|
US5272065A
(en)
|
1983-10-20 |
1993-12-21 |
Research Foundation Of State University Of New York |
Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
|
|
US4873192A
(en)
|
1987-02-17 |
1989-10-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Process for site specific mutagenesis without phenotypic selection
|
|
US6140466A
(en)
|
1994-01-18 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger protein derivatives and methods therefor
|
|
EP0937098B1
(en)
|
1995-06-07 |
2002-08-14 |
Invitrogen Corporation |
Recombinational cloning in vitro using engineered recombination sites
|
|
JP4206154B2
(ja)
|
1997-11-13 |
2009-01-07 |
大日本住友製薬株式会社 |
変異型ｌｏｘＰ配列とその応用
|
|
PT1034262E
(pt)
|
1997-11-18 |
2005-10-31 |
Pioneer Hi Bred Int |
Composicoes e metodos para a modificacao genetica de plantas
|
|
AU745960C
(en)
|
1997-11-18 |
2003-09-18 |
Pioneer Hi-Bred International, Inc. |
A novel method for the integration of foreign DNA into eukaryoticgenomes
|
|
US5929301A
(en)
|
1997-11-18 |
1999-07-27 |
Pioneer Hi-Bred International |
Nucleic acid sequence encoding FLP recombinase
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US6794136B1
(en)
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
|
DE60044142D1
(de)
|
1999-07-23 |
2010-05-20 |
Univ California |
Dna-rekombination in eukaryotischen zellen mittels des rekombinationszentrums vom bakteriophag phic31
|
|
WO2001011058A1
(en)
|
1999-08-09 |
2001-02-15 |
Monsanto Technology Llc |
Novel cloning methods and vectors
|
|
JP4787440B2
(ja)
|
1999-09-30 |
2011-10-05 |
泉 斎藤 |
変異型ｆｒｔ配列を含有してなるｄｎａ
|
|
AU2001257331A1
(en)
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences, Inc. |
Methods for designing exogenous regulatory molecules
|
|
US20030082561A1
(en)
|
2000-07-21 |
2003-05-01 |
Takashi Sera |
Zinc finger domain recognition code and uses thereof
|
|
US7273923B2
(en)
|
2001-01-22 |
2007-09-25 |
Sangamo Biosciences, Inc. |
Zinc finger proteins for DNA binding and gene regulation in plants
|
|
GB0108491D0
(en)
|
2001-04-04 |
2001-05-23 |
Gendaq Ltd |
Engineering zinc fingers
|
|
AT5356U1
(de)
|
2001-07-16 |
2002-06-25 |
Uv & P Umweltman Verfahrenstec |
Verfahren zur immobilisierung von verbrennungsrückständen
|
|
EP1421187B1
(en)
|
2001-07-27 |
2007-10-10 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Systems for in vivo site-directed mutagenesis using oligonucleotides
|
|
WO2009095742A1
(en)
|
2008-01-31 |
2009-08-06 |
Cellectis |
New i-crei derived single-chain meganuclease and uses thereof
|
|
US8206965B2
(en)
|
2002-03-15 |
2012-06-26 |
Cellectis S.A. |
Hybrid and single chain meganucleases and use thereof
|
|
EP1504092B2
(en)
|
2002-03-21 |
2014-06-25 |
Sangamo BioSciences, Inc. |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
|
|
AU2003290518A1
(en)
|
2002-09-06 |
2004-04-23 |
Fred Hutchinson Cancer Research Center |
Methods and compositions concerning designed highly-specific nucleic acid binding proteins
|
|
US20060206949A1
(en)
|
2003-01-28 |
2006-09-14 |
Sylvain Arnould |
Custom-made meganuclease and use thereof
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
EP2927318B1
(en)
|
2003-08-08 |
2020-05-20 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
EP1591521A1
(en)
|
2004-04-30 |
2005-11-02 |
Cellectis |
I-Dmo I derivatives with enhanced activity at 37 degrees C and use thereof
|
|
WO2006097784A1
(en)
|
2005-03-15 |
2006-09-21 |
Cellectis |
I-crei meganuclease variants with modified specificity, method of preparation and uses thereof
|
|
ATE466933T1
(de)
|
2005-03-15 |
2010-05-15 |
Cellectis |
I-crei-meganuklease-varianten mit modifizierter spezifität sowie verfahren zu ihrer herstellung und verwendung
|
|
WO2007034262A1
(en)
|
2005-09-19 |
2007-03-29 |
Cellectis |
Heterodimeric meganucleases and use thereof
|
|
WO2007060495A1
(en)
|
2005-10-25 |
2007-05-31 |
Cellectis |
I-crei homing endonuclease variants having novel cleavage specificity and use thereof
|
|
WO2007049095A1
(en)
|
2005-10-25 |
2007-05-03 |
Cellectis |
Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
|
|
JP2010500029A
(ja)
|
2006-08-11 |
2010-01-07 |
ダウ アグロサイエンシィズ エルエルシー |
ジンクフィンガーヌクレアーゼ媒介相同組換え
|
|
WO2009001159A1
(en)
|
2007-06-25 |
2008-12-31 |
Cellectis |
Method for enhancing the cleavage activity of i-crei derived meganucleases
|
|
US20140112904A9
(en)
|
2007-06-06 |
2014-04-24 |
Cellectis |
Method for enhancing the cleavage activity of i-crei derived meganucleases
|
|
AU2008305590A1
(en)
|
2007-09-27 |
2009-04-02 |
Sangamo Therapeutics, Inc. |
Genomic editing in zebrafish using zinc finger nucleases
|
|
EP2597155B1
(en)
|
2007-10-25 |
2016-11-23 |
Sangamo BioSciences, Inc. |
Methods and compositions for targeted integration
|
|
WO2010001189A1
(en)
|
2008-07-03 |
2010-01-07 |
Cellectis |
The crystal structure of i-dmoi in complex with its dna target, improved chimeric meganucleases and uses thereof
|
|
EP2329017A2
(en)
|
2008-08-04 |
2011-06-08 |
Cellectis |
Novel method to generate meganucleases with altered characteristics
|
|
EP2180058A1
(en)
|
2008-10-23 |
2010-04-28 |
Cellectis |
Meganuclease recombination system
|
|
EP2358875B1
(en)
|
2008-11-19 |
2015-08-12 |
Amyris, Inc. |
Compositions and methods for the assembly of polynucleotides
|
|
EP3156494B8
(en)
|
2008-12-04 |
2018-09-19 |
Sangamo Therapeutics, Inc. |
Genome editing in rats using zinc-finger nucleases
|
|
EP2206723A1
(en)
|
2009-01-12 |
2010-07-14 |
Bonas, Ulla |
Modular DNA-binding domains
|
|
PT2816112T
(pt)
|
2009-12-10 |
2018-11-20 |
Univ Iowa State Res Found Inc |
Modificação do adn modificada pelo efector tal
|
|
NZ600733A
(en)
*
|
2010-01-22 |
2014-09-26 |
Dow Agrosciences Llc |
Engineered landing pads for gene targeting in plants
|
|
US7919605B1
(en)
|
2010-08-30 |
2011-04-05 |
Amyris, Inc. |
Nucleic acids, compositions and methods for the excision of target nucleic acids
|
|
US20140115726A1
(en)
|
2011-04-05 |
2014-04-24 |
Cellectis |
New tale-protein scaffolds and uses thereof
|
|
CA2834375C
(en)
|
2011-04-27 |
2020-07-14 |
Amyris, Inc. |
Methods for genomic modification
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
CA2877962C
(en)
*
|
2012-06-29 |
2018-06-05 |
Massachusetts Institute Of Technology |
Massively parallel combinatorial genetics
|
|
BR112015031639A2
(pt)
*
|
2013-06-19 |
2019-09-03 |
Sigma Aldrich Co Llc |
integração alvo
|
|
US9476065B2
(en)
*
|
2013-12-19 |
2016-10-25 |
Amyris, Inc. |
Methods for genomic integration
|
|
US20180298377A1
(en)
*
|
2015-10-29 |
2018-10-18 |
The Research Foundation For The State University Of New York |
Genomic combinatorial screening platform
|