JP2020505376A5 - - Google Patents
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- Publication number
- JP2020505376A5 JP2020505376A5 JP2019539779A JP2019539779A JP2020505376A5 JP 2020505376 A5 JP2020505376 A5 JP 2020505376A5 JP 2019539779 A JP2019539779 A JP 2019539779A JP 2019539779 A JP2019539779 A JP 2019539779A JP 2020505376 A5 JP2020505376 A5 JP 2020505376A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heterocycle
- pharmaceutically acceptable
- prodrug
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000623 heterocyclic group Chemical group 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 21
- 239000000651 prodrug Substances 0.000 claims 20
- 229940002612 prodrug Drugs 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 20
- 239000012453 solvate Substances 0.000 claims 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims 16
- 125000002950 monocyclic group Chemical group 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000004585 polycyclic heterocycle group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052698 phosphorus Inorganic materials 0.000 claims 4
- 125000003367 polycyclic group Chemical group 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 3
- 150000004677 hydrates Chemical class 0.000 claims 3
- -1 C 6 alkyne Chemical class 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 2
- 125000003003 spiro group Chemical group 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000005101 LEOPARD Syndrome Diseases 0.000 claims 1
- 206010062901 Multiple lentigines syndrome Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000037538 Myelomonocytic Juvenile Leukemia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010029748 Noonan syndrome Diseases 0.000 claims 1
- 208000010708 Noonan syndrome with multiple lentigines Diseases 0.000 claims 1
- 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 claims 1
- 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 201000005992 juvenile myelomonocytic leukemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022187880A JP2023018094A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449529P | 2017-01-23 | 2017-01-23 | |
| US62/449,529 | 2017-01-23 | ||
| PCT/US2018/013018 WO2018136264A1 (en) | 2017-01-23 | 2018-01-09 | Pyridine compounds as allosteric shp2 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187880A Division JP2023018094A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505376A JP2020505376A (ja) | 2020-02-20 |
| JP2020505376A5 true JP2020505376A5 (enExample) | 2021-02-12 |
| JP7240320B2 JP7240320B2 (ja) | 2023-03-15 |
Family
ID=61054565
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539779A Active JP7240320B2 (ja) | 2017-01-23 | 2018-01-09 | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
| JP2022187880A Pending JP2023018094A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187880A Pending JP2023018094A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11673896B2 (enExample) |
| EP (2) | EP4230623A3 (enExample) |
| JP (2) | JP7240320B2 (enExample) |
| KR (1) | KR20190110588A (enExample) |
| CN (1) | CN110431134A (enExample) |
| AU (1) | AU2018210196B2 (enExample) |
| BR (1) | BR112019014527A2 (enExample) |
| CA (1) | CA3051054A1 (enExample) |
| IL (1) | IL268031B (enExample) |
| MX (1) | MX2019008696A (enExample) |
| RU (1) | RU2019126455A (enExample) |
| SG (1) | SG11201906412SA (enExample) |
| WO (1) | WO2018136264A1 (enExample) |
Families Citing this family (106)
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| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
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| JP7044375B2 (ja) | 2016-05-31 | 2022-03-30 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｐｔｐｎ１１の複素環式阻害剤 |
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- 2018-01-09 SG SG11201906412SA patent/SG11201906412SA/en unknown
- 2018-01-09 RU RU2019126455A patent/RU2019126455A/ru unknown
- 2018-01-09 AU AU2018210196A patent/AU2018210196B2/en not_active Ceased
- 2018-01-09 EP EP23163674.7A patent/EP4230623A3/en not_active Withdrawn
- 2018-01-09 JP JP2019539779A patent/JP7240320B2/ja active Active
- 2018-01-09 BR BR112019014527-3A patent/BR112019014527A2/pt not_active Application Discontinuation
- 2018-01-09 CA CA3051054A patent/CA3051054A1/en not_active Abandoned
- 2018-01-09 WO PCT/US2018/013018 patent/WO2018136264A1/en not_active Ceased
- 2018-01-09 MX MX2019008696A patent/MX2019008696A/es unknown
- 2018-01-09 EP EP18701882.5A patent/EP3571189B1/en active Active
- 2018-01-09 KR KR1020197024603A patent/KR20190110588A/ko not_active Ceased
- 2018-01-09 CN CN201880019182.3A patent/CN110431134A/zh active Pending
-
2019
- 2019-07-14 IL IL268031A patent/IL268031B/en unknown
- 2019-07-22 US US16/518,796 patent/US11673896B2/en active Active
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2022
- 2022-11-25 JP JP2022187880A patent/JP2023018094A/ja active Pending
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2023
- 2023-04-25 US US18/138,917 patent/US20240092795A1/en not_active Abandoned
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