JP2020514267A5 - - Google Patents
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- Publication number
- JP2020514267A5 JP2020514267A5 JP2019533465A JP2019533465A JP2020514267A5 JP 2020514267 A5 JP2020514267 A5 JP 2020514267A5 JP 2019533465 A JP2019533465 A JP 2019533465A JP 2019533465 A JP2019533465 A JP 2019533465A JP 2020514267 A5 JP2020514267 A5 JP 2020514267A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- trifluoromethyl
- carboxamide
- triazole
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437384P | 2016-12-21 | 2016-12-21 | |
| US62/437,384 | 2016-12-21 | ||
| PCT/US2017/067516 WO2018119036A1 (en) | 2016-12-21 | 2017-12-20 | Pyrazole derivatives as malt1 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020514267A JP2020514267A (ja) | 2020-05-21 |
| JP2020514267A5 true JP2020514267A5 (https=) | 2021-02-04 |
| JP7138641B2 JP7138641B2 (ja) | 2022-09-16 |
Family
ID=61628454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533465A Active JP7138641B2 (ja) | 2016-12-21 | 2017-12-20 | Ｍａｌｔ１阻害剤としてのピラゾール誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US10954214B2 (https=) |
| EP (1) | EP3558969B1 (https=) |
| JP (1) | JP7138641B2 (https=) |
| KR (1) | KR102583317B1 (https=) |
| CN (1) | CN110214136A (https=) |
| AR (1) | AR110421A1 (https=) |
| AU (2) | AU2017382185C1 (https=) |
| BR (1) | BR112019012355A2 (https=) |
| CA (1) | CA3048027A1 (https=) |
| CL (1) | CL2019001709A1 (https=) |
| CO (1) | CO2019006622A2 (https=) |
| EA (1) | EA201991503A1 (https=) |
| ES (1) | ES2992411T3 (https=) |
| IL (1) | IL267343B2 (https=) |
| MA (1) | MA47125A (https=) |
| MX (2) | MX392673B (https=) |
| PE (1) | PE20191755A1 (https=) |
| PH (1) | PH12019501212A1 (https=) |
| TN (1) | TN2019000192A1 (https=) |
| TW (1) | TWI795381B (https=) |
| UA (1) | UA127920C2 (https=) |
| UY (1) | UY37537A (https=) |
| WO (1) | WO2018119036A1 (https=) |
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| EP3484866B1 (en) | 2016-07-14 | 2022-09-07 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
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| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| JP7101678B2 (ja) | 2016-12-22 | 2022-07-15 | インサイト・コーポレイション | 免疫調節剤としての複素環式化合物 |
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| JOP20190152A1 (ar) | 2016-12-21 | 2019-06-20 | Novartis Ag | مضادات الميوستاتين، الآكتيفين أو مستقبلات الآكتيفين للاستخدام في علاج السمنة والحالات ذات الصلة |
| MX2019007161A (es) | 2016-12-21 | 2020-02-12 | Mereo Biopharma 3 Ltd | Uso de anticuerpos anti-esclerostina en el tratamiento de osteogenesis imperfecta. |
| US20200009135A1 (en) | 2017-02-01 | 2020-01-09 | Medivir Ab | Therapeutic applications of malt1 inhibitors |
| WO2018165385A1 (en) | 2017-03-08 | 2018-09-13 | Cornell University | Inhibitors of malt1 and uses thereof |
| WO2018226150A1 (en) | 2017-06-05 | 2018-12-13 | Medivir Aktiebolag | Pyrazolopyrimidine as malt-1 inhibitors |
| AU2018395291A1 (en) | 2017-12-28 | 2020-07-30 | The General Hospital Corporation | Targeting the CBM signalosome complex induces regulatory T cells to inflame the tumor microenvironment |
| EP3756268A1 (de) | 2018-02-23 | 2020-12-30 | Industrieanlagen-Betriebsgesellschaft mbH | Vorrichtung zum erzeugen eines magnetfelds, insbesondere für ein induktives ladesystem, und primäreinrichtung eines induktiven ladesystems zum dynamischen aufladen von fahrzeugen |
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| AU2019289222B2 (en) | 2018-06-18 | 2023-07-13 | Janssen Pharmaceutica Nv | Pyrazole derivatives as MALT1 inhibitors |
| US12269813B2 (en) | 2019-02-22 | 2025-04-08 | Janssen Pharmaceutica Nv | Crystalline form of 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-pyrazole-4-carboxamide monohydrate |
| US20220175760A1 (en) | 2019-02-22 | 2022-06-09 | Janssen Pharmaceutica Nv | Pharmaceutical formulations |
| EP3953345B1 (en) | 2019-04-11 | 2023-04-05 | Janssen Pharmaceutica NV | Pyridine rings containing derivatives as malt1 inhibitors |
| KR20220116460A (ko) | 2019-11-22 | 2022-08-23 | 얀센 파마슈티카 엔.브이. | NF-kB 전좌 분석을 사용하여 MALT1 억제제의 효능을 평가하기 위한 방법 |
| US20210155990A1 (en) | 2019-11-22 | 2021-05-27 | Janssen Pharmaceutica Nv | Nf-kb regulated gene expression assay for assessing efficacy of malt1 inhibitors |
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| JP2023538099A (ja) | 2020-08-21 | 2023-09-06 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍａｌｔ１阻害剤と、ポリエチレングリコールの脂肪酸との混合物と、を含む、医薬製剤 |
| TW202227067A (zh) | 2020-08-21 | 2022-07-16 | 比利時商健生藥品公司 | Ｍａｌｔ１抑制劑之無定形形式及其配製物 |
| BR112023017689A2 (pt) | 2021-03-03 | 2023-11-14 | Janssen Pharmaceutica Nv | Método de tratamento de uma condição com o uso de uma dose terapeuticamente eficaz do inibidor de malt1 jnj-67856633 (1-(1-oxo-1,2-di-hidroisoquinolin-5-il)-5-(trifluorometil)-n(2-(trifluorometil)piridin-4-il)-1h-pirazol-4-carboxamida) |
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2017
- 2017-12-19 TW TW106144535A patent/TWI795381B/zh not_active IP Right Cessation
- 2017-12-20 US US15/847,999 patent/US10954214B2/en active Active
- 2017-12-20 EA EA201991503A patent/EA201991503A1/ru unknown
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- 2017-12-20 AU AU2017382185A patent/AU2017382185C1/en active Active
- 2017-12-20 BR BR112019012355A patent/BR112019012355A2/pt not_active Application Discontinuation
- 2017-12-20 TN TNP/2019/000192A patent/TN2019000192A1/en unknown
- 2017-12-20 WO PCT/US2017/067516 patent/WO2018119036A1/en not_active Ceased
- 2017-12-20 UA UAA201908268A patent/UA127920C2/uk unknown
- 2017-12-20 ES ES17851862T patent/ES2992411T3/es active Active
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- 2017-12-20 KR KR1020197021137A patent/KR102583317B1/ko active Active
- 2017-12-20 CN CN201780079706.3A patent/CN110214136A/zh active Pending
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2019
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2020
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2022
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