|
US6773669B1
(en)
|
1995-03-10 |
2004-08-10 |
Maxcyte, Inc. |
Flow electroporation chamber and method
|
|
US6090617A
(en)
|
1996-12-05 |
2000-07-18 |
Entremed, Inc. |
Flow electroporation chamber with electrodes having a crystalline metal nitride coating
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
WO2001083751A2
(en)
|
2000-04-28 |
2001-11-08 |
Sangamo Biosciences, Inc. |
Methods for binding an exogenous molecule to cellular chromatin
|
|
US7029916B2
(en)
|
2001-02-21 |
2006-04-18 |
Maxcyte, Inc. |
Apparatus and method for flow electroporation of biological samples
|
|
MXPA03009622A
(es)
|
2001-04-23 |
2005-03-07 |
Amaxa Gmbh |
Solucion amortiguadora para electroporacion y metodo que comprende el uso de la misma.
|
|
WO2003018751A2
(en)
|
2001-08-22 |
2003-03-06 |
Maxcyte, Inc. |
Apparatus and method for electroporation of biological samples
|
|
US20050136040A1
(en)
|
2001-10-11 |
2005-06-23 |
Imperial College Innovations Limited |
Control of gene expression using a complex of an oligonucleotide and a regulatory peptide
|
|
GB0124391D0
(en)
|
2001-10-11 |
2001-11-28 |
Gene Expression Technologies L |
Control of gene expression
|
|
EP1504092B2
(en)
|
2002-03-21 |
2014-06-25 |
Sangamo BioSciences, Inc. |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
|
|
ITMI20030821A1
(it)
|
2003-04-18 |
2004-10-19 |
Internat Ct For Genetic En Gineering And |
Polipeptidi chimerici e loro uso.
|
|
US20060182736A1
(en)
|
2003-06-10 |
2006-08-17 |
Kim Jin-Soo |
Transducible dna-binding proteins
|
|
US8133733B2
(en)
|
2003-10-24 |
2012-03-13 |
Gencia Corporation |
Nonviral vectors for delivering polynucleotides to target tissues
|
|
ES2294757T3
(es)
|
2004-03-15 |
2008-04-01 |
Amaxa Ag |
Recipiente y dispositivo para generar campos electricos en espacios de reaccion individuales.
|
|
KR101301929B1
(ko)
|
2004-05-12 |
2013-09-02 |
맥스시티 인코포레이티드 |
조절된 유동 전기 천공 챔버에 관한 방법 및 장치
|
|
EP1766004B1
(en)
|
2004-06-12 |
2016-08-31 |
Invitrogen Singapore Pte. Ltd. |
Electroporator having an elongated hollow member
|
|
EP1607484B1
(de)
|
2004-06-14 |
2014-04-02 |
Lonza Cologne GmbH |
Verfahren und Schaltungsanordnung zur Behandlung von biologischem Material
|
|
EP1774036A4
(en)
|
2004-06-14 |
2008-10-15 |
Univ Texas At Austin |
GEN-TARGETING IN EUKARYOTIC CELLS BY GROUP II INTRON-RIBONUCLEOPROTEIN PARTICLES
|
|
US7991559B2
(en)
|
2004-11-30 |
2011-08-02 |
Maxcyte Inc. |
Computerized electroporation
|
|
US10022457B2
(en)
|
2005-08-05 |
2018-07-17 |
Gholam A. Peyman |
Methods to regulate polarization and enhance function of cells
|
|
CA2619833C
(en)
|
2005-08-26 |
2017-05-09 |
Danisco A/S |
Use of crispr associated genes (cas)
|
|
CA2660485C
(en)
|
2006-08-11 |
2016-04-12 |
Sangamo Biosciences, Inc. |
Zinc finger nuclease-mediated homologous recombination
|
|
JP5779090B2
(ja)
|
2008-04-09 |
2015-09-16 |
マックスサイト インコーポレーティッド |
新規に単離された細胞の治療組成物の操作および送達
|
|
EP2310500B1
(en)
|
2008-07-18 |
2015-03-11 |
Maxcyte, Inc. |
Methods for optimizing electroporation
|
|
US20110239315A1
(en)
|
2009-01-12 |
2011-09-29 |
Ulla Bonas |
Modular dna-binding domains and methods of use
|
|
US9221886B2
(en)
|
2009-04-28 |
2015-12-29 |
President And Fellows Of Harvard College |
Supercharged proteins for cell penetration
|
|
WO2011059836A2
(en)
|
2009-10-29 |
2011-05-19 |
Trustees Of Dartmouth College |
T cell receptor-deficient t cell compositions
|
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
|
EP3456826B1
(en)
|
2009-12-10 |
2023-06-28 |
Regents of the University of Minnesota |
Tal effector-mediated dna modification
|
|
KR101880536B1
(ko)
|
2010-04-26 |
2018-07-23 |
상가모 테라퓨틱스, 인코포레이티드 |
아연 핑거 뉴클레아제를 사용하는 로사 좌위의 게놈 편집
|
|
US8876458B2
(en)
|
2011-01-25 |
2014-11-04 |
United Technologies Corporation |
Blade outer air seal assembly and support
|
|
WO2013074916A1
(en)
|
2011-11-18 |
2013-05-23 |
Board Of Regents, The University Of Texas System |
Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US20130236504A1
(en)
|
2012-03-06 |
2013-09-12 |
Medical University Of South Carolina |
Delivery System for Enhancing Drug Efficacy
|
|
PL4289948T3
(pl)
|
2012-05-25 |
2025-06-02 |
The Regents Of The University Of California |
Sposoby i kompozycje do modyfikacji kierowanego na rna docelowego dna i do nakierowanej na rna modulacji transkrypcji
|
|
EP2912175B1
(en)
|
2012-10-23 |
2018-08-22 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
|
CN105142669B
(zh)
|
2012-12-06 |
2018-07-03 |
西格马-奥尔德里奇有限责任公司 |
基于crispr的基因组修饰和调控
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
CN105658796B
(zh)
|
2012-12-12 |
2021-10-26 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
EP4282970A3
(en)
|
2012-12-17 |
2024-01-17 |
President and Fellows of Harvard College |
Rna-guided human genome engineering
|
|
KR20140101203A
(ko)
|
2013-02-08 |
2014-08-19 |
이정민 |
자동 버핑장치
|
|
IL289396B2
(en)
|
2013-03-15 |
2023-12-01 |
The General Hospital Coporation |
Using truncated guide rnas (tru-grnas) to increase specificity for rna-guided genome editing
|
|
WO2014153470A2
(en)
|
2013-03-21 |
2014-09-25 |
Sangamo Biosciences, Inc. |
Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
|
|
WO2014161821A1
(en)
|
2013-04-02 |
2014-10-09 |
Bayer Cropscience Nv |
Targeted genome engineering in eukaryotes
|
|
US9890393B2
(en)
|
2013-05-29 |
2018-02-13 |
Cellectis |
Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system
|
|
ES2883131T3
(es)
|
2013-05-29 |
2021-12-07 |
Cellectis |
Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US10822606B2
(en)
|
2013-09-27 |
2020-11-03 |
The Regents Of The University Of California |
Optimized small guide RNAs and methods of use
|
|
CN105899665B
(zh)
|
2013-10-17 |
2019-10-22 |
桑格摩生物科学股份有限公司 |
用于核酸酶介导的基因组工程改造的递送方法和组合物
|
|
CA2930590C
(en)
|
2013-11-15 |
2021-02-16 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Engineering neural stem cells using homologous recombination
|
|
US10787684B2
(en)
*
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
JP2017501149A
(ja)
|
2013-12-12 |
2017-01-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
粒子送達構成成分を用いた障害及び疾患の標的化のためのｃｒｉｓｐｒ−ｃａｓ系及び組成物の送達、使用及び治療適用
|
|
WO2015089354A1
(en)
*
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
|
|
EP3653229A1
(en)
|
2013-12-12 |
2020-05-20 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
|
|
WO2015086795A1
(en)
|
2013-12-13 |
2015-06-18 |
Cellectis |
Cas9 nuclease platform for microalgae genome engineering
|
|
JP2017510542A
(ja)
|
2014-01-31 |
2017-04-13 |
ファクター バイオサイエンス インコーポレイテッド |
核酸生成及び送達のための方法及び製品
|
|
WO2015115903A1
(en)
|
2014-02-03 |
2015-08-06 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Site-specific dna break-induced genome editing using engineered nucleases
|
|
US20170175128A1
(en)
|
2014-04-18 |
2017-06-22 |
Editas Medicine, Inc. |
Crispr-cas-related methods, compositions and components for cancer immunotherapy
|
|
CA2951707A1
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
US10280402B2
(en)
|
2014-08-06 |
2019-05-07 |
College Of Medicine Pochon Cha University Industry-Academic Cooperation Foundation |
Immune-compatible cells created by nuclease-mediated editing of genes encoding HLA
|
|
US10570418B2
(en)
|
2014-09-02 |
2020-02-25 |
The Regents Of The University Of California |
Methods and compositions for RNA-directed target DNA modification
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
US9879283B2
(en)
|
2014-10-09 |
2018-01-30 |
Life Technologies Corporation |
CRISPR oligonucleotides and gene editing
|
|
AU2015339743C1
(en)
|
2014-10-31 |
2021-04-22 |
The Trustees Of The University Of Pennsylvania |
Altering gene expression in modified T cells and uses thereof
|
|
WO2016097751A1
(en)
|
2014-12-18 |
2016-06-23 |
The University Of Bath |
Method of cas9 mediated genome engineering
|
|
JP2018509387A
(ja)
|
2015-01-21 |
2018-04-05 |
フェーズアールエックス インコーポレイテッド |
細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム
|
|
JP6886404B2
(ja)
*
|
2015-01-30 |
2021-06-16 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ |
初代造血細胞におけるタンパク質送達
|
|
US12129471B2
(en)
|
2015-02-23 |
2024-10-29 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
WO2016172359A2
(en)
|
2015-04-24 |
2016-10-27 |
The Regents Of The University Of California |
Systems for detecting, monitoring or treating diseases or conditions using engineered cells and methods for making and using them
|
|
MX2017015239A
(es)
|
2015-05-29 |
2018-02-19 |
Juno Therapeutics Inc |
Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas.
|
|
AU2016278959A1
(en)
|
2015-06-17 |
2018-01-18 |
The Uab Research Foundation |
CRISPR/Cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
|
|
JP2018518182A
(ja)
|
2015-06-17 |
2018-07-12 |
ザ ユーエービー リサーチ ファンデーション |
ゲノム編集のためのｃｒｉｓｐｒ／ｃａｓ９複合体
|
|
US20170000743A1
(en)
|
2015-07-02 |
2017-01-05 |
Vindico NanoBio Technology Inc. |
Compositions and Methods for Delivery of Gene Editing Tools Using Polymeric Vesicles
|
|
AU2016291778B2
(en)
|
2015-07-13 |
2021-05-06 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
WO2017035659A1
(en)
|
2015-09-01 |
2017-03-09 |
The Hospital For Sick Children |
Method and compositions for removing duplicated copy number variations (cnvs) for genetic disorders and related uses
|
|
WO2017053729A1
(en)
|
2015-09-25 |
2017-03-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nuclease-mediated genome editing of primary cells and enrichment thereof
|
|
WO2017058751A1
(en)
|
2015-09-28 |
2017-04-06 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
DK3359184T3
(da)
|
2015-10-05 |
2020-06-15 |
Prec Biosciences Inc |
Genetisk modificerede celler, der omfatter et modificeret gen fra konstant alfaregion i human t-cellereceptor
|
|
US20180327706A1
(en)
|
2015-10-19 |
2018-11-15 |
The Methodist Hospital |
Crispr-cas9 delivery to hard-to-transfect cells via membrane deformation
|
|
CN108368522A
(zh)
|
2015-10-20 |
2018-08-03 |
10X 基因组学有限公司 |
用于高通量单细胞遗传操作的方法和系统
|
|
WO2017070429A1
(en)
|
2015-10-22 |
2017-04-27 |
Regents Of The University Of Minnesota |
Methods involving editing polynucleotides that encode t cell receptor
|
|
AU2016349504B2
(en)
|
2015-11-04 |
2023-02-09 |
Fate Therapeutics, Inc. |
Genomic engineering of pluripotent cells
|
|
EP4163374A1
(en)
|
2015-11-23 |
2023-04-12 |
The Regents of the University of California |
Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9
|
|
IL259576B
(en)
*
|
2015-12-04 |
2022-09-01 |
Novartis Ag |
grna molecule containing tracr and crrna, pharmaceutical composition containing it and method for preparing cells for immunotherapy
|
|
WO2017106528A2
(en)
|
2015-12-18 |
2017-06-22 |
Sangamo Biosciences, Inc. |
Targeted disruption of the t cell receptor
|
|
EP3397760A2
(en)
|
2015-12-30 |
2018-11-07 |
Avectas Limited |
Vector-free delivery of gene editing proteins and compositions to cells and tissues
|
|
RU2018135819A
(ru)
|
2016-03-11 |
2020-04-13 |
Блубёрд Био, Инк. |
Иммунные эффекторные клетки с отредактированным геномом
|
|
CA3020330A1
(en)
|
2016-04-07 |
2017-10-12 |
Bluebird Bio, Inc. |
Chimeric antigen receptor t cell compositions
|
|
EP4711465A2
(en)
|
2016-04-14 |
2026-03-18 |
Fred Hutchinson Cancer Center |
Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
|
|
US10188749B2
(en)
|
2016-04-14 |
2019-01-29 |
Fred Hutchinson Cancer Research Center |
Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
|
|
SG11201808831TA
(en)
|
2016-04-15 |
2018-11-29 |
Memorial Sloan Kettering Cancer Center |
Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
|
|
US11248216B2
(en)
|
2016-04-25 |
2022-02-15 |
The Regents Of The University Of California |
Methods and compositions for genomic editing
|
|
WO2017186718A1
(en)
*
|
2016-04-25 |
2017-11-02 |
Universität Basel |
Allele editing and applications thereof
|
|
IL262409B2
(en)
|
2016-04-29 |
2025-12-01 |
Basf Plant Science Co Gmbh |
Improved methods for modification of target nucleic acids
|
|
US20190136224A1
(en)
|
2016-05-31 |
2019-05-09 |
Massachusetts Institute Of Technology |
Hydrodynamically Controlled Electric Fields for High Throughput Transformation & High Throughput Parallel Transformation Platform
|
|
US11713458B2
(en)
|
2016-06-20 |
2023-08-01 |
Octapharma Ag |
Means and methods for modifying multiple alleles
|
|
CN110312799A
(zh)
|
2016-08-17 |
2019-10-08 |
博德研究所 |
新型crispr酶和系统
|
|
US11999931B2
(en)
|
2016-08-20 |
2024-06-04 |
The Regents Of The University Of California |
High-throughput system and method for the temporary permeabilization of cells
|
|
JP6837879B2
(ja)
|
2016-08-26 |
2021-03-03 |
日東電工株式会社 |
粘着テープ
|
|
CN118909050A
(zh)
|
2016-10-12 |
2024-11-08 |
费尔丹生物公司 |
用于将多肽负荷递送至靶真核细胞的合理设计的合成肽穿梭剂，其用途、方法和试剂盒
|
|
WO2018073391A1
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Targeted gene insertion for improved immune cells therapy
|
|
WO2018073393A2
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
|
|
EP3541937A4
(en)
|
2016-11-18 |
2020-06-24 |
Christopher Bradley |
REPAIR OF MASSIVELY MULTIPLEXED HOMOLOGICAL TEMPLATE FOR FULL GENERATION
|
|
CA3045134A1
(en)
|
2016-12-14 |
2018-06-21 |
Ligandal, Inc. |
Compositions and methods for nucleic acid and/or protein payload delivery
|
|
AU2017388874A1
(en)
|
2016-12-30 |
2019-07-18 |
Berkeley Lights, Inc. |
Methods for selection and generation of genome edited T cells
|
|
MX2019015188A
(es)
|
2017-06-15 |
2020-08-03 |
Univ California |
Inserciones de adn no virales orientadas.
|
|
JP7101419B2
(ja)
|
2017-10-27 |
2022-07-15 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
内因性ｔ細胞受容体の標的置換
|
|
CN117904055A
(zh)
|
2017-10-30 |
2024-04-19 |
派克特制药公司 |
原代细胞基因编辑
|