JP2022078245A5 - - Google Patents
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- JP2022078245A5 JP2022078245A5 JP2022035753A JP2022035753A JP2022078245A5 JP 2022078245 A5 JP2022078245 A5 JP 2022078245A5 JP 2022035753 A JP2022035753 A JP 2022035753A JP 2022035753 A JP2022035753 A JP 2022035753A JP 2022078245 A5 JP2022078245 A5 JP 2022078245A5
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- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical group CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims 4
- 108090000368 Fibroblast growth factor 8 Proteins 0.000 claims 4
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- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical group C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 4
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- BRZYSWJRSDMWLG-CAXSIQPQSA-N geneticin Natural products O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](C(C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-CAXSIQPQSA-N 0.000 claims 3
- 210000002569 neuron Anatomy 0.000 claims 3
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- 102100021239 G protein-activated inward rectifier potassium channel 2 Human genes 0.000 claims 2
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- 102100033928 Sodium-dependent dopamine transporter Human genes 0.000 claims 2
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- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims 2
- FYBHCRQFSFYWPY-UHFFFAOYSA-N purmorphamine Chemical compound C1CCCCC1N1C2=NC(OC=3C4=CC=CC=C4C=CC=3)=NC(NC=3C=CC(=CC=3)N3CCOCC3)=C2N=C1 FYBHCRQFSFYWPY-UHFFFAOYSA-N 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
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- JMIFGARJSWXZSH-UHFFFAOYSA-N DMH1 Chemical compound C1=CC(OC(C)C)=CC=C1C1=CN2N=CC(C=3C4=CC=CC=C4N=CC=3)=C2N=C1 JMIFGARJSWXZSH-UHFFFAOYSA-N 0.000 claims 1
- 230000000970 DNA cross-linking effect Effects 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 108091006027 G proteins Proteins 0.000 claims 1
- 102000030782 GTP binding Human genes 0.000 claims 1
- 108091000058 GTP-Binding Proteins 0.000 claims 1
- 108010048671 Homeodomain Proteins Proteins 0.000 claims 1
- 102000009331 Homeodomain Proteins Human genes 0.000 claims 1
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 1
- 101000595674 Homo sapiens Pituitary homeobox 3 Proteins 0.000 claims 1
- 102100036088 Pituitary homeobox 3 Human genes 0.000 claims 1
- 102000004257 Potassium Channel Human genes 0.000 claims 1
- 101000713578 Rattus norvegicus Tubulin beta-3 chain Proteins 0.000 claims 1
- 102000001435 Synapsin Human genes 0.000 claims 1
- 108050009621 Synapsin Proteins 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 210000001259 mesencephalon Anatomy 0.000 claims 1
- 230000000394 mitotic effect Effects 0.000 claims 1
- 108700007229 noggin Proteins 0.000 claims 1
- 102000045246 noggin Human genes 0.000 claims 1
- 239000003865 nucleic acid synthesis inhibitor Substances 0.000 claims 1
- 108020001213 potassium channel Proteins 0.000 claims 1
- 239000011435 rock Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375590P | 2016-08-16 | 2016-08-16 | |
| US62/375,590 | 2016-08-16 | ||
| PCT/US2017/047124 WO2018035214A1 (en) | 2016-08-16 | 2017-08-16 | Methods for differentiating pluripotent cells |
| JP2019508965A JP7120993B2 (ja) | 2016-08-16 | 2017-08-16 | 多能性細胞を分化させるための方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508965A Division JP7120993B2 (ja) | 2016-08-16 | 2017-08-16 | 多能性細胞を分化させるための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022078245A JP2022078245A (ja) | 2022-05-24 |
| JP2022078245A5 true JP2022078245A5 (https=) | 2022-06-14 |
| JP7600165B2 JP7600165B2 (ja) | 2024-12-16 |
Family
ID=59714142
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508965A Active JP7120993B2 (ja) | 2016-08-16 | 2017-08-16 | 多能性細胞を分化させるための方法 |
| JP2022035753A Active JP7600165B2 (ja) | 2016-08-16 | 2022-03-09 | 多能性細胞を分化させるための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508965A Active JP7120993B2 (ja) | 2016-08-16 | 2017-08-16 | 多能性細胞を分化させるための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10590383B2 (https=) |
| EP (3) | EP4328301A3 (https=) |
| JP (2) | JP7120993B2 (https=) |
| KR (2) | KR102625865B1 (https=) |
| CN (2) | CN109844102B (https=) |
| AU (2) | AU2017313065B2 (https=) |
| CA (1) | CA3033205A1 (https=) |
| DK (1) | DK3500664T3 (https=) |
| ES (1) | ES2901379T3 (https=) |
| WO (1) | WO2018035214A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190018000A1 (en) | 2016-01-12 | 2019-01-17 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| US11913022B2 (en) | 2017-01-25 | 2024-02-27 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| US12497591B2 (en) * | 2018-03-07 | 2025-12-16 | Sorbonne Universite | Compositions and methods for efficient amplification of retinal progenitors cells |
| CN108456659B (zh) | 2018-03-14 | 2020-05-05 | 浙江霍德生物工程有限公司 | 3d大脑类器官的制备方法 |
| EP4700387A2 (en) | 2018-03-23 | 2026-02-25 | Cedars-Sinai Medical Center | Methods of use of islet cells |
| WO2019195800A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Novel differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
| WO2019195798A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip |
| EP3787613B1 (en) | 2018-04-30 | 2026-03-11 | Cedars-Sinai Medical Center | Pkc activation for use in treating early onset sporadic parkinson's disease |
| WO2020237104A1 (en) * | 2019-05-23 | 2020-11-26 | The Mclean Hospital Corporation | Autologous cell replacement therapy for parkinson's disease |
| EP4021477A4 (en) * | 2019-08-29 | 2023-12-13 | Memorial Sloan Kettering Cancer Center | METHOD FOR GENERATING AND ISOLATING MID-DOPAMINE NEURONS |
| EP4032974A4 (en) * | 2019-09-20 | 2023-12-06 | Korea Research Institute of Bioscience and Biotechnology | Production method for induced dopaminergic neuronal progenitors, using direct reprogramming |
| KR20220158046A (ko) | 2020-03-25 | 2022-11-29 | 사나 바이오테크놀로지, 인크. | 신경계 장애 및 병태의 치료를 위한 면역저하성 신경 세포 |
| US12104170B2 (en) | 2020-06-26 | 2024-10-01 | Minerva Biotechnologies Corporation | Methods for deriving dopaminergic neurons from pluripotent stem cells |
| CN116635047A (zh) * | 2020-06-26 | 2023-08-22 | 米纳瓦生物技术公司 | 用于从多能干细胞衍生多巴胺能神经元的方法 |
| KR20230044539A (ko) * | 2020-08-17 | 2023-04-04 | 인스티튜트 오브 주올로지, 차이니즈 아카데미 오브 사이언스 | 신경 세포를 위한 확장 배양 배지 및 배양 방법 |
| CN114292814A (zh) * | 2020-09-22 | 2022-04-08 | 上海跃赛生物科技有限公司 | 一种多能干细胞分化为中脑黒质多巴胺能神经细胞的方法 |
| TWI808661B (zh) | 2021-03-05 | 2023-07-11 | 日商旭化成股份有限公司 | 氧化還原液流電池用電極及氧化還原液流電池用電極之製造方法 |
| WO2022216911A1 (en) | 2021-04-07 | 2022-10-13 | FUJIFILM Cellular Dynamics, Inc. | Dopaminergic precursor cells and methods of use |
| CN115873797B (zh) * | 2021-09-29 | 2024-08-13 | 北京干细胞与再生医学研究院 | 一种视网膜色素上皮细胞的扩增培养基及培养方法 |
| EP4606888A1 (en) * | 2022-10-20 | 2025-08-27 | K Pharma, Inc. | Novel production method for neural stem cell/neural progenitor cell |
| FR3151340A1 (fr) * | 2023-07-21 | 2025-01-24 | Treefrog Therapeutics | Différenciation neurale à partir de cellules pluripotentes |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| CA2277278A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| US20020168766A1 (en) | 2000-01-11 | 2002-11-14 | Gold Joseph D. | Genetically altered human pluripotent stem cells |
| WO2001088100A1 (en) | 2000-05-16 | 2001-11-22 | Kyowa Hakko Kogyo Co., Ltd. | Novel method of inducing the differentiation of embryonic stem cells into ectodermal cells and use thereof |
| WO2001088104A2 (en) | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
| UY27224A1 (es) | 2001-03-23 | 2002-10-31 | Bayer Corp | Inhibidores de la rho-quinasa |
| PE20020958A1 (es) | 2001-03-23 | 2002-11-14 | Bayer Corp | Inhibidores de la rho-quinasa |
| WO2003006950A2 (en) | 2001-07-12 | 2003-01-23 | Geron Corporation | Cells of the cardiomyocyte lineage produced from human pluripotent stem cells |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| JP4505228B2 (ja) | 2002-01-10 | 2010-07-21 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | Ｒｈｏ−キナーゼ阻害剤 |
| MXPA04007196A (es) | 2002-01-23 | 2005-06-08 | Bayer Pharmaceuticals Corp | Inhibidores de rho-quinasa. |
| EP1470121B1 (en) | 2002-01-23 | 2012-07-11 | Bayer HealthCare LLC | Pyrimidine derivatives as rho-kinase inhibitors |
| ES2273047T3 (es) | 2002-10-28 | 2007-05-01 | Bayer Healthcare Ag | Fenilaminopirimidinas sustituidas con heteroariloxi como inhibidores de rho-cinasa. |
| WO2005080554A1 (ja) | 2004-02-23 | 2005-09-01 | Kyoto University | 胚性幹細胞の分化調節方法 |
| WO2005123902A1 (ja) | 2004-06-18 | 2005-12-29 | Riken | 無血清浮遊培養による胚性幹細胞の神経分化誘導法 |
| AU2005282414C1 (en) | 2004-09-08 | 2011-04-07 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells |
| US20070116680A1 (en) | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
| WO2008089351A1 (en) | 2007-01-17 | 2008-07-24 | Wisconsin Alumni Research Foundation | Improved culture of stem cells |
| EP3279314A1 (en) | 2008-06-04 | 2018-02-07 | Cellular Dynamics International, Inc. | Methods for the production of ips cells using non-viral approach |
| ES2633935T3 (es) | 2008-12-05 | 2017-09-26 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Método y medio para la diferenciación neural de células pluripotentes |
| WO2010096496A2 (en) * | 2009-02-17 | 2010-08-26 | Memorial Sloan-Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
| WO2010141801A2 (en) | 2009-06-05 | 2010-12-09 | Cellular Dynamics International, Inc. | Reprogramming t cells and hematophietic cells |
| DK2694644T3 (en) | 2011-03-30 | 2018-04-16 | Cellular Dynamics Int Inc | Priming of pluripotent stem cells for neural differentiation |
| EP3693455A1 (en) * | 2011-11-04 | 2020-08-12 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (da) neurons for engraftment |
| EP3031908B1 (en) | 2013-08-06 | 2018-12-05 | Takeda Pharmaceutical Company Limited | Method for producing dopaminergic neurons |
| AU2014352773B2 (en) * | 2013-11-21 | 2021-04-29 | Memorial Sloan-Kettering Cancer Center | Specification of functional cranial placode derivatives from human pluripotent stem cells |
| ES2939807T3 (es) * | 2014-03-21 | 2023-04-27 | Fujifilm Cellular Dynamics Inc | Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización |
| US9830679B2 (en) | 2014-03-25 | 2017-11-28 | Google Llc | Shared virtual reality |
| AU2016270793B2 (en) | 2015-06-01 | 2022-06-09 | Memorial Sloan-Kettering Cancer Center | Methods of in vitro differentiation of midbrain dopamine (MDA) neurons |
-
2017
- 2017-08-16 KR KR1020227020165A patent/KR102625865B1/ko active Active
- 2017-08-16 EP EP23202144.4A patent/EP4328301A3/en active Pending
- 2017-08-16 CN CN201780063703.0A patent/CN109844102B/zh active Active
- 2017-08-16 EP EP21197831.7A patent/EP4001403A1/en active Pending
- 2017-08-16 US US15/678,432 patent/US10590383B2/en active Active
- 2017-08-16 WO PCT/US2017/047124 patent/WO2018035214A1/en not_active Ceased
- 2017-08-16 CA CA3033205A patent/CA3033205A1/en active Pending
- 2017-08-16 DK DK17758363.0T patent/DK3500664T3/da active
- 2017-08-16 EP EP17758363.0A patent/EP3500664B1/en active Active
- 2017-08-16 KR KR1020197007694A patent/KR102487142B1/ko active Active
- 2017-08-16 JP JP2019508965A patent/JP7120993B2/ja active Active
- 2017-08-16 ES ES17758363T patent/ES2901379T3/es active Active
- 2017-08-16 CN CN202311347195.2A patent/CN117467608A/zh active Pending
- 2017-08-16 AU AU2017313065A patent/AU2017313065B2/en active Active
-
2020
- 2020-02-05 US US16/782,772 patent/US20200172862A1/en active Pending
-
2021
- 2021-09-01 AU AU2021225187A patent/AU2021225187B2/en active Active
-
2022
- 2022-03-09 JP JP2022035753A patent/JP7600165B2/ja active Active
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