PL3303564T3 - Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda) - Google Patents

Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda)

Info

Publication number
PL3303564T3
PL3303564T3 PL16804350T PL16804350T PL3303564T3 PL 3303564 T3 PL3303564 T3 PL 3303564T3 PL 16804350 T PL16804350 T PL 16804350T PL 16804350 T PL16804350 T PL 16804350T PL 3303564 T3 PL3303564 T3 PL 3303564T3
Authority
PL
Poland
Prior art keywords
mda
neurons
methods
vitro differentiation
midbrain dopamine
Prior art date
Application number
PL16804350T
Other languages
English (en)
Inventor
Lorenz Studer
Stefan Irion
Mark Tomishima
Sonja KRIKS
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of PL3303564T3 publication Critical patent/PL3303564T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
PL16804350T 2015-06-01 2016-06-01 Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda) PL3303564T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562169444P 2015-06-01 2015-06-01
US201562169379P 2015-06-01 2015-06-01
PCT/US2016/035312 WO2016196661A1 (en) 2015-06-01 2016-06-01 Methods of in vitro differentiation of midbrain dopamine (mda) neurons
EP16804350.3A EP3303564B1 (en) 2015-06-01 2016-06-01 Methods of in vitro differentiation of midbrain dopamine (mda) neurons

Publications (1)

Publication Number Publication Date
PL3303564T3 true PL3303564T3 (pl) 2022-05-09

Family

ID=57441792

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16804350T PL3303564T3 (pl) 2015-06-01 2016-06-01 Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda)

Country Status (17)

Country Link
US (2) US10858625B2 (pl)
EP (3) EP3303564B1 (pl)
JP (4) JP6974180B2 (pl)
KR (2) KR20220020416A (pl)
AU (2) AU2016270793B2 (pl)
CA (1) CA2987617A1 (pl)
DK (1) DK3303564T3 (pl)
ES (1) ES2910032T3 (pl)
HR (1) HRP20220482T1 (pl)
HU (1) HUE058258T2 (pl)
IL (2) IL255992B (pl)
LT (1) LT3303564T (pl)
PL (1) PL3303564T3 (pl)
PT (1) PT3303564T (pl)
RS (1) RS63157B1 (pl)
SI (1) SI3303564T1 (pl)
WO (1) WO2016196661A1 (pl)

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JP2019503703A (ja) * 2016-02-05 2019-02-14 メモリアル スローン ケタリング キャンサー センター 幹細胞由来外胚葉系統前駆体を分化する方法
EP4328301A2 (en) * 2016-08-16 2024-02-28 FUJIFILM Cellular Dynamics, Inc. Methods for differentiating pluripotent cells
EP3614837A4 (en) * 2017-04-26 2020-12-30 Memorial Sloan-Kettering Cancer Center READY-TO-USE CRYOPRESERVED CELLS
US20200173983A1 (en) * 2017-07-17 2020-06-04 Miltenyi Biotec B.V. & Co. KG A method for single cell protein expression profiling of floorplate mesencephalic dopaminergic progenitor cells
WO2019032680A1 (en) * 2017-08-08 2019-02-14 Regents Of The University Of Minnesota METHODS OF GENERATING AND USING ORGANOIDS AND ASSOCIATED CELLS
CN114174498A (zh) * 2019-05-23 2022-03-11 麦可林医院公司 用于帕金森氏病的自体细胞替代疗法
EP4038181A1 (en) 2019-07-25 2022-08-10 The Scripps Research Institute Methods of identifying dopaminergic neurons and progenitor cells
EP4021477A4 (en) * 2019-08-29 2023-12-13 Memorial Sloan Kettering Cancer Center METHOD FOR GENERATING AND ISOLATING MID-DOPAMINE NEURONS
JP2022549224A (ja) * 2019-09-20 2022-11-24 コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー ダイレクトリプログラミングを用いる、誘導型ドーパミン作動性神経前駆細胞の製造方法
WO2021195426A1 (en) 2020-03-25 2021-09-30 Sana Biotechnology, Inc. Hypoimmunogenic neural cells for the treatment of neurological disorders and conditions
WO2021216622A1 (en) 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
WO2021216623A1 (en) 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
CN116635047A (zh) * 2020-06-26 2023-08-22 米纳瓦生物技术公司 用于从多能干细胞衍生多巴胺能神经元的方法
CA3183958A1 (en) * 2020-06-26 2021-12-30 Minerva Biotechnologies Corporation Methods for deriving dopaminergic neurons from pluripotent stem cells
WO2022216911A1 (en) * 2021-04-07 2022-10-13 FUJIFILM Cellular Dynamics, Inc. Dopaminergic precursor cells and methods of use
WO2023004370A1 (en) 2021-07-21 2023-01-26 Aspen Neuroscience, Inc. Aav-based modulation of gba1 and related compositions and uses thereof
US20230081881A1 (en) 2021-07-21 2023-03-16 Aspen Neuroscience, Inc. Transposon-based modulation of gba1 and related compositions and uses thereof
WO2023086894A1 (en) 2021-11-12 2023-05-19 Axent Biosciences Inc. Methods for production of functional neurons
WO2023201361A1 (en) 2022-04-15 2023-10-19 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells

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WO2000068431A2 (en) 1999-05-06 2000-11-16 Mount Sinai School Of Medicine Of New York University Dna-based steganography
AU6319901A (en) * 2000-05-17 2001-11-26 Geron Corp Neural progenitor cell populations
AU2005278897A1 (en) * 2004-09-02 2006-03-09 Neuro Therapeutics Ab Methods and materials relating to enhanced production of dopamine neurons
WO2006071778A2 (en) * 2004-12-23 2006-07-06 Ethicon Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
EP2422794A3 (en) 2006-03-07 2013-03-13 Geeta Shroff Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
WO2008008266A2 (en) 2006-07-07 2008-01-17 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
WO2010096496A2 (en) 2009-02-17 2010-08-26 Memorial Sloan-Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
AU2011258634B2 (en) 2010-05-25 2015-03-26 Memorial Sloan-Kettering Cancer Center Method of nociceptor differentiation of human embryonic stem cells and uses thereof
US20110296542A1 (en) 2010-05-28 2011-12-01 Kevin Ka-Wang Wang Exogenous matrix-supported topical application of stem cells to organ surface
EP2773748B1 (en) * 2011-11-04 2019-12-25 Memorial Sloan Kettering Cancer Center Midbrain dopamine (da) neurons for engraftment
US20150159135A1 (en) 2012-06-15 2015-06-11 Baylor College Of Medicine Perineurium Derived Adult Stem Cells and Methods of Use
CA2910394A1 (en) 2013-04-26 2014-10-30 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
KR101696874B1 (ko) * 2013-07-31 2017-01-16 한국생명공학연구원 직접 리프로그래밍을 통한 유도 도파민성 전구세포 제조방법
JP6419073B2 (ja) * 2013-08-06 2018-11-07 武田薬品工業株式会社 ドパミン神経細胞の製造方法
CN105849255A (zh) * 2013-09-05 2016-08-10 国立大学法人京都大学 新的产多巴胺神经前体细胞诱导方法
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Also Published As

Publication number Publication date
EP4070803A1 (en) 2022-10-12
AU2016270793B2 (en) 2022-06-09
EP3303564A1 (en) 2018-04-11
KR20180014743A (ko) 2018-02-09
AU2022228216A1 (en) 2022-10-06
WO2016196661A1 (en) 2016-12-08
JP6974180B2 (ja) 2021-12-01
JP2018522538A (ja) 2018-08-16
PT3303564T (pt) 2022-06-02
IL255992B (en) 2022-04-01
ES2910032T3 (es) 2022-05-11
CA2987617A1 (en) 2016-12-08
SI3303564T1 (sl) 2022-07-29
KR20220020416A (ko) 2022-02-18
EP3303564A4 (en) 2018-10-31
LT3303564T (lt) 2022-05-10
JP2020146060A (ja) 2020-09-17
HRP20220482T1 (hr) 2022-07-08
JP2022031961A (ja) 2022-02-22
EP4079314A1 (en) 2022-10-26
JP2023181494A (ja) 2023-12-21
IL255992A (en) 2018-01-31
US20180094242A1 (en) 2018-04-05
KR102358878B1 (ko) 2022-02-08
US20210123018A1 (en) 2021-04-29
US10858625B2 (en) 2020-12-08
EP3303564B1 (en) 2022-02-23
AU2016270793A1 (en) 2017-12-14
DK3303564T3 (da) 2022-04-04
IL291532A (en) 2022-05-01
HUE058258T2 (hu) 2022-07-28
RS63157B1 (sr) 2022-05-31

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