SMT202200263T1 - Procedimenti di differenziazione in vitro di neuroni dopaminergici mesencefalici (mda) - Google Patents
Procedimenti di differenziazione in vitro di neuroni dopaminergici mesencefalici (mda)Info
- Publication number
- SMT202200263T1 SMT202200263T1 SM20220263T SMT202200263T SMT202200263T1 SM T202200263 T1 SMT202200263 T1 SM T202200263T1 SM 20220263 T SM20220263 T SM 20220263T SM T202200263 T SMT202200263 T SM T202200263T SM T202200263 T1 SMT202200263 T1 SM T202200263T1
- Authority
- SM
- San Marino
- Prior art keywords
- mda
- neurons
- methods
- vitro differentiation
- midbrain dopamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Developmental Biology & Embryology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- General Engineering & Computer Science (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562169444P | 2015-06-01 | 2015-06-01 | |
| US201562169379P | 2015-06-01 | 2015-06-01 | |
| PCT/US2016/035312 WO2016196661A1 (en) | 2015-06-01 | 2016-06-01 | Methods of in vitro differentiation of midbrain dopamine (mda) neurons |
| EP16804350.3A EP3303564B1 (en) | 2015-06-01 | 2016-06-01 | Methods of in vitro differentiation of midbrain dopamine (mda) neurons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT202200263T1 true SMT202200263T1 (it) | 2022-07-21 |
Family
ID=57441792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM20220263T SMT202200263T1 (it) | 2015-06-01 | 2016-06-01 | Procedimenti di differenziazione in vitro di neuroni dopaminergici mesencefalici (mda) |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10858625B2 (https=) |
| EP (3) | EP4070803B1 (https=) |
| JP (5) | JP6974180B2 (https=) |
| KR (4) | KR102358878B1 (https=) |
| AU (3) | AU2016270793B2 (https=) |
| CY (1) | CY1125423T1 (https=) |
| DK (2) | DK4070803T3 (https=) |
| ES (2) | ES2910032T3 (https=) |
| HR (1) | HRP20220482T1 (https=) |
| HU (1) | HUE058258T2 (https=) |
| IL (4) | IL291532B2 (https=) |
| LT (1) | LT3303564T (https=) |
| PL (1) | PL3303564T3 (https=) |
| PT (2) | PT3303564T (https=) |
| RS (1) | RS63157B1 (https=) |
| SI (1) | SI3303564T1 (https=) |
| SM (1) | SMT202200263T1 (https=) |
| WO (1) | WO2016196661A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6998772B2 (ja) * | 2015-04-09 | 2022-02-04 | ビオラミナ アーベー | 神経変性疾患の処置における使用のための幹細胞由来のドパミン作用性細胞を生成するための方法および組成物 |
| AU2016270793B2 (en) * | 2015-06-01 | 2022-06-09 | Memorial Sloan-Kettering Cancer Center | Methods of in vitro differentiation of midbrain dopamine (MDA) neurons |
| KR20180105236A (ko) * | 2016-02-05 | 2018-09-27 | 메모리얼 슬로안-케터링 캔서 센터 | 줄기 세포-유래 외배엽 계통 전구체의 분화 방법 |
| KR102625865B1 (ko) * | 2016-08-16 | 2024-01-16 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 만능 세포를 분화시키는 방법 |
| KR20190141218A (ko) * | 2017-04-26 | 2019-12-23 | 메모리얼 슬로안 케터링 캔서 센터 | 사용 준비된 냉동보존 세포 |
| WO2019016113A1 (en) | 2017-07-17 | 2019-01-24 | Miltenyi Biotec Gmbh | METHOD FOR PROFILING EXPRESSION OF UNICELLULAR PROTEIN FROM DOPAMINERGIC PROGENITOR CELLS OF MESENCEPHALIC FLOOR |
| WO2019032680A1 (en) * | 2017-08-08 | 2019-02-14 | Regents Of The University Of Minnesota | METHODS OF GENERATING AND USING ORGANOIDS AND ASSOCIATED CELLS |
| JP2022514298A (ja) | 2018-12-19 | 2022-02-10 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | オルガノイドおよびその組織を作製および使用するための方法 |
| WO2020237104A1 (en) * | 2019-05-23 | 2020-11-26 | The Mclean Hospital Corporation | Autologous cell replacement therapy for parkinson's disease |
| JP7810357B2 (ja) | 2019-07-25 | 2026-02-03 | ザ スクリプス リサーチ インスティテュート | ドーパミン作動性ニューロン及び前駆細胞を特定する方法 |
| EP4021477A4 (en) * | 2019-08-29 | 2023-12-13 | Memorial Sloan Kettering Cancer Center | METHOD FOR GENERATING AND ISOLATING MID-DOPAMINE NEURONS |
| EP4032974A4 (en) * | 2019-09-20 | 2023-12-06 | Korea Research Institute of Bioscience and Biotechnology | Production method for induced dopaminergic neuronal progenitors, using direct reprogramming |
| KR20220158046A (ko) | 2020-03-25 | 2022-11-29 | 사나 바이오테크놀로지, 인크. | 신경계 장애 및 병태의 치료를 위한 면역저하성 신경 세포 |
| WO2021216623A1 (en) | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom |
| US20250263752A1 (en) | 2020-04-21 | 2025-08-21 | Aspen Neuroscience, Inc. | Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom |
| US12104170B2 (en) * | 2020-06-26 | 2024-10-01 | Minerva Biotechnologies Corporation | Methods for deriving dopaminergic neurons from pluripotent stem cells |
| CN116635047A (zh) * | 2020-06-26 | 2023-08-22 | 米纳瓦生物技术公司 | 用于从多能干细胞衍生多巴胺能神经元的方法 |
| CN114292814A (zh) * | 2020-09-22 | 2022-04-08 | 上海跃赛生物科技有限公司 | 一种多能干细胞分化为中脑黒质多巴胺能神经细胞的方法 |
| WO2022216911A1 (en) * | 2021-04-07 | 2022-10-13 | FUJIFILM Cellular Dynamics, Inc. | Dopaminergic precursor cells and methods of use |
| WO2023004370A1 (en) | 2021-07-21 | 2023-01-26 | Aspen Neuroscience, Inc. | Aav-based modulation of gba1 and related compositions and uses thereof |
| WO2023004366A1 (en) | 2021-07-21 | 2023-01-26 | Aspen Neuroscience, Inc. | Transposon-based modulation of gba1 and related compositions and uses thereof |
| WO2023086894A1 (en) | 2021-11-12 | 2023-05-19 | Axent Biosciences Inc. | Methods for production of functional neurons |
| WO2023201361A1 (en) | 2022-04-15 | 2023-10-19 | Aspen Neuroscience, Inc. | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
| US12565639B2 (en) * | 2023-06-13 | 2026-03-03 | Aspen Neuroscience, Inc. | Methods for differentiating dopaminergic neurons from stem cells |
| CN117448271B (zh) * | 2023-12-22 | 2024-07-16 | 上海元戊医学技术有限公司 | 一种诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法 |
| WO2025166063A1 (en) | 2024-01-31 | 2025-08-07 | Bluerock Therapeutics Lp | Igfbp2 in cell culture |
| WO2025252180A1 (zh) * | 2024-06-05 | 2025-12-11 | 中国科学院脑科学与智能技术卓越创新中心 | 中脑多巴胺能祖细胞群的体外制备方法 |
| WO2026006245A1 (en) | 2024-06-25 | 2026-01-02 | Bluerock Therapeutics Lp | Three-dimensional culturing of pluripotent stem cells for improved differentiability |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000068431A2 (en) | 1999-05-06 | 2000-11-16 | Mount Sinai School Of Medicine Of New York University | Dna-based steganography |
| WO2001088104A2 (en) * | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
| EP1791949A2 (en) * | 2004-09-02 | 2007-06-06 | Neuro Therapeutics AB | Methods and materials relating to enhanced production of dopamine neurons |
| WO2006071778A2 (en) * | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| JP5649786B2 (ja) | 2006-03-07 | 2015-01-07 | ギータ シュロフ | ヒト胚性幹細胞およびそれらの誘導体を含む組成物、使用方法、ならびに調製方法 |
| WO2008008266A2 (en) | 2006-07-07 | 2008-01-17 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Biohybrid elastomeric scaffolds and methods of use thereof |
| WO2010096496A2 (en) | 2009-02-17 | 2010-08-26 | Memorial Sloan-Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
| DK3578988T3 (da) | 2010-05-25 | 2025-02-24 | Memorial Sloan Kettering Cancer Center | Fremgangsmåde til nociceptordifferentiering af humane embryonale stamceller og anvendelse heraf |
| US20110296542A1 (en) | 2010-05-28 | 2011-12-01 | Kevin Ka-Wang Wang | Exogenous matrix-supported topical application of stem cells to organ surface |
| EP3693455A1 (en) * | 2011-11-04 | 2020-08-12 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (da) neurons for engraftment |
| WO2013188744A1 (en) | 2012-06-15 | 2013-12-19 | Baylor College Of Medicine | Perineurium derived adult stem cells and methods of use |
| EP3498824A1 (en) | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
| KR101696874B1 (ko) * | 2013-07-31 | 2017-01-16 | 한국생명공학연구원 | 직접 리프로그래밍을 통한 유도 도파민성 전구세포 제조방법 |
| EP3031908B1 (en) * | 2013-08-06 | 2018-12-05 | Takeda Pharmaceutical Company Limited | Method for producing dopaminergic neurons |
| AU2014316100B2 (en) * | 2013-09-05 | 2020-11-05 | Eisai R&D Management Co., Ltd. | New method for inducing dopamine-producing neural precursor cells |
| AU2014352773B2 (en) | 2013-11-21 | 2021-04-29 | Memorial Sloan-Kettering Cancer Center | Specification of functional cranial placode derivatives from human pluripotent stem cells |
| ES2939807T3 (es) * | 2014-03-21 | 2023-04-27 | Fujifilm Cellular Dynamics Inc | Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización |
| AU2016270793B2 (en) * | 2015-06-01 | 2022-06-09 | Memorial Sloan-Kettering Cancer Center | Methods of in vitro differentiation of midbrain dopamine (MDA) neurons |
-
2016
- 2016-06-01 AU AU2016270793A patent/AU2016270793B2/en active Active
- 2016-06-01 JP JP2017562028A patent/JP6974180B2/ja active Active
- 2016-06-01 PT PT168043503T patent/PT3303564T/pt unknown
- 2016-06-01 RS RS20220353A patent/RS63157B1/sr unknown
- 2016-06-01 EP EP22157782.8A patent/EP4070803B1/en active Active
- 2016-06-01 ES ES16804350T patent/ES2910032T3/es active Active
- 2016-06-01 DK DK22157782.8T patent/DK4070803T3/da active
- 2016-06-01 ES ES22157782T patent/ES3057638T3/es active Active
- 2016-06-01 PT PT221577828T patent/PT4070803T/pt unknown
- 2016-06-01 IL IL291532A patent/IL291532B2/en unknown
- 2016-06-01 EP EP22176877.3A patent/EP4079314B1/en active Active
- 2016-06-01 SM SM20220263T patent/SMT202200263T1/it unknown
- 2016-06-01 PL PL16804350T patent/PL3303564T3/pl unknown
- 2016-06-01 EP EP16804350.3A patent/EP3303564B1/en active Active
- 2016-06-01 KR KR1020177037050A patent/KR102358878B1/ko active Active
- 2016-06-01 KR KR1020257025403A patent/KR20250118858A/ko active Pending
- 2016-06-01 KR KR1020247021208A patent/KR102841407B1/ko active Active
- 2016-06-01 SI SI201631535T patent/SI3303564T1/sl unknown
- 2016-06-01 DK DK16804350.3T patent/DK3303564T3/da active
- 2016-06-01 IL IL320440A patent/IL320440A/en unknown
- 2016-06-01 HU HUE16804350A patent/HUE058258T2/hu unknown
- 2016-06-01 LT LTEPPCT/US2016/035312T patent/LT3303564T/lt unknown
- 2016-06-01 WO PCT/US2016/035312 patent/WO2016196661A1/en not_active Ceased
- 2016-06-01 HR HRP20220482TT patent/HRP20220482T1/hr unknown
- 2016-06-01 KR KR1020227003399A patent/KR102679619B1/ko active Active
- 2016-06-01 IL IL313799A patent/IL313799B2/en unknown
-
2017
- 2017-11-22 US US15/820,941 patent/US10858625B2/en active Active
- 2017-11-29 IL IL255992A patent/IL255992B/en unknown
-
2020
- 2020-06-12 JP JP2020102332A patent/JP7737787B2/ja active Active
- 2020-11-09 US US17/093,126 patent/US12084679B2/en active Active
-
2021
- 2021-12-20 JP JP2021205897A patent/JP2022031961A/ja not_active Withdrawn
-
2022
- 2022-04-20 CY CY20221100297T patent/CY1125423T1/el unknown
- 2022-09-09 AU AU2022228216A patent/AU2022228216B2/en active Active
-
2023
- 2023-11-02 JP JP2023188483A patent/JP2023181494A/ja not_active Withdrawn
-
2024
- 2024-08-09 US US18/799,294 patent/US20240400987A1/en active Pending
-
2025
- 2025-11-18 JP JP2025197316A patent/JP2026015509A/ja active Pending
-
2026
- 2026-01-30 AU AU2026200680A patent/AU2026200680A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SMT202200263T1 (it) | Procedimenti di differenziazione in vitro di neuroni dopaminergici mesencefalici (mda) | |
| DK3119881T3 (da) | Production of midbrain dopaminergic neurons and methods for the use thereof | |
| EP3238481A4 (en) | Method and apparatus of latency measurement for lte-wlan aggregation | |
| EP3128045A4 (en) | Cylinder plating apparatus and method | |
| SG11201610052TA (en) | Photo-controlled removal of targets in vitro and in vivo | |
| ZA201802902B (en) | Methods and apparatuses for configuration of measurement restrictions | |
| ZA201703398B (en) | Pharmaceutical composition and methods | |
| IL253174A0 (en) | Nanoparticles and methods for their preparation | |
| ZA201608823B (en) | Processes for the preparation of azd5363 and novel intermediate used therein | |
| GB201513084D0 (en) | Apparatus for measure of quantity and associated method of manufacturing | |
| GB201412554D0 (en) | In vitro mesodermal differentiation | |
| IL254732A0 (en) | In vitro preservation of therapeutic cells | |
| PT3503885T (pt) | Composição farmacêutica e métodos de utilização | |
| HUP1400543A2 (hu) | Eljárás és köztitermék apixaban elõállítására | |
| GB201416858D0 (en) | Methods of in Vitro Oocyte Development | |
| GB201612453D0 (en) | Methods and apparatus for measuring deformation | |
| EP3230440A4 (en) | Compositions and methods for neuronal differentiation of cells | |
| HUP1500647A2 (en) | Intermediate of baricitinib and process for its preparation | |
| SG11201704578RA (en) | Methods and apparatus for manufacture of ophthalmic lenses | |
| TWM490537U (en) | Structure of stand | |
| GB201406801D0 (en) | MRI Apparatus and methods | |
| GB2526175B (en) | Design method and apparatus for the manufacture of an article | |
| AU2014904953A0 (en) | Compositions and methods for neuronal differentiation of cells | |
| GB201403177D0 (en) | Preparation and analysis of iminosugar acids | |
| GB201406780D0 (en) | MRI apparatus and methods |