JP2019500848A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019500848A5 JP2019500848A5 JP2018520406A JP2018520406A JP2019500848A5 JP 2019500848 A5 JP2019500848 A5 JP 2019500848A5 JP 2018520406 A JP2018520406 A JP 2018520406A JP 2018520406 A JP2018520406 A JP 2018520406A JP 2019500848 A5 JP2019500848 A5 JP 2019500848A5
- Authority
- JP
- Japan
- Prior art keywords
- tcr
- abtcr
- domain
- tcr subunit
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims description 71
- 108091007433 antigens Proteins 0.000 claims description 71
- 102000036639 antigens Human genes 0.000 claims description 71
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 65
- 210000004027 cell Anatomy 0.000 claims description 50
- 229920001184 polypeptide Polymers 0.000 claims description 34
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 34
- 239000012636 effector Substances 0.000 claims description 32
- 150000007523 nucleic acids Chemical class 0.000 claims description 20
- 239000012634 fragment Substances 0.000 claims description 14
- 108091008874 T cell receptors Proteins 0.000 claims description 11
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 11
- 230000011664 signaling Effects 0.000 claims description 9
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims description 2
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims description 2
- 101000621309 Homo sapiens Wilms tumor protein Proteins 0.000 claims description 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims description 2
- 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 claims description 2
- 101710123134 Ice-binding protein Proteins 0.000 claims description 2
- 101710082837 Ice-structuring protein Proteins 0.000 claims description 2
- 102000036673 PRAME Human genes 0.000 claims description 2
- 108060006580 PRAME Proteins 0.000 claims description 2
- 101710107540 Type-2 ice-structuring protein Proteins 0.000 claims description 2
- 229940072221 immunoglobulins Drugs 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 3
- 238000000034 method Methods 0.000 description 27
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 210000001744 T-lymphocyte Anatomy 0.000 description 6
- 230000003834 intracellular effect Effects 0.000 description 6
- 108010075254 C-Peptide Proteins 0.000 description 4
- 210000004899 c-terminal region Anatomy 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 3
- 101710160107 Outer membrane protein A Proteins 0.000 description 3
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 241000711549 Hepacivirus C Species 0.000 description 2
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 description 2
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 2
- 241001502974 Human gammaherpesvirus 8 Species 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 241000701806 Human papillomavirus Species 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000000139 costimulatory effect Effects 0.000 description 2
- 230000004068 intracellular signaling Effects 0.000 description 2
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 description 1
- 208000006468 Adrenal Cortex Neoplasms Diseases 0.000 description 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 description 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 description 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 102100031507 Fc receptor-like protein 5 Human genes 0.000 description 1
- 101150032879 Fcrl5 gene Proteins 0.000 description 1
- 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
- 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 description 1
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 description 1
- 101001103033 Homo sapiens Tyrosine-protein kinase transmembrane receptor ROR2 Proteins 0.000 description 1
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000007452 Plasmacytoma Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 102100039616 Tyrosine-protein kinase transmembrane receptor ROR2 Human genes 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 208000006990 cholangiocarcinoma Diseases 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 210000000581 natural killer T-cell Anatomy 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 208000028591 pheochromocytoma Diseases 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021204862A JP2022050431A (ja) | 2015-10-23 | 2021-12-17 | 抗体/t細胞受容体キメラ構築物およびその使用 |
| JP2024015749A JP2024062997A (ja) | 2015-10-23 | 2024-02-05 | 抗体/t細胞受容体キメラ構築物およびその使用 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245944P | 2015-10-23 | 2015-10-23 | |
| US62/245,944 | 2015-10-23 | ||
| US201662304918P | 2016-03-07 | 2016-03-07 | |
| US62/304,918 | 2016-03-07 | ||
| US201662345649P | 2016-06-03 | 2016-06-03 | |
| US62/345,649 | 2016-06-03 | ||
| US201662369694P | 2016-08-01 | 2016-08-01 | |
| US62/369,694 | 2016-08-01 | ||
| PCT/US2016/058305 WO2017070608A1 (en) | 2015-10-23 | 2016-10-21 | Antibody/t-cell receptor chimeric constructs and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021204862A Division JP2022050431A (ja) | 2015-10-23 | 2021-12-17 | 抗体/t細胞受容体キメラ構築物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019500848A JP2019500848A (ja) | 2019-01-17 |
| JP2019500848A5 true JP2019500848A5 (https=) | 2019-12-05 |
| JP7316042B2 JP7316042B2 (ja) | 2023-07-27 |
Family
ID=58558140
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520406A Active JP7316042B2 (ja) | 2015-10-23 | 2016-10-21 | 抗体/t細胞受容体キメラ構築物およびその使用 |
| JP2021204862A Pending JP2022050431A (ja) | 2015-10-23 | 2021-12-17 | 抗体/t細胞受容体キメラ構築物およびその使用 |
| JP2024015749A Pending JP2024062997A (ja) | 2015-10-23 | 2024-02-05 | 抗体/t細胞受容体キメラ構築物およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021204862A Pending JP2022050431A (ja) | 2015-10-23 | 2021-12-17 | 抗体/t細胞受容体キメラ構築物およびその使用 |
| JP2024015749A Pending JP2024062997A (ja) | 2015-10-23 | 2024-02-05 | 抗体/t細胞受容体キメラ構築物およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US11421013B2 (https=) |
| EP (2) | EP3842450A1 (https=) |
| JP (3) | JP7316042B2 (https=) |
| KR (2) | KR102777395B1 (https=) |
| CN (4) | CN107614519B (https=) |
| AU (2) | AU2016342041B2 (https=) |
| CA (1) | CA3001137A1 (https=) |
| DK (1) | DK3365364T5 (https=) |
| ES (1) | ES2979220T3 (https=) |
| IL (3) | IL258405B (https=) |
| MX (1) | MX2018004721A (https=) |
| MY (1) | MY194628A (https=) |
| PH (1) | PH12018500861A1 (https=) |
| RU (2) | RU2767209C2 (https=) |
| SG (3) | SG10201913245UA (https=) |
| TW (2) | TWI780031B (https=) |
| WO (1) | WO2017070608A1 (https=) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3227339T1 (sl) | 2014-12-05 | 2022-02-28 | Memorial Sloan-Kettering Cancer Center | Himerni antigenski receptorji, ki ciljajo na receptor, povezan z G-proteinom, in njihova uporaba |
| EP3227324A4 (en) * | 2014-12-05 | 2018-08-29 | Memorial Sloan Kettering Cancer Center | Antibodies targeting g-protein coupled receptor and methods of use |
| CN107995913B (zh) | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| EP3842450A1 (en) * | 2015-10-23 | 2021-06-30 | Eureka Therapeutics, Inc. | Antibody/t-cell receptor chimeric constructs and uses thereof |
| GB201604458D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against cancers |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| EP4596707A3 (en) | 2016-09-19 | 2025-10-08 | University of Southern California | Non-radioactive cytotoxicity assays |
| CN110352068A (zh) * | 2016-12-02 | 2019-10-18 | 南加利福尼亚大学 | 合成的免疫受体及其使用方法 |
| IL270138B2 (en) | 2017-04-26 | 2025-08-01 | Eureka Therapeutics Inc | Structures that specifically recognize glypican 3 and their uses |
| WO2018200585A1 (en) | 2017-04-26 | 2018-11-01 | Eureka Therapeutics, Inc. | Cells expressing chimeric antigen receptors and secondary effectors and uses thereof |
| SG11202000025SA (en) | 2017-07-14 | 2020-02-27 | Immatics Biotechnologies Gmbh | Improved dual specificity polypeptide molecule |
| WO2019051001A1 (en) * | 2017-09-06 | 2019-03-14 | California Institute Of Technology | SIGNALING AND BIFUNCTIONAL RECEPTORS HAVING ANTIGENS (SABR) |
| CN117843810A (zh) * | 2017-09-22 | 2024-04-09 | 上海药明生物技术有限公司 | 新型双特异性多肽复合物 |
| AU2018337142B2 (en) | 2017-09-22 | 2025-07-03 | Wuxi Biologics Ireland Limited. | Novel bispecific CD3/CD19 polypeptide complexes |
| MX2020004185A (es) * | 2017-09-27 | 2021-01-08 | Univ Southern California | Nuevas plataformas para coestimulacion, nuevos diseños car y otras mejoras para terapia celular adoptiva. |
| JP7447006B2 (ja) | 2017-11-01 | 2024-03-11 | ジュノー セラピューティクス インコーポレイテッド | B細胞成熟抗原(bcma)に特異的なキメラ抗原受容体 |
| GB201718088D0 (en) * | 2017-11-01 | 2017-12-13 | Autolus Ltd | Vectors |
| CN109971715A (zh) * | 2017-12-28 | 2019-07-05 | 深圳华大生命科学研究院 | 一种扩增特异性car-t细胞的培养方法 |
| JPWO2019151392A1 (ja) * | 2018-01-31 | 2021-02-04 | 国立大学法人東北大学 | 抗原特異的mhc発現調節法 |
| GB201801920D0 (en) * | 2018-02-06 | 2018-03-21 | Autolus Ltd | Polypeptides and methods |
| CA3090791A1 (en) * | 2018-02-11 | 2019-08-15 | Memorial Sloan-Kettering Cancer Center | Non-hla restricted t cell receptors and uses thereof |
| CA3091143A1 (en) | 2018-02-15 | 2019-08-22 | Memorial Sloan-Kettering Cancer Center | Foxp3 targeting agent compositions and methods of use for adoptive cell therapy |
| SG11202008568WA (en) * | 2018-03-09 | 2020-10-29 | Sorrento Therapeutics Inc | Dimeric antigen receptors (dar) |
| EP3768699B1 (en) * | 2018-03-23 | 2025-11-12 | Gavish-Galilee Bio Applications Ltd. | Genetically reprogrammed tregs expressing membrane-bound il-10 |
| CN112888709B (zh) * | 2018-03-30 | 2024-10-29 | 优瑞科生物技术公司 | 标靶cd22的构建体和其用途 |
| CN110407927B (zh) * | 2018-04-26 | 2022-09-09 | 香雪生命科学技术(广东)有限公司 | 一种识别afp抗原的tcr |
| MX2020012927A (es) * | 2018-06-01 | 2021-03-25 | Univ Southern California | Diversos dominios de enlace de antigenos, nuevas plataformas y otras mejoras para terapia celular. |
| SG11202012342WA (en) * | 2018-06-18 | 2021-01-28 | Eureka Therapeutics Inc | Constructs targeting prostate-specific membrane antigen (psma) and uses thereof |
| MX2021000827A (es) * | 2018-08-03 | 2021-03-25 | Chugai Pharmaceutical Co Ltd | Molecula de union a antigeno que contiene dos dominios de union a antigeno que estan enlazados entre si. |
| CN110818802B (zh) * | 2018-08-08 | 2022-02-08 | 华夏英泰(北京)生物技术有限公司 | 一种嵌合t细胞受体star及其应用 |
| BR112021005472A2 (pt) * | 2018-09-28 | 2021-06-15 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno compreendendo uma região variável do anticorpo alterada |
| KR20210113169A (ko) | 2018-11-01 | 2021-09-15 | 주노 쎄러퓨티크스 인코퍼레이티드 | Β세포 성숙 항원에 특이적인 키메라 항원 수용체를 이용한 치료 방법 |
| MX2021005751A (es) | 2018-11-16 | 2021-10-01 | Memorial Sloan Kettering Cancer Center | Anticuerpos contra mucina 16 y métodos de uso de los mismos. |
| EP3883955A1 (en) * | 2018-11-19 | 2021-09-29 | Board of Regents, The University of Texas System | A modular, polycistronic vector for car and tcr transduction |
| US12325734B2 (en) | 2019-01-15 | 2025-06-10 | Altor Bioscience Llc | Human immunodeficiency virus-specific T cell receptors |
| CN110006724B (zh) * | 2019-04-17 | 2021-06-04 | 郑州安图生物工程股份有限公司 | 采用巴氏和革兰氏染色方法检测滴虫用试剂 |
| DE102019121007A1 (de) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigenbindende Proteine, die spezifisch an MAGE-A binden |
| EP4010697A4 (en) * | 2019-08-05 | 2022-10-12 | Charles River Laboratories, Inc. | ANTIGEN-BINDING MOLECULES AND THEIR SCREENING METHODS |
| WO2021030153A2 (en) * | 2019-08-09 | 2021-02-18 | A2 Biotherapeutics, Inc. | Engineered t cell receptors and uses thereof |
| JP2022546577A (ja) * | 2019-09-05 | 2022-11-04 | ソレント・セラピューティクス・インコーポレイテッド | Bcmaと結合する二量体抗原受容体(dar) |
| CA3154287A1 (en) * | 2019-09-12 | 2021-03-18 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| KR20220122656A (ko) | 2019-12-06 | 2022-09-02 | 주노 쎄러퓨티크스 인코퍼레이티드 | Gprc5d-표적화 결합 도메인에 대한 항-이디오타입 항체 및 관련 조성물 및 방법 |
| WO2021135178A1 (zh) * | 2019-12-30 | 2021-07-08 | 华夏英泰(北京)生物技术有限公司 | 一种增强型t细胞受体star及其应用 |
| AU2021205501A1 (en) * | 2020-01-10 | 2022-08-18 | TCR2 Therapeutics Inc. | Compositions and methods for autoimmunity regulation |
| CN111320703A (zh) * | 2020-03-11 | 2020-06-23 | 北京双赢科创生物科技有限公司 | 靶向cd22的嵌合抗原受体及其应用 |
| JP2023518049A (ja) | 2020-03-16 | 2023-04-27 | ユニバーシティ オブ サザン カリフォルニア | 新規な抗原結合ドメインおよびそれを組み込んだ合成抗原受容体 |
| IL296511A (en) | 2020-03-20 | 2022-11-01 | Lyell Immunopharma Inc | Novel recombinant cell surface markers |
| US12365871B2 (en) | 2020-04-28 | 2025-07-22 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| KR102931002B1 (ko) * | 2020-05-07 | 2026-02-24 | 브리스타 이뮤노테크 리미티드 | 개선된 t 세포 수용체-공동자극 분자 키메라 |
| KR20230058013A (ko) * | 2020-05-25 | 2023-05-02 | 브리스타 이뮤노테크 리미티드 | 향상된 합성 t 세포 수용체 및 항원 수용체 |
| KR20230133878A (ko) * | 2021-01-19 | 2023-09-19 | 우시 바이올로직스 아일랜드 리미티드 | 안정성 및 발현이 향상된 폴리펩티드 복합체 |
| WO2022164959A1 (en) | 2021-01-27 | 2022-08-04 | Lyell Immunopharma, Inc. | Improved immune cell therapy |
| KR20230150833A (ko) | 2021-02-25 | 2023-10-31 | 라이엘 이뮤노파마, 인크. | 세포 배양 방법 |
| EP4301782A1 (en) | 2021-03-05 | 2024-01-10 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
| US12162940B2 (en) | 2021-05-05 | 2024-12-10 | Immatics Biotechnologies Gmbh | BMA031 antigen binding polypeptides |
| EP4334361A1 (en) | 2021-05-05 | 2024-03-13 | Immatics Biotechnologies GmbH | Antigen binding proteins specifically binding prame |
| KR20240038974A (ko) * | 2021-07-29 | 2024-03-26 | 난트셀, 인크. | 바이러스 감염 및 암의 예방 및 치료를 위한 변형된 t 세포 수용체 |
| JP2024531915A (ja) | 2021-08-05 | 2024-09-03 | ジーオー セラピューティクス,インコーポレイテッド | 抗グリコmuc抗体およびその使用 |
| CA3230934A1 (en) | 2021-09-03 | 2023-03-09 | Go Therapeutics, Inc. | Anti-glyco-cmet antibodies and their uses |
| AU2022339819A1 (en) | 2021-09-03 | 2024-04-11 | Go Therapeutics, Inc. | Anti-glyco-lamp1 antibodies and their uses |
| WO2023070041A1 (en) | 2021-10-21 | 2023-04-27 | Lyell Immunopharma, Inc. | Enhanced immune cell therapy |
| KR20240112376A (ko) | 2021-10-28 | 2024-07-18 | 라이엘 이뮤노파마, 인크. | c-Jun을 발현하는 세포를 배양하는 방법 |
| US20230181644A1 (en) | 2021-10-28 | 2023-06-15 | Lyell Immunopharma, Inc. | Methods of generating cells |
| JP2024540099A (ja) | 2021-10-28 | 2024-10-31 | ライエル・イミュノファーマ・インコーポレイテッド | Ror1結合タンパク質を発現する細胞を培養する方法 |
| WO2023133540A1 (en) | 2022-01-07 | 2023-07-13 | Lyell Immunopharma, Inc. | Il-12 affinity variants |
| CN116063457A (zh) * | 2022-04-27 | 2023-05-05 | 恒瑞源正(广州)生物科技有限公司 | Mage-a1特异性t细胞受体及其用途 |
| CN119790063A (zh) | 2022-07-22 | 2025-04-08 | 莱尔免疫制药股份有限公司 | 免疫细胞疗法 |
| WO2024064958A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| WO2024064952A1 (en) | 2022-09-23 | 2024-03-28 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells overexpressing c-jun |
| WO2024062138A1 (en) | 2022-09-23 | 2024-03-28 | Mnemo Therapeutics | Immune cells comprising a modified suv39h1 gene |
| WO2024077174A1 (en) | 2022-10-05 | 2024-04-11 | Lyell Immunopharma, Inc. | Methods for culturing nr4a-deficient cells |
| WO2024100136A1 (en) * | 2022-11-08 | 2024-05-16 | Gadeta B.V. | Novel method for obtaining gamma t-cell (or delta t-cell) receptor chains (or gamma delta t-cell receptors) or fragments thereof that mediate an anti-tumour or an anti-infective response |
| WO2024103251A1 (zh) * | 2022-11-15 | 2024-05-23 | 原启生物科技(上海)有限责任公司 | 抗afp/hla02 tcr样抗体及其用途 |
| CN121358761A (zh) * | 2023-01-05 | 2026-01-16 | 安吉勒斯治疗公司 | 用于基因转导及调控合成与免疫受体活性的方法和组合物 |
| WO2024148369A1 (en) | 2023-01-07 | 2024-07-11 | Lyell Immunopharma, Inc. | Targeted il-12 affinity variants |
| WO2024182539A1 (en) | 2023-02-28 | 2024-09-06 | Lyell Immunopharma, Inc. | Methods of culturing reprogrammed cells |
| AU2024309243A1 (en) | 2023-06-27 | 2026-01-29 | Lyell Immunopharma, Inc. | Il-12 stability variants |
| CN121909034A (zh) | 2023-07-24 | 2026-04-21 | 斯特兰德生物科技公司 | 用于产生用于体外细胞疗法的工程化免疫细胞的基于rna的合成回路 |
| WO2025047925A1 (ja) * | 2023-08-31 | 2025-03-06 | 国立大学法人三重大学 | ハイブリッドt細胞受容体 |
| WO2025217398A1 (en) | 2024-04-10 | 2025-10-16 | Lyell Immunopharma, Inc. | Methods for culturing cells with improved culture medium |
| WO2026006604A1 (en) | 2024-06-26 | 2026-01-02 | Lyell Immunopharma, Inc. | Feeder cell replacement |
Family Cites Families (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5906936A (en) | 1988-05-04 | 1999-05-25 | Yeda Research And Development Co. Ltd. | Endowing lymphocytes with antibody specificity |
| IL86278A (en) * | 1988-05-04 | 2003-06-24 | Yeda Res & Dev | Endowing cells with antibody specificity using chimeric t cell receptor |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US5585358A (en) | 1993-07-06 | 1996-12-17 | Yissum Research Development Corporation Of The Hebrew University Of Jerusalem | Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| JPH11510375A (ja) | 1995-06-30 | 1999-09-14 | コベンハブンズ ユニバーサイテッド | ペプチド−mhc複合体を指向するファージディスプレイライブラリーからの組換え抗体 |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| AU757961B2 (en) * | 1998-09-30 | 2003-03-13 | Sankyo Company Limited | Anti-Fas antibodies |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU784983B2 (en) | 1999-12-15 | 2006-08-17 | Genentech Inc. | Shotgun scanning, a combinatorial method for mapping functional protein epitopes |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| CA2406864A1 (en) | 2000-02-24 | 2001-08-30 | Life Technologies Corporation | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| CN101289511A (zh) | 2000-04-11 | 2008-10-22 | 杰南技术公司 | 多价抗体及其应用 |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| AU2001297703B2 (en) | 2000-11-07 | 2006-10-19 | City Of Hope | CD19-specific redirected immune cells |
| US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| CA2467633C (en) | 2001-12-03 | 2012-03-27 | Abgenix, Inc. | Antibody categorization based on binding characteristics |
| US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| AU2003216341A1 (en) * | 2002-02-20 | 2003-09-09 | Dyax Corporation | Mhc-peptide complex binding ligands |
| SI2332989T1 (sl) | 2002-05-22 | 2015-06-30 | Esbatech, An Alcon Biomedical Research Unit Llc | Imunoglobulinski bralni okvirji, ki kaĺ˝ejo izboljĺ ano stabilnost v intraceliäśnem okolju, in postopki za njihovo identifikacijo |
| EP1513879B1 (en) | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
| CA2510003A1 (en) | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
| SI1629011T1 (sl) | 2003-05-31 | 2010-05-31 | Micromet Ag | Humane molekule za vezavo anti hu cd |
| US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
| AU2005247950B2 (en) | 2004-05-27 | 2012-02-02 | Receptor Logic, Inc. | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| EP3050963B1 (en) | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
| KR20080031001A (ko) * | 2005-06-02 | 2008-04-07 | 아스트라제네카 아베 | Cd20에 대한 항체 및 그의 용도 |
| WO2007002223A2 (en) | 2005-06-20 | 2007-01-04 | Medarex, Inc. | Cd19 antibodies and their uses |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| CN101316610A (zh) | 2005-09-22 | 2008-12-03 | 艾润·R·科恩 | T细胞受体恒定区的免疫原性片段及其衍生的肽 |
| EP1957531B1 (en) | 2005-11-07 | 2016-04-13 | Genentech, Inc. | Binding polypeptides with diversified and consensus vh/vl hypervariable sequences |
| WO2007064919A2 (en) | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| ES2547248T3 (es) | 2006-04-28 | 2015-10-02 | Delenex Therapeutics Ag | Anticuerpos que se unen al dominio extracelular del receptor Tirosina cinasa ALK |
| CA2651174A1 (en) * | 2006-05-03 | 2007-11-15 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Chimeric t cell receptors and related materials and methods of use |
| JP2009536527A (ja) | 2006-05-09 | 2009-10-15 | ジェネンテック・インコーポレーテッド | 最適化されたスキャフォールドを備えた結合ポリペプチド |
| WO2007143104A2 (en) | 2006-06-01 | 2007-12-13 | Receptor Logic, Ltd. | Antibodies as t cell receptor mimics, methods of production and uses thereof |
| KR101456728B1 (ko) | 2006-09-08 | 2014-10-31 | 메디뮨 엘엘씨 | 인간화 항-cd19 항체, 및 이것의 종양학, 이식 및 자가면역 질환의 치료에서의 용도 |
| AU2008247819B2 (en) | 2007-05-01 | 2013-02-14 | Research Development Foundation | Immunoglobulin Fc libraries |
| CN100592373C (zh) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | 液晶显示面板驱动装置及其驱动方法 |
| MX351227B (es) | 2008-06-25 | 2017-09-14 | Athenix Corp | Genes de toxinas y métodos para su uso. |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| WO2010059543A1 (en) | 2008-11-20 | 2010-05-27 | Merck Sharp & Dohme Corp. | Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use |
| US20100153133A1 (en) | 2008-12-16 | 2010-06-17 | International Business Machines Corporation | Generating Never-Event Cohorts from Patient Care Data |
| WO2010091637A1 (en) | 2009-02-10 | 2010-08-19 | Shenogen Pharma Group Ltd. | Antibodies and methods for treating estrogen receptor-associated diseases |
| EP2258719A1 (en) | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
| AU2010277561A1 (en) | 2009-07-30 | 2012-02-09 | Helmholtz-Zentrum Fur Infektionsforschung Gmbh | Compositions for generating an antigen specific immune response |
| AU2010309438A1 (en) | 2009-10-22 | 2012-06-07 | Ricardo J. Moro | Peptides that bind the alpha-fetoprotein (AFP) receptor and uses thereof |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| PT2552959T (pt) | 2010-03-26 | 2017-04-21 | Memorial Sloan Kettering Cancer Center | Anticorpos para muc16 e métodos de utilização dos mesmos |
| WO2012050374A2 (en) | 2010-10-13 | 2012-04-19 | Innocell, Inc. | Immunotherapy for solid tumors |
| KR20140033029A (ko) | 2011-04-01 | 2014-03-17 | 메모리얼 슬로안-케터링 캔서 센터 | 에이치엘에이 에이2에 의해 제공된 더블유티1 펩타이드에 특이적인 티 세포 수용체 유사 항체 |
| US10239952B2 (en) | 2011-04-01 | 2019-03-26 | Memorial Sloan Kettering Cancer Center | Anti-WT1/HLA bi-specific antibody |
| UY34317A (es) * | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| US20130280220A1 (en) | 2012-04-20 | 2013-10-24 | Nabil Ahmed | Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes |
| EP2843051B1 (en) | 2012-04-23 | 2018-06-06 | GeneFrontier Corporation | Anti-human cd69 antibody, and use thereof for medical purposes |
| CN103319595B (zh) | 2012-07-04 | 2016-12-28 | 中国药科大学 | 抗人afp单链抗体以及融合抗原肽的制备方法和应用 |
| KR20150029714A (ko) | 2012-07-13 | 2015-03-18 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 이중특이적 항체의 공-도입에 의한 car 세포의 활성 증강 |
| WO2014014796A1 (en) | 2012-07-18 | 2014-01-23 | Eli Lilly And Company | Multi-specific igg-(fab)2 constructs containing t-cell receptor constant domains |
| CN104769103B (zh) | 2012-09-04 | 2018-06-08 | 塞勒克提斯公司 | 多链嵌合抗原受体和其用途 |
| AU2013327136A1 (en) | 2012-10-02 | 2015-04-16 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| CN102993305B (zh) | 2012-11-16 | 2015-05-13 | 上海赛伦生物技术有限公司 | 人源抗人表皮生长因子受体抗体及其编码基因与应用 |
| CA2894885A1 (en) | 2012-12-13 | 2014-06-19 | University Of Virginia Patent Foundation | Target peptides for ovarian cancer therapy and diagnostics |
| CN104968491A (zh) | 2013-02-06 | 2015-10-07 | 旭硝子株式会社 | 透明面材以及使用该透明面材的显示装置 |
| CN103965362B (zh) | 2013-02-06 | 2019-02-01 | 上海细胞治疗集团有限公司 | 一种可使t细胞趋向肿瘤部位的嵌合趋化因子受体 |
| US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| JP6346266B2 (ja) * | 2013-03-21 | 2018-06-20 | サンガモ セラピューティクス, インコーポレイテッド | 操作されたジンクフィンガータンパク質ヌクレアーゼを使用するt細胞受容体遺伝子の標的化された破壊 |
| KR101536668B1 (ko) | 2013-06-18 | 2015-07-15 | 사회복지법인 삼성생명공익재단 | 인간 및 마우스 c-Met에 교차결합하는 항체 및 그의 용도 |
| GB201313377D0 (en) | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| WO2015063069A1 (en) | 2013-10-28 | 2015-05-07 | Benjamin Felder | Chimeric antigen receptors with antigen binding domains derived from gamma delta t cell receptors |
| JP6553069B2 (ja) | 2013-11-07 | 2019-07-31 | メモリアル スローン ケタリング キャンサー センター | 抗wt1/hla二重特異性抗体 |
| CN104087592B (zh) | 2014-05-13 | 2016-01-27 | 天津医科大学总医院 | Afp158-166特异性tcr基因及其转基因t细胞及体外增殖方法及用途 |
| KR20240135036A (ko) | 2014-12-05 | 2024-09-10 | 메모리얼 슬로안 케터링 캔서 센터 | B-세포 성숙화 항원을 표적화하는 항체 및 사용 방법 |
| EP3227324A4 (en) | 2014-12-05 | 2018-08-29 | Memorial Sloan Kettering Cancer Center | Antibodies targeting g-protein coupled receptor and methods of use |
| US11673957B2 (en) | 2015-03-10 | 2023-06-13 | Eureka Therapeutics, Inc. | Anti-ROR2 antibodies |
| CN107667120B (zh) | 2015-03-17 | 2022-03-08 | 纪念斯隆-凯特林癌症中心 | 抗muc16抗体及其应用 |
| AU2016243026B2 (en) | 2015-04-03 | 2022-03-31 | Eureka Therapeutics, Inc. | Constructs targeting AFP peptide/MHC complexes and uses thereof |
| CN107847570A (zh) | 2015-05-08 | 2018-03-27 | 优瑞科生物技术公司 | 靶向hpv16‑e7肽/mhc复合体的构建体及其用途 |
| EP3842072A1 (en) | 2015-05-18 | 2021-06-30 | Eureka Therapeutics, Inc. | Anti-ror1 antibodies |
| CN107995913B (zh) | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| TW201702272A (zh) | 2015-05-22 | 2017-01-16 | 美國紀念斯隆 凱特琳癌症中心 | Prame肽專一性類t細胞受體抗體 |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| KR20180023949A (ko) | 2015-06-09 | 2018-03-07 | 메모리얼 슬로안-케터링 캔서 센터 | 인간 hla에 의해 제시된 ebv 잠복성 막 단백질 2a 펩티드에 특이적인 t 세포 수용체-유사 항체 작용제 |
| CN107922471A (zh) | 2015-06-24 | 2018-04-17 | 优瑞科生物技术公司 | 靶向ny‑eso‑1肽/mhc复合物的构建体及其用途 |
| WO2017004252A1 (en) | 2015-06-30 | 2017-01-05 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with mhc chimeric receptors and methods of use in immunotherapy |
| US20200087400A1 (en) | 2015-07-22 | 2020-03-19 | Eureka Therapeutics, Inc. | Constructs targeting psa peptide/mhc complexes and uses thereof |
| IL299203A (en) | 2015-10-13 | 2023-02-01 | Eureka Therapeutics Inc ׂ A Delaware Corp | Antibody factors specific for human differentiation group 19 and their uses |
| EP3842450A1 (en) | 2015-10-23 | 2021-06-30 | Eureka Therapeutics, Inc. | Antibody/t-cell receptor chimeric constructs and uses thereof |
| CN105331585A (zh) | 2015-11-13 | 2016-02-17 | 科济生物医药(上海)有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
| KR20180089497A (ko) | 2015-12-04 | 2018-08-08 | 메모리얼 슬로안-케터링 캔서 센터 | Fc 수용체-유사 5를 표적화하는 항체 및 사용 방법 |
| US11505599B2 (en) | 2016-01-14 | 2022-11-22 | Memorial Sloan-Kettering Cancer Center | T cell receptor-like antibodies specific for Foxp3-derived peptides |
| WO2018057967A2 (en) | 2016-09-23 | 2018-03-29 | Eureka Therapeutics, Inc. | Constructs targeting hiv peptide/mhc complexes and uses thereof |
| IL270138B2 (en) | 2017-04-26 | 2025-08-01 | Eureka Therapeutics Inc | Structures that specifically recognize glypican 3 and their uses |
| CN112888709B (zh) | 2018-03-30 | 2024-10-29 | 优瑞科生物技术公司 | 标靶cd22的构建体和其用途 |
| SG11202012342WA (en) | 2018-06-18 | 2021-01-28 | Eureka Therapeutics Inc | Constructs targeting prostate-specific membrane antigen (psma) and uses thereof |
| MX2021005751A (es) | 2018-11-16 | 2021-10-01 | Memorial Sloan Kettering Cancer Center | Anticuerpos contra mucina 16 y métodos de uso de los mismos. |
| WO2020227538A1 (en) | 2019-05-08 | 2020-11-12 | Memorial Sloan Kettering Cancer Center | Humanized antibodies to mucin-16 and methods of use thereof |
-
2016
- 2016-10-21 EP EP20214936.5A patent/EP3842450A1/en active Pending
- 2016-10-21 RU RU2018118652A patent/RU2767209C2/ru active
- 2016-10-21 AU AU2016342041A patent/AU2016342041B2/en active Active
- 2016-10-21 IL IL258405A patent/IL258405B/en unknown
- 2016-10-21 EP EP16858388.8A patent/EP3365364B1/en active Active
- 2016-10-21 MX MX2018004721A patent/MX2018004721A/es unknown
- 2016-10-21 CN CN201680023511.2A patent/CN107614519B/zh active Active
- 2016-10-21 US US15/769,724 patent/US11421013B2/en active Active
- 2016-10-21 ES ES16858388T patent/ES2979220T3/es active Active
- 2016-10-21 MY MYPI2018000550A patent/MY194628A/en unknown
- 2016-10-21 JP JP2018520406A patent/JP7316042B2/ja active Active
- 2016-10-21 IL IL295398A patent/IL295398B2/en unknown
- 2016-10-21 CN CN202210865517.1A patent/CN116059316A/zh active Pending
- 2016-10-21 DK DK16858388.8T patent/DK3365364T5/da active
- 2016-10-21 IL IL314725A patent/IL314725A/en unknown
- 2016-10-21 CA CA3001137A patent/CA3001137A1/en active Pending
- 2016-10-21 SG SG10201913245UA patent/SG10201913245UA/en unknown
- 2016-10-21 SG SG11201802895QA patent/SG11201802895QA/en unknown
- 2016-10-21 WO PCT/US2016/058305 patent/WO2017070608A1/en not_active Ceased
- 2016-10-21 SG SG10201913247XA patent/SG10201913247XA/en unknown
- 2016-10-21 CN CN202210862478.XA patent/CN115927191A/zh active Pending
- 2016-10-21 KR KR1020187014004A patent/KR102777395B1/ko active Active
- 2016-10-21 CN CN202210861652.9A patent/CN115925973A/zh active Pending
- 2016-10-21 RU RU2022103665A patent/RU2022103665A/ru unknown
- 2016-10-21 KR KR1020257007002A patent/KR20250036959A/ko active Pending
- 2016-10-24 TW TW105134336A patent/TWI780031B/zh active
- 2016-10-24 TW TW111134706A patent/TWI856368B/zh active
-
2017
- 2017-12-01 US US15/829,793 patent/US10098951B2/en active Active
-
2018
- 2018-04-20 PH PH12018500861A patent/PH12018500861A1/en unknown
- 2018-09-04 US US16/121,475 patent/US10464988B2/en active Active
-
2019
- 2019-10-29 US US16/667,781 patent/US10822389B2/en active Active
-
2021
- 2021-02-22 US US17/181,913 patent/US11976105B2/en active Active
- 2021-12-17 JP JP2021204862A patent/JP2022050431A/ja active Pending
-
2022
- 2022-02-25 AU AU2022201334A patent/AU2022201334B2/en active Active
- 2022-04-08 US US17/716,667 patent/US20220348629A1/en not_active Abandoned
-
2024
- 2024-02-05 JP JP2024015749A patent/JP2024062997A/ja active Pending
-
2025
- 2025-01-30 US US19/041,816 patent/US20250361286A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019500848A5 (https=) | ||
| RU2018118652A (ru) | Химерные конструкции антитело/т-клеточный рецептор и их применения | |
| US20250188145A1 (en) | Tcr and peptides | |
| CN102695717B (zh) | T细胞受体 | |
| CN108135998B (zh) | 高亲合力hpv t细胞受体 | |
| JP6639233B2 (ja) | Mage−a1を認識する高結合活性結合分子 | |
| JP6985934B2 (ja) | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 | |
| JP2023021396A (ja) | キメラ抗原受容体 | |
| KR20190016960A (ko) | γδ T-세포 집단의 선택적 확장을 위한 방법 및 그의 조성물 | |
| CN106749620B (zh) | 识别mage-a1抗原短肽的t细胞受体 | |
| EP3500678A1 (en) | Retroviral and lentiviral vectors | |
| US20180223255A1 (en) | Activation and Expansion of T Cells | |
| WO2020020359A1 (en) | Nef-containing t cells and methods of producing thereof | |
| JP2021524248A5 (https=) | ||
| JPWO2019173324A5 (https=) | ||
| JP2021532742A5 (https=) | ||
| KR20230013257A (ko) | 종양 미세환경의 역전을 위한 융합 단백질 및 이의 응용 | |
| JP7606510B2 (ja) | Ebv-由来抗原に特異的なtcr構築物 | |
| JP7747724B2 (ja) | マウス定常領域を伴うtcrを発現する細胞を選択的に増幅するための方法 | |
| CN110776562A (zh) | 一种识别afp抗原的t细胞受体 | |
| Lyu et al. | A novel and simple method to produce large amounts of recombinant soluble peptide/major histocompatibility complex monomers for analysis of antigen-specific human T cell receptors | |
| ES2877820T3 (es) | Composiciones y métodos para la clonación rápida de receptores de células T | |
| CN112041432A (zh) | Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法 | |
| CN107129537A (zh) | 抗乙型肝炎病毒的免疫反应性细胞 | |
| JP7518915B2 (ja) | Cd3融合タンパク質およびその使用 |