JP2018537410A5 - - Google Patents

Info

Publication number

JP2018537410A5

JP2018537410A5 JP2018516820A JP2018516820A JP2018537410A5 JP 2018537410 A5 JP2018537410 A5 JP 2018537410A5 JP 2018516820 A JP2018516820 A JP 2018516820A JP 2018516820 A JP2018516820 A JP 2018516820A JP 2018537410 A5 JP2018537410 A5 JP 2018537410A5

Authority

JP

Japan

Prior art keywords

antibody

chain

modified

antigen

binding

Prior art date

2016-09-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108090001123 antibodies Proteins 0.000 claims 29
• 102000004965 antibodies Human genes 0.000 claims 29
• 230000027455 binding Effects 0.000 claims 19
• 102100007033 JCHAIN Human genes 0.000 claims 15
• 101710026201 JCHAIN Proteins 0.000 claims 15
• 239000000427 antigen Substances 0.000 claims 11
• 102000038129 antigens Human genes 0.000 claims 11
• 108091007172 antigens Proteins 0.000 claims 11
• 239000000178 monomer Substances 0.000 claims 6
• 210000004027 cells Anatomy 0.000 claims 4
• 101710044770 sll1951 Proteins 0.000 claims 4
• 102000004190 Enzymes Human genes 0.000 claims 3
• 108090000790 Enzymes Proteins 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical group O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 claims 2
• 102100007290 CD274 Human genes 0.000 claims 2
• 101710012053 CD274 Proteins 0.000 claims 2
• 230000035693 Fab Effects 0.000 claims 2
• 101710004393 HAVCR2 Proteins 0.000 claims 2
• 102100016384 HAVCR2 Human genes 0.000 claims 2
• 102000004854 Immunoglobulin M Human genes 0.000 claims 2
• 108060004270 LAG3 Proteins 0.000 claims 2
• 102100017213 LAG3 Human genes 0.000 claims 2
• 102100013504 RPL17 Human genes 0.000 claims 2
• 108060007796 SPATA2 Proteins 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 claims 2
• 102100009333 BTLA Human genes 0.000 claims 1
• 101700047069 BTLA Proteins 0.000 claims 1
• 102100005826 CD19 Human genes 0.000 claims 1
• 101700087100 CD19 Proteins 0.000 claims 1
• 101700020617 CD22 Proteins 0.000 claims 1
• 102100000189 CD22 Human genes 0.000 claims 1
• 101700056583 CD27 Proteins 0.000 claims 1
• 102100019459 CD27 Human genes 0.000 claims 1
• 102100016493 CD33 Human genes 0.000 claims 1
• 101700017647 CD33 Proteins 0.000 claims 1
• 102100003279 CD38 Human genes 0.000 claims 1
• 101700044948 CD38 Proteins 0.000 claims 1
• 101710040446 CD40 Proteins 0.000 claims 1
• 102100013137 CD40 Human genes 0.000 claims 1
• 102100019283 CD52 Human genes 0.000 claims 1
• 108010065524 CD52 Antigen Proteins 0.000 claims 1
• 102100005830 CD70 Human genes 0.000 claims 1
• 101700017377 CD70 Proteins 0.000 claims 1
• 101700077824 CNN1 Proteins 0.000 claims 1
• 102100001891 CTAG1A Human genes 0.000 claims 1
• 101710004449 CTAG1A Proteins 0.000 claims 1
• 102100005310 CTLA4 Human genes 0.000 claims 1
• 101700054183 CTLA4 Proteins 0.000 claims 1
• 102100016662 ERBB2 Human genes 0.000 claims 1
• 101700025368 ERBB2 Proteins 0.000 claims 1
• 101700041204 ERBB3 Proteins 0.000 claims 1
• 102100009850 ERBB3 Human genes 0.000 claims 1
• 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 1
• 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 1
• 102100003018 MAGEA1 Human genes 0.000 claims 1
• 101710027659 MAGEA1 Proteins 0.000 claims 1
• 101710027717 MAGED4B Proteins 0.000 claims 1
• 102100000165 MS4A1 Human genes 0.000 claims 1
• 101710010909 MS4A1 Proteins 0.000 claims 1
• 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
• 101710037934 QRSL1 Proteins 0.000 claims 1
• 102100006947 TAGLN Human genes 0.000 claims 1
• 101710025884 TAGLN Proteins 0.000 claims 1
• 102100006047 TIGIT Human genes 0.000 claims 1
• 101700052319 TIGIT Proteins 0.000 claims 1
• 102100008790 TNFRSF14 Human genes 0.000 claims 1
• 101710038603 TNFRSF18 Proteins 0.000 claims 1
• 102100003096 TNFRSF18 Human genes 0.000 claims 1
• 101710040448 TNFRSF4 Proteins 0.000 claims 1
• 102100013135 TNFRSF4 Human genes 0.000 claims 1
• 102100009537 TNFRSF9 Human genes 0.000 claims 1
• 101710040535 TNFRSF9 Proteins 0.000 claims 1
• 102100015314 VSIR Human genes 0.000 claims 1
• 101710036075 VSIR Proteins 0.000 claims 1
• 150000001299 aldehydes Chemical class 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 239000000611 antibody drug conjugate Substances 0.000 claims 1
• 108091008116 antibody drug conjugates Proteins 0.000 claims 1
• 230000001588 bifunctional Effects 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 238000001212 derivatisation Methods 0.000 claims 1
• 125000005442 diisocyanate group Chemical group 0.000 claims 1
• 239000000539 dimer Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 102000017256 epidermal growth factor-activated receptor activity proteins Human genes 0.000 claims 1
• 108040009258 epidermal growth factor-activated receptor activity proteins Proteins 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 229910052731 fluorine Inorganic materials 0.000 claims 1
• 150000002222 fluorine compounds Chemical class 0.000 claims 1
• 230000003899 glycosylation Effects 0.000 claims 1
• 238000006206 glycosylation reaction Methods 0.000 claims 1
• 201000005787 hematologic cancer Diseases 0.000 claims 1
• -1 imide esters Chemical class 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 238000003780 insertion Methods 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 230000019491 signal transduction Effects 0.000 claims 1
• CNHYKKNIIGEXAY-UHFFFAOYSA-N thiolan-2-imine Chemical compound N=C1CCCS1 CNHYKKNIIGEXAY-UHFFFAOYSA-N 0.000 claims 1
• NIGUVXFURDGQKZ-KRAHZTDDSA-N α-Neup5Ac-(2->3)-β-D-Galp-(1->4)-[α-L-Fucp-(1->3)]-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-KRAHZTDDSA-N 0.000 claims 1