JP2022546482A5 - - Google Patents
Info
- Publication number
- JP2022546482A5 JP2022546482A5 JP2022513499A JP2022513499A JP2022546482A5 JP 2022546482 A5 JP2022546482 A5 JP 2022546482A5 JP 2022513499 A JP2022513499 A JP 2022513499A JP 2022513499 A JP2022513499 A JP 2022513499A JP 2022546482 A5 JP2022546482 A5 JP 2022546482A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- surface marker
- express
- signaling
- negative surface
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025172808A JP2026001236A (ja) | 2019-08-29 | 2025-10-14 | 中脳ドーパミンニューロンの生成及び単離方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962893674P | 2019-08-29 | 2019-08-29 | |
| US62/893,674 | 2019-08-29 | ||
| PCT/US2020/048733 WO2021042027A1 (en) | 2019-08-29 | 2020-08-31 | Methods of generating and isolating midbrain dopamine neurons |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025172808A Division JP2026001236A (ja) | 2019-08-29 | 2025-10-14 | 中脳ドーパミンニューロンの生成及び単離方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022546482A JP2022546482A (ja) | 2022-11-04 |
| JP2022546482A5 true JP2022546482A5 (https=) | 2023-09-08 |
| JP7759870B2 JP7759870B2 (ja) | 2025-10-24 |
Family
ID=74686069
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022513499A Active JP7759870B2 (ja) | 2019-08-29 | 2020-08-31 | 中脳ドーパミンニューロンの生成及び単離方法 |
| JP2025172808A Pending JP2026001236A (ja) | 2019-08-29 | 2025-10-14 | 中脳ドーパミンニューロンの生成及び単離方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025172808A Pending JP2026001236A (ja) | 2019-08-29 | 2025-10-14 | 中脳ドーパミンニューロンの生成及び単離方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220177835A1 (https=) |
| EP (1) | EP4021477A4 (https=) |
| JP (2) | JP7759870B2 (https=) |
| KR (1) | KR20220051388A (https=) |
| CN (2) | CN121227633A (https=) |
| AU (1) | AU2020336221A1 (https=) |
| BR (1) | BR112022003826A2 (https=) |
| CA (1) | CA3152522A1 (https=) |
| IL (1) | IL290930A (https=) |
| MX (1) | MX2022002532A (https=) |
| PH (1) | PH12022550496A1 (https=) |
| WO (1) | WO2021042027A1 (https=) |
| ZA (1) | ZA202202994B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3792346B1 (en) | 2019-09-13 | 2023-07-26 | Miltenyi Biotec B.V. & Co. KG | Method for the generation of a cell composition of ventral midbrain dopaminergic progenitor cells |
| AU2022247250A1 (en) | 2021-03-30 | 2023-11-09 | Trailhead Biosystems Inc. | Methods and compositions for generating oligodendrocyte progenitor cells |
| JP2024523738A (ja) | 2021-07-14 | 2024-06-28 | ノヴォ ノルディスク アー／エス | ニューロンおよびその前駆体が富化された細胞集団を提供するための方法 |
| CN117089520A (zh) * | 2021-10-28 | 2023-11-21 | 中国科学院动物研究所 | 一种中脑多巴胺细胞群、其制造方法以及用途 |
| JP2025524856A (ja) * | 2022-07-21 | 2025-08-01 | トレイルヘッド バイオシステムズ インコーポレイテッド | 神経前駆細胞からヒト中脳ドーパミン作動性ニューロンを作製するための方法および組成物 |
| US12565639B2 (en) | 2023-06-13 | 2026-03-03 | Aspen Neuroscience, Inc. | Methods for differentiating dopaminergic neurons from stem cells |
| WO2025166063A1 (en) | 2024-01-31 | 2025-08-07 | Bluerock Therapeutics Lp | Igfbp2 in cell culture |
| CN117838835B (zh) * | 2024-02-01 | 2024-11-08 | 暨南大学 | 成纤维细胞生长因子17蛋白和/或其激活剂在制备治疗阿尔兹海默病药物中的应用 |
| WO2025252180A1 (zh) * | 2024-06-05 | 2025-12-11 | 中国科学院脑科学与智能技术卓越创新中心 | 中脑多巴胺能祖细胞群的体外制备方法 |
| CN119776284B (zh) * | 2025-03-13 | 2025-06-20 | 首都医科大学宣武医院 | 含有多巴胺能荧光报告系统的细胞及异步共培养方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7632679B2 (en) * | 2002-07-16 | 2009-12-15 | The Trustees Of Columbia University In The City Of New York | Systems and methods for screening for modulators of neural differentiation |
| WO2010096496A2 (en) * | 2009-02-17 | 2010-08-26 | Memorial Sloan-Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
| JP6090937B2 (ja) * | 2011-07-27 | 2017-03-08 | 国立大学法人京都大学 | 新規ドーパミン産生神経前駆細胞マーカー |
| EP3693455A1 (en) * | 2011-11-04 | 2020-08-12 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (da) neurons for engraftment |
| EP2614829A1 (en) * | 2012-01-11 | 2013-07-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons |
| AU2014316100B2 (en) * | 2013-09-05 | 2020-11-05 | Eisai R&D Management Co., Ltd. | New method for inducing dopamine-producing neural precursor cells |
| JP6998772B2 (ja) * | 2015-04-09 | 2022-02-04 | ビオラミナ アーベー | 神経変性疾患の処置における使用のための幹細胞由来のドパミン作用性細胞を生成するための方法および組成物 |
| AU2016270793B2 (en) * | 2015-06-01 | 2022-06-09 | Memorial Sloan-Kettering Cancer Center | Methods of in vitro differentiation of midbrain dopamine (MDA) neurons |
| KR102625865B1 (ko) * | 2016-08-16 | 2024-01-16 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 만능 세포를 분화시키는 방법 |
-
2020
- 2020-08-31 EP EP20856169.6A patent/EP4021477A4/en active Pending
- 2020-08-31 MX MX2022002532A patent/MX2022002532A/es unknown
- 2020-08-31 CN CN202511379930.7A patent/CN121227633A/zh active Pending
- 2020-08-31 JP JP2022513499A patent/JP7759870B2/ja active Active
- 2020-08-31 WO PCT/US2020/048733 patent/WO2021042027A1/en not_active Ceased
- 2020-08-31 BR BR112022003826A patent/BR112022003826A2/pt unknown
- 2020-08-31 CN CN202080075663.3A patent/CN114650836B/zh active Active
- 2020-08-31 KR KR1020227010271A patent/KR20220051388A/ko active Pending
- 2020-08-31 AU AU2020336221A patent/AU2020336221A1/en active Pending
- 2020-08-31 PH PH1/2022/550496A patent/PH12022550496A1/en unknown
- 2020-08-31 CA CA3152522A patent/CA3152522A1/en active Pending
-
2022
- 2022-02-25 US US17/681,113 patent/US20220177835A1/en active Pending
- 2022-02-27 IL IL290930A patent/IL290930A/en unknown
- 2022-03-11 ZA ZA2022/02994A patent/ZA202202994B/en unknown
-
2025
- 2025-10-14 JP JP2025172808A patent/JP2026001236A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022546482A5 (https=) | ||
| JP2023520466A5 (https=) | ||
| JP6262205B2 (ja) | ヒト多能性幹細胞からの神経幹細胞およびドーパミン作動性ニューロンの誘導方法 | |
| AU2014316100B2 (en) | New method for inducing dopamine-producing neural precursor cells | |
| Park et al. | In vitro and in vivo analyses of human embryonic stem cell‐derived dopamine neurons | |
| Itsykson et al. | Derivation of neural precursors from human embryonic stem cells in the presence of noggin | |
| Dhara et al. | Human neural progenitor cells derived from embryonic stem cells in feeder-free cultures | |
| JP2022078245A5 (https=) | ||
| IL313799B1 (en) | Processes for in vitro differentiation of midbrain dopamine neurons | |
| Schwartz et al. | Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells | |
| JP2019535265A5 (https=) | ||
| CN116981768A (zh) | 将人类体细胞化学重编程为多能细胞 | |
| EP2598635B1 (en) | Corticogenesis of human pluripotent cells | |
| CN114375328B (zh) | 包含胶质前体细胞的细胞聚集体的制备方法 | |
| CN108103021A (zh) | 一种新型人源诱导型神经干细胞的制备方法及其应用 | |
| JP2019503703A5 (https=) | ||
| JPWO2021045217A5 (https=) | ||
| KR20120109461A (ko) | 화학물질의 독성 예측 방법 | |
| CN105392881A (zh) | 体细胞基于小分子转化为神经嵴细胞 | |
| KR20240035561A (ko) | 인간 중뇌 신경 전구 세포를 생성하기 위한 방법 및 조성물 | |
| US20240117303A1 (en) | Methods and compositions for generating human midbrain dopaminergic neurons from neural progenitor cells | |
| JP7125977B2 (ja) | 底板中脳ドーパミン作動性前駆細胞の単一細胞タンパク質発現プロファイリングの方法 | |
| Cazillis et al. | In vitro induction of neural differentiation of embryonic stem (ES) cells closely mimics molecular mechanisms of embryonic brain development | |
| HK40057032B (zh) | 用於经由定向分化将前体细胞转化为胃组织的方法和系统 | |
| Najafi et al. | Differentiation of Mouse Embryonic Stem Cells into Dorsal Interneurons of the Spinal Cord Using BMP4 and Activin A |