Device and Method, and Computer Readable Storage Medium |
| EP4137510A4 (en) * | 2020-04-16 | 2023-11-01 | YiChen Therapeutics Limited | PD-1 MUTANT POLYPEPTIDE AND PRODUCTION AND USE THEREOF |
| US12157771B2 (en) * | 2020-05-06 | 2024-12-03 | Dragonfly Therapeutics, Inc. | Proteins binding NKG2D, CD16 and CLEC12A |
| CN117730096A (zh) * | 2020-08-05 | 2024-03-19 | 蜻蜓疗法股份有限公司 | 结合nkg2d、cd16和egfr的蛋白质 |
| CN112029001B (zh) * | 2020-09-02 | 2022-09-06 | 南京北恒生物科技有限公司 | 靶向nk激活性受体的嵌合抗原受体 |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| CN115246886A (zh) * | 2021-04-27 | 2022-10-28 | 丹生医药技术(上海)有限公司 | 一种抗egfr/vegf双功能融合蛋白及其用途 |
| AU2022309554A1 (en) * | 2021-07-14 | 2024-02-22 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Antigen-binding molecule specifically binding to hgfr and egfr, and pharmaceutical use thereof |
| CN116284430A (zh) * | 2021-07-30 | 2023-06-23 | 广东菲鹏制药股份有限公司 | 靶向肿瘤的il15融合蛋白及其应用 |
| EP4402178A2 (en) * | 2021-09-16 | 2024-07-24 | Biohaven Therapeutics Ltd. | Conjugated antibodies for treating diseases |
| WO2023154796A2 (en) * | 2022-02-09 | 2023-08-17 | Dragonfly Therapeutics, Inc. | Pharmaceutical formulations and therapeutic uses of multi-specific binding proteins that bind egfr, nkg2d, and cd16 |
| EP4565621A1 (en) * | 2022-08-05 | 2025-06-11 | Chimagen Biosciences, Ltd | Multi-specific antibodies targeting a dimerizable tumor antigen and an immunostimulatory antigen |
| CN121100134A (zh) * | 2023-04-14 | 2025-12-09 | 山东先声生物制药有限公司 | 一种靶向人cd16和肿瘤抗原的多特异性抗体 |
| WO2025011471A1 (en) * | 2023-07-07 | 2025-01-16 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Egfr/c-met bispecific binding protein and use thereof |
| WO2025011470A1 (en) * | 2023-07-07 | 2025-01-16 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Egfr/c-met bispecific binding protein and use thereof |
| TW202517675A (zh) * | 2023-07-19 | 2025-05-01 | 大陸商映恩生物製藥（蘇州）有限公司 | 一種雙特異性抗體、其藥物偶聯物及其用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007048849A1 (en) * | 2005-10-28 | 2007-05-03 | Novo Nordisk A/S | Fusion proteins that bind effector lymphocytes and target cells |
| AU2008254951A1 (en) * | 2007-05-14 | 2008-11-27 | Biogen Idec Ma Inc. | Single-chain Fc (ScFc) regions, binding polypeptides comprising same, and methods related thereto |
| TWI468174B (zh) | 2007-12-14 | 2015-01-11 | Novo Nordisk As | 針對人類ｎｋｇ２ｄ的抗體及其用途 |
| WO2010017103A2 (en) | 2008-08-04 | 2010-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Fully human anti-human nkg2d monoclonal antibodies |
| UY32808A (es) * | 2009-07-29 | 2011-02-28 | Abbott Lab | Inmunoglobulinas como dominio variable dual y usos de las mismas |
| US9334331B2 (en) * | 2010-11-17 | 2016-05-10 | Chugai Seiyaku Kabushiki Kaisha | Bispecific antibodies |
| WO2012158818A2 (en) * | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| US8790651B2 (en) * | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| EP2922874A4 (en) * | 2012-11-21 | 2016-10-19 | Wuhan Yzy Biopharma Co Ltd | BISPECIFIC ANTIBODIES |
| EP2951203B1 (en) * | 2013-03-15 | 2019-05-22 | Xencor, Inc. | Heterodimeric proteins |
| WO2015095412A1 (en) | 2013-12-19 | 2015-06-25 | Zhong Wang | Bispecific antibody with two single-domain antigen-binding fragments |
| NZ720353A (en) * | 2013-12-30 | 2019-12-20 | Epimab Biotherapeutics Inc | Fabs-in-tandem immunoglobulin and uses thereof |
| CN113549153A (zh) * | 2014-05-29 | 2021-10-26 | 宏观基因有限公司 | 三特异性结合分子和其使用方法 |
| SG11201701385WA (en) * | 2014-08-28 | 2017-03-30 | Academisch Ziekenhuis Leiden | Cd94/nkg2a and/or cd94/nkg2b antibody, vaccine combinations |
| WO2016070959A1 (en) * | 2014-11-03 | 2016-05-12 | Merck Patent Gmbh | Methods for generating bispecific shark variable antibody domains and use thereof |
| NZ771568A (en) * | 2015-01-02 | 2024-11-29 | Takeda Pharmaceuticals Co | Bispecific antibodies against plasma kallikrein and factor xii |
| WO2016122701A1 (en) * | 2015-01-26 | 2016-08-04 | Macrogenics, Inc. | Anti-dr5 antibodies and molecules comprising dr5-binding domains thereof |
| CN107530424A (zh) | 2015-02-20 | 2018-01-02 | 俄亥俄州国家创新基金会 | 针对nkg2d和肿瘤相关抗原的二价抗体 |
| US20180147257A1 (en) * | 2015-05-22 | 2018-05-31 | The Board Of Trustees Of The Leland Stanford Junior University | Btn3a ectodomain proteins and methods of use |
| GB201517538D0 (en) * | 2015-10-05 | 2015-11-18 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers |
| IL304871A (en) * | 2016-01-11 | 2023-10-01 | Inhibrx Inc | Multispecific and multivalent binding fusion proteins - 41BB, preparations containing them and their uses |
| WO2017134301A1 (en) * | 2016-02-05 | 2017-08-10 | Orionis Biosciences Nv | Clec9a binding agents |
| CN109310766A (zh) * | 2016-02-26 | 2019-02-05 | 伊蒙纽斯私人有限公司 | 多特异性分子 |
-
2018
- 2018-08-16 JP JP2020508477A patent/JP2020531438A/ja active Pending
- 2018-08-16 CA CA3112990A patent/CA3112990A1/en active Pending
- 2018-08-16 KR KR1020217006762A patent/KR20210029298A/ko not_active Abandoned
- 2018-08-16 AU AU2018318698A patent/AU2018318698A1/en not_active Abandoned
- 2018-08-16 MX MX2020001805A patent/MX2020001805A/es unknown
- 2018-08-16 CA CA3176049A patent/CA3176049A1/en active Pending
- 2018-08-16 US US16/638,559 patent/US20200216544A1/en not_active Abandoned
- 2018-08-16 CN CN202110256674.8A patent/CN113004391A/zh active Pending
- 2018-08-16 SG SG10202102251YA patent/SG10202102251YA/en unknown
- 2018-08-16 KR KR1020207007137A patent/KR20200037388A/ko not_active Ceased
- 2018-08-16 CA CA3073117A patent/CA3073117A1/en not_active Abandoned
- 2018-08-16 WO PCT/US2018/000212 patent/WO2019035939A1/en not_active Ceased
- 2018-08-16 BR BR112020003050-3A patent/BR112020003050A2/pt not_active IP Right Cessation
- 2018-08-16 CN CN201880053214.1A patent/CN111065649A/zh active Pending
- 2018-08-16 SG SG11201913969SA patent/SG11201913969SA/en unknown
- 2018-08-16 EP EP18846836.7A patent/EP3668893A4/en not_active Withdrawn
- 2018-08-16 EP EP21164058.6A patent/EP3882270A3/en not_active Withdrawn
-
2020
- 2020-02-09 IL IL272553A patent/IL272553A/en unknown
- 2020-02-14 MX MX2021002969A patent/MX2021002969A/es unknown
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2021
- 2021-03-01 US US17/188,978 patent/US20210261668A1/en not_active Abandoned
- 2021-03-05 AU AU2021201451A patent/AU2021201451A1/en not_active Abandoned
- 2021-03-07 IL IL281305A patent/IL281305A/en unknown
- 2021-03-09 JP JP2021037440A patent/JP2021098732A/ja active Pending