JP2019516378A5 - - Google Patents

Download PDF

Info

Publication number
JP2019516378A5
JP2019516378A5 JP2018560571A JP2018560571A JP2019516378A5 JP 2019516378 A5 JP2019516378 A5 JP 2019516378A5 JP 2018560571 A JP2018560571 A JP 2018560571A JP 2018560571 A JP2018560571 A JP 2018560571A JP 2019516378 A5 JP2019516378 A5 JP 2019516378A5
Authority
JP
Japan
Prior art keywords
sequence
host cell
component
exogenous
landing pad
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018560571A
Other languages
English (en)
Japanese (ja)
Other versions
JP7093310B2 (ja
JP2019516378A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/033369 external-priority patent/WO2017201311A2/en
Publication of JP2019516378A publication Critical patent/JP2019516378A/ja
Publication of JP2019516378A5 publication Critical patent/JP2019516378A5/ja
Application granted granted Critical
Publication of JP7093310B2 publication Critical patent/JP7093310B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018560571A 2016-05-18 2017-05-18 外因性ランディングパッドへの核酸のゲノム組込みのための組成物および方法 Active JP7093310B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662338412P 2016-05-18 2016-05-18
US62/338,412 2016-05-18
PCT/US2017/033369 WO2017201311A2 (en) 2016-05-18 2017-05-18 Compositions and methods for genomic integration of nucleic acids into exogenous landing pads

Publications (3)

Publication Number Publication Date
JP2019516378A JP2019516378A (ja) 2019-06-20
JP2019516378A5 true JP2019516378A5 (enExample) 2020-06-18
JP7093310B2 JP7093310B2 (ja) 2022-06-29

Family

ID=59014740

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018560571A Active JP7093310B2 (ja) 2016-05-18 2017-05-18 外因性ランディングパッドへの核酸のゲノム組込みのための組成物および方法

Country Status (4)

Country Link
US (2) US11293033B2 (enExample)
EP (2) EP4219731A3 (enExample)
JP (1) JP7093310B2 (enExample)
WO (1) WO2017201311A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015330699B2 (en) 2014-10-10 2021-12-02 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
WO2016073990A2 (en) 2014-11-07 2016-05-12 Editas Medicine, Inc. Methods for improving crispr/cas-mediated genome-editing
EP3353296B1 (en) 2015-09-24 2020-11-04 Editas Medicine, Inc. Use of exonucleases to improve crispr/cas-mediated genome editing
US11597924B2 (en) 2016-03-25 2023-03-07 Editas Medicine, Inc. Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
WO2017180694A1 (en) 2016-04-13 2017-10-19 Editas Medicine, Inc. Cas9 fusion molecules gene editing systems, and methods of use thereof
KR101839109B1 (ko) * 2016-09-22 2018-03-15 ㈜프론트바이오 퍼플콘 추출물을 함유하는 피부 질환의 예방 또는 치료용 약제학적 조성물
WO2019014564A1 (en) 2017-07-14 2019-01-17 Editas Medicine, Inc. SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
SI3997118T1 (sl) 2019-07-11 2025-06-30 Clara Foods Co. Sestavek napitka, ki obsega rekombinantni ovomukoidni protein
CA3166728A1 (en) * 2020-01-07 2021-07-15 Limmatech Biologics Ag Engineered leishmania cells
US11739359B2 (en) * 2020-05-01 2023-08-29 Microsoft Technology Licensing, Llc Universal template strands for enzymatic polynucleotide synthesis
EP4170028A4 (en) * 2020-06-19 2023-10-18 MGI Tech Co., Ltd. CREATION OF A PCR-FREE LIBRARY WITH HIGH COMPATIBILITY AND SEQUENCING METHODS
AU2021348266A1 (en) * 2020-09-25 2023-04-20 Bondi Bio Pty Ltd Standardised cyanobacterial strain engineering
CA3229003A1 (en) * 2021-08-25 2023-03-02 Kothai Nachiar Devi PARTHIBAN Preparation of libraries of protein variants expressed in eukaryotic cells
CN114134091B (zh) * 2021-11-08 2024-04-12 中国科学院武汉病毒研究所 细菌基因组绝缘位点的鉴定方法及应用
WO2024050054A1 (en) * 2022-08-31 2024-03-07 The Regents Of The University Of California High throughput characterization of bacterial promoters from their host environments
WO2024076688A2 (en) * 2022-10-05 2024-04-11 The Regents Of The University Of California Synthetic genomic safe harbors and methods thereof
CN120731271A (zh) * 2023-04-21 2025-09-30 诺维信公司 多拷贝宿主细胞的生成
AR134546A1 (es) * 2023-12-05 2026-01-28 Hoffmann La Roche Monitoreo de poblaciones de células que producen biomoléculas

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272065A (en) 1983-10-20 1993-12-21 Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
NZ500843A (en) 1995-06-07 2002-03-28 Invitrogen Corp A method of DNA recombination which is selectable to select for cells containing a product and against cells only harbouring the insert donor
JP4206154B2 (ja) 1997-11-13 2009-01-07 大日本住友製薬株式会社 変異型loxP配列とその応用
US5929301A (en) 1997-11-18 1999-07-27 Pioneer Hi-Bred International Nucleic acid sequence encoding FLP recombinase
WO1999025840A1 (en) 1997-11-18 1999-05-27 Pioneer Hi-Bred International, Inc. A novel method for the integration of foreign dna into eukaryoticgenomes
NZ503859A (en) 1997-11-18 2003-02-28 Pioneer Hi Bred Int Non-identical minimal recombination sites (FRT) which are non-identical for targeted integration of nucleotide sequences into transformed plants
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
AU6364800A (en) 1999-07-23 2001-02-13 Regents Of The University Of California, The Dna recombination in eukaryotic cells by the bacteriophage phic31 recombination system
AU6529900A (en) 1999-08-09 2001-03-05 Monsanto Technology Llc Novel cloning methods and vectors
WO2001023545A1 (fr) 1999-09-30 2001-04-05 Sumitomo Pharmaceuticals Company, Limited Adn contenant des sequences frt allelomorphes
WO2001083819A2 (en) 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Methods for designing exogenous regulatory molecules
US20030082561A1 (en) 2000-07-21 2003-05-01 Takashi Sera Zinc finger domain recognition code and uses thereof
CA2435394C (en) 2001-01-22 2018-01-09 Sangamo Biosciences, Inc. Modified zinc finger binding proteins
GB0108491D0 (en) 2001-04-04 2001-05-23 Gendaq Ltd Engineering zinc fingers
AT5356U1 (de) 2001-07-16 2002-06-25 Uv & P Umweltman Verfahrenstec Verfahren zur immobilisierung von verbrennungsrückständen
US7314712B2 (en) * 2001-07-27 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Systems for in vivo site-directed mutagenesis using oligonucleotides
AU2003215869B2 (en) 2002-03-15 2008-04-24 Cellectis Hybrid and single chain meganucleases and use thereof
WO2009095742A1 (en) 2008-01-31 2009-08-06 Cellectis New i-crei derived single-chain meganuclease and uses thereof
US20030232410A1 (en) 2002-03-21 2003-12-18 Monika Liljedahl Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
AU2003290518A1 (en) 2002-09-06 2004-04-23 Fred Hutchinson Cancer Research Center Methods and compositions concerning designed highly-specific nucleic acid binding proteins
AU2004208031B2 (en) 2003-01-28 2009-10-08 Cellectis Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof.
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
JP4555292B2 (ja) 2003-08-08 2010-09-29 サンガモ バイオサイエンシズ インコーポレイテッド 標的化された切断及び組換えの方法及び組成物
EP1591521A1 (en) 2004-04-30 2005-11-02 Cellectis I-Dmo I derivatives with enhanced activity at 37 degrees C and use thereof
WO2006097784A1 (en) 2005-03-15 2006-09-21 Cellectis I-crei meganuclease variants with modified specificity, method of preparation and uses thereof
WO2007034262A1 (en) 2005-09-19 2007-03-29 Cellectis Heterodimeric meganucleases and use thereof
AU2006224248B2 (en) 2005-03-15 2011-01-06 Cellectis I-Crei meganuclease variants with modified specificity, method of preparation and uses thereof
WO2007049095A1 (en) 2005-10-25 2007-05-03 Cellectis Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
WO2007060495A1 (en) 2005-10-25 2007-05-31 Cellectis I-crei homing endonuclease variants having novel cleavage specificity and use thereof
KR101439568B1 (ko) 2006-08-11 2014-09-12 다우 아그로사이언시즈 엘엘씨 아연 손가락 뉴클레아제-매개 상동 재조합
WO2009001159A1 (en) 2007-06-25 2008-12-31 Cellectis Method for enhancing the cleavage activity of i-crei derived meganucleases
EP2770052A1 (en) 2007-06-06 2014-08-27 Cellectis Method for enhancing the cleavage activity of I-CreI derived meganucleases
WO2010015899A2 (en) 2008-08-04 2010-02-11 Cellectis Novel method to generate meganucleases with altered characteristics
US20090203140A1 (en) 2007-09-27 2009-08-13 Sangamo Biosciences, Inc. Genomic editing in zebrafish using zinc finger nucleases
AU2008317354B2 (en) 2007-10-25 2014-04-10 Ospedale San Raffaele S.R.L. Methods and compositions for targeted integration
WO2010001189A1 (en) 2008-07-03 2010-01-07 Cellectis The crystal structure of i-dmoi in complex with its dna target, improved chimeric meganucleases and uses thereof
EP2180058A1 (en) 2008-10-23 2010-04-28 Cellectis Meganuclease recombination system
AU2009316660B2 (en) 2008-11-19 2015-01-29 Amrys, Inc. Compositions and methods for the assembly of polynucleotides
AU2009322964B2 (en) 2008-12-04 2014-10-09 Sangamo Therapeutics, Inc. Genome editing in rats using zinc-finger nucleases
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
NO2510096T3 (enExample) 2009-12-10 2015-03-21
GEP201606587B (en) * 2010-01-22 2017-01-10 Dow Agrosciences Llc Engineered landing pads for gene targeting in plants
US7919605B1 (en) 2010-08-30 2011-04-05 Amyris, Inc. Nucleic acids, compositions and methods for the excision of target nucleic acids
JP5996630B2 (ja) 2011-04-05 2016-09-21 セレクティスCellectis コンパクトtale−ヌクレアーゼを作製する方法及びその使用
WO2012149470A1 (en) * 2011-04-27 2012-11-01 Amyris, Inc. Methods for genomic modification
GB201122458D0 (en) 2011-12-30 2012-02-08 Univ Wageningen Modified cascade ribonucleoproteins and uses thereof
US9637739B2 (en) 2012-03-20 2017-05-02 Vilnius University RNA-directed DNA cleavage by the Cas9-crRNA complex
CN104508130B (zh) * 2012-06-29 2016-09-28 麻省理工学院 大规模并行组合遗传学
EP3011011A4 (en) * 2013-06-19 2017-05-31 Sigma-Aldrich Co. LLC Targeted integration
AU2014368982B2 (en) 2013-12-19 2021-03-25 Amyris, Inc. Methods for genomic integration
WO2017075529A1 (en) * 2015-10-29 2017-05-04 The Research Foundation For The State University Of New York Genomic combinatorial screening platform

Similar Documents

Publication Publication Date Title
JP2022046466A5 (enExample)
JP2021500072A5 (enExample)
JP2024073596A5 (enExample)
WO2016094845A3 (en) Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
JP2017510293A5 (enExample)
JP2017532042A5 (enExample)
JP6430631B2 (ja) リンカー要素、及び、それを使用してシーケンシングライブラリーを構築する方法
JP2019536425A5 (enExample)
JP2021112211A5 (enExample)
JP2017512767A5 (enExample)
RU2018124657A (ru) Способы редактирования генов и композиции для устранения риска активации вируса jc и пмл (прогрессирующая мультифокальная лейкоэнцефалопатия) во время иммуносупрессивной терапии
JP2016536991A5 (enExample)
JP2016521993A5 (enExample)
JP2022526646A5 (enExample)
JP2020517299A5 (enExample)
JP2017070287A5 (enExample)
JP2016500262A5 (enExample)
Becker et al. Isolation of the repertoire of VSG expression site containing telomeres of Trypanosoma brucei 427 using transformation-associated recombination in yeast
JP2017520580A5 (enExample)
WO2017066497A3 (en) Genome engineering with type i crispr systems in eukaryotic cells
RU2016104056A (ru) Мультиплексная геномная инженерия, направляемая рнк
JP2020527938A5 (enExample)
CN109963944A (zh) 体外敲除T细胞中靶基因的方法以及该方法中使用的crRNA
JP2017528140A5 (enExample)
JP2021513866A5 (enExample)