CA3030615A1 - Accessing spinal network to enable respiratory function - Google Patents

Accessing spinal network to enable respiratory function Download PDF

Info

Publication number
CA3030615A1
CA3030615A1 CA3030615A CA3030615A CA3030615A1 CA 3030615 A1 CA3030615 A1 CA 3030615A1 CA 3030615 A CA3030615 A CA 3030615A CA 3030615 A CA3030615 A CA 3030615A CA 3030615 A1 CA3030615 A1 CA 3030615A1
Authority
CA
Canada
Prior art keywords
stimulation
respiration
respiratory
epidural
frequency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3030615A
Other languages
English (en)
French (fr)
Inventor
Daniel C. Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CA3030615A1 publication Critical patent/CA3030615A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/3611—Respiration control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36175—Pulse width or duty cycle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Electrotherapy Devices (AREA)
  • Magnetic Treatment Devices (AREA)
CA3030615A 2015-07-13 2016-07-11 Accessing spinal network to enable respiratory function Pending CA3030615A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562191892P 2015-07-13 2015-07-13
US62/191,892 2015-07-13
PCT/US2016/041802 WO2017011410A1 (en) 2015-07-13 2016-07-11 Accessing spinal network to enable respiratory function

Publications (1)

Publication Number Publication Date
CA3030615A1 true CA3030615A1 (en) 2017-01-19

Family

ID=57757566

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3030615A Pending CA3030615A1 (en) 2015-07-13 2016-07-11 Accessing spinal network to enable respiratory function

Country Status (6)

Country Link
US (2) US20180185642A1 (enExample)
EP (2) EP3322477B1 (enExample)
JP (2) JP6983148B2 (enExample)
CA (1) CA3030615A1 (enExample)
HK (1) HK1255688A1 (enExample)
WO (1) WO2017011410A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2823592C (en) 2011-01-03 2021-11-23 The Regents Of The University Of California High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
ES2728143T3 (es) 2011-11-11 2019-10-22 Univ California Estimulación transcutánea de la médula espinal: herramienta no invasiva para la activación del circuito locomotor
US9393409B2 (en) 2011-11-11 2016-07-19 Neuroenabling Technologies, Inc. Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function
WO2014144785A1 (en) 2013-03-15 2014-09-18 The Regents Of The University Of California Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion
CA2925754C (en) 2013-09-27 2023-02-21 The Regents Of The University Of California Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects
US10751533B2 (en) 2014-08-21 2020-08-25 The Regents Of The University Of California Regulation of autonomic control of bladder voiding after a complete spinal cord injury
EP3185946B1 (en) 2014-08-27 2019-10-09 The Regents Of The University Of California Multi-electrode array for spinal cord epidural stimulation
US11298533B2 (en) 2015-08-26 2022-04-12 The Regents Of The University Of California Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject
US11097122B2 (en) 2015-11-04 2021-08-24 The Regents Of The University Of California Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel
EP3573517B1 (en) * 2017-01-24 2023-10-18 The Regents of the University of California Accessing spinal network to enable respiratory function
WO2018148844A1 (en) 2017-02-17 2018-08-23 The University Of British Columbia Apparatus and methods for maintaining physiological functions
US12434068B2 (en) 2017-05-23 2025-10-07 The Regents Of The University Of California Accessing spinal networks to address sexual dysfunction
DE20168827T1 (de) 2017-06-30 2021-01-21 Gtx Medical B.V. System zur neuromodulierung
WO2019050896A2 (en) * 2017-09-05 2019-03-14 University Of Florida Research Foundation, Inc. STIMULATION OF NEURONES MOTORS OF SPINAL CORD BY ELECTRICAL SIGNALS
US12357828B2 (en) 2017-12-05 2025-07-15 Ecole Polytechnique Federale De Lausanne (Epfl) System for planning and/or providing neuromodulation
US11992684B2 (en) 2017-12-05 2024-05-28 Ecole Polytechnique Federale De Lausanne (Epfl) System for planning and/or providing neuromodulation
KR102118530B1 (ko) * 2018-02-23 2020-06-03 김민규 펄스 자기장을 이용한 미주신경 자극 방법 및 장치
US12478777B2 (en) 2018-08-23 2025-11-25 The Regents Of The University Of California Non-invasive spinal cord stimulation for nerve root palsy, cauda equina syndrome, and restoration of upper extremity function
EP3653256B1 (en) 2018-11-13 2022-03-30 ONWARD Medical N.V. Control system for movement reconstruction and/or restoration for a patient
EP3695878B1 (en) 2019-02-12 2023-04-19 ONWARD Medical N.V. A system for neuromodulation
EP3972683A4 (en) 2019-05-22 2023-11-08 The Regents Of The University Of California TRANSCUTANEOUS ELECTRICAL SPINAL CORD NEUROMODULATOR AND USES THEREOF
EP3824948A1 (en) 2019-11-19 2021-05-26 ONWARD Medical B.V. A planning and/or control system for a neuromodulation system
EP3827871A1 (en) 2019-11-27 2021-06-02 ONWARD Medical B.V. Neuromodulation system
DE19211738T1 (de) 2019-11-27 2021-09-09 Onward Medical B.V. Neuromodulationssystem
EP3875142A1 (en) * 2020-03-04 2021-09-08 ONWARD Medical B.V. A neuromodulation system
US12168096B2 (en) * 2021-01-27 2024-12-17 Chimei Medical Center Ventilator-weaning timing prediction system, program product thereof and method for building and using the same
JP2024513975A (ja) * 2021-04-14 2024-03-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 呼吸筋をコンディショニングするための脊髄刺激療法
US12623080B2 (en) 2023-06-21 2026-05-12 Onward Medical N.V. Neuromodulation system

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066272A (en) 1990-06-29 1991-11-19 The Johns Hopkins University Magnetic nerve stimulator
US6086525A (en) 1994-11-28 2000-07-11 Neotonus, Inc. Magnetic nerve stimulator for exciting peripheral nerves
US6500110B1 (en) 1996-08-15 2002-12-31 Neotonus, Inc. Magnetic nerve stimulation seat device
US6463327B1 (en) * 1998-06-11 2002-10-08 Cprx Llc Stimulatory device and methods to electrically stimulate the phrenic nerve
US6234985B1 (en) * 1998-06-11 2001-05-22 Cprx Llc Device and method for performing cardiopulmonary resuscitation
US7146221B2 (en) 2001-11-16 2006-12-05 The Regents Of The University Of California Flexible electrode array for artifical vision
US20110288609A1 (en) * 2003-10-15 2011-11-24 Rmx, Llc Therapeutic diaphragm stimulation device and method
US7422555B2 (en) * 2003-12-30 2008-09-09 Jacob Zabara Systems and methods for therapeutically treating neuro-psychiatric disorders and other illnesses
EP1750799A2 (en) * 2004-05-04 2007-02-14 The Cleveland Clinic Foundation Methods of treating medical conditions by neuromodulation of the sympathetic nervous system
WO2005114720A2 (en) 2004-05-14 2005-12-01 California Institute Of Technology Parylene-based flexible multi-electrode arrays for neuronal stimulation and recording and methods for manufacturing the same
US20070060954A1 (en) * 2005-02-25 2007-03-15 Tracy Cameron Method of using spinal cord stimulation to treat neurological disorders or conditions
US7657316B2 (en) * 2005-02-25 2010-02-02 Boston Scientific Neuromodulation Corporation Methods and systems for stimulating a motor cortex of the brain to treat a medical condition
US7702385B2 (en) * 2005-11-16 2010-04-20 Boston Scientific Neuromodulation Corporation Electrode contact configurations for an implantable stimulator
WO2006102591A2 (en) * 2005-03-24 2006-09-28 Vanderbilt University Respiratory triggered, bilateral laryngeal stimulator to restore normal ventilation in vocal fold paralysis
US8036750B2 (en) * 2005-06-13 2011-10-11 Cardiac Pacemakers, Inc. System for neural control of respiration
CN1879906A (zh) 2005-06-15 2006-12-20 郑云峰 中枢神经系统磁刺激装置及其使用方法
US8676324B2 (en) 2005-11-10 2014-03-18 ElectroCore, LLC Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
US8099146B1 (en) 2006-03-23 2012-01-17 Pacesetter, Inc. System and method for calibrating a blood oxygen saturation sensor for use with an implantable medical device
US20090108969A1 (en) 2007-10-31 2009-04-30 Los Alamos National Security Apparatus and method for transcranial and nerve magnetic stimulation
US8352036B2 (en) * 2009-01-19 2013-01-08 Anthony DiMarco Respiratory muscle activation by spinal cord stimulation
JP2012519574A (ja) * 2009-03-09 2012-08-30 カーディアック ペースメイカーズ， インコーポレイテッド リンパ管に埋め込み可能な電極を含む自律神経調整のためのシステム
US9403001B2 (en) 2009-03-20 2016-08-02 ElectroCore, LLC Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders
US9174045B2 (en) 2009-03-20 2015-11-03 ElectroCore, LLC Non-invasive electrical and magnetic nerve stimulators used to treat overactive bladder and urinary incontinence
CA2823592C (en) 2011-01-03 2021-11-23 The Regents Of The University Of California High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
CN103608067A (zh) 2011-01-21 2014-02-26 加利福尼亚理工学院 脊髓刺激法的聚对二甲苯基微电极阵列植入
US10173048B2 (en) * 2011-03-10 2019-01-08 Electrocore, Inc. Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
US9808164B2 (en) 2011-09-30 2017-11-07 Medtronic, Inc. Evaluation of cardiac dyssynchrony based on chest wall motion and electrical cardiac activity
JP6359528B2 (ja) * 2012-06-21 2018-07-18 ラングペーサー メディカル インコーポレイテッドＬｕｎｇｐａｃｅｒ Ｍｅｄｉｃａｌ Ｉｎｃ． 経血管横隔膜ペーシング・システム及び使用方法
WO2014144785A1 (en) * 2013-03-15 2014-09-18 The Regents Of The University Of California Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion
CA2925754C (en) * 2013-09-27 2023-02-21 The Regents Of The University Of California Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects
EP3185946B1 (en) * 2014-08-27 2019-10-09 The Regents Of The University Of California Multi-electrode array for spinal cord epidural stimulation
CN107405481A (zh) * 2014-08-27 2017-11-28 加利福尼亚大学董事会 制造用于脊髓硬膜外刺激的多电极阵列的方法

Also Published As

Publication number Publication date
EP4710997A3 (en) 2026-03-25
EP3322477A1 (en) 2018-05-23
JP2022016548A (ja) 2022-01-21
JP6983148B2 (ja) 2021-12-17
JP2018524113A (ja) 2018-08-30
HK1255688A1 (zh) 2019-08-23
US20250295923A1 (en) 2025-09-25
US20180185642A1 (en) 2018-07-05
EP3322477B1 (en) 2025-12-10
JP7520800B2 (ja) 2024-07-23
EP3322477A4 (en) 2019-03-20
WO2017011410A1 (en) 2017-01-19
EP4710997A2 (en) 2026-03-18

Similar Documents

Publication Publication Date Title
US20250295923A1 (en) Accessing spinal network to enable respiratory function
EP4299106B1 (en) Accessing spinal network to enable respiratory function
Fregosi et al. Long‐term facilitation of inspiratory intercostal nerve activity following carotid sinus nerve stimulation in cats.
US20050137645A1 (en) Novel method for the adjustment of human and animal vagus nerve stimulation
RU2536280C2 (ru) Адаптивная система терапии (варианты) и система терапии аксонов
Binks et al. High strength stimulation of the vagus nerve in awake humans: a lack of cardiorespiratory effects
JP2013525029A (ja) 疼痛管理システム
WO2007007058A1 (en) Method and apparatus for regulating blood pressure
US20170072219A1 (en) Materials and approaches for optical stimulation of the peripheral nervous system
US8065014B2 (en) Method for promoting selective reinnervation of denervated tissue
WO2003072186A2 (en) Neurostimulation for affecting sleep disorders
JP2019506960A (ja) 神経調整デバイス
JP2024513975A (ja) 呼吸筋をコンディショニングするための脊髄刺激療法
Milner et al. A5 region modulation of the cardiorespiratory responses evoked from parabrachial cell bodies in the anaesthetised rat
Mickle et al. Closed-loop cervical epidural stimulation partially restores ipsilesional diaphragm EMG after acute C2 hemisection
Ellrich et al. Electrophysiology of sensory and sensorimotor processing in mice under general anesthesia
JP2018523542A5 (enExample)
HK40018951B (en) Accessing spinal network to enable respiratory function
HK40018951A (en) Accessing spinal network to enable respiratory function
KR20250019024A (ko) 신경 자극용 치료제를 전달하기 위한 시스템, 디바이스, 및 방법
US20250135201A1 (en) Selective neurostimulation of peripheral nerves with reduced off-target activation
EP4635557A1 (en) System for inhibiting action potential conduction in a nerve
Wilkinson et al. Responses of feline medial medullary reticular formation neurons with projections to the C5–C6 ventral horn to vestibular stimulation
Popp et al. Intermittent phrenic afferent activation induces phrenic motor plasticity
WO2024216100A1 (en) Multi-modal neuromodulation

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210709

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 8TH ANNIV.) - STANDARD

Year of fee payment: 8

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20241022

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20241219

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20241219

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20250210

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION

Effective date: 20250606

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250609

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 9TH ANNIV.) - STANDARD

Year of fee payment: 9

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250707

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250707

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20250717

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20250717

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20260218