JP2014524746A5 - - Google Patents
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- JP2014524746A5 JP2014524746A5 JP2014520383A JP2014520383A JP2014524746A5 JP 2014524746 A5 JP2014524746 A5 JP 2014524746A5 JP 2014520383 A JP2014520383 A JP 2014520383A JP 2014520383 A JP2014520383 A JP 2014520383A JP 2014524746 A5 JP2014524746 A5 JP 2014524746A5
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- cancer
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- 206010028980 Neoplasm Diseases 0.000 claims description 98
- 101000825949 Homo sapiens R-spondin-2 Proteins 0.000 claims description 28
- 201000011510 cancer Diseases 0.000 claims description 28
- 102100022763 R-spondin-2 Human genes 0.000 claims description 26
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 16
- 108060000903 Beta-catenin Proteins 0.000 claims description 15
- 102000040430 polynucleotide Human genes 0.000 claims description 15
- 108091033319 polynucleotide Proteins 0.000 claims description 15
- 239000002157 polynucleotide Substances 0.000 claims description 15
- 206010009944 Colon cancer Diseases 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 13
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 12
- 229920001184 polypeptide Polymers 0.000 claims description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- 102000015735 Beta-catenin Human genes 0.000 claims description 11
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 11
- 201000002528 pancreatic cancer Diseases 0.000 claims description 11
- 229940124597 therapeutic agent Drugs 0.000 claims description 10
- 206010006187 Breast cancer Diseases 0.000 claims description 9
- 208000026310 Breast neoplasm Diseases 0.000 claims description 9
- 208000020816 lung neoplasm Diseases 0.000 claims description 9
- 230000011664 signaling Effects 0.000 claims description 9
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- 230000004614 tumor growth Effects 0.000 claims description 8
- 210000004408 hybridoma Anatomy 0.000 claims description 7
- 201000001441 melanoma Diseases 0.000 claims description 7
- 239000002773 nucleotide Substances 0.000 claims description 7
- 125000003729 nucleotide group Chemical group 0.000 claims description 7
- 210000004881 tumor cell Anatomy 0.000 claims description 7
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 6
- 102100031036 Leucine-rich repeat-containing G-protein coupled receptor 5 Human genes 0.000 claims description 6
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 6
- 230000027455 binding Effects 0.000 claims description 6
- 208000005017 glioblastoma Diseases 0.000 claims description 6
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 6
- 208000014018 liver neoplasm Diseases 0.000 claims description 6
- 208000037841 lung tumor Diseases 0.000 claims description 6
- 101001063456 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 claims description 5
- 230000004913 activation Effects 0.000 claims description 5
- 230000004069 differentiation Effects 0.000 claims description 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 5
- 210000000130 stem cell Anatomy 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 3
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims description 3
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 3
- 206010019695 Hepatic neoplasm Diseases 0.000 claims description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 206010038389 Renal cancer Diseases 0.000 claims description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 3
- 239000000427 antigen Substances 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 239000002246 antineoplastic agent Substances 0.000 claims description 3
- 230000024245 cell differentiation Effects 0.000 claims description 3
- 201000010881 cervical cancer Diseases 0.000 claims description 3
- 229940127089 cytotoxic agent Drugs 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 201000010536 head and neck cancer Diseases 0.000 claims description 3
- 201000010982 kidney cancer Diseases 0.000 claims description 3
- 201000007270 liver cancer Diseases 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 208000023958 prostate neoplasm Diseases 0.000 claims description 3
- 230000009870 specific binding Effects 0.000 claims description 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
- 208000024719 uterine cervix neoplasm Diseases 0.000 claims description 3
- 102000047209 human Rspo2 Human genes 0.000 claims description 2
- 229940121396 wnt pathway inhibitor Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 3
- 101710174256 Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 91
- 101000825954 Homo sapiens R-spondin-1 Proteins 0.000 description 22
- 102100022762 R-spondin-1 Human genes 0.000 description 19
- 230000035772 mutation Effects 0.000 description 16
- 108700001666 APC Genes Proteins 0.000 description 12
- 230000000415 inactivating effect Effects 0.000 description 12
- 102000037126 Leucine-rich repeat-containing G-protein-coupled receptors Human genes 0.000 description 8
- 108091006332 Leucine-rich repeat-containing G-protein-coupled receptors Proteins 0.000 description 8
- 238000003556 assay Methods 0.000 description 8
- 101000825960 Homo sapiens R-spondin-3 Proteins 0.000 description 6
- 102100022766 R-spondin-3 Human genes 0.000 description 6
- 238000010208 microarray analysis Methods 0.000 description 6
- 238000012163 sequencing technique Methods 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 101000825962 Homo sapiens R-spondin-4 Proteins 0.000 description 4
- 102100022759 R-spondin-4 Human genes 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 102000050526 human RSPO1 Human genes 0.000 description 3
- 101001063463 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 4 Proteins 0.000 description 2
- 101000981765 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 6 Proteins 0.000 description 2
- 101100531974 Homo sapiens RSPO2 gene Proteins 0.000 description 2
- 102100031035 Leucine-rich repeat-containing G-protein coupled receptor 4 Human genes 0.000 description 2
- 102100024140 Leucine-rich repeat-containing G-protein coupled receptor 6 Human genes 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical group O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 description 1
- 239000004037 angiogenesis inhibitor Substances 0.000 description 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508403P | 2011-07-15 | 2011-07-15 | |
| US61/508,403 | 2011-07-15 | ||
| US201161521547P | 2011-08-09 | 2011-08-09 | |
| US61/521,547 | 2011-08-09 | ||
| US201161570629P | 2011-12-14 | 2011-12-14 | |
| US61/570,629 | 2011-12-14 | ||
| PCT/US2012/046746 WO2013012747A1 (en) | 2011-07-15 | 2012-07-13 | Rspo binding agents and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017094648A Division JP2017169578A (ja) | 2011-07-15 | 2017-05-11 | Ｒｓｐｏ結合剤およびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524746A JP2014524746A (ja) | 2014-09-25 |
| JP2014524746A5 true JP2014524746A5 (enExample) | 2015-09-03 |
| JP6185463B2 JP6185463B2 (ja) | 2017-08-23 |
Family
ID=47558408
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520383A Expired - Fee Related JP6185463B2 (ja) | 2011-07-15 | 2012-07-13 | Ｒｓｐｏ結合剤およびその使用法 |
| JP2017094648A Ceased JP2017169578A (ja) | 2011-07-15 | 2017-05-11 | Ｒｓｐｏ結合剤およびその使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017094648A Ceased JP2017169578A (ja) | 2011-07-15 | 2017-05-11 | Ｒｓｐｏ結合剤およびその使用法 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US8802097B2 (enExample) |
| EP (2) | EP3401329A1 (enExample) |
| JP (2) | JP6185463B2 (enExample) |
| KR (1) | KR20140048276A (enExample) |
| CN (2) | CN106167526A (enExample) |
| AU (1) | AU2012284254B2 (enExample) |
| BR (1) | BR112014000765A2 (enExample) |
| CA (1) | CA2841745A1 (enExample) |
| CL (1) | CL2014000114A1 (enExample) |
| IL (1) | IL230429A0 (enExample) |
| MX (1) | MX349198B (enExample) |
| RU (1) | RU2014101669A (enExample) |
| WO (1) | WO2013012747A1 (enExample) |
| ZA (1) | ZA201400525B (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE466106T1 (de) | 2003-10-10 | 2010-05-15 | Deutsches Krebsforsch | Zusammensetzungen für die diagnose und therapie von erkrankungen, die im zusammenhang mit einer anomalen expression von futrinen (r-spondinen) stehen |
| EP2066694B1 (en) | 2006-09-29 | 2015-11-04 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| AU2007312538B2 (en) | 2006-10-20 | 2012-10-04 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Rspondins as modulators of angiogenesis and vasculogenesis |
| JP5931336B2 (ja) | 2007-07-02 | 2016-06-08 | オンコメッド ファーマシューティカルズ インコーポレイテッド | がんを処置および診断するための組成物および方法 |
| JP5808053B2 (ja) * | 2009-11-17 | 2015-11-10 | 国立大学法人 岡山大学 | 歯髄細胞から象牙芽細胞への分化誘導方法 |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| WO2013012747A1 (en) | 2011-07-15 | 2013-01-24 | Oncomed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
| EP2872175A4 (en) | 2012-07-13 | 2016-04-20 | Oncomed Pharm Inc | RSPO3-BONDING SUBSTANCES AND USES THEREOF |
| AU2014244444A1 (en) * | 2013-03-14 | 2015-09-24 | Amgen Inc. | CHRDL-1 antigen binding proteins and methods of treatment |
| MX2016004802A (es) * | 2013-10-18 | 2016-07-18 | Genentech Inc | Anticuerpos anti-r-espondina (anti-rspo) y metodos de uso. |
| CN103724415B (zh) * | 2013-12-31 | 2015-05-27 | 中山大学 | 斜带石斑鱼性别调控基因Rspo1及其制备方法和应用 |
| EP3166627A1 (en) | 2014-07-11 | 2017-05-17 | Genentech, Inc. | Notch pathway inhibition |
| US20170247437A1 (en) * | 2014-08-15 | 2017-08-31 | Oncomed Pharmaceuticals, Inc. | Rspo1 binding agents and uses thereof |
| US10064937B2 (en) | 2014-09-16 | 2018-09-04 | Oncomed Pharmaceuticals, Inc. | Treatment of dermal fibrosis |
| MA41123A (fr) * | 2014-12-02 | 2017-10-10 | Oncomed Pharm Inc | Polythérapie pour le traitement du cancer |
| WO2017040660A1 (en) * | 2015-08-31 | 2017-03-09 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| WO2017070567A1 (en) * | 2015-10-21 | 2017-04-27 | The Research Foundation For The State University Of New York | Klebsiella pneumoniae antibodies and methods to treat klebsiella pneumoniae infections |
| WO2017069628A2 (en) * | 2015-10-23 | 2017-04-27 | Merus N.V. | Binding molecules that inhibit cancer growth |
| CN106913880B (zh) * | 2015-12-24 | 2021-02-12 | 上海交通大学 | 一种含有rspo1的靶向给药系统及其制备与应用 |
| JP6966176B2 (ja) | 2016-03-01 | 2021-11-10 | イサム リサーチ ディベロップメント カンパニー オブ ザ ヘブルー ユニバーシティ オブ エルサレム エルティーディー． | ヒトポリオウイルス受容体（ｐｖｒ）に特異的な抗体 |
| CN105925576B (zh) * | 2016-03-24 | 2018-04-20 | 嘉兴市第一医院 | 针对哺乳动物R‑Spondin3基因靶点的小干扰RNA、短发卡RNA及载体和应用 |
| WO2017180864A1 (en) | 2016-04-14 | 2017-10-19 | Genentech, Inc. | Anti-rspo3 antibodies and methods of use |
| WO2017189963A1 (en) * | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| TWI874301B (zh) | 2017-08-09 | 2025-03-01 | 荷蘭商美勒斯公司 | 結合表皮生長因子受體(EGFR)及cMET的抗體 |
| US11021540B2 (en) * | 2017-09-07 | 2021-06-01 | Augusta University Research Institute, Inc. | Antibodies to programmed cell death protein 1 |
| CN109529040B (zh) * | 2017-09-21 | 2020-11-13 | 华东师范大学 | LGR4和R-spondin结合抑制剂及其在肿瘤治疗中的用途 |
| EP3720492A4 (en) * | 2017-12-07 | 2021-12-08 | National Health Research Institutes | ANTI-RSPO3 ANTIBODIES |
| CN110339364B (zh) * | 2018-04-02 | 2021-02-12 | 上海邦耀生物科技有限公司 | Lgr4/rspo阻断剂与抗免疫检查点抑制剂联合用于肿瘤的免疫治疗 |
| EP3773658A4 (en) | 2018-04-06 | 2022-04-27 | Dana-Farber Cancer Institute, Inc. | KIR3DL3 AS HLA2 RECEPTOR, ANTI-HHLA2 ANTIBODY AND ITS USES |
| US12497464B1 (en) | 2018-08-03 | 2025-12-16 | Berkeley Therapeutics, Inc. | Antibody, antibody fragments or peptide for treating cancer and methods of formation and administration |
| GB201901710D0 (en) * | 2019-02-07 | 2019-03-27 | Nordic Bioscience As | Collagen type 23 assay |
| CN110467663B (zh) * | 2019-06-18 | 2022-05-10 | 华南农业大学 | Rspo3基因在母猪卵巢颗粒细胞中的应用 |
| EP4012021A4 (en) * | 2019-08-05 | 2022-11-30 | Genex Health Co.,Ltd | METHOD FOR CULTIVATION OF PRIMARY CELLS OF SOLID TUMORS IN LUNG CANCER AND PRIMARY TUMOR CELLS OF PLEEURAL EFFORT IN LUNG CANCER AND SUPPORTING REAGENT |
| US20230338466A1 (en) * | 2020-06-03 | 2023-10-26 | Children's Hospital Medical Center | Compositions and methods comprising r-spondins for treatment of tumors |
| CN112457400B (zh) * | 2020-12-09 | 2022-03-08 | 福州迈新生物技术开发有限公司 | 抗β-catenin蛋白单克隆抗体、细胞系及其制备方法和应用 |
| KR20240137086A (ko) | 2022-01-28 | 2024-09-19 | 조지아뮨 인코포레이티드 | Pd-1 작용제인 세포예정사 단백질 1에 대한 항체 |
| CN117700533B (zh) * | 2023-02-09 | 2024-07-16 | 义翘神州(泰州)科技有限公司 | 猴痘病毒a29小鼠单克隆包被抗体及检测抗体 |
| KR102551095B1 (ko) * | 2023-03-21 | 2023-07-04 | 순천향대학교 산학협력단 | 신규한 항-인간 알스폰딘2 항체 및 이의 용도 |
| KR102554222B1 (ko) * | 2023-03-21 | 2023-07-11 | 순천향대학교 산학협력단 | 신규한 항-인간 알스폰딘3 항체 및 이의 용도 |
Family Cites Families (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588585A (en) | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| DK0546073T3 (da) | 1990-08-29 | 1998-02-02 | Genpharm Int | Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| US20070124581A1 (en) | 1992-05-17 | 2007-05-31 | Reena Khare | Cell adhesion and extracellular matrix proteins |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6828422B1 (en) | 1995-08-18 | 2004-12-07 | Morphosys Ag | Protein/(poly)peptide libraries |
| DE69621940T2 (de) | 1995-08-18 | 2003-01-16 | Morphosys Ag | Protein-/(poly)peptidbibliotheken |
| AU7159898A (en) | 1997-04-25 | 1998-11-24 | Genetics Institute Inc. | Secreted proteins and polynucleotides encoding them |
| US6004528A (en) | 1997-09-18 | 1999-12-21 | Bergstein; Ivan | Methods of cancer diagnosis and therapy targeted against the cancer stemline |
| CA2304828A1 (en) | 1997-09-24 | 1999-04-01 | Merck & Co., Inc. | G-protein coupled glycoprotein hormone receptor hg38 |
| US20020065394A1 (en) | 1998-03-18 | 2002-05-30 | Kenneth Jacobs | Secreted proteins and polynucleotides encoding them |
| WO1999048921A1 (en) | 1998-03-26 | 1999-09-30 | The Board Of Trustees Of The Leland Stanford Junior University | Novel mammalian g-protein coupled receptors having extracellular leucine rich repeat regions |
| US6485972B1 (en) | 1998-10-15 | 2002-11-26 | President And Fellows Of Harvard College | WNT signalling in reproductive organs |
| US20030166047A1 (en) | 1999-05-06 | 2003-09-04 | Millennium Pharmaceuticals, Inc. | Lgr6 nucleic acids and uses thereof |
| WO2001002588A2 (en) | 1999-07-02 | 2001-01-11 | Morphosys Ag | Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests |
| AU6117000A (en) | 1999-07-26 | 2001-02-13 | Genentech Inc. | Novel polynucleotides and method of use thereof |
| AU2001234944A1 (en) | 2000-02-03 | 2001-08-14 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| US6824973B2 (en) | 2000-02-03 | 2004-11-30 | Kirin Beer Kabushiki Kaisha | Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide |
| WO2001074164A1 (en) | 2000-03-31 | 2001-10-11 | The General Hospital Corporation | Methods of modulating hair growth |
| WO2001077169A2 (en) | 2000-04-05 | 2001-10-18 | Kirin Beer Kabushiki Kaisha | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
| EP1156062A1 (en) | 2000-05-12 | 2001-11-21 | GPC Biotech AG | Immunomodulatory human MHC class II antigen-binding peptides/proteins |
| AU2001263006A1 (en) | 2000-05-18 | 2001-11-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| US20030139341A1 (en) | 2000-05-30 | 2003-07-24 | Shyam Ramakrishnan | Regulation of human lgr4-like g protein -coupled receptor |
| US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| CA2431600C (en) | 2000-12-12 | 2012-04-17 | Medimmune, Inc. | Molecules with extended half-lives, compositions and uses thereof |
| US6768004B2 (en) | 2001-01-11 | 2004-07-27 | Mueller Sybille | Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies |
| US20040077048A1 (en) | 2002-01-30 | 2004-04-22 | Warren Bridget A. | Protein modification and maintenance molecules |
| US20030032034A1 (en) | 2001-03-05 | 2003-02-13 | Tang Y. Tom | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
| US20100292155A1 (en) | 2001-03-05 | 2010-11-18 | Arca Biopharma, Inc. | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
| US7411052B2 (en) | 2001-03-05 | 2008-08-12 | Nuvelo, Inc. | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
| EP1395610A2 (en) | 2001-06-11 | 2004-03-10 | Kirin Beer Kabushiki Kaisha | Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and dna coding for the same |
| AU2002314495A1 (en) | 2001-06-20 | 2003-01-02 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| US20030022217A1 (en) | 2001-07-02 | 2003-01-30 | Pe Corporation (Ny) | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
| AU2002332767A1 (en) | 2001-08-30 | 2003-04-14 | Nuvelo | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
| AU2002342010A1 (en) | 2001-10-03 | 2003-04-14 | Incyte Genomics Inc. | Secreted proteins |
| US20070237770A1 (en) | 2001-11-30 | 2007-10-11 | Albert Lai | Novel compositions and methods in cancer |
| US20040197778A1 (en) | 2002-12-26 | 2004-10-07 | Sagres Discovery, Inc. | Novel compositions and methods in cancer |
| EP1461023A4 (en) | 2001-12-07 | 2005-08-31 | Univ Michigan | Prospective Identification and Characterization of Breast Cancer Strain Cells |
| EP1504099A4 (en) | 2001-12-10 | 2006-05-10 | Nuvelo Inc | NEW NUCLEIC ACIDS AND POLYPEPTIDES |
| US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| AU2003223124A1 (en) | 2002-04-26 | 2003-11-10 | Kirin Beer Kabushiki Kaisha | Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell or hematopoietic progenitor cell, and dna coding for the same |
| EP1380644A1 (en) | 2002-07-08 | 2004-01-14 | Kylix B.V. | The use of specified TCF target genes to identify drugs for the treatment of cancer, in particular colorectal cancer, in which TCF/beta-catenin/WNT signalling plays a central role |
| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| US7365168B2 (en) | 2002-10-15 | 2008-04-29 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| WO2004074436A2 (en) | 2003-02-19 | 2004-09-02 | Incyte Corporation | Methods of use of a gpcr in the diagnosis and treatment of colon and lung cancer |
| US20050003405A1 (en) | 2003-04-30 | 2005-01-06 | Hua-Chien Chen | Treatment and diagnostics of cancer |
| WO2005005601A2 (en) | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US20050054829A1 (en) | 2003-07-22 | 2005-03-10 | Wiley Steven R. | Compositions and methods relating to TSP-30a, b, c and d |
| DE10339820A1 (de) | 2003-08-22 | 2005-03-17 | Hinzmann, Bernd, Dr. | Verwendung von an GPR49 bindenden Substanzen zur Diagnose und Behandlung von Krebs |
| US9046537B2 (en) | 2003-09-22 | 2015-06-02 | Enzo Biochem, Inc. | Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain |
| ATE466106T1 (de) | 2003-10-10 | 2010-05-15 | Deutsches Krebsforsch | Zusammensetzungen für die diagnose und therapie von erkrankungen, die im zusammenhang mit einer anomalen expression von futrinen (r-spondinen) stehen |
| WO2005040828A2 (en) | 2003-10-24 | 2005-05-06 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 49 (gpr49) |
| EP1697415A1 (en) | 2003-11-12 | 2006-09-06 | Biogen Idec MA Inc. | NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO |
| US20050256044A1 (en) | 2004-01-27 | 2005-11-17 | Boyle Bryan J | Gastrointestinal proliferative factor and uses thereof |
| JP2007526455A (ja) | 2004-02-03 | 2007-09-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌を特徴付ける、制御する、診断する、および処置するための組成物ならびに方法 |
| US20080187954A1 (en) | 2004-03-10 | 2008-08-07 | Lonza Ltd. | Method For Producing Antibodies |
| KR20070072510A (ko) | 2004-08-30 | 2007-07-04 | 론자 바이올로직스 피엘씨 | 항체 정제를 위한 친화도- 및 이온 교환- 크로마토그래피 |
| MX2007002883A (es) | 2004-09-13 | 2007-06-15 | Macrogenics Inc | Anticuerpos humanizados contra el virus de nilo occidental y usos terapeuticos y profilacticos del mismo. |
| AU2005318171B2 (en) | 2004-12-20 | 2011-09-29 | Crucell Holland B.V. | Binding molecules capable of neutralizing West Nile virus and uses thereof |
| US7439327B2 (en) | 2005-01-18 | 2008-10-21 | Nuvelo, Inc. | Stem cell factor-like proteins and uses thereof |
| EP2083088A3 (en) | 2005-04-07 | 2009-10-14 | Novartis Vaccines and Diagnostics, Inc. | Cancer-related genes |
| US20090036369A1 (en) | 2005-07-26 | 2009-02-05 | Kirin Pharma Kabushiki Kaisha | Anti-tumor agents comprising r-spondins |
| US7541431B2 (en) | 2005-09-07 | 2009-06-02 | Maine Medical Center | Cristin/R-spondin ligands active in the Wnt signaling pathway and methods, compositions and kits relating thereto |
| US20090118176A1 (en) | 2005-10-07 | 2009-05-07 | Emtage Peter C R | Stem Cell Factor-Like Protein Scfa1 and Uses Thereof |
| AU2006308847C1 (en) | 2005-10-31 | 2012-05-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| GB0603683D0 (en) | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
| CA2654019A1 (en) | 2006-06-02 | 2007-12-13 | Aveo Pharmaceuticals, Inc. | Hepatocyte growth factor (hgf) binding proteins |
| EP2361934A3 (en) | 2006-06-02 | 2011-11-02 | Aveo Pharmaceuticals, Inc. | Hepatocyte growth factor (HGF) binding proteins |
| JP2009539403A (ja) | 2006-06-13 | 2009-11-19 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 癌を診断および処置するための組成物および方法 |
| USRE47123E1 (en) | 2006-07-18 | 2018-11-13 | Sanofi | EPHA2 receptor antagonist antibodies |
| JP2008044926A (ja) | 2006-08-14 | 2008-02-28 | Trustees Of Columbia Univ In The City Of New York | Ｗｎｔ信号伝達に関係した分泌タンパク質 |
| BRPI0714751A2 (pt) | 2006-09-08 | 2014-06-24 | Genentech Inc | "antagonistas wnt , composição , ácido nucléico , vetor , célula hospedeira , artigo manufaturado , método de inibição da sinalização wnt , método para detectar a presença de uam proteina wnt , método para modular a expressão de um gene wnt alvo em uma célula , método para tratar terapeuticamente um câncer mediado por wnt e usos de uns antagonistas wnt na manufatura de um medicamento " |
| EP2066694B1 (en) | 2006-09-29 | 2015-11-04 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| AU2007312538B2 (en) | 2006-10-20 | 2012-10-04 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Rspondins as modulators of angiogenesis and vasculogenesis |
| WO2008075796A1 (ja) | 2006-12-21 | 2008-06-26 | Kyowa Hakko Kirin Co., Ltd. | 血球回復促進剤 |
| WO2008088524A2 (en) | 2006-12-28 | 2008-07-24 | Nuvelo, Inc. | Thrombospondin-domain-deficient r-spondin 1 protein as gastrointestinal tract epithelial proliferation factor |
| US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| BRPI0812562A2 (pt) | 2007-06-12 | 2019-09-24 | Trubion Pharmaceuticals Inc | composições terapêuticas anti-cd20 e métodos |
| JP5931336B2 (ja) | 2007-07-02 | 2016-06-08 | オンコメッド ファーマシューティカルズ インコーポレイテッド | がんを処置および診断するための組成物および方法 |
| US20120082659A1 (en) | 2007-10-02 | 2012-04-05 | Hartmut Land | Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations |
| EP2188630A4 (en) | 2007-10-02 | 2010-11-03 | Univ Rochester | METHODS AND COMPOSITIONS RELATED TO SYNERGISTIC ANSWERS TO ONCOGENIC MUTATIONS |
| CA2705509A1 (en) | 2007-11-14 | 2009-05-22 | Forerunner Pharma Research Co., Ltd. | Diagnosis and treatment of cancer using anti-gpr49 antibody |
| EP2238154B1 (en) | 2008-01-18 | 2015-09-16 | Bio-Rad Laboratories, Inc. | Enhanced purification of phosphorylated and non-phosphorylated biomolecules by apatite chromatography |
| US8187601B2 (en) | 2008-07-01 | 2012-05-29 | Aveo Pharmaceuticals, Inc. | Fibroblast growth factor receptor 3 (FGFR3) binding proteins |
| WO2010016766A2 (en) | 2008-08-08 | 2010-02-11 | Koninklijke Nederlandse Akademie Van Wetenschappen | Antibodies recognizing endogenous human lgr5 and/or lgr6 |
| SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
| RU2521669C2 (ru) | 2008-10-31 | 2014-07-10 | Торэй Индастриз, Инк. | Способ иммунологического анализа белка cxcl1 человека |
| US20120039912A1 (en) | 2009-04-15 | 2012-02-16 | Galapagos Sasu | Rspondin-3 inhibition in bone disorders |
| WO2010129284A1 (en) | 2009-04-27 | 2010-11-11 | The Trustees Of The University Of Pennsylvania | Inhibition of hair follicle growth by the wnt inhibitor dkk1 |
| US9067986B2 (en) | 2009-04-27 | 2015-06-30 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| EP2442798A4 (en) | 2009-06-18 | 2013-03-13 | Wyeth Llc | LYOPHILIZED FORMULATIONS FOR SMALL-SCALE MODULAR IMMUNOPHARMACEUTICAL AGENTS |
| US8318162B2 (en) | 2009-07-16 | 2012-11-27 | Xoma Technology Ltd. | Antibodies to high molecular weight melanoma associated antigen |
| RU2595409C2 (ru) | 2009-09-03 | 2016-08-27 | Мерк Шарп И Доум Корп., | Анти-gitr-антитела |
| US20120263730A1 (en) | 2009-12-23 | 2012-10-18 | Deutsches Krebsforschungszentrum | Receptors of rspo2 and rspo3 |
| US8663950B2 (en) | 2010-01-11 | 2014-03-04 | Arizona Board Of Regents | Production of a monoclonal antibody therapeutic against west nile virus in plants |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| CN102812044A (zh) | 2010-01-12 | 2012-12-05 | 昂考梅德药品有限公司 | Wnt结合剂及其用途 |
| KR20120117931A (ko) | 2010-02-12 | 2012-10-24 | 온코메드 파마슈티칼스, 인크. | 폴리펩타이드를 발현하는 세포를 확인 및 분리하는 방법 |
| AU2011352167A1 (en) | 2010-12-28 | 2013-07-11 | Caris Mpi, Inc. | Molecular profiling for cancer |
| GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
| CA2834243C (en) | 2011-04-28 | 2019-08-27 | Sbi Biotech Co., Ltd. | Anti-human receptor-type protein tyrosine phosphatase .sigma. antibody |
| WO2013012747A1 (en) | 2011-07-15 | 2013-01-24 | Oncomed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
| JP2014530816A (ja) | 2011-10-14 | 2014-11-20 | ノバルティスアーゲー | Ｗｎｔ経路関連疾患のための抗体および方法 |
| WO2013067057A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
| ES2697674T3 (es) | 2011-11-01 | 2019-01-25 | Bionomics Inc | Procedimientos para bloquear el crecimiento de células madre cancerosas |
| US20130209473A1 (en) | 2012-02-11 | 2013-08-15 | Genentech, Inc. | R-spondin translocations and methods using the same |
| AR090549A1 (es) | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
| EP2872175A4 (en) | 2012-07-13 | 2016-04-20 | Oncomed Pharm Inc | RSPO3-BONDING SUBSTANCES AND USES THEREOF |
| EP2968348A4 (en) | 2013-03-12 | 2016-11-09 | Curegenix Inc | COMPOUNDS FOR THE TREATMENT OF CANCER |
| CA2913924A1 (en) | 2013-05-30 | 2014-12-04 | Order-Made Medical Research Inc. | Reagent including anti-lgr6 antibodies for detection and diagnosis of cancer |
| MX2016004802A (es) | 2013-10-18 | 2016-07-18 | Genentech Inc | Anticuerpos anti-r-espondina (anti-rspo) y metodos de uso. |
| US9777052B2 (en) | 2014-12-02 | 2017-10-03 | The Board Of Regents Of The University Of Oklahoma | R-spondin variants, compositions, and methods of use |
| MA41123A (fr) | 2014-12-02 | 2017-10-10 | Oncomed Pharm Inc | Polythérapie pour le traitement du cancer |
-
2012
- 2012-07-13 WO PCT/US2012/046746 patent/WO2013012747A1/en not_active Ceased
- 2012-07-13 CN CN201610353524.8A patent/CN106167526A/zh active Pending
- 2012-07-13 RU RU2014101669/10A patent/RU2014101669A/ru not_active Application Discontinuation
- 2012-07-13 EP EP18162940.3A patent/EP3401329A1/en not_active Withdrawn
- 2012-07-13 AU AU2012284254A patent/AU2012284254B2/en not_active Ceased
- 2012-07-13 MX MX2014000555A patent/MX349198B/es active IP Right Grant
- 2012-07-13 CN CN201280045135.9A patent/CN104023746B/zh not_active Expired - Fee Related
- 2012-07-13 EP EP12814264.3A patent/EP2731625B1/en active Active
- 2012-07-13 KR KR1020147003901A patent/KR20140048276A/ko not_active Ceased
- 2012-07-13 CA CA2841745A patent/CA2841745A1/en not_active Abandoned
- 2012-07-13 BR BR112014000765A patent/BR112014000765A2/pt unknown
- 2012-07-13 JP JP2014520383A patent/JP6185463B2/ja not_active Expired - Fee Related
- 2012-07-13 US US13/549,050 patent/US8802097B2/en not_active Expired - Fee Related
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2014
- 2014-01-13 IL IL230429A patent/IL230429A0/en unknown
- 2014-01-15 CL CL2014000114A patent/CL2014000114A1/es unknown
- 2014-01-22 ZA ZA2014/00525A patent/ZA201400525B/en unknown
- 2014-06-27 US US14/318,247 patent/US9109024B2/en not_active Expired - Fee Related
- 2014-06-27 US US14/318,253 patent/US9109025B2/en not_active Expired - Fee Related
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2015
- 2015-07-09 US US14/795,811 patent/US9644034B2/en not_active Expired - Fee Related
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2017
- 2017-04-05 US US15/480,081 patent/US20170298143A1/en not_active Abandoned
- 2017-05-11 JP JP2017094648A patent/JP2017169578A/ja not_active Ceased
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