SG11201908994RA - Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy - Google Patents

Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

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Publication number
SG11201908994RA
SG11201908994RA SG11201908994RA SG11201908994RA SG 11201908994R A SG11201908994R A SG 11201908994RA SG 11201908994R A SG11201908994R A SG 11201908994RA SG 11201908994R A SG11201908994R A SG 11201908994RA
Authority
SG
Singapore
Prior art keywords
international
tils
october
pct
processes
Prior art date
Application number
Inventor
Seth Wardell
James Bender
Michael Lotze
Original Assignee
Iovance Biotherapeutics Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61569356&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201908994R(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Iovance Biotherapeutics Inc filed Critical Iovance Biotherapeutics Inc
Publication of SG11201908994RA publication Critical patent/SG11201908994RA/en

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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    • A01N1/10—Preservation of living parts
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
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    • A61K2039/55527—Interleukins
    • A61K2039/55533—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT onion °nolo OH 1101 H mum° oimIE (10) International Publication Number WO 2018/182817 Al (51) International Patent Classification: C12N 5/0783 (2010.01) C12M 1/04 (2006.01) (21) International Application Number: PCT/US2018/012633 (22) International Filing Date: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/478,506 62/539,410 62/548,306 62/554,538 62/559,374 62/567,121 62/577,655 62/582,874 62/596,374 05 January 2018 (05.01.2018) English English Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) 29 March 2017 (29.03.2017) US 31 July 2017 (31.07.2017) US 21 August 2017 (21.08.2017) US 05 September 2017 (05.09.2017) US 15 September 2017 (15.09.2017) US 02 October 2017 (02.10.2017) US 26 October 2017 (26.10.2017) US 07 November 2017 (07.11.2017) US 08 December 2017 (08.12.2017) US Applicant: IOVANCE BIOTHERAPEUTICS, INC. [US/US]; 999 Skyway Road, Suite 150, San Carlos, CA 94070 (US). Inventors; and Applicants: WARDELL, Seth [US/US]; 30204 USF Hol- ly Drive, Tampa, FL 33620 (US). BENDER, James [US/US]; 3 Cloverdale, Rancho Santa Margarita, CA 92688 (US). LOTZE, Michael, T. [US/US]; 5134 Westminster Place, Pittsburgh, PA 15232 (US). Agent: MACDOUGALL, Christina, A. et al.; Morgan, Lewis, & Bockius LLP, One Market, Spear Tower, San Fan- cisco, CA 94105 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, N GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, co co (54) Title: PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IM- MUNOTHERAPY 00 (57) : The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic O populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as C well as decreased costs. Such TILs fmd use in therapeutic treatment regimens.
SG11201908994R 2017-03-29 2018-01-05 Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy SG11201908994RA (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201762478506P 2017-03-29 2017-03-29
US201762539410P 2017-07-31 2017-07-31
US201762548306P 2017-08-21 2017-08-21
US201762554538P 2017-09-05 2017-09-05
US201762559374P 2017-09-15 2017-09-15
US201762567121P 2017-10-02 2017-10-02
US201762577655P 2017-10-26 2017-10-26
US201762582874P 2017-11-07 2017-11-07
US201762596374P 2017-12-08 2017-12-08
PCT/US2018/012633 WO2018182817A1 (en) 2017-03-29 2018-01-05 Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

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SG11201908994RA true SG11201908994RA (en) 2019-10-30

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SG11201908994R SG11201908994RA (en) 2017-03-29 2018-01-05 Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

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