JP2020515257A5 - - Google Patents
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- JP2020515257A5 JP2020515257A5 JP2019553050A JP2019553050A JP2020515257A5 JP 2020515257 A5 JP2020515257 A5 JP 2020515257A5 JP 2019553050 A JP2019553050 A JP 2019553050A JP 2019553050 A JP2019553050 A JP 2019553050A JP 2020515257 A5 JP2020515257 A5 JP 2020515257A5
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- til
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- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 171
- 238000000034 method Methods 0.000 claims 58
- 206010028980 Neoplasm Diseases 0.000 claims 38
- 239000000203 mixture Substances 0.000 claims 30
- 230000007704 transition Effects 0.000 claims 28
- 230000001225 therapeutic effect Effects 0.000 claims 23
- 238000001802 infusion Methods 0.000 claims 18
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 17
- 108010002350 Interleukin-2 Proteins 0.000 claims 16
- 239000006143 cell culture medium Substances 0.000 claims 14
- 239000012634 fragment Substances 0.000 claims 14
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 12
- 238000012258 culturing Methods 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 7
- 238000005138 cryopreservation Methods 0.000 claims 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 6
- 108010074328 Interferon-gamma Proteins 0.000 claims 6
- 102100037850 Interferon gamma Human genes 0.000 claims 5
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 5
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 5
- 230000002338 cryopreservative effect Effects 0.000 claims 4
- 210000003162 effector t lymphocyte Anatomy 0.000 claims 4
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 3
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 3
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 208000021039 metastatic melanoma Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims 2
- 241000701806 Human papillomavirus Species 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 239000012595 freezing medium Substances 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 229960000390 fludarabine Drugs 0.000 claims 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022173682A JP7772680B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2022173683A JP7814287B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2022173684A JP7817138B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2024187597A JP2025023951A (ja) | 2017-03-29 | 2024-10-24 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762478506P | 2017-03-29 | 2017-03-29 | |
| US62/478,506 | 2017-03-29 | ||
| US201762539410P | 2017-07-31 | 2017-07-31 | |
| US62/539,410 | 2017-07-31 | ||
| US201762548306P | 2017-08-21 | 2017-08-21 | |
| US62/548,306 | 2017-08-21 | ||
| US201762554538P | 2017-09-05 | 2017-09-05 | |
| US62/554,538 | 2017-09-05 | ||
| US201762559374P | 2017-09-15 | 2017-09-15 | |
| US62/559,374 | 2017-09-15 | ||
| US201762567121P | 2017-10-02 | 2017-10-02 | |
| US62/567,121 | 2017-10-02 | ||
| US201762577655P | 2017-10-26 | 2017-10-26 | |
| US62/577,655 | 2017-10-26 | ||
| US201762582874P | 2017-11-07 | 2017-11-07 | |
| US62/582,874 | 2017-11-07 | ||
| US201762596374P | 2017-12-08 | 2017-12-08 | |
| US62/596,374 | 2017-12-08 | ||
| PCT/US2018/012633 WO2018182817A1 (en) | 2017-03-29 | 2018-01-05 | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022173684A Division JP7817138B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2022173682A Division JP7772680B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2022173683A Division JP7814287B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515257A JP2020515257A (ja) | 2020-05-28 |
| JP2020515257A5 true JP2020515257A5 (https=) | 2021-02-18 |
| JP7169291B2 JP7169291B2 (ja) | 2022-11-10 |
Family
ID=61569356
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553050A Active JP7169291B2 (ja) | 2017-03-29 | 2018-01-05 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2020552291A Active JP7522037B2 (ja) | 2017-03-29 | 2018-06-29 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用 |
| JP2022173683A Active JP7814287B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2022173682A Active JP7772680B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2022173684A Active JP7817138B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2024187597A Pending JP2025023951A (ja) | 2017-03-29 | 2024-10-24 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020552291A Active JP7522037B2 (ja) | 2017-03-29 | 2018-06-29 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用 |
| JP2022173683A Active JP7814287B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2022173682A Active JP7772680B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2022173684A Active JP7817138B2 (ja) | 2017-03-29 | 2022-10-28 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
| JP2024187597A Pending JP2025023951A (ja) | 2017-03-29 | 2024-10-24 | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用方法 |
Country Status (37)
Families Citing this family (123)
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