JP2018524113A5 - - Google Patents
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- JP2018524113A5 JP2018524113A5 JP2018501208A JP2018501208A JP2018524113A5 JP 2018524113 A5 JP2018524113 A5 JP 2018524113A5 JP 2018501208 A JP2018501208 A JP 2018501208A JP 2018501208 A JP2018501208 A JP 2018501208A JP 2018524113 A5 JP2018524113 A5 JP 2018524113A5
- Authority
- JP
- Japan
- Prior art keywords
- stimulator
- stimulation
- sensor
- treatment
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000638 stimulation Effects 0.000 claims 27
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 13
- 230000000241 respiratory effect Effects 0.000 claims 8
- 201000004193 respiratory failure Diseases 0.000 claims 6
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 5
- 208000034972 Sudden Infant Death Diseases 0.000 claims 5
- 206010042440 Sudden infant death syndrome Diseases 0.000 claims 5
- 230000033001 locomotion Effects 0.000 claims 5
- 210000000278 spinal cord Anatomy 0.000 claims 5
- 239000000556 agonist Substances 0.000 claims 4
- 210000000779 thoracic wall Anatomy 0.000 claims 4
- 210000000038 chest Anatomy 0.000 claims 3
- 230000007794 irritation Effects 0.000 claims 3
- 230000001730 monoaminergic effect Effects 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- QJPPEMXOOWNICQ-UHFFFAOYSA-N 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)piperazine Chemical compound O1CCOC2=C1C=CC=C2N(CC1)CCN1C1CC2=CC=CC=C2C1 QJPPEMXOOWNICQ-UHFFFAOYSA-N 0.000 claims 2
- ASXGJMSKWNBENU-UHFFFAOYSA-N 8-OH-DPAT Chemical group C1=CC(O)=C2CC(N(CCC)CCC)CCC2=C1 ASXGJMSKWNBENU-UHFFFAOYSA-N 0.000 claims 2
- GHWJEDJMOVUXEC-UHFFFAOYSA-N 9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol Chemical compound C1NCCC=2C(Cl)=C(O)C(O)=CC=2C1C1=CC=CC=C1 GHWJEDJMOVUXEC-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 claims 2
- 229960002495 buspirone Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000005389 magnetism Effects 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 claims 1
- GOTMKOSCLKVOGG-OAHLLOKOSA-N (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Chemical compound C1([C@@H]2C3=CC(O)=C(Cl)C=C3CCN(C2)C)=CC=CC=C1 GOTMKOSCLKVOGG-OAHLLOKOSA-N 0.000 claims 1
- WPVVMKYQOMJPIN-UHFFFAOYSA-N 1-(6-chloro-2-pyridinyl)-4-piperidinamine Chemical compound C1CC(N)CCN1C1=CC=CC(Cl)=N1 WPVVMKYQOMJPIN-UHFFFAOYSA-N 0.000 claims 1
- 239000003477 4 aminobutyric acid receptor stimulating agent Substances 0.000 claims 1
- -1 4-amino- (6 -Chloro-2-pyridyl) Chemical group 0.000 claims 1
- AADCDMQTJNYOSS-LBPRGKRZSA-N 5-chloro-3-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide Chemical compound CCN1CCC[C@H]1CNC(=O)C1=C(O)C(CC)=CC(Cl)=C1OC AADCDMQTJNYOSS-LBPRGKRZSA-N 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 1
- 229940127427 Glycine Agonists Drugs 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- WJAJPNHVVFWKKL-UHFFFAOYSA-N Methoxamine Chemical compound COC1=CC=C(OC)C(C(O)C(C)N)=C1 WJAJPNHVVFWKKL-UHFFFAOYSA-N 0.000 claims 1
- SBPRIAGPYFYCRT-UHFFFAOYSA-N N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide Chemical compound COC1=CC=CC=C1N1CCN(CCN(C(=O)C2CCCCC2)C=2N=CC=CC=2)CC1 SBPRIAGPYFYCRT-UHFFFAOYSA-N 0.000 claims 1
- 206010040880 Skin irritation Diseases 0.000 claims 1
- BLGXFZZNTVWLAY-CCZXDCJGSA-N Yohimbine Natural products C1=CC=C2C(CCN3C[C@@H]4CC[C@@H](O)[C@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-CCZXDCJGSA-N 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 206010001053 acute respiratory failure Diseases 0.000 claims 1
- BLGXFZZNTVWLAY-UHFFFAOYSA-N beta-Yohimbin Natural products C1=CC=C2C(CCN3CC4CCC(O)C(C4CC33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-UHFFFAOYSA-N 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 229960002896 clonidine Drugs 0.000 claims 1
- 229940052760 dopamine agonists Drugs 0.000 claims 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000000624 ear auricle Anatomy 0.000 claims 1
- 229950007535 eticlopride Drugs 0.000 claims 1
- 210000002683 foot Anatomy 0.000 claims 1
- 210000001061 forehead Anatomy 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- FPCCSQOGAWCVBH-UHFFFAOYSA-N ketanserin Chemical compound C1=CC(F)=CC=C1C(=O)C1CCN(CCN2C(C3=CC=CC=C3NC2=O)=O)CC1 FPCCSQOGAWCVBH-UHFFFAOYSA-N 0.000 claims 1
- 229960005417 ketanserin Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960005192 methoxamine Drugs 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000002474 noradrenergic effect Effects 0.000 claims 1
- 229960005343 ondansetron Drugs 0.000 claims 1
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 claims 1
- 229960001289 prazosin Drugs 0.000 claims 1
- FTSUPYGMFAPCFZ-ZWNOBZJWSA-N quinpirole Chemical compound C([C@H]1CCCN([C@@H]1C1)CCC)C2=C1C=NN2 FTSUPYGMFAPCFZ-ZWNOBZJWSA-N 0.000 claims 1
- 229950001037 quinpirole Drugs 0.000 claims 1
- XRXDAJYKGWNHTQ-UHFFFAOYSA-N quipazine Chemical compound C1CNCCN1C1=CC=C(C=CC=C2)C2=N1 XRXDAJYKGWNHTQ-UHFFFAOYSA-N 0.000 claims 1
- 229950002315 quipazine Drugs 0.000 claims 1
- 230000000284 resting effect Effects 0.000 claims 1
- 239000000952 serotonin receptor agonist Substances 0.000 claims 1
- 230000036556 skin irritation Effects 0.000 claims 1
- 231100000475 skin irritation Toxicity 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 claims 1
- 229960000317 yohimbine Drugs 0.000 claims 1
- AADVZSXPNRLYLV-UHFFFAOYSA-N yohimbine carboxylic acid Natural products C1=CC=C2C(CCN3CC4CCC(C(C4CC33)C(O)=O)O)=C3NC2=C1 AADVZSXPNRLYLV-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021188658A JP7520800B2 (ja) | 2015-07-13 | 2021-11-19 | 呼吸機能を可能にするために脊髄ネットワークにアクセスすること |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562191892P | 2015-07-13 | 2015-07-13 | |
| US62/191,892 | 2015-07-13 | ||
| PCT/US2016/041802 WO2017011410A1 (en) | 2015-07-13 | 2016-07-11 | Accessing spinal network to enable respiratory function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021188658A Division JP7520800B2 (ja) | 2015-07-13 | 2021-11-19 | 呼吸機能を可能にするために脊髄ネットワークにアクセスすること |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524113A JP2018524113A (ja) | 2018-08-30 |
| JP2018524113A5 true JP2018524113A5 (enExample) | 2019-09-05 |
| JP6983148B2 JP6983148B2 (ja) | 2021-12-17 |
Family
ID=57757566
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501208A Active JP6983148B2 (ja) | 2015-07-13 | 2016-07-11 | 呼吸機能を可能にするために脊髄ネットワークにアクセスすること |
| JP2021188658A Active JP7520800B2 (ja) | 2015-07-13 | 2021-11-19 | 呼吸機能を可能にするために脊髄ネットワークにアクセスすること |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021188658A Active JP7520800B2 (ja) | 2015-07-13 | 2021-11-19 | 呼吸機能を可能にするために脊髄ネットワークにアクセスすること |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20180185642A1 (enExample) |
| EP (1) | EP3322477B1 (enExample) |
| JP (2) | JP6983148B2 (enExample) |
| CA (1) | CA3030615A1 (enExample) |
| HK (1) | HK1255688A1 (enExample) |
| WO (1) | WO2017011410A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012204526B2 (en) | 2011-01-03 | 2016-05-19 | California Institute Of Technology | High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury |
| EP2776120B1 (en) | 2011-11-11 | 2020-09-09 | Neuroenabling Technologies, Inc. | Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function |
| US9415218B2 (en) | 2011-11-11 | 2016-08-16 | The Regents Of The University Of California | Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry |
| WO2014144785A1 (en) | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion |
| EP3782698A1 (en) | 2013-09-27 | 2021-02-24 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re- enable volitional control of hand function in tetraplegic subjects |
| EP4442332A3 (en) | 2014-08-21 | 2025-01-01 | The Regents Of The University Of California | Regulation of autonomic control of bladder voiding after a complete spinal cord injury |
| EP3662968A1 (en) | 2014-08-27 | 2020-06-10 | The Regents Of The University Of California | Multi-electrode array for spinal cord epidural stimulation |
| US11298533B2 (en) | 2015-08-26 | 2022-04-12 | The Regents Of The University Of California | Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject |
| US11097122B2 (en) | 2015-11-04 | 2021-08-24 | The Regents Of The University Of California | Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel |
| WO2018140531A1 (en) * | 2017-01-24 | 2018-08-02 | The Regents Of The University Of California | Accessing spinal network to enable respiratory function |
| WO2018148844A1 (en) | 2017-02-17 | 2018-08-23 | The University Of British Columbia | Apparatus and methods for maintaining physiological functions |
| US12434068B2 (en) | 2017-05-23 | 2025-10-07 | The Regents Of The University Of California | Accessing spinal networks to address sexual dysfunction |
| EP3974021B1 (en) | 2017-06-30 | 2023-06-14 | ONWARD Medical N.V. | A system for neuromodulation |
| WO2019050896A2 (en) * | 2017-09-05 | 2019-03-14 | University Of Florida Research Foundation, Inc. | STIMULATION OF NEURONES MOTORS OF SPINAL CORD BY ELECTRICAL SIGNALS |
| US12357828B2 (en) | 2017-12-05 | 2025-07-15 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for planning and/or providing neuromodulation |
| US11992684B2 (en) | 2017-12-05 | 2024-05-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for planning and/or providing neuromodulation |
| KR102118530B1 (ko) * | 2018-02-23 | 2020-06-03 | 김민규 | 펄스 자기장을 이용한 미주신경 자극 방법 및 장치 |
| WO2020041633A1 (en) | 2018-08-23 | 2020-02-27 | The Regents Of The University Of California | Non-invasive spinal cord stimulation for nerve root palsy, cauda equina syndrome, and restoration of upper extremity function |
| DE18205821T1 (de) | 2018-11-13 | 2020-12-24 | Gtx Medical B.V. | Steuerungssystem zur bewegungsrekonstruktion und/oder wiederherstellung für einen patienten |
| EP3695878B1 (en) | 2019-02-12 | 2023-04-19 | ONWARD Medical N.V. | A system for neuromodulation |
| DE19211738T1 (de) | 2019-11-27 | 2021-09-09 | Onward Medical B.V. | Neuromodulationssystem |
| DE19211698T1 (de) | 2019-11-27 | 2021-09-02 | Onward Medical B.V. | Neuromodulation system |
| DE20160841T1 (de) * | 2020-03-04 | 2021-12-09 | Onward Medical B.V. | Ein neuromodulationssystem |
| US12168096B2 (en) * | 2021-01-27 | 2024-12-17 | Chimei Medical Center | Ventilator-weaning timing prediction system, program product thereof and method for building and using the same |
| CA3215317A1 (en) * | 2021-04-14 | 2022-10-20 | Daniel C. Lu | Spinal cord stimulation for conditioning respiratory muscles |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6234985B1 (en) | 1998-06-11 | 2001-05-22 | Cprx Llc | Device and method for performing cardiopulmonary resuscitation |
| US6463327B1 (en) | 1998-06-11 | 2002-10-08 | Cprx Llc | Stimulatory device and methods to electrically stimulate the phrenic nerve |
| US20110288609A1 (en) * | 2003-10-15 | 2011-11-24 | Rmx, Llc | Therapeutic diaphragm stimulation device and method |
| US7422555B2 (en) * | 2003-12-30 | 2008-09-09 | Jacob Zabara | Systems and methods for therapeutically treating neuro-psychiatric disorders and other illnesses |
| WO2006007048A2 (en) * | 2004-05-04 | 2006-01-19 | The Cleveland Clinic Foundation | Methods of treating medical conditions by neuromodulation of the sympathetic nervous system |
| US7657316B2 (en) * | 2005-02-25 | 2010-02-02 | Boston Scientific Neuromodulation Corporation | Methods and systems for stimulating a motor cortex of the brain to treat a medical condition |
| US20070060954A1 (en) * | 2005-02-25 | 2007-03-15 | Tracy Cameron | Method of using spinal cord stimulation to treat neurological disorders or conditions |
| US7702385B2 (en) * | 2005-11-16 | 2010-04-20 | Boston Scientific Neuromodulation Corporation | Electrode contact configurations for an implantable stimulator |
| US7805195B2 (en) * | 2005-03-24 | 2010-09-28 | Vanderbilt University | Respiratory triggered, bilateral laryngeal stimulator to restore normal ventilation in vocal fold paralysis |
| US8036750B2 (en) * | 2005-06-13 | 2011-10-11 | Cardiac Pacemakers, Inc. | System for neural control of respiration |
| US8352036B2 (en) * | 2009-01-19 | 2013-01-08 | Anthony DiMarco | Respiratory muscle activation by spinal cord stimulation |
| US20100228310A1 (en) * | 2009-03-09 | 2010-09-09 | Shuros Allan C | Systems and methods for autonomic nerve modulation |
| US10279163B2 (en) * | 2011-03-10 | 2019-05-07 | Electrocore, Inc. | Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders |
| AU2013280184B2 (en) * | 2012-06-21 | 2017-08-24 | Lungpacer Medical Inc. | Transvascular diaphragm pacing systems and methods of use |
| WO2014144785A1 (en) * | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion |
| EP3782698A1 (en) * | 2013-09-27 | 2021-02-24 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re- enable volitional control of hand function in tetraplegic subjects |
| KR20170066351A (ko) * | 2014-08-27 | 2017-06-14 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 척수 경막외 자극을 위한 다중-전극 어레이를 제조하는 방법들 |
| EP3662968A1 (en) * | 2014-08-27 | 2020-06-10 | The Regents Of The University Of California | Multi-electrode array for spinal cord epidural stimulation |
-
2016
- 2016-07-11 JP JP2018501208A patent/JP6983148B2/ja active Active
- 2016-07-11 US US15/740,323 patent/US20180185642A1/en active Pending
- 2016-07-11 HK HK18114836.9A patent/HK1255688A1/zh unknown
- 2016-07-11 WO PCT/US2016/041802 patent/WO2017011410A1/en not_active Ceased
- 2016-07-11 CA CA3030615A patent/CA3030615A1/en active Pending
- 2016-07-11 EP EP16825005.8A patent/EP3322477B1/en active Active
-
2021
- 2021-11-19 JP JP2021188658A patent/JP7520800B2/ja active Active
-
2025
- 2025-06-04 US US19/227,985 patent/US20250295923A1/en active Pending
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