ES2884073T3 - Nuevos derivados antihelmínticos de quinolina-3-carboxamida - Google Patents
Nuevos derivados antihelmínticos de quinolina-3-carboxamida Download PDFInfo
- Publication number
- ES2884073T3 ES2884073T3 ES17791438T ES17791438T ES2884073T3 ES 2884073 T3 ES2884073 T3 ES 2884073T3 ES 17791438 T ES17791438 T ES 17791438T ES 17791438 T ES17791438 T ES 17791438T ES 2884073 T3 ES2884073 T3 ES 2884073T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- group
- halogen atoms
- haloalkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 Cc1c(*)c(C)nc(*)c1* Chemical compound Cc1c(*)c(C)nc(*)c1* 0.000 description 42
- LCRLKHKYLJVOQO-UHFFFAOYSA-N C=CC1c(cc(cc2Cl)Cl)c2OCC1 Chemical compound C=CC1c(cc(cc2Cl)Cl)c2OCC1 LCRLKHKYLJVOQO-UHFFFAOYSA-N 0.000 description 1
- RIGKAIKCEXMKCZ-UHFFFAOYSA-N CC1c(ccc(F)c2)c2OCC1 Chemical compound CC1c(ccc(F)c2)c2OCC1 RIGKAIKCEXMKCZ-UHFFFAOYSA-N 0.000 description 1
- KIVMHRPOVXQJPI-UHFFFAOYSA-N CCOC(c(cnc1c2ccc(F)c1Br)c2N(C)C)=O Chemical compound CCOC(c(cnc1c2ccc(F)c1Br)c2N(C)C)=O KIVMHRPOVXQJPI-UHFFFAOYSA-N 0.000 description 1
- AXQWGMXCLAXHTK-UHFFFAOYSA-N CCOC(c1c(CBr)c2cccc(Br)c2nc1)=O Chemical compound CCOC(c1c(CBr)c2cccc(Br)c2nc1)=O AXQWGMXCLAXHTK-UHFFFAOYSA-N 0.000 description 1
- OABRXUVCSYDGKW-DEOSSOPVSA-N CCOc(c(cccc1-c2cc(Cl)cc(Cl)c2)c1nc1)c1C(N[C@@H]1c2ccccc2CC1)=O Chemical compound CCOc(c(cccc1-c2cc(Cl)cc(Cl)c2)c1nc1)c1C(N[C@@H]1c2ccccc2CC1)=O OABRXUVCSYDGKW-DEOSSOPVSA-N 0.000 description 1
- FARVSSLSGAIQMM-UHFFFAOYSA-N Cc(cc1)cc2c1nc[n]2C Chemical compound Cc(cc1)cc2c1nc[n]2C FARVSSLSGAIQMM-UHFFFAOYSA-N 0.000 description 1
- MZIUWAIRPKKUHT-UHFFFAOYSA-N Cc1c2[o]cnc2cc(C(OC)=O)c1 Chemical compound Cc1c2[o]cnc2cc(C(OC)=O)c1 MZIUWAIRPKKUHT-UHFFFAOYSA-N 0.000 description 1
- JEMHCGAIQBUYDF-UHFFFAOYSA-N Cc1c2[o]cnc2ccc1 Chemical compound Cc1c2[o]cnc2ccc1 JEMHCGAIQBUYDF-UHFFFAOYSA-N 0.000 description 1
- LNXFAOXOYJADQI-UHFFFAOYSA-N Cc1c2[s]cnc2ccc1 Chemical compound Cc1c2[s]cnc2ccc1 LNXFAOXOYJADQI-UHFFFAOYSA-N 0.000 description 1
- PIUXNZAIHQAHBY-UHFFFAOYSA-N Cc1c2nc[s]c2ccc1 Chemical compound Cc1c2nc[s]c2ccc1 PIUXNZAIHQAHBY-UHFFFAOYSA-N 0.000 description 1
- GGNIPCKMLVNQDR-VWLOTQADSA-N Cc1cc(C)cc(-c2cccc3c2ncc(C(N[C@@H](CCC2)c4c2cccc4)=O)c3Cl)c1 Chemical compound Cc1cc(C)cc(-c2cccc3c2ncc(C(N[C@@H](CCC2)c4c2cccc4)=O)c3Cl)c1 GGNIPCKMLVNQDR-VWLOTQADSA-N 0.000 description 1
- HWHNFJYQDMSYAF-UHFFFAOYSA-N Cc1nnn[n]1C Chemical compound Cc1nnn[n]1C HWHNFJYQDMSYAF-UHFFFAOYSA-N 0.000 description 1
- XLRHRUONQGYWDT-QHCPKHFHSA-N O=C(c(cnc1c2ccc(F)c1-c1cccc(Cl)c1Cl)c2N1CCOCC1)N[C@@H]1c2ccccc2OCC1 Chemical compound O=C(c(cnc1c2ccc(F)c1-c1cccc(Cl)c1Cl)c2N1CCOCC1)N[C@@H]1c2ccccc2OCC1 XLRHRUONQGYWDT-QHCPKHFHSA-N 0.000 description 1
- BCTADWLIMIJVIC-HNNXBMFYSA-N O=C(c(cnc1c2cccc1Br)c2Cl)N[C@@H]1c2ccccc2OCC1 Chemical compound O=C(c(cnc1c2cccc1Br)c2Cl)N[C@@H]1c2ccccc2OCC1 BCTADWLIMIJVIC-HNNXBMFYSA-N 0.000 description 1
- HZVFTDIWUKPCDI-SANMLTNESA-N O=C(c1c(C2CCOCC2)c(cccc2-c3cc(Cl)cc(Cl)c3)c2nc1)N[C@@H]1c2ccccc2OCC1 Chemical compound O=C(c1c(C2CCOCC2)c(cccc2-c3cc(Cl)cc(Cl)c3)c2nc1)N[C@@H]1c2ccccc2OCC1 HZVFTDIWUKPCDI-SANMLTNESA-N 0.000 description 1
- YQCPZYVJVIGXDZ-QHCPKHFHSA-N O=C(c1c(C2COC2)c(cccc2-c(cc(cc3F)F)c3F)c2nc1)N[C@@H]1c(cccc2)c2OCC1 Chemical compound O=C(c1c(C2COC2)c(cccc2-c(cc(cc3F)F)c3F)c2nc1)N[C@@H]1c(cccc2)c2OCC1 YQCPZYVJVIGXDZ-QHCPKHFHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16198550 | 2016-11-11 | ||
| PCT/EP2017/078319 WO2018087036A1 (en) | 2016-11-11 | 2017-11-06 | New anthelmintic quinoline-3-carboxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2884073T3 true ES2884073T3 (es) | 2021-12-10 |
Family
ID=57321155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17791438T Active ES2884073T3 (es) | 2016-11-11 | 2017-11-06 | Nuevos derivados antihelmínticos de quinolina-3-carboxamida |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US10889573B2 (https=) |
| EP (1) | EP3538512B1 (https=) |
| JP (1) | JP7165129B2 (https=) |
| KR (1) | KR102595730B1 (https=) |
| CN (1) | CN109890793B (https=) |
| AU (1) | AU2017357503B2 (https=) |
| CA (1) | CA3043298A1 (https=) |
| CL (1) | CL2019001292A1 (https=) |
| CO (1) | CO2019004776A2 (https=) |
| DK (1) | DK3538512T3 (https=) |
| DO (1) | DOP2019000117A (https=) |
| ES (1) | ES2884073T3 (https=) |
| IL (1) | IL266407B (https=) |
| MX (1) | MX2019005569A (https=) |
| MY (1) | MY196327A (https=) |
| NZ (1) | NZ752550A (https=) |
| PH (1) | PH12019501034A1 (https=) |
| PL (1) | PL3538512T3 (https=) |
| PT (1) | PT3538512T (https=) |
| SG (1) | SG11201903059SA (https=) |
| SI (1) | SI3538512T1 (https=) |
| TW (1) | TWI821165B (https=) |
| UA (1) | UA126119C2 (https=) |
| UY (1) | UY37480A (https=) |
| WO (1) | WO2018087036A1 (https=) |
| ZA (1) | ZA201903708B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11485733B2 (en) | 2017-06-30 | 2022-11-01 | Bayer Animal Health Gmbh | Azaquinoline derivatives |
| SG11202000266VA (en) * | 2017-08-04 | 2020-02-27 | Bayer Animal Health Gmbh | Quinoline derivatives for treating infections with helminths |
| KR20200099548A (ko) * | 2017-12-15 | 2020-08-24 | 바이엘 애니멀 헬스 게엠베하 | 구충제 4-아미노-퀴놀린-3-카르복스아미드 유도체를 제조하는 방법 |
| JP7403472B2 (ja) * | 2018-05-09 | 2023-12-22 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規キノリン誘導体 |
| AU2019301510B2 (en) | 2018-07-09 | 2024-06-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelminthic heterocyclic compounds |
| EP3643711A1 (en) | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| CN113490527B (zh) * | 2018-12-18 | 2024-10-25 | 瑞士伊兰科动物保健有限公司 | 双环衍生物 |
| NZ777370A (en) | 2018-12-18 | 2024-11-29 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| BR112021024726A2 (pt) * | 2019-06-07 | 2022-01-18 | Elanco Tiergesundheit Ag | Novos derivados bicíclicos |
| TWI865563B (zh) | 2019-07-30 | 2024-12-11 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| EP4077322A1 (en) | 2019-12-18 | 2022-10-26 | Intervet International B.V. | Anthelmintic compounds comprising azaindoles structure |
| AU2020406093A1 (en) * | 2019-12-18 | 2022-06-16 | Intervet International B.V. | Anthelmintic compounds comprising a quinoline structure |
| JP2023521342A (ja) * | 2020-04-09 | 2023-05-24 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 駆虫性化合物としての置換縮合アジン類 |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| WO2022106469A2 (en) | 2020-11-18 | 2022-05-27 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| CN116685584A (zh) * | 2020-11-18 | 2023-09-01 | 礼蓝动物保健有限公司 | 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物 |
| CN116888124A (zh) * | 2020-12-04 | 2023-10-13 | 礼蓝动物保健有限公司 | 二环衍生物 |
| TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
| US20240043385A1 (en) | 2020-12-11 | 2024-02-08 | Intervet Inc. | Anthelmintic compounds comprising a pyridine structure |
| US20240043446A1 (en) | 2020-12-11 | 2024-02-08 | Intervet Inc. | Anthelmintic compounds comprising a thienopyridine structure |
| EP4148052A1 (en) | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| UY39995A (es) | 2021-11-01 | 2023-05-15 | Boehringer Ingelheim Vetmedica GmbH | Compuestos de pirrolopiridazina como antihelmínticos |
| WO2024213752A1 (en) | 2023-04-14 | 2024-10-17 | Elanco Animal Health Gmbh | Long-term prevention and/or treatment of a disease by slo-1 inhibitors |
| IL326231A (en) | 2023-08-02 | 2026-03-01 | Intervet Int Bv | Carboxamide-4-quinoline compounds with anthelmintic activity |
| WO2026078157A2 (en) | 2024-10-10 | 2026-04-16 | Elanco Animal Health Gmbh | Slo-1 modulators for prevention and/or treatment of a disease |
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