JP2018522593A5 - - Google Patents
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- Publication number
- JP2018522593A5 JP2018522593A5 JP2018525513A JP2018525513A JP2018522593A5 JP 2018522593 A5 JP2018522593 A5 JP 2018522593A5 JP 2018525513 A JP2018525513 A JP 2018525513A JP 2018525513 A JP2018525513 A JP 2018525513A JP 2018522593 A5 JP2018522593 A5 JP 2018522593A5
- Authority
- JP
- Japan
- Prior art keywords
- serum
- heat shock
- stem cells
- composition
- free medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000000130 stem cell Anatomy 0.000 claims 17
- 210000001808 exosome Anatomy 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 13
- 230000035939 shock Effects 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 239000012679 serum free medium Substances 0.000 claims 12
- 230000003938 response to stress Effects 0.000 claims 11
- 238000012258 culturing Methods 0.000 claims 10
- 210000004872 soft tissue Anatomy 0.000 claims 6
- 239000002609 medium Substances 0.000 claims 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 4
- 238000005119 centrifugation Methods 0.000 claims 3
- 101710163595 Chaperone protein DnaK Proteins 0.000 claims 2
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 claims 2
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000002826 placenta Anatomy 0.000 claims 2
- 241000195940 Bryophyta Species 0.000 claims 1
- 208000002260 Keloid Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000002845 discoloration Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 210000001117 keloid Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 235000011929 mousse Nutrition 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199696P | 2015-07-31 | 2015-07-31 | |
| US62/199,696 | 2015-07-31 | ||
| PCT/US2016/044453 WO2017023689A1 (en) | 2015-07-31 | 2016-07-28 | Exosome compositions and use thereof for soft tissue repair |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522593A JP2018522593A (ja) | 2018-08-16 |
| JP2018522593A5 true JP2018522593A5 (https=) | 2018-09-27 |
| JP6719559B2 JP6719559B2 (ja) | 2020-07-08 |
Family
ID=57943605
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525513A Active JP6719559B2 (ja) | 2015-07-31 | 2016-07-28 | 軟組織修復のための、エキソソーム組成物およびその使用 |
| JP2018525514A Active JP6980955B2 (ja) | 2015-07-31 | 2016-07-28 | エキソソーム組成物ならびに調製方法ならびに皮膚および毛髪の調節および調整のためのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525514A Active JP6980955B2 (ja) | 2015-07-31 | 2016-07-28 | エキソソーム組成物ならびに調製方法ならびに皮膚および毛髪の調節および調整のためのその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20180147420A1 (https=) |
| EP (2) | EP3328403A4 (https=) |
| JP (2) | JP6719559B2 (https=) |
| CA (2) | CA2993227C (https=) |
| ES (1) | ES2952050T3 (https=) |
| HR (1) | HRP20230865T1 (https=) |
| HU (1) | HUE063486T2 (https=) |
| PL (1) | PL3328397T3 (https=) |
| RS (1) | RS64469B1 (https=) |
| SM (1) | SMT202300249T1 (https=) |
| WO (2) | WO2017023690A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018039100A2 (en) * | 2016-08-23 | 2018-03-01 | Albert Einstein College Of Medicine, Inc. | Stem cell-produced microvesicles for treating tendon pathologies |
| CN107080753A (zh) * | 2017-04-20 | 2017-08-22 | 深圳市赛欧细胞生物科技有限公司 | 一种人脐带间充质干细胞源外泌体的美容制剂 |
| CN107006452A (zh) * | 2017-04-20 | 2017-08-04 | 深圳市赛欧细胞生物科技有限公司 | 一种人脐带间充质干细胞源外泌体冻干保存方法及其应用 |
| CN107245472B (zh) * | 2017-06-08 | 2021-08-06 | 北京智能宝生物科技有限公司 | 一种人间充质干细胞外泌体冻干粉的制备方法、使用方法 |
| KR20190003316A (ko) | 2017-06-30 | 2019-01-09 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도 |
| JP7037205B2 (ja) * | 2017-06-30 | 2022-03-16 | エクソコバイオ インコーポレイテッド | 幹細胞由来のエキソソームを有効成分として含む組成物のかゆみの抑制又は改善の用途 |
| WO2019004738A2 (ko) * | 2017-06-30 | 2019-01-03 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부염 개선 용도 |
| US11590175B2 (en) * | 2017-08-23 | 2023-02-28 | Merakris Therapeutics Llc | Compositions containing amniotic components and methods for preparation and use thereof |
| US12281330B2 (en) | 2017-09-11 | 2025-04-22 | SymbioCellTech | Adaptation of hollow-fiber-based cell culture technology for the manufacturing of (1) neo-islets, employed for the treatment of type 1 and type 2 diabetes mellitus, and (2) the generation of exosomes from various cell types, used in the treatment of different organ injuries and diseases |
| US11766402B2 (en) | 2017-11-16 | 2023-09-26 | Board Of Regents, The University Of Texas System | Methods for production of MSC-derived exosomes |
| WO2019103381A1 (ko) * | 2017-11-24 | 2019-05-31 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부장벽 강화 내지 기능 개선 용도 |
| KR20190060646A (ko) * | 2017-11-24 | 2019-06-03 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부장벽 강화 내지 기능 개선 용도 |
| KR102039302B1 (ko) * | 2017-11-24 | 2019-10-31 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부장벽 강화 내지 기능 개선 용도 |
| WO2019118817A1 (en) | 2017-12-14 | 2019-06-20 | Mayo Foundation For Medical Education And Research | Purified exosome products, method of making, and methods of using |
| WO2019139762A1 (en) * | 2018-01-09 | 2019-07-18 | Zen-Bio, Inc. | Exosome compositions and use thereof for joint disorders and diseases |
| EP3775258A4 (en) | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| WO2019213518A1 (en) * | 2018-05-04 | 2019-11-07 | Figene, Llc | Pain-reducing effects of fibroblasts and treatment of pain |
| RU2710368C2 (ru) * | 2018-05-29 | 2019-12-26 | Станислав Евгеньевич Волчков | Способ получения и концентрирования микроРНК-содержащих экзосом мультипотентных мезенхимально-стромальных клеток для применения в косметических и лекарственных средствах для стимуляции регенеративных процессов и замедления процессов старения |
| JP2021526556A (ja) | 2018-05-30 | 2021-10-07 | ダイレクト バイオロジクス エルエルシー | 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞（ｍｓｃ）の調製物を含む助剤、ならびにその使用方法 |
| WO2019231133A1 (ko) * | 2018-05-31 | 2019-12-05 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물 |
| KR102649069B1 (ko) * | 2018-05-31 | 2024-03-19 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 안면 홍조 개선용 조성물 |
| CN108715834B (zh) * | 2018-06-01 | 2021-09-14 | 天晴干细胞股份有限公司 | 一种富含cd41+、cd81+微囊的血小板裂解液制备方法 |
| KR102176845B1 (ko) * | 2018-10-02 | 2020-11-10 | 주식회사 스템온 | 유도된 엑소좀을 포함하는 피부 재생 및 상처 치유용 조성물 |
| AU2019374153B2 (en) | 2018-11-04 | 2025-11-06 | Fibrobiologics, Inc. | Treatment of cachexia using fibroblast cells and products thereof |
| BR112021015549A2 (pt) | 2019-02-07 | 2021-10-26 | Direct Biologics Llc | Método para tratar osteoartrite com uma combinação de exossomos de células tronco mesenquimais, células tronco mesenquimais sinoviais e andaimes |
| AU2020228303B2 (en) | 2019-02-28 | 2025-09-18 | Merakris Therapeutics Llc | Amniotic fluid-derived extracellular vesicles and uses thereof for wound healing |
| WO2020180311A1 (en) * | 2019-03-06 | 2020-09-10 | Zen-Bio, Inc. | Plant-based exosome compositions and use thereof for rejuvenating skin |
| KR20220002317A (ko) * | 2019-04-29 | 2022-01-06 | 다이렉트 바이오로직스 엘엘씨 | 특징규명된 중간엽 줄기세포 성장인자 및 엑소좀을 이용한 치주 질환의 치료 방법 |
| CA3146433A1 (en) | 2019-07-18 | 2021-01-21 | Direct Biologics Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| JP2021040551A (ja) * | 2019-09-11 | 2021-03-18 | 富士フイルム株式会社 | 培地組成物、キット、間葉系幹細胞組成物の製造方法、間葉系幹細胞組成物、間葉系幹細胞、細胞培養上清および細胞外小胞 |
| CN110559254A (zh) * | 2019-10-20 | 2019-12-13 | 张新梅 | 一种外泌体组合物、其制备方法及应用 |
| MX2022005107A (es) * | 2019-11-04 | 2023-01-11 | Omar Mohamed Salah Eldin Ahmed Eltookhy | Metodo de recubrimiento y secado de vesiculas extracelulares derivadas de celulas madre heterogeneas. |
| CN110721198A (zh) * | 2019-11-08 | 2020-01-24 | 赵凯 | 一种预防癫痫产生脑损伤的外泌体喷雾的制作工艺 |
| JP7778377B2 (ja) * | 2020-01-20 | 2025-12-02 | イーブイ、セル、バイオテック、（コアンチョウ）、カンパニー、リミテッド | 小胞及びその使用 |
| CN113134015B (zh) * | 2020-01-20 | 2023-11-17 | 医微细胞生物技术(广州)有限公司 | 细胞外囊泡及其在皮肤产品的用途 |
| US12077780B2 (en) | 2020-02-14 | 2024-09-03 | Allergan Sales, Llc | Conditioned medium from cells cultured under hypoxic conditions and uses thereof |
| US12590310B2 (en) | 2020-04-22 | 2026-03-31 | Direct Biologics, Llc | Methods and compositions for treating inflammatory conditions associated with infectious disease |
| US20240390551A1 (en) * | 2021-01-20 | 2024-11-28 | Research & Business Foundation Sungkyunkwan University | Filler composition for reducing skin wrinkles comprising stem cell-derived exosomes, hyaluronic acid, and bdde and method for preparing same |
| KR102368442B1 (ko) * | 2021-02-19 | 2022-02-28 | 주식회사 엑소코바이오 | 생리활성이 강화된 엑소좀의 생산방법 및 이의 응용 |
| TW202235614A (zh) * | 2021-03-11 | 2022-09-16 | 長新生醫國際股份有限公司 | 幹細胞凍乾粉之製造方法 |
| CN113041259B (zh) * | 2021-03-23 | 2023-05-12 | 哈尔滨科技实业开发有限公司 | 牙髓干细胞外泌体制剂及制备方法和应用 |
| KR20230166109A (ko) * | 2021-03-31 | 2023-12-06 | 뉴트라슈티컬 웰니스 인크. | 식물 유래 엑소좀-유사 나노소포 또는 엑소좀을 포함하는 조성물 및 그의 사용 방법 |
| CN113384518A (zh) * | 2021-07-27 | 2021-09-14 | 山西遗传资源细胞库有限公司 | 一种干细胞外泌体应用于面膜的方法 |
| JPWO2023079655A1 (https=) * | 2021-11-04 | 2023-05-11 | ||
| CN113940912B (zh) * | 2021-12-09 | 2024-04-16 | 深圳市泓浩生物科技有限公司 | 抗衰老的组合物及其应用 |
| CN116099056A (zh) * | 2023-04-07 | 2023-05-12 | 云南云科特色植物提取实验室有限公司 | 一种含仿生纹理结构的人工皮肤及其制备方法 |
| CN116790482A (zh) * | 2023-06-12 | 2023-09-22 | 成都诺医德医学检验实验室有限公司 | 一种刺激皮肤类器官分泌外泌体的方法 |
| US20250041348A1 (en) * | 2023-08-03 | 2025-02-06 | Wisconsin Alumni Research Foundation | Extracellular vesicle therapy to treat orthopedic injury |
| US12502407B2 (en) | 2024-04-25 | 2025-12-23 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
| CN118576721A (zh) * | 2024-05-27 | 2024-09-03 | 深圳市中安康华生物科技有限公司 | 一种外泌体复合生物制剂及其制备方法与应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5348945A (en) * | 1990-04-06 | 1994-09-20 | Wake Forest University | Method of treatment with hsp70 |
| US5593682A (en) * | 1995-12-29 | 1997-01-14 | Eastman Chemical Company | Skin treating composition |
| AT409379B (de) * | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| JP2004331602A (ja) * | 2003-05-09 | 2004-11-25 | Arysta Lifescience Corp | 皮膚外用剤 |
| EP1514539A3 (en) * | 2003-05-14 | 2005-05-04 | Signal Investment & Management Co. | Micro-encapsulated topical analgesic for pain relief and sleeve comprising it |
| US20060143782A1 (en) * | 2004-10-07 | 2006-07-06 | Sherry Ajluni | Glove with skin lotion |
| US8022037B2 (en) * | 2007-01-08 | 2011-09-20 | University Of Southern California | Skin wound healing compositions and methods of use thereof |
| CN102014934B (zh) * | 2008-02-22 | 2014-08-20 | 新加坡科技研究局 | 间充质干细胞颗粒 |
| WO2012026712A2 (ko) * | 2010-08-23 | 2012-03-01 | 주식회사 강스템홀딩스 | Ｎｏｄ２의 아고니스트를 처리한 줄기세포 또는 그 배양물을 포함하는 면역질환 또는 염증질환의 예방 또는 치료용 약학조성물 |
| JP5911874B2 (ja) * | 2010-10-18 | 2016-04-27 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 発毛を促進又は増強するためのエキソソームの使用 |
| US9119974B2 (en) * | 2011-03-04 | 2015-09-01 | Ahmed H. Al-Qahtani | Skin cream |
| CA2829586C (en) * | 2011-03-11 | 2021-03-02 | Children's Medical Center Corporation | Methods and compositions relating to mesenchymal stem cell exosomes |
| JP3171007U (ja) * | 2011-06-28 | 2011-10-13 | ヘルスアシスト株式会社 | 腕肩美容パックシート |
| US9427450B2 (en) * | 2012-01-31 | 2016-08-30 | Xon Cells, Inc. | Therapeutic immune modulation by stem cell secreted exosomes |
| EP2687219A1 (en) * | 2012-07-18 | 2014-01-22 | Universität Duisburg-Essen | Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions |
| CN105209881B (zh) * | 2013-03-13 | 2021-01-22 | 迈阿密大学 | 从细胞培养上清液和生物流体分离并纯化微泡的方法 |
| WO2014197747A1 (en) * | 2013-06-05 | 2014-12-11 | The Trustees Of Columbia University In The City Of New York | Exosomes for orofacial diagnostics and therapeutics |
| JP6253361B2 (ja) * | 2013-11-21 | 2017-12-27 | ポーラ化成工業株式会社 | 皮膚外用剤 |
| JP2015101541A (ja) * | 2013-11-21 | 2015-06-04 | ポーラ化成工業株式会社 | 皮膚関連酵素活性化剤 |
| US9464272B2 (en) * | 2013-12-12 | 2016-10-11 | Stemnion, Inc. | Cell-derived composition |
| CN104488850B (zh) * | 2014-11-28 | 2016-11-02 | 广州赛莱拉干细胞科技股份有限公司 | 一种制备人羊膜间充质干细胞外泌体冻干粉的方法 |
-
2016
- 2016-07-28 WO PCT/US2016/044458 patent/WO2017023690A1/en not_active Ceased
- 2016-07-28 WO PCT/US2016/044453 patent/WO2017023689A1/en not_active Ceased
- 2016-07-28 JP JP2018525513A patent/JP6719559B2/ja active Active
- 2016-07-28 SM SM20230249T patent/SMT202300249T1/it unknown
- 2016-07-28 EP EP16833568.5A patent/EP3328403A4/en not_active Withdrawn
- 2016-07-28 CA CA2993227A patent/CA2993227C/en active Active
- 2016-07-28 PL PL16833569.3T patent/PL3328397T3/pl unknown
- 2016-07-28 HU HUE16833569A patent/HUE063486T2/hu unknown
- 2016-07-28 RS RS20230599A patent/RS64469B1/sr unknown
- 2016-07-28 CA CA2993224A patent/CA2993224A1/en not_active Abandoned
- 2016-07-28 JP JP2018525514A patent/JP6980955B2/ja active Active
- 2016-07-28 ES ES16833569T patent/ES2952050T3/es active Active
- 2016-07-28 EP EP16833569.3A patent/EP3328397B1/en active Active
- 2016-07-28 HR HRP20230865TT patent/HRP20230865T1/hr unknown
-
2018
- 2018-01-31 US US15/884,545 patent/US20180147420A1/en not_active Abandoned
- 2018-01-31 US US15/884,921 patent/US20180177828A1/en not_active Abandoned
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