JP2018522538A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018522538A5 JP2018522538A5 JP2017562028A JP2017562028A JP2018522538A5 JP 2018522538 A5 JP2018522538 A5 JP 2018522538A5 JP 2017562028 A JP2017562028 A JP 2017562028A JP 2017562028 A JP2017562028 A JP 2017562028A JP 2018522538 A5 JP2018522538 A5 JP 2018522538A5
- Authority
- JP
- Japan
- Prior art keywords
- signaling
- activator
- cells
- days
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 61
- 230000011664 signaling Effects 0.000 claims description 57
- 210000004027 cell Anatomy 0.000 claims description 48
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 44
- 239000012190 activator Substances 0.000 claims description 37
- 102000013814 Wnt Human genes 0.000 claims description 31
- 108050003627 Wnt Proteins 0.000 claims description 31
- 102000003693 Hedgehog Proteins Human genes 0.000 claims description 25
- 108090000031 Hedgehog Proteins Proteins 0.000 claims description 25
- 229960003638 dopamine Drugs 0.000 claims description 22
- 210000002569 neuron Anatomy 0.000 claims description 22
- 239000003112 inhibitor Substances 0.000 claims description 20
- 210000001259 mesencephalon Anatomy 0.000 claims description 16
- 239000002243 precursor Substances 0.000 claims description 15
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 10
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 10
- 229940112869 bone morphogenetic protein Drugs 0.000 claims description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 241000283984 Rodentia Species 0.000 claims description 8
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 8
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 8
- 108010087745 Hepatocyte Nuclear Factor 3-beta Proteins 0.000 claims description 6
- 102100029284 Hepatocyte nuclear factor 3-beta Human genes 0.000 claims description 6
- 102100040290 LIM homeobox transcription factor 1-alpha Human genes 0.000 claims description 6
- 101710178355 LIM homeobox transcription factor 1-alpha Proteins 0.000 claims description 6
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 6
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 5
- CDOVNWNANFFLFJ-UHFFFAOYSA-N 4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline Chemical compound C1CNCCN1C1=CC=C(C2=CN3N=CC(=C3N=C2)C=2C3=CC=CC=C3N=CC=2)C=C1 CDOVNWNANFFLFJ-UHFFFAOYSA-N 0.000 claims description 4
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims description 4
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims description 4
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 claims description 4
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 claims description 4
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims description 4
- 108091000117 Tyrosine 3-Monooxygenase Proteins 0.000 claims description 4
- 102000048218 Tyrosine 3-monooxygenases Human genes 0.000 claims description 4
- 229960005070 ascorbic acid Drugs 0.000 claims description 4
- 235000010323 ascorbic acid Nutrition 0.000 claims description 4
- 239000011668 ascorbic acid Substances 0.000 claims description 4
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims description 4
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 230000035800 maturation Effects 0.000 claims description 4
- VFSUUTYAEQOIMW-YHBQERECSA-N 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide Chemical compound C1C[C@@H](NC)CC[C@@H]1N(C(=O)C1=C(C2=CC=CC=C2S1)Cl)CC1=CC=CC(C=2C=CN=CC=2)=C1 VFSUUTYAEQOIMW-YHBQERECSA-N 0.000 claims description 3
- 208000018737 Parkinson disease Diseases 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical compound CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims description 2
- DWJXYEABWRJFSP-XOBRGWDASA-N DAPT Chemical compound N([C@@H](C)C(=O)N[C@H](C(=O)OC(C)(C)C)C=1C=CC=CC=1)C(=O)CC1=CC(F)=CC(F)=C1 DWJXYEABWRJFSP-XOBRGWDASA-N 0.000 claims description 2
- 101001121800 Neisseria meningitidis Polysialic acid O-acetyltransferase Proteins 0.000 claims description 2
- 102000052547 Wnt-1 Human genes 0.000 claims description 2
- 108700020987 Wnt-1 Proteins 0.000 claims description 2
- 102000044880 Wnt3A Human genes 0.000 claims description 2
- 108700013515 Wnt3A Proteins 0.000 claims description 2
- 238000011977 dual antiplatelet therapy Methods 0.000 claims description 2
- 230000002349 favourable effect Effects 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 108010059616 Activins Proteins 0.000 claims 2
- 229920000742 Cotton Polymers 0.000 claims 2
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 2
- 101150026563 NR4A2 gene Proteins 0.000 claims 2
- 108091005735 TGF-beta receptors Proteins 0.000 claims 2
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims 2
- 239000000488 activin Substances 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- FHYUGAJXYORMHI-UHFFFAOYSA-N SB 431542 Chemical compound C1=CC(C(=O)N)=CC=C1C1=NC(C=2C=C3OCOC3=CC=2)=C(C=2N=CC=CC=2)N1 FHYUGAJXYORMHI-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 102000045246 noggin Human genes 0.000 claims 1
- 108700007229 noggin Proteins 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- -1 1,3-benzodioxol-5-yl Chemical group 0.000 description 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 2
- 102000007399 Nuclear hormone receptor Human genes 0.000 description 1
- 108020005497 Nuclear hormone receptor Proteins 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 108020004017 nuclear receptors Proteins 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020102332A JP7737787B2 (ja) | 2015-06-01 | 2020-06-12 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562169444P | 2015-06-01 | 2015-06-01 | |
| US201562169379P | 2015-06-01 | 2015-06-01 | |
| US62/169,444 | 2015-06-01 | ||
| US62/169,379 | 2015-06-01 | ||
| PCT/US2016/035312 WO2016196661A1 (en) | 2015-06-01 | 2016-06-01 | Methods of in vitro differentiation of midbrain dopamine (mda) neurons |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020102332A Division JP7737787B2 (ja) | 2015-06-01 | 2020-06-12 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522538A JP2018522538A (ja) | 2018-08-16 |
| JP2018522538A5 true JP2018522538A5 (https=) | 2019-07-04 |
| JP6974180B2 JP6974180B2 (ja) | 2021-12-01 |
Family
ID=57441792
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562028A Active JP6974180B2 (ja) | 2015-06-01 | 2016-06-01 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
| JP2020102332A Active JP7737787B2 (ja) | 2015-06-01 | 2020-06-12 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
| JP2021205897A Withdrawn JP2022031961A (ja) | 2015-06-01 | 2021-12-20 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
| JP2023188483A Withdrawn JP2023181494A (ja) | 2015-06-01 | 2023-11-02 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
| JP2025197316A Pending JP2026015509A (ja) | 2015-06-01 | 2025-11-18 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020102332A Active JP7737787B2 (ja) | 2015-06-01 | 2020-06-12 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
| JP2021205897A Withdrawn JP2022031961A (ja) | 2015-06-01 | 2021-12-20 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
| JP2023188483A Withdrawn JP2023181494A (ja) | 2015-06-01 | 2023-11-02 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
| JP2025197316A Pending JP2026015509A (ja) | 2015-06-01 | 2025-11-18 | 中脳ドーパミン（ｍＤＡ）ニューロンのｉｎ ｖｉｔｒｏ分化の方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10858625B2 (https=) |
| EP (3) | EP4070803B1 (https=) |
| JP (5) | JP6974180B2 (https=) |
| KR (4) | KR102358878B1 (https=) |
| AU (3) | AU2016270793B2 (https=) |
| CY (1) | CY1125423T1 (https=) |
| DK (2) | DK4070803T3 (https=) |
| ES (2) | ES2910032T3 (https=) |
| HR (1) | HRP20220482T1 (https=) |
| HU (1) | HUE058258T2 (https=) |
| IL (4) | IL291532B2 (https=) |
| LT (1) | LT3303564T (https=) |
| PL (1) | PL3303564T3 (https=) |
| PT (2) | PT3303564T (https=) |
| RS (1) | RS63157B1 (https=) |
| SI (1) | SI3303564T1 (https=) |
| SM (1) | SMT202200263T1 (https=) |
| WO (1) | WO2016196661A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6998772B2 (ja) * | 2015-04-09 | 2022-02-04 | ビオラミナ アーベー | 神経変性疾患の処置における使用のための幹細胞由来のドパミン作用性細胞を生成するための方法および組成物 |
| AU2016270793B2 (en) * | 2015-06-01 | 2022-06-09 | Memorial Sloan-Kettering Cancer Center | Methods of in vitro differentiation of midbrain dopamine (MDA) neurons |
| KR20180105236A (ko) * | 2016-02-05 | 2018-09-27 | 메모리얼 슬로안-케터링 캔서 센터 | 줄기 세포-유래 외배엽 계통 전구체의 분화 방법 |
| KR102625865B1 (ko) * | 2016-08-16 | 2024-01-16 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 만능 세포를 분화시키는 방법 |
| KR20190141218A (ko) * | 2017-04-26 | 2019-12-23 | 메모리얼 슬로안 케터링 캔서 센터 | 사용 준비된 냉동보존 세포 |
| WO2019016113A1 (en) | 2017-07-17 | 2019-01-24 | Miltenyi Biotec Gmbh | METHOD FOR PROFILING EXPRESSION OF UNICELLULAR PROTEIN FROM DOPAMINERGIC PROGENITOR CELLS OF MESENCEPHALIC FLOOR |
| WO2019032680A1 (en) * | 2017-08-08 | 2019-02-14 | Regents Of The University Of Minnesota | METHODS OF GENERATING AND USING ORGANOIDS AND ASSOCIATED CELLS |
| JP2022514298A (ja) | 2018-12-19 | 2022-02-10 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | オルガノイドおよびその組織を作製および使用するための方法 |
| WO2020237104A1 (en) * | 2019-05-23 | 2020-11-26 | The Mclean Hospital Corporation | Autologous cell replacement therapy for parkinson's disease |
| JP7810357B2 (ja) | 2019-07-25 | 2026-02-03 | ザ スクリプス リサーチ インスティテュート | ドーパミン作動性ニューロン及び前駆細胞を特定する方法 |
| EP4021477A4 (en) * | 2019-08-29 | 2023-12-13 | Memorial Sloan Kettering Cancer Center | METHOD FOR GENERATING AND ISOLATING MID-DOPAMINE NEURONS |
| EP4032974A4 (en) * | 2019-09-20 | 2023-12-06 | Korea Research Institute of Bioscience and Biotechnology | Production method for induced dopaminergic neuronal progenitors, using direct reprogramming |
| KR20220158046A (ko) | 2020-03-25 | 2022-11-29 | 사나 바이오테크놀로지, 인크. | 신경계 장애 및 병태의 치료를 위한 면역저하성 신경 세포 |
| WO2021216623A1 (en) | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom |
| US20250263752A1 (en) | 2020-04-21 | 2025-08-21 | Aspen Neuroscience, Inc. | Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom |
| US12104170B2 (en) * | 2020-06-26 | 2024-10-01 | Minerva Biotechnologies Corporation | Methods for deriving dopaminergic neurons from pluripotent stem cells |
| CN116635047A (zh) * | 2020-06-26 | 2023-08-22 | 米纳瓦生物技术公司 | 用于从多能干细胞衍生多巴胺能神经元的方法 |
| CN114292814A (zh) * | 2020-09-22 | 2022-04-08 | 上海跃赛生物科技有限公司 | 一种多能干细胞分化为中脑黒质多巴胺能神经细胞的方法 |
| WO2022216911A1 (en) * | 2021-04-07 | 2022-10-13 | FUJIFILM Cellular Dynamics, Inc. | Dopaminergic precursor cells and methods of use |
| WO2023004370A1 (en) | 2021-07-21 | 2023-01-26 | Aspen Neuroscience, Inc. | Aav-based modulation of gba1 and related compositions and uses thereof |
| WO2023004366A1 (en) | 2021-07-21 | 2023-01-26 | Aspen Neuroscience, Inc. | Transposon-based modulation of gba1 and related compositions and uses thereof |
| WO2023086894A1 (en) | 2021-11-12 | 2023-05-19 | Axent Biosciences Inc. | Methods for production of functional neurons |
| WO2023201361A1 (en) | 2022-04-15 | 2023-10-19 | Aspen Neuroscience, Inc. | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
| US12565639B2 (en) * | 2023-06-13 | 2026-03-03 | Aspen Neuroscience, Inc. | Methods for differentiating dopaminergic neurons from stem cells |
| CN117448271B (zh) * | 2023-12-22 | 2024-07-16 | 上海元戊医学技术有限公司 | 一种诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法 |
| WO2025166063A1 (en) | 2024-01-31 | 2025-08-07 | Bluerock Therapeutics Lp | Igfbp2 in cell culture |
| WO2025252180A1 (zh) * | 2024-06-05 | 2025-12-11 | 中国科学院脑科学与智能技术卓越创新中心 | 中脑多巴胺能祖细胞群的体外制备方法 |
| WO2026006245A1 (en) | 2024-06-25 | 2026-01-02 | Bluerock Therapeutics Lp | Three-dimensional culturing of pluripotent stem cells for improved differentiability |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000068431A2 (en) | 1999-05-06 | 2000-11-16 | Mount Sinai School Of Medicine Of New York University | Dna-based steganography |
| WO2001088104A2 (en) * | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
| EP1791949A2 (en) * | 2004-09-02 | 2007-06-06 | Neuro Therapeutics AB | Methods and materials relating to enhanced production of dopamine neurons |
| WO2006071778A2 (en) * | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| JP5649786B2 (ja) | 2006-03-07 | 2015-01-07 | ギータ シュロフ | ヒト胚性幹細胞およびそれらの誘導体を含む組成物、使用方法、ならびに調製方法 |
| WO2008008266A2 (en) | 2006-07-07 | 2008-01-17 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Biohybrid elastomeric scaffolds and methods of use thereof |
| WO2010096496A2 (en) | 2009-02-17 | 2010-08-26 | Memorial Sloan-Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
| DK3578988T3 (da) | 2010-05-25 | 2025-02-24 | Memorial Sloan Kettering Cancer Center | Fremgangsmåde til nociceptordifferentiering af humane embryonale stamceller og anvendelse heraf |
| US20110296542A1 (en) | 2010-05-28 | 2011-12-01 | Kevin Ka-Wang Wang | Exogenous matrix-supported topical application of stem cells to organ surface |
| EP3693455A1 (en) * | 2011-11-04 | 2020-08-12 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (da) neurons for engraftment |
| WO2013188744A1 (en) | 2012-06-15 | 2013-12-19 | Baylor College Of Medicine | Perineurium derived adult stem cells and methods of use |
| EP3498824A1 (en) | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
| KR101696874B1 (ko) * | 2013-07-31 | 2017-01-16 | 한국생명공학연구원 | 직접 리프로그래밍을 통한 유도 도파민성 전구세포 제조방법 |
| EP3031908B1 (en) * | 2013-08-06 | 2018-12-05 | Takeda Pharmaceutical Company Limited | Method for producing dopaminergic neurons |
| AU2014316100B2 (en) * | 2013-09-05 | 2020-11-05 | Eisai R&D Management Co., Ltd. | New method for inducing dopamine-producing neural precursor cells |
| AU2014352773B2 (en) | 2013-11-21 | 2021-04-29 | Memorial Sloan-Kettering Cancer Center | Specification of functional cranial placode derivatives from human pluripotent stem cells |
| ES2939807T3 (es) * | 2014-03-21 | 2023-04-27 | Fujifilm Cellular Dynamics Inc | Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización |
| AU2016270793B2 (en) * | 2015-06-01 | 2022-06-09 | Memorial Sloan-Kettering Cancer Center | Methods of in vitro differentiation of midbrain dopamine (MDA) neurons |
-
2016
- 2016-06-01 AU AU2016270793A patent/AU2016270793B2/en active Active
- 2016-06-01 JP JP2017562028A patent/JP6974180B2/ja active Active
- 2016-06-01 PT PT168043503T patent/PT3303564T/pt unknown
- 2016-06-01 RS RS20220353A patent/RS63157B1/sr unknown
- 2016-06-01 EP EP22157782.8A patent/EP4070803B1/en active Active
- 2016-06-01 ES ES16804350T patent/ES2910032T3/es active Active
- 2016-06-01 DK DK22157782.8T patent/DK4070803T3/da active
- 2016-06-01 ES ES22157782T patent/ES3057638T3/es active Active
- 2016-06-01 PT PT221577828T patent/PT4070803T/pt unknown
- 2016-06-01 IL IL291532A patent/IL291532B2/en unknown
- 2016-06-01 EP EP22176877.3A patent/EP4079314B1/en active Active
- 2016-06-01 SM SM20220263T patent/SMT202200263T1/it unknown
- 2016-06-01 PL PL16804350T patent/PL3303564T3/pl unknown
- 2016-06-01 EP EP16804350.3A patent/EP3303564B1/en active Active
- 2016-06-01 KR KR1020177037050A patent/KR102358878B1/ko active Active
- 2016-06-01 KR KR1020257025403A patent/KR20250118858A/ko active Pending
- 2016-06-01 KR KR1020247021208A patent/KR102841407B1/ko active Active
- 2016-06-01 SI SI201631535T patent/SI3303564T1/sl unknown
- 2016-06-01 DK DK16804350.3T patent/DK3303564T3/da active
- 2016-06-01 IL IL320440A patent/IL320440A/en unknown
- 2016-06-01 HU HUE16804350A patent/HUE058258T2/hu unknown
- 2016-06-01 LT LTEPPCT/US2016/035312T patent/LT3303564T/lt unknown
- 2016-06-01 WO PCT/US2016/035312 patent/WO2016196661A1/en not_active Ceased
- 2016-06-01 HR HRP20220482TT patent/HRP20220482T1/hr unknown
- 2016-06-01 KR KR1020227003399A patent/KR102679619B1/ko active Active
- 2016-06-01 IL IL313799A patent/IL313799B2/en unknown
-
2017
- 2017-11-22 US US15/820,941 patent/US10858625B2/en active Active
- 2017-11-29 IL IL255992A patent/IL255992B/en unknown
-
2020
- 2020-06-12 JP JP2020102332A patent/JP7737787B2/ja active Active
- 2020-11-09 US US17/093,126 patent/US12084679B2/en active Active
-
2021
- 2021-12-20 JP JP2021205897A patent/JP2022031961A/ja not_active Withdrawn
-
2022
- 2022-04-20 CY CY20221100297T patent/CY1125423T1/el unknown
- 2022-09-09 AU AU2022228216A patent/AU2022228216B2/en active Active
-
2023
- 2023-11-02 JP JP2023188483A patent/JP2023181494A/ja not_active Withdrawn
-
2024
- 2024-08-09 US US18/799,294 patent/US20240400987A1/en active Pending
-
2025
- 2025-11-18 JP JP2025197316A patent/JP2026015509A/ja active Pending
-
2026
- 2026-01-30 AU AU2026200680A patent/AU2026200680A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018522538A5 (https=) | ||
| Urbán et al. | Quiescence of adult mammalian neural stem cells: a highly regulated rest | |
| JP7617066B2 (ja) | 移植用中脳ドーパミン（ｄａ）ニューロン | |
| HRP20220482T1 (hr) | Postupci in vitro diferencijacije neurona dopamina srednjeg mozga (mda) | |
| Bermingham-McDonogh et al. | Regulated reprogramming in the regeneration of sensory receptor cells | |
| JP2018531011A6 (ja) | 中脳オルガノイドを作製するための手段及び方法 | |
| JP2018531011A (ja) | 中脳オルガノイドを作製するための手段及び方法 | |
| US20230233617A1 (en) | Methods for differentiating stem cells into dopaminergic progenitor cells | |
| JP7669048B2 (ja) | 神経細胞を分化させる方法ならびに関連する組成物および使用方法 | |
| JP7630181B2 (ja) | 神経幹細胞の誘導およびオルガノイド形成におけるＴＧＦ－β阻害剤の使用 | |
| JP2022546482A5 (https=) | ||
| JP6474806B2 (ja) | 体細胞の神経堤細胞への低分子による変換 | |
| Takaki et al. | The 5-hydroxytryptamine 4 receptor agonist-induced actions and enteric neurogenesis in the gut | |
| CN112368004A (zh) | 细胞组合物和其用途 | |
| Jarmalavičiūtė et al. | A new experimental model for neuronal and glial differentiation using stem cells derived from human exfoliated deciduous teeth | |
| Lee et al. | Atoh1 as a coordinator of sensory hair cell development and regeneration in the cochlea | |
| KR20180101228A (ko) | 신경세포 분화용 배지 조성물 및 상기 배지 조성물을 이용한 체세포로부터 신경세포로의 분화 방법 | |
| AU2022200831A1 (en) | Novel glia-like cells differentiated from somatic cells, preparation method therefor, cocktail composition for preparing same, cell therapeutic agent for preventing or treating neurological disorders, comprising same, and method for preventing and treating neurological disorders by administering same | |
| Li et al. | Efficient derivation of dopaminergic neurons from SOX1− floor plate cells under defined culture conditions | |
| Wang et al. | Directed differentiation of human embryonic stem cells into parathyroid cells and establishment of parathyroid organoids | |
| JP2024501130A (ja) | ヒト多能性幹細胞由来の脊髄ニューロンサブタイプの効率的且つ迅速なスペシフィケーション | |
| Doulames et al. | Human deep cortical neurons promote regeneration and recovery after cervical spinal cord injury | |
| KR20190063792A (ko) | 슈반세포 분화용 배지 조성물 및 상기 배지 조성물을 이용한 체세포로부터 슈반세포로의 분화 방법 | |
| Duginski | Mitochondrial Dynamics in an LRRK2 G2019S Model of Parkinson's Disease | |
| HK40048035A (en) | Cell aggregation including olfactory neuron or precursor cell thereof, and method for producing same |