BR112019014527A2 - Compostos de piridina como inibidores de shp2 alostéricos - Google Patents

Info

Publication number

BR112019014527A2

BR112019014527A2 BR112019014527-3A BR112019014527A BR112019014527A2 BR 112019014527 A2 BR112019014527 A2 BR 112019014527A2 BR 112019014527 A BR112019014527 A BR 112019014527A BR 112019014527 A2 BR112019014527 A2 BR 112019014527A2

Authority

BR

Brazil

Prior art keywords

alkyl

optionally substituted

formula

heterocycle

cycloalkyl

Prior art date

2017-01-23

Links

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• 101710116241 Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 title claims description 68
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• 239000003112 inhibitor Substances 0.000 title abstract description 3
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• UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims description 706
• 125000000217 alkyl group Chemical group 0.000 claims description 623
• 150000001875 compounds Chemical class 0.000 claims description 487
• 125000000623 heterocyclic group Chemical group 0.000 claims description 439
• 125000002950 monocyclic group Chemical group 0.000 claims description 297
• 125000001072 heteroaryl group Chemical group 0.000 claims description 236
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 227
• 229910052736 halogen Inorganic materials 0.000 claims description 221
• 150000002367 halogens Chemical class 0.000 claims description 220
• 125000004429 atom Chemical group 0.000 claims description 192
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• 125000000392 cycloalkenyl group Chemical group 0.000 claims description 181
• 125000003118 aryl group Chemical group 0.000 claims description 176
• 229910052757 nitrogen Inorganic materials 0.000 claims description 136
• 150000003839 salts Chemical class 0.000 claims description 136
• 125000003342 alkenyl group Chemical group 0.000 claims description 133
• 239000000651 prodrug Substances 0.000 claims description 126
• 229940002612 prodrug Drugs 0.000 claims description 126
• 239000012453 solvate Substances 0.000 claims description 124
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 108
• 125000005842 heteroatom Chemical group 0.000 claims description 104
• 229910052717 sulfur Inorganic materials 0.000 claims description 104
• 125000000304 alkynyl group Chemical group 0.000 claims description 103
• 229910052760 oxygen Inorganic materials 0.000 claims description 100
• 229910052698 phosphorus Inorganic materials 0.000 claims description 100
• 125000003367 polycyclic group Chemical group 0.000 claims description 59
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 55
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 52
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• 238000000034 method Methods 0.000 claims description 41
• 125000002911 monocyclic heterocycle group Chemical group 0.000 claims description 40
• 229910052799 carbon Inorganic materials 0.000 claims description 38
• 125000004076 pyridyl group Chemical group 0.000 claims description 34
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• 229910052731 fluorine Inorganic materials 0.000 claims description 18
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 17
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• 239000011737 fluorine Substances 0.000 claims description 17
• 125000004432 carbon atom Chemical group C* 0.000 claims description 16
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• VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 claims 1
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• 125000004122 cyclic group Chemical group 0.000 description 12
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• 238000006243 chemical reaction Methods 0.000 description 8
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• KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 description 7
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