PT3303564T - Métodos de diferenciação in vitro de neurónios de dopamina de mesencéfalo (mda) - Google Patents

Métodos de diferenciação in vitro de neurónios de dopamina de mesencéfalo (mda)

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Publication number
PT3303564T
PT3303564T PT168043503T PT16804350T PT3303564T PT 3303564 T PT3303564 T PT 3303564T PT 168043503 T PT168043503 T PT 168043503T PT 16804350 T PT16804350 T PT 16804350T PT 3303564 T PT3303564 T PT 3303564T
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PT
Portugal
Prior art keywords
midbrane
mda
methods
vitro differentiation
dopamine neurons
Prior art date
Application number
PT168043503T
Other languages
English (en)
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of PT3303564T publication Critical patent/PT3303564T/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
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PT168043503T 2015-06-01 2016-06-01 Métodos de diferenciação in vitro de neurónios de dopamina de mesencéfalo (mda) PT3303564T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562169379P 2015-06-01 2015-06-01
US201562169444P 2015-06-01 2015-06-01

Publications (1)

Publication Number Publication Date
PT3303564T true PT3303564T (pt) 2022-06-02

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PT168043503T PT3303564T (pt) 2015-06-01 2016-06-01 Métodos de diferenciação in vitro de neurónios de dopamina de mesencéfalo (mda)
PT221577828T PT4070803T (pt) 2015-06-01 2016-06-01 Métodos de diferenciamento in vitro de neurônios de dopamina do médio cerebro (mda)

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT221577828T PT4070803T (pt) 2015-06-01 2016-06-01 Métodos de diferenciamento in vitro de neurônios de dopamina do médio cerebro (mda)

Country Status (18)

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US (3) US10858625B2 (pt)
EP (3) EP4079314B1 (pt)
JP (5) JP6974180B2 (pt)
KR (4) KR102841407B1 (pt)
AU (3) AU2016270793B2 (pt)
CY (1) CY1125423T1 (pt)
DK (2) DK3303564T3 (pt)
ES (2) ES2910032T3 (pt)
HR (1) HRP20220482T1 (pt)
HU (1) HUE058258T2 (pt)
IL (4) IL320440A (pt)
LT (1) LT3303564T (pt)
PL (1) PL3303564T3 (pt)
PT (2) PT3303564T (pt)
RS (1) RS63157B1 (pt)
SI (1) SI3303564T1 (pt)
SM (1) SMT202200263T1 (pt)
WO (1) WO2016196661A1 (pt)

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EP4001403A1 (en) * 2016-08-16 2022-05-25 FUJIFILM Cellular Dynamics, Inc. Methods for differentiating pluripotent cells
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WO2019032680A1 (en) * 2017-08-08 2019-02-14 Regents Of The University Of Minnesota METHODS OF GENERATING AND USING ORGANOIDS AND ASSOCIATED CELLS
JP2022514298A (ja) 2018-12-19 2022-02-10 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ オルガノイドおよびその組織を作製および使用するための方法
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AU2020315932A1 (en) 2019-07-25 2022-03-10 Aspen Neuroscience, Inc. Methods of identifying dopaminergic neurons and progenitor cells
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US20230165909A1 (en) 2020-04-21 2023-06-01 Aspen Neuroscience, Inc. Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
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US12104170B2 (en) * 2020-06-26 2024-10-01 Minerva Biotechnologies Corporation Methods for deriving dopaminergic neurons from pluripotent stem cells
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JP2024543407A (ja) 2021-11-12 2024-11-21 アクセント バイオサイエンシーズ インコーポレイテッド 機能的ニューロンの生成のための方法
KR20250007548A (ko) 2022-04-15 2025-01-14 아스펜 뉴로사이언스 인코포레이티드 세포의 분화 상태를 분류하는 방법 및 관련 분화된 세포 조성물
WO2024259119A2 (en) * 2023-06-13 2024-12-19 Aspen Neuroscience, Inc. Methods for differentiating dopaminergic neurons from stem cells
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Publication number Publication date
CA2987617A1 (en) 2016-12-08
JP2026015509A (ja) 2026-01-29
WO2016196661A1 (en) 2016-12-08
EP4079314A1 (en) 2022-10-26
EP3303564A1 (en) 2018-04-11
HUE058258T2 (hu) 2022-07-28
IL255992A (en) 2018-01-31
AU2022228216B2 (en) 2026-02-19
KR102679619B1 (ko) 2024-07-01
EP4070803A1 (en) 2022-10-12
ES3057638T3 (en) 2026-03-03
RS63157B1 (sr) 2022-05-31
DK3303564T3 (da) 2022-04-04
ES2910032T3 (es) 2022-05-11
US20210123018A1 (en) 2021-04-29
US20240400987A1 (en) 2024-12-05
EP4079314B1 (en) 2025-10-29
IL313799B2 (en) 2025-09-01
SI3303564T1 (sl) 2022-07-29
JP2022031961A (ja) 2022-02-22
JP2023181494A (ja) 2023-12-21
JP7737787B2 (ja) 2025-09-11
IL313799B1 (en) 2025-05-01
KR102358878B1 (ko) 2022-02-08
IL255992B (en) 2022-04-01
AU2026200680A1 (en) 2026-02-19
IL291532B1 (en) 2024-08-01
LT3303564T (lt) 2022-05-10
EP3303564B1 (en) 2022-02-23
JP6974180B2 (ja) 2021-12-01
HRP20220482T1 (hr) 2022-07-08
AU2022228216A1 (en) 2022-10-06
IL313799A (en) 2024-08-01
US20180094242A1 (en) 2018-04-05
AU2016270793B2 (en) 2022-06-09
EP3303564A4 (en) 2018-10-31
PL3303564T3 (pl) 2022-05-09
IL291532A (en) 2022-05-01
US10858625B2 (en) 2020-12-08
US12084679B2 (en) 2024-09-10
KR20250118858A (ko) 2025-08-06
KR20180014743A (ko) 2018-02-09
JP2020146060A (ja) 2020-09-17
JP2018522538A (ja) 2018-08-16
KR20240101884A (ko) 2024-07-02
DK4070803T3 (da) 2026-01-12
IL291532B2 (en) 2024-12-01
EP4070803B1 (en) 2025-10-08
AU2016270793A1 (en) 2017-12-14
KR102841407B1 (ko) 2025-08-01
CY1125423T1 (el) 2024-12-13
KR20220020416A (ko) 2022-02-18
PT4070803T (pt) 2026-01-08
SMT202200263T1 (it) 2022-07-21
IL320440A (en) 2025-06-01

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