|
JPS58201994A
(ja)
|
1982-05-21 |
1983-11-25 |
Hideaki Hagiwara |
抗原特異的ヒト免疫グロブリンの生産方法
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
JPH06508511A
(ja)
|
1990-07-10 |
1994-09-29 |
ケンブリッジ アンティボディー テクノロジー リミティド |
特異的な結合ペアーの構成員の製造方法
|
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
|
ATE181571T1
(de)
|
1991-09-23 |
1999-07-15 |
Medical Res Council |
Methoden zur herstellung humanisierter antikörper
|
|
JPH07501451A
(ja)
|
1991-11-25 |
1995-02-16 |
エンゾン・インコーポレイテッド |
多価抗原結合タンパク質
|
|
ATE463573T1
(de)
|
1991-12-02 |
2010-04-15 |
Medimmune Ltd |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
|
EP0746609A4
(en)
|
1991-12-17 |
1997-12-17 |
Genpharm Int |
NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES
|
|
EP0656941B1
(en)
|
1992-03-24 |
2005-06-01 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
JPH07509137A
(ja)
|
1992-07-24 |
1995-10-12 |
セル ジェネシス，インク． |
異種抗体の生産
|
|
US5573924A
(en)
*
|
1992-09-08 |
1996-11-12 |
Immunex Corporation |
CD27 ligand
|
|
US5648267A
(en)
|
1992-11-13 |
1997-07-15 |
Idec Pharmaceuticals Corporation |
Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
|
|
JPH08509612A
(ja)
|
1993-04-26 |
1996-10-15 |
ジェンファーム インターナショナル インコーポレイテッド |
異種抗体を産生することができるトランスジェニック非ヒト動物
|
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
|
EP0731842A1
(en)
|
1993-12-03 |
1996-09-18 |
Medical Research Council |
Recombinant binding proteins and peptides
|
|
KR100261941B1
(ko)
|
1994-07-13 |
2000-07-15 |
나가야마 오사무 |
사람의 인터루킨-8에 대한 재구성 사람항체
|
|
SK40599A3
(en)
|
1996-09-26 |
2000-06-12 |
Chugai Pharmaceutical Co Ltd |
Antibody against human parathormone related peptides
|
|
ES2434961T5
(es)
|
1998-04-20 |
2018-01-18 |
Roche Glycart Ag |
Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
|
|
US6852318B1
(en)
|
1998-05-08 |
2005-02-08 |
The Regents Of The University Of California |
Methods for detecting and inhibiting angiogenesis
|
|
EP1176195B1
(en)
|
1999-04-09 |
2013-05-22 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
|
US6984522B2
(en)
*
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
US8044259B2
(en)
|
2000-08-03 |
2011-10-25 |
The Regents Of The University Of Michigan |
Determining the capability of a test compound to affect solid tumor stem cells
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
CN102311986B
(zh)
|
2000-10-06 |
2015-08-19 |
协和发酵麒麟株式会社 |
产生抗体组合物的细胞
|
|
AU2002220265A1
(en)
|
2000-11-03 |
2002-05-15 |
University Of Vermont And State Agricultural College |
Compositions for inhibiting grb7
|
|
EP1338198B1
(en)
|
2000-12-01 |
2007-11-28 |
Central Institute For Experimental Animals |
Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse
|
|
JP2005500018A
(ja)
|
2001-04-02 |
2005-01-06 |
アイデック ファーマスーティカルズ コーポレイション |
ＧｎＴＩＩＩと同時発現する組換え抗体
|
|
AU2003238897A1
(en)
*
|
2002-06-05 |
2003-12-22 |
Avalon Pharmaceuticals, Inc. |
Cancer-linked gene as target for chemotherapy
|
|
US7393531B2
(en)
|
2003-01-21 |
2008-07-01 |
Arius Research Inc. |
Cytotoxicity mediation of cells evidencing surface expression of MCSP
|
|
US20070053884A1
(en)
|
2003-05-16 |
2007-03-08 |
Kyowa Hakko Kogyo Co., Ltd |
Novel adult tissue-derived stem cell and use thereof
|
|
JP2005035943A
(ja)
|
2003-07-16 |
2005-02-10 |
Chemo Sero Therapeut Res Inst |
悪性腫瘍細胞増殖抑制剤
|
|
CA2447400A1
(en)
|
2003-09-12 |
2005-03-12 |
The Hospital For Sick Children |
Brain tumor stem cells
|
|
CA2542121A1
(en)
|
2003-10-09 |
2005-04-21 |
Kyowa Hakko Kogyo Co., Ltd. |
Genomically modified cell neutralized to serum-free system
|
|
JP2005206508A
(ja)
*
|
2004-01-22 |
2005-08-04 |
Chemo Sero Therapeut Res Inst |
悪性腫瘍細胞増殖抑制抗体
|
|
SG151294A1
(en)
*
|
2004-03-23 |
2009-04-30 |
Biogen Idec Inc |
Receptor coupling agents and therapeutic uses thereof
|
|
WO2005111076A1
(en)
*
|
2004-05-12 |
2005-11-24 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Nectin 4 (n4) as a marker for cancer prognosis
|
|
US20080152700A1
(en)
|
2004-06-01 |
2008-06-26 |
Reza Sheikhnejad |
Methods and compositions for the inhibition of gene expression
|
|
WO2006014999A2
(en)
*
|
2004-07-27 |
2006-02-09 |
Five Prime Therapeutics, Inc. |
Compositions and methods of use for modulators of nectin 4, semaphorin 4b, igsf9, and kiaa0152 in treating disease
|
|
WO2006039678A2
(en)
|
2004-09-29 |
2006-04-13 |
Central Institue For Experimental Animals |
Establishment of highly metastatic cell lines using nog mice
|
|
CA2629330C
(en)
|
2004-11-12 |
2018-05-22 |
Cambridge University Technical Services Ltd. |
Methods and means related to cancer stem cells
|
|
WO2006051984A1
(ja)
|
2004-11-15 |
2006-05-18 |
Kirin Beer Kabushiki Kaisha |
癌細胞の転移抑制方法およびそのために使用する医薬組成物
|
|
CN101203241B
(zh)
*
|
2005-04-19 |
2012-02-22 |
西雅图基因公司 |
人源化抗-cd70结合物和其应用
|
|
WO2006138275A2
(en)
|
2005-06-13 |
2006-12-28 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
AU2006273892A1
(en)
*
|
2005-07-26 |
2007-02-01 |
Procure Therapeutics Limited |
Prostate stem cell markers
|
|
KR20080056167A
(ko)
*
|
2005-09-26 |
2008-06-20 |
메다렉스, 인코포레이티드 |
씨디70에 대한 인간 모노크로날 항체
|
|
US20070220621A1
(en)
|
2005-10-31 |
2007-09-20 |
Clarke Michael F |
Genetic characterization and prognostic significance of cancer stem cells in cancer
|
|
US7723112B2
(en)
|
2005-10-31 |
2010-05-25 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
EP1792979A1
(en)
|
2005-12-01 |
2007-06-06 |
Stiftung Caesar Center of Advanced European Studies and Research |
Cell culture system for the enrichment and expansion of stem cells
|
|
WO2007064945A2
(en)
|
2005-12-01 |
2007-06-07 |
Pronai Therapeutics, Inc. |
Cancer therapies and pharmaceutical compositions used therein
|
|
WO2007124125A2
(en)
*
|
2006-04-21 |
2007-11-01 |
Stowers Institute For Medical Research |
Methods of identifying stem cells in normal and cancerous tissues and related progeny cells
|
|
WO2007132883A1
(ja)
|
2006-05-17 |
2007-11-22 |
Yokohama City University |
肝臓癌の鑑別、疾患ステージの判定又は予後の予測方法及びキット
|
|
CA2658003A1
(en)
|
2006-06-06 |
2007-12-21 |
University Of Tennessee Research Foundation |
Compositions enriched in neoplastic stem cells and methods comprising same
|
|
WO2009045201A1
(en)
*
|
2006-08-02 |
2009-04-09 |
Biogen Idec Ma Inc. |
Cancer stem cells
|
|
JP5286265B2
(ja)
|
2006-08-11 |
2013-09-11 |
アーオー−フォルシュングスインスティチュート ダボス |
均一な幹細胞群を取得するための特定種類へ分化させるのにかかわる幹細胞の識別及び選択
|
|
EA200970250A1
(ru)
*
|
2006-09-05 |
2010-02-26 |
Медарекс, Инк. |
Антитела к костным морфогенетическим белкам и их рецепторам и способы их применения
|
|
EP2076587A4
(en)
|
2006-09-11 |
2009-12-09 |
Univ Florida |
ISOLATION, EXPANSION AND USE OF TUMOR STAMMING CELLS
|
|
GB2442059A
(en)
|
2006-09-19 |
2008-03-26 |
Ist Superiore Sanita |
Test for cancer of the gastrointestinal tract
|
|
CA2665528C
(en)
*
|
2006-10-12 |
2018-01-23 |
The University Of Tokyo |
Diagnosis and treatment of cancer using anti-ereg antibody
|
|
JP2008102012A
(ja)
|
2006-10-19 |
2008-05-01 |
Kanazawa Univ |
癌幹細胞の同定および単離方法
|
|
US8309354B2
(en)
|
2007-01-22 |
2012-11-13 |
Macrogenics West, Inc. |
Human cancer stem cells
|
|
JP2008182912A
(ja)
|
2007-01-29 |
2008-08-14 |
Nippon Kayaku Co Ltd |
癌幹細胞の培養方法、および癌幹細胞
|
|
KR20100021601A
(ko)
*
|
2007-05-14 |
2010-02-25 |
바이오겐 아이덱 엠에이 인코포레이티드 |
단일-쇄 Ｆｃ(ＳｃＦｃ) 부분, 이를 포함하는 결합 폴리펩타이드, 및 이에 관련된 방법
|
|
WO2008149803A1
(ja)
|
2007-06-06 |
2008-12-11 |
The University Of Tokyo |
表面抗原マーカーを用いた急性リンパ性白血病における癌幹細胞の分離同定方法
|
|
EP3009148B1
(en)
|
2007-07-02 |
2018-08-22 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for treating and diagnosing cancer
|
|
WO2009023194A2
(en)
|
2007-08-10 |
2009-02-19 |
Whitehead Institute For Biomedical Research |
Hormone responsive tissue culture system and uses thereof
|
|
EP2022848A1
(en)
|
2007-08-10 |
2009-02-11 |
Hubrecht Institut |
A method for identifying, expanding, and removing adult stem cells and cancer stem cells
|
|
CA2700457A1
(en)
|
2007-10-01 |
2009-04-09 |
Austin Smith |
Neural tumor stem cells and methods of use thereof
|
|
WO2009064301A1
(en)
*
|
2007-11-15 |
2009-05-22 |
The Johns Hopkins University |
Methods for detecting and monitoring circulating cancer stem cells
|
|
EP2239555A1
(en)
|
2007-12-14 |
2010-10-13 |
Chugai Seiyaku Kabushiki Kaisha |
Novel method of preparing specimen having excellent abilities to maintain tissue morphology and maintain nucleic acid qualities
|
|
US7951549B2
(en)
|
2008-03-07 |
2011-05-31 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
ES2458541T5
(en)
*
|
2008-05-02 |
2025-08-04 |
Seagen Inc |
Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
|
|
WO2010009121A2
(en)
|
2008-07-15 |
2010-01-21 |
University Of Florida Research Foundation, Inc. |
Colon stem cells associated with colitis and colorectal cancer and methods of use
|
|
WO2010016766A2
(en)
|
2008-08-08 |
2010-02-11 |
Koninklijke Nederlandse Akademie Van Wetenschappen |
Antibodies recognizing endogenous human lgr5 and/or lgr6
|
|
WO2010067487A1
(en)
*
|
2008-12-12 |
2010-06-17 |
Oncotherapy Science, Inc. |
Nectin-4 for target genes of cancer therapy and diagnosis
|
|
WO2010102244A1
(en)
*
|
2009-03-06 |
2010-09-10 |
Kalobios Pharmaceuticals, Inc. |
Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3
|
|
WO2010113117A2
(en)
*
|
2009-03-30 |
2010-10-07 |
Edimer Biotech S.A. |
Preparation of isolated agonist anti-edar monoclonal antibodies
|
|
AU2010239368A1
(en)
*
|
2009-04-20 |
2011-11-10 |
Genentech, Inc. |
Adjuvant cancer therapy
|
|
TW201105347A
(en)
*
|
2009-04-28 |
2011-02-16 |
Chugai Pharmaceutical Co Ltd |
Pharmaceutical compositions for maintenance therapy containing HLA class I-recognizing antibody as the active ingredient
|
|
JP5808052B2
(ja)
*
|
2009-05-29 |
2015-11-10 |
中外製薬株式会社 |
Ｅｇｆファミリーリガンドのアンタゴニストを成分とする医薬組成物
|
|
WO2011027308A1
(en)
|
2009-09-03 |
2011-03-10 |
Koninklijke Philips Electronics N.V. |
Novel tumor markers
|
|
US11536713B2
(en)
|
2009-12-25 |
2022-12-27 |
Chugai Seiyaku Kabushiki Kaisha |
Method for searching and screening for target of anti-cancer agent using non-human animal model having NOG established cancer cell line transplanted therein
|
|
US9217032B2
(en)
|
2010-01-08 |
2015-12-22 |
Les Laboratoires Servier |
Methods for treating colorectal cancer
|
|
CN103328626B
(zh)
|
2010-10-06 |
2017-02-08 |
中外制药株式会社 |
癌干细胞群及其制备方法
|
|
US9164105B2
(en)
*
|
2011-01-13 |
2015-10-20 |
Industry-Academic Cooperation Foundation, Yonsei University |
Pancreatic cancer biomarker using the characteristics of pancreatic cancer stem cells, and use thereof
|
|
US9890218B2
(en)
|
2011-06-30 |
2018-02-13 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimerized polypeptide
|
|
EP2749641B1
(en)
|
2011-09-07 |
2021-06-02 |
Chugai Seiyaku Kabushiki Kaisha |
Cancer stem cell isolation
|
|
US20140302511A1
(en)
|
2011-10-28 |
2014-10-09 |
Pharmalogicals Research Pte. Ltd. |
Cancer stem cell-specific molecule
|
|
TWI593705B
(zh)
|
2011-12-28 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
|
|
ES2876009T3
(es)
|
2012-12-27 |
2021-11-11 |
Chugai Pharmaceutical Co Ltd |
Polipéptido heterodimerizado
|
|
US10504315B2
(en)
|
2013-08-05 |
2019-12-10 |
Ncr Corporation |
Clamping of media items
|