JP7240320B2 - アロステリックｓｈｐ２阻害剤としてのピリジン化合物 - Google Patents
アロステリックｓｈｐ２阻害剤としてのピリジン化合物 Download PDFInfo
- Publication number
- JP7240320B2 JP7240320B2 JP2019539779A JP2019539779A JP7240320B2 JP 7240320 B2 JP7240320 B2 JP 7240320B2 JP 2019539779 A JP2019539779 A JP 2019539779A JP 2019539779 A JP2019539779 A JP 2019539779A JP 7240320 B2 JP7240320 B2 JP 7240320B2
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- Prior art keywords
- alkyl
- optionally substituted
- heterocycle
- cycloalkyl
- formula
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022187880A JP2023018094A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449529P | 2017-01-23 | 2017-01-23 | |
| US62/449,529 | 2017-01-23 | ||
| PCT/US2018/013018 WO2018136264A1 (en) | 2017-01-23 | 2018-01-09 | Pyridine compounds as allosteric shp2 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187880A Division JP2023018094A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505376A JP2020505376A (ja) | 2020-02-20 |
| JP2020505376A5 JP2020505376A5 (enExample) | 2021-02-12 |
| JP7240320B2 true JP7240320B2 (ja) | 2023-03-15 |
Family
ID=61054565
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539779A Active JP7240320B2 (ja) | 2017-01-23 | 2018-01-09 | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
| JP2022187880A Pending JP2023018094A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187880A Pending JP2023018094A (ja) | 2017-01-23 | 2022-11-25 | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11673896B2 (enExample) |
| EP (2) | EP4230623A3 (enExample) |
| JP (2) | JP7240320B2 (enExample) |
| KR (1) | KR20190110588A (enExample) |
| CN (1) | CN110431134A (enExample) |
| AU (1) | AU2018210196B2 (enExample) |
| BR (1) | BR112019014527A2 (enExample) |
| CA (1) | CA3051054A1 (enExample) |
| IL (1) | IL268031B (enExample) |
| MX (1) | MX2019008696A (enExample) |
| RU (1) | RU2019126455A (enExample) |
| SG (1) | SG11201906412SA (enExample) |
| WO (1) | WO2018136264A1 (enExample) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| JP7044375B2 (ja) | 2016-05-31 | 2022-03-30 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｐｔｐｎ１１の複素環式阻害剤 |
| AU2017283769B2 (en) | 2016-06-14 | 2019-08-15 | Novartis Ag | Compounds and compositions for inhibiting the activity of SHP2 |
| PH12019500056B1 (en) | 2016-07-12 | 2024-01-31 | Revolution Medicines Inc | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
| WO2018057884A1 (en) | 2016-09-22 | 2018-03-29 | Relay Therapeutics, Inc. | Shp2 phosphatase inhibitors and methods of use thereof |
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| US11591336B2 (en) | 2017-05-26 | 2023-02-28 | D. E. Shaw Research, Llc | Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors |
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- 2018-01-09 CA CA3051054A patent/CA3051054A1/en not_active Abandoned
- 2018-01-09 WO PCT/US2018/013018 patent/WO2018136264A1/en not_active Ceased
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| JP2002512628A (ja) | 1997-06-13 | 2002-04-23 | スージェン・インコーポレーテッド | タンパク質チロシン酵素関連の細胞信号伝達を調節するための新規ヘテロアリール化合物 |
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| WO2015107494A1 (en) | 2014-01-17 | 2015-07-23 | Novartis Ag | 1 -(triazin-3-yi_/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions thereof for inhibiting the activity of shp2 |
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| EP4230623A3 (en) | 2023-10-11 |
| RU2019126455A (ru) | 2021-02-24 |
| US11673896B2 (en) | 2023-06-13 |
| IL268031A (en) | 2019-09-26 |
| EP4230623A2 (en) | 2023-08-23 |
| US20240092795A1 (en) | 2024-03-21 |
| EP3571189B1 (en) | 2023-03-29 |
| US20200017517A1 (en) | 2020-01-16 |
| AU2018210196B2 (en) | 2022-06-02 |
| MX2019008696A (es) | 2019-09-13 |
| WO2018136264A1 (en) | 2018-07-26 |
| BR112019014527A2 (pt) | 2020-02-27 |
| EP3571189A1 (en) | 2019-11-27 |
| JP2023018094A (ja) | 2023-02-07 |
| IL268031B (en) | 2022-06-01 |
| KR20190110588A (ko) | 2019-09-30 |
| SG11201906412SA (en) | 2019-08-27 |
| AU2018210196A1 (en) | 2019-08-15 |
| RU2019126455A3 (enExample) | 2021-05-17 |
| CN110431134A (zh) | 2019-11-08 |
| JP2020505376A (ja) | 2020-02-20 |
| WO2018136264A9 (en) | 2018-10-25 |
| CA3051054A1 (en) | 2018-07-26 |
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