KR102625865B1 - 만능 세포를 분화시키는 방법 - Google Patents

만능 세포를 분화시키는 방법 Download PDF

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KR102625865B1
KR102625865B1 KR1020227020165A KR20227020165A KR102625865B1 KR 102625865 B1 KR102625865 B1 KR 102625865B1 KR 1020227020165 A KR1020227020165 A KR 1020227020165A KR 20227020165 A KR20227020165 A KR 20227020165A KR 102625865 B1 KR102625865 B1 KR 102625865B1
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cells
pharmaceutical composition
inhibitor
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크리스토퍼 더블유. 맥마혼
로렌 이. 리틀
웬 보 왕
나다니엘 에이. 엘리엇
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후지필름 셀룰러 다이내믹스, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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KR1020227020165A 2016-08-16 2017-08-16 만능 세포를 분화시키는 방법 Active KR102625865B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662375590P 2016-08-16 2016-08-16
US62/375,590 2016-08-16
PCT/US2017/047124 WO2018035214A1 (en) 2016-08-16 2017-08-16 Methods for differentiating pluripotent cells
KR1020197007694A KR102487142B1 (ko) 2016-08-16 2017-08-16 만능 세포를 분화시키는 방법

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KR20220088800A KR20220088800A (ko) 2022-06-28
KR102625865B1 true KR102625865B1 (ko) 2024-01-16

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US (2) US10590383B2 (https=)
EP (3) EP4328301A3 (https=)
JP (2) JP7120993B2 (https=)
KR (2) KR102625865B1 (https=)
CN (2) CN109844102B (https=)
AU (2) AU2017313065B2 (https=)
CA (1) CA3033205A1 (https=)
DK (1) DK3500664T3 (https=)
ES (1) ES2901379T3 (https=)
WO (1) WO2018035214A1 (https=)

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EP4021477A4 (en) * 2019-08-29 2023-12-13 Memorial Sloan Kettering Cancer Center METHOD FOR GENERATING AND ISOLATING MID-DOPAMINE NEURONS
EP4032974A4 (en) * 2019-09-20 2023-12-06 Korea Research Institute of Bioscience and Biotechnology Production method for induced dopaminergic neuronal progenitors, using direct reprogramming
KR20220158046A (ko) 2020-03-25 2022-11-29 사나 바이오테크놀로지, 인크. 신경계 장애 및 병태의 치료를 위한 면역저하성 신경 세포
US12104170B2 (en) 2020-06-26 2024-10-01 Minerva Biotechnologies Corporation Methods for deriving dopaminergic neurons from pluripotent stem cells
CN116635047A (zh) * 2020-06-26 2023-08-22 米纳瓦生物技术公司 用于从多能干细胞衍生多巴胺能神经元的方法
KR20230044539A (ko) * 2020-08-17 2023-04-04 인스티튜트 오브 주올로지, 차이니즈 아카데미 오브 사이언스 신경 세포를 위한 확장 배양 배지 및 배양 방법
CN114292814A (zh) * 2020-09-22 2022-04-08 上海跃赛生物科技有限公司 一种多能干细胞分化为中脑黒质多巴胺能神经细胞的方法
TWI808661B (zh) 2021-03-05 2023-07-11 日商旭化成股份有限公司 氧化還原液流電池用電極及氧化還原液流電池用電極之製造方法
WO2022216911A1 (en) 2021-04-07 2022-10-13 FUJIFILM Cellular Dynamics, Inc. Dopaminergic precursor cells and methods of use
CN115873797B (zh) * 2021-09-29 2024-08-13 北京干细胞与再生医学研究院 一种视网膜色素上皮细胞的扩增培养基及培养方法
EP4606888A1 (en) * 2022-10-20 2025-08-27 K Pharma, Inc. Novel production method for neural stem cell/neural progenitor cell
FR3151340A1 (fr) * 2023-07-21 2025-01-24 Treefrog Therapeutics Différenciation neurale à partir de cellules pluripotentes

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