JP2019535706A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019535706A5 JP2019535706A5 JP2019524276A JP2019524276A JP2019535706A5 JP 2019535706 A5 JP2019535706 A5 JP 2019535706A5 JP 2019524276 A JP2019524276 A JP 2019524276A JP 2019524276 A JP2019524276 A JP 2019524276A JP 2019535706 A5 JP2019535706 A5 JP 2019535706A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen atoms
- halogenoalkyl
- group
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000005843 halogen group Chemical group 0.000 claims 284
- 229910052736 halogen Inorganic materials 0.000 claims 150
- 150000002367 halogens Chemical group 0.000 claims 142
- 229910052739 hydrogen Inorganic materials 0.000 claims 114
- 239000001257 hydrogen Substances 0.000 claims 113
- 125000004093 cyano group Chemical group *C#N 0.000 claims 98
- 125000001424 substituent group Chemical group 0.000 claims 82
- 150000002431 hydrogen Chemical group 0.000 claims 81
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 74
- -1 -OH Chemical group 0.000 claims 63
- 150000001875 compounds Chemical class 0.000 claims 58
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 47
- 229910052731 fluorine Inorganic materials 0.000 claims 45
- 239000011737 fluorine Substances 0.000 claims 45
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 42
- 125000004043 oxo group Chemical group O=* 0.000 claims 39
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 35
- 125000001072 heteroaryl group Chemical group 0.000 claims 35
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 34
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 33
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 32
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 31
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 31
- 229910052801 chlorine Inorganic materials 0.000 claims 30
- 239000000460 chlorine Chemical group 0.000 claims 30
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 29
- 229910052799 carbon Inorganic materials 0.000 claims 27
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims 18
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 18
- 229910052717 sulfur Inorganic materials 0.000 claims 18
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 17
- 125000002950 monocyclic group Chemical group 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 12
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 11
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 10
- 125000001153 fluoro group Chemical group F* 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 150000001204 N-oxides Chemical class 0.000 claims 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 8
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 7
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 7
- 229910052794 bromium Inorganic materials 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 6
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 6
- AHHWIHXENZJRFG-UHFFFAOYSA-N oxetane Chemical compound C1COC1 AHHWIHXENZJRFG-UHFFFAOYSA-N 0.000 claims 6
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 5
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N benzocyclopentane Natural products C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 125000002757 morpholinyl group Chemical group 0.000 claims 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 4
- 125000004758 (C1-C4) alkoxyimino group Chemical group 0.000 claims 3
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- BBVIDBNAYOIXOE-UHFFFAOYSA-N 1,2,4-oxadiazole Chemical compound C=1N=CON=1 BBVIDBNAYOIXOE-UHFFFAOYSA-N 0.000 claims 2
- WNBQDDAKLKODPH-UHFFFAOYSA-N 1,2,4-triazolidine Chemical compound C1NCNN1 WNBQDDAKLKODPH-UHFFFAOYSA-N 0.000 claims 2
- CIISBYKBBMFLEZ-UHFFFAOYSA-N 1,2-oxazolidine Chemical compound C1CNOC1 CIISBYKBBMFLEZ-UHFFFAOYSA-N 0.000 claims 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 claims 2
- 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Chemical compound C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 claims 2
- NKSZCPBUWGZONP-UHFFFAOYSA-N 3,4-dihydroisoquinoline Chemical compound C1=CC=C2C=NCCC2=C1 NKSZCPBUWGZONP-UHFFFAOYSA-N 0.000 claims 2
- CGYYAUFHKJHMCK-UHFFFAOYSA-N 3,9-dioxa-7-azabicyclo[3.3.1]nonane Chemical compound C1OCC2CNCC1O2 CGYYAUFHKJHMCK-UHFFFAOYSA-N 0.000 claims 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- POOPWPIOIMBTOH-UHFFFAOYSA-N 8-oxa-3-azabicyclo[3.2.1]octane Chemical compound C1NCC2CCC1O2 POOPWPIOIMBTOH-UHFFFAOYSA-N 0.000 claims 2
- BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 claims 2
- WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical compound C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 claims 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 239000011630 iodine Substances 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical compound C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 2
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims 2
- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 229930192474 thiophene Natural products 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 claims 1
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims 1
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 claims 1
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 claims 1
- ZKRNFYHDRLBLJL-UHFFFAOYSA-N 4-oxa-7-azaspiro[2.5]octane Chemical compound C1CC11OCCNC1 ZKRNFYHDRLBLJL-UHFFFAOYSA-N 0.000 claims 1
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 claims 1
- WDJAQSJMDRFZIX-UHFFFAOYSA-N 6-oxa-3-azabicyclo[3.1.1]heptane Chemical compound C1NCC2CC1O2 WDJAQSJMDRFZIX-UHFFFAOYSA-N 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- 206010061201 Helminthic infection Diseases 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical group [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 230000000507 anthelmentic effect Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003230 pyrimidines Chemical class 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- NXZIGGBPLGAPTI-UHFFFAOYSA-N tert-butyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CC2OC21 NXZIGGBPLGAPTI-UHFFFAOYSA-N 0.000 claims 1
- XSROQCDVUIHRSI-UHFFFAOYSA-N thietane Chemical compound C1CSC1 XSROQCDVUIHRSI-UHFFFAOYSA-N 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 0 Cc1c(*)c(C)nc(*)c1* Chemical compound Cc1c(*)c(C)nc(*)c1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16198550 | 2016-11-11 | ||
| EP16198550.2 | 2016-11-11 | ||
| PCT/EP2017/078319 WO2018087036A1 (en) | 2016-11-11 | 2017-11-06 | New anthelmintic quinoline-3-carboxamide derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535706A JP2019535706A (ja) | 2019-12-12 |
| JP2019535706A5 true JP2019535706A5 (https=) | 2020-12-17 |
| JP7165129B2 JP7165129B2 (ja) | 2022-11-02 |
Family
ID=57321155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019524276A Active JP7165129B2 (ja) | 2016-11-11 | 2017-11-06 | 新規な駆虫性キノリン－３－カルボキサミド誘導体 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US10889573B2 (https=) |
| EP (1) | EP3538512B1 (https=) |
| JP (1) | JP7165129B2 (https=) |
| KR (1) | KR102595730B1 (https=) |
| CN (1) | CN109890793B (https=) |
| AU (1) | AU2017357503B2 (https=) |
| CA (1) | CA3043298A1 (https=) |
| CL (1) | CL2019001292A1 (https=) |
| CO (1) | CO2019004776A2 (https=) |
| DK (1) | DK3538512T3 (https=) |
| DO (1) | DOP2019000117A (https=) |
| ES (1) | ES2884073T3 (https=) |
| IL (1) | IL266407B (https=) |
| MX (1) | MX2019005569A (https=) |
| MY (1) | MY196327A (https=) |
| NZ (1) | NZ752550A (https=) |
| PH (1) | PH12019501034A1 (https=) |
| PL (1) | PL3538512T3 (https=) |
| PT (1) | PT3538512T (https=) |
| SG (1) | SG11201903059SA (https=) |
| SI (1) | SI3538512T1 (https=) |
| TW (1) | TWI821165B (https=) |
| UA (1) | UA126119C2 (https=) |
| UY (1) | UY37480A (https=) |
| WO (1) | WO2018087036A1 (https=) |
| ZA (1) | ZA201903708B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11485733B2 (en) | 2017-06-30 | 2022-11-01 | Bayer Animal Health Gmbh | Azaquinoline derivatives |
| SG11202000266VA (en) * | 2017-08-04 | 2020-02-27 | Bayer Animal Health Gmbh | Quinoline derivatives for treating infections with helminths |
| KR20200099548A (ko) * | 2017-12-15 | 2020-08-24 | 바이엘 애니멀 헬스 게엠베하 | 구충제 4-아미노-퀴놀린-3-카르복스아미드 유도체를 제조하는 방법 |
| JP7403472B2 (ja) * | 2018-05-09 | 2023-12-22 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規キノリン誘導体 |
| AU2019301510B2 (en) | 2018-07-09 | 2024-06-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelminthic heterocyclic compounds |
| EP3643711A1 (en) | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| CN113490527B (zh) * | 2018-12-18 | 2024-10-25 | 瑞士伊兰科动物保健有限公司 | 双环衍生物 |
| NZ777370A (en) | 2018-12-18 | 2024-11-29 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| BR112021024726A2 (pt) * | 2019-06-07 | 2022-01-18 | Elanco Tiergesundheit Ag | Novos derivados bicíclicos |
| TWI865563B (zh) | 2019-07-30 | 2024-12-11 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| EP4077322A1 (en) | 2019-12-18 | 2022-10-26 | Intervet International B.V. | Anthelmintic compounds comprising azaindoles structure |
| AU2020406093A1 (en) * | 2019-12-18 | 2022-06-16 | Intervet International B.V. | Anthelmintic compounds comprising a quinoline structure |
| JP2023521342A (ja) * | 2020-04-09 | 2023-05-24 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 駆虫性化合物としての置換縮合アジン類 |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| WO2022106469A2 (en) | 2020-11-18 | 2022-05-27 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| CN116685584A (zh) * | 2020-11-18 | 2023-09-01 | 礼蓝动物保健有限公司 | 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物 |
| CN116888124A (zh) * | 2020-12-04 | 2023-10-13 | 礼蓝动物保健有限公司 | 二环衍生物 |
| TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
| US20240043385A1 (en) | 2020-12-11 | 2024-02-08 | Intervet Inc. | Anthelmintic compounds comprising a pyridine structure |
| US20240043446A1 (en) | 2020-12-11 | 2024-02-08 | Intervet Inc. | Anthelmintic compounds comprising a thienopyridine structure |
| EP4148052A1 (en) | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| UY39995A (es) | 2021-11-01 | 2023-05-15 | Boehringer Ingelheim Vetmedica GmbH | Compuestos de pirrolopiridazina como antihelmínticos |
| WO2024213752A1 (en) | 2023-04-14 | 2024-10-17 | Elanco Animal Health Gmbh | Long-term prevention and/or treatment of a disease by slo-1 inhibitors |
| IL326231A (en) | 2023-08-02 | 2026-03-01 | Intervet Int Bv | Carboxamide-4-quinoline compounds with anthelmintic activity |
| WO2026078157A2 (en) | 2024-10-10 | 2026-04-16 | Elanco Animal Health Gmbh | Slo-1 modulators for prevention and/or treatment of a disease |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4343804A (en) * | 1979-03-26 | 1982-08-10 | A. H. Robins Company, Inc. | 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds |
| KR840000768A (ko) * | 1982-07-23 | 1984-02-27 | 박이은 | 무연통의 무연탄 난로 |
| DE3639877A1 (de) | 1986-11-21 | 1988-05-26 | Bayer Ag | Hetarylalkyl substituierte 5- und 6-ringheterocyclen |
| US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| GB0213715D0 (en) | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
| TWI312272B (en) | 2003-05-12 | 2009-07-21 | Sumitomo Chemical Co | Pyrimidine compound and pests controlling composition containing the same |
| GB0414438D0 (en) | 2004-06-28 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
| WO2006043635A1 (ja) | 2004-10-20 | 2006-04-27 | Kumiai Chemical Industry Co., Ltd. | ３－トリアゾリルフェニルスルフィド誘導体及びそれを有効成分として含有する殺虫・殺ダニ・殺線虫剤 |
| CA2603345C (en) * | 2005-04-01 | 2017-05-02 | Insa Rouen | New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents |
| US8338607B2 (en) | 2005-10-06 | 2012-12-25 | Nippon Soda Co., Ltd. | Cyclic amine compounds and agents for pest control |
| JP2008214323A (ja) | 2007-03-08 | 2008-09-18 | Kyowa Hakko Kogyo Co Ltd | 皮膚疾患の治療及び／または予防剤 |
| WO2008154442A1 (en) | 2007-06-08 | 2008-12-18 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline urea derivatives |
| JP5268461B2 (ja) | 2008-07-14 | 2013-08-21 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤 |
| CN101337937B (zh) | 2008-08-12 | 2010-12-22 | 国家农药创制工程技术研究中心 | 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物 |
| CN101337940B (zh) | 2008-08-12 | 2012-05-02 | 国家农药创制工程技术研究中心 | 具杀虫活性的含氮杂环二氯烯丙醚类化合物 |
| CN101715774A (zh) | 2008-10-09 | 2010-06-02 | 浙江化工科技集团有限公司 | 一个具有杀虫活性化合物制备及用途 |
| EP2184273A1 (de) | 2008-11-05 | 2010-05-12 | Bayer CropScience AG | Halogen-substituierte Verbindungen als Pestizide |
| GB0820344D0 (en) | 2008-11-06 | 2008-12-17 | Syngenta Ltd | Herbicidal compositions |
| AU2009324389B2 (en) | 2008-12-12 | 2016-04-28 | Syngenta Crop Protection Ag | Spiroheterocyclic N-oxypiperidines as pesticides |
| WO2011036074A1 (en) * | 2009-09-24 | 2011-03-31 | Basf Se | Aminoquinazoline compounds for combating invertebrate pests |
| WO2011085575A1 (zh) | 2010-01-15 | 2011-07-21 | 江苏省农药研究所股份有限公司 | 邻杂环甲酰苯胺类化合物及其合成方法和应用 |
| AR081721A1 (es) | 2010-02-25 | 2012-10-17 | Nippon Soda Co | Compuesto de amina ciclica y acaricida |
| BR112012030408A2 (pt) | 2010-05-31 | 2015-09-29 | Syngenta Participations Ag | método de melhoramento de culturas |
| AU2011297160B2 (en) | 2010-08-31 | 2014-11-20 | Mitsui Chemicals Crop & Life Solutions, Inc. | Noxious organism control agent |
| CN101967139B (zh) | 2010-09-14 | 2013-06-05 | 中化蓝天集团有限公司 | 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用 |
| WO2012112363A1 (en) | 2011-02-14 | 2012-08-23 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2013050317A1 (en) | 2011-10-03 | 2013-04-11 | Syngenta Limited | Polymorphs of an isoxazoline derivative |
| CN102391261A (zh) | 2011-10-14 | 2012-03-28 | 上海交通大学 | 一种n-取代噁二嗪类化合物及其制备方法和应用 |
| TW201326128A (zh) * | 2011-11-28 | 2013-07-01 | Du Pont | 磺醯胺驅蟲劑 |
| WO2013096151A1 (en) | 2011-12-22 | 2013-06-27 | Glaxosmithkline Llc | Chemical compounds |
| TWI566701B (zh) | 2012-02-01 | 2017-01-21 | 日本農藥股份有限公司 | 芳烷氧基嘧啶衍生物及包含該衍生物作為有效成分的農園藝用殺蟲劑及其使用方法 |
| WO2013118071A1 (en) | 2012-02-09 | 2013-08-15 | Glenmark Pharmaceuticals S.A. | BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS |
| EP2830421B1 (en) | 2012-03-30 | 2017-03-01 | Basf Se | N-substituted pyridinylidene thiocarbonyl compounds and their use for combating animal pests |
| EP2647626A1 (en) | 2012-04-03 | 2013-10-09 | Syngenta Participations AG. | 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides |
| BR122014028247A2 (pt) | 2012-04-27 | 2019-05-07 | Dow Agrosciences Llc | composições pesticidas, processo para controlar praga, uso de uma molécula, processo para aumentar a saúde, rendimento, vigor, qualidade ou tolerância de uma planta e processos para produção de compostos |
| US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| JP2016508972A (ja) * | 2012-12-20 | 2016-03-24 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 殺ダニ剤及び殺虫剤としてのアリールスルフィド誘導体及びアリールスルホキシド誘導体 |
| CN103109816B (zh) | 2013-01-25 | 2014-09-10 | 青岛科技大学 | 硫代苯甲酰胺类化合物及其应用 |
| CN103232431B (zh) | 2013-01-25 | 2014-11-05 | 青岛科技大学 | 一种二卤代吡唑酰胺类化合物及其应用 |
| US20140275503A1 (en) | 2013-03-13 | 2014-09-18 | Dow Agrosciences Llc | Process for the preparation of certain triaryl rhamnose carbamates |
| JP6595985B2 (ja) | 2013-05-23 | 2019-10-23 | シンジェンタ パーティシペーションズ アーゲー | タンク混合配合物 |
| CN103265527B (zh) | 2013-06-07 | 2014-08-13 | 江苏省农用激素工程技术研究中心有限公司 | 邻氨基苯甲酰胺化合物及其制备方法和应用 |
| CN103524422B (zh) | 2013-10-11 | 2015-05-27 | 中国农业科学院植物保护研究所 | 苯并咪唑衍生物及其制备方法和用途 |
| JP2016539092A (ja) | 2013-10-17 | 2016-12-15 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除性化合物の製造方法 |
| EP3057429A4 (en) | 2013-10-17 | 2017-08-09 | Dow AgroSciences LLC | Processes for the preparation of pesticidal compounds |
| AR098475A1 (es) * | 2013-11-26 | 2016-06-01 | Bayer Cropscience Ag | Compuestos pesticidas y usos |
| US9938292B2 (en) * | 2014-03-24 | 2018-04-10 | Guangdong Zhongsheng Pharmaceutical Co., Ltd | Quinoline derivatives as SMO inhibitors |
| TW201613866A (en) | 2014-07-07 | 2016-04-16 | Bayer Cropscience Ag | Process for preparing fluorinated iminopyridine compounds |
| CA2975982C (en) | 2015-02-17 | 2018-11-27 | Nippon Soda Co., Ltd. | Agrochemical composition |
| CN108430992A (zh) | 2015-12-17 | 2018-08-21 | 阿斯特克斯医疗公司 | 作为h-pgds抑制剂的喹啉-3-甲酰胺 |
-
2017
- 2017-11-06 JP JP2019524276A patent/JP7165129B2/ja active Active
- 2017-11-06 UA UAA201906455A patent/UA126119C2/uk unknown
- 2017-11-06 KR KR1020197013186A patent/KR102595730B1/ko active Active
- 2017-11-06 DK DK17791438.9T patent/DK3538512T3/da active
- 2017-11-06 WO PCT/EP2017/078319 patent/WO2018087036A1/en not_active Ceased
- 2017-11-06 NZ NZ752550A patent/NZ752550A/en unknown
- 2017-11-06 MX MX2019005569A patent/MX2019005569A/es unknown
- 2017-11-06 ES ES17791438T patent/ES2884073T3/es active Active
- 2017-11-06 PT PT177914389T patent/PT3538512T/pt unknown
- 2017-11-06 SI SI201730854T patent/SI3538512T1/sl unknown
- 2017-11-06 CN CN201780069050.7A patent/CN109890793B/zh active Active
- 2017-11-06 EP EP17791438.9A patent/EP3538512B1/en active Active
- 2017-11-06 PL PL17791438T patent/PL3538512T3/pl unknown
- 2017-11-06 AU AU2017357503A patent/AU2017357503B2/en active Active
- 2017-11-06 CA CA3043298A patent/CA3043298A1/en active Pending
- 2017-11-06 SG SG11201903059SA patent/SG11201903059SA/en unknown
- 2017-11-06 MY MYPI2019002590A patent/MY196327A/en unknown
- 2017-11-06 US US16/348,797 patent/US10889573B2/en active Active
- 2017-11-10 TW TW106138957A patent/TWI821165B/zh active
- 2017-11-10 UY UY0001037480A patent/UY37480A/es not_active Application Discontinuation
-
2019
- 2019-05-02 IL IL266407A patent/IL266407B/en unknown
- 2019-05-09 PH PH12019501034A patent/PH12019501034A1/en unknown
- 2019-05-10 DO DO2019000117A patent/DOP2019000117A/es unknown
- 2019-05-10 CO CONC2019/0004776A patent/CO2019004776A2/es unknown
- 2019-05-10 CL CL2019001292A patent/CL2019001292A1/es unknown
- 2019-06-10 ZA ZA2019/03708A patent/ZA201903708B/en unknown
-
2020
- 2020-10-30 US US17/085,880 patent/US11505545B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019535706A5 (https=) | ||
| CA3011189C (en) | 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines | |
| ES2829270T3 (es) | Derivados de sulfonamida aromáticos | |
| JP6387360B2 (ja) | 変異ｉｄｈの阻害薬としての３−ピリミジン−４−イル−オキサゾリジン−２−オン | |
| JP2019513776A5 (https=) | ||
| KR102229608B1 (ko) | Ror 감마 조절제로서의 신규한 화합물 | |
| JP6251275B2 (ja) | ナトリウムチャンネル阻害剤、その製造方法およびその用途 | |
| AU2017275209B2 (en) | Sulfonamide compound or salt thereof | |
| RU2012123388A (ru) | Композиции и способы лечения колита | |
| AU2012345557A1 (en) | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease | |
| CN103003269B (zh) | 取代的杂环基苄基吡唑及其用途 | |
| JP2014526500A5 (https=) | ||
| JP2021523168A5 (https=) | ||
| WO2013011033A1 (de) | 3-(fluorvinyl)pyrazole und ihre verwendung | |
| MX2011004779A (es) | Compuestos de arilo sustituido y su uso como inhibidores de hif. | |
| EA037643B1 (ru) | Замещенные фенилоксазолидиноны для антимикробной терапии | |
| JP2005538111A5 (https=) | ||
| JP2015524835A5 (https=) | ||
| JP2013530139A (ja) | ヒドロキシアルキルベンジルピラゾール類およびその使用 | |
| JPWO2021204930A5 (https=) | ||
| US20190284136A1 (en) | Indoline derivatives | |
| JP2008520611A5 (https=) | ||
| RU2019117917A (ru) | Новые антигельминтые хинолин-3-карбоксамидные производные | |
| CN107567439B (zh) | 2-高哌嗪-1-基-4h-1,3-苯并噻嗪-4-酮衍生物和制备2-(高)哌嗪-1,3-苯并噻嗪-4-酮盐酸盐的方法 | |
| EP2934537A1 (en) | Factor ixa inhibitors |