RS63157B1 - Metode in vitro diferencijacije dopaminskih (mda) neurona srednjeg mozga - Google Patents

Metode in vitro diferencijacije dopaminskih (mda) neurona srednjeg mozga

Info

Publication number
RS63157B1
RS63157B1 RS20220353A RSP20220353A RS63157B1 RS 63157 B1 RS63157 B1 RS 63157B1 RS 20220353 A RS20220353 A RS 20220353A RS P20220353 A RSP20220353 A RS P20220353A RS 63157 B1 RS63157 B1 RS 63157B1
Authority
RS
Serbia
Prior art keywords
mda
neurons
methods
vitro differentiation
midbrain dopamine
Prior art date
Application number
RS20220353A
Other languages
English (en)
Inventor
Lorenz Studer
Stefan Irion
Mark Tomishima
Sonja Kriks
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of RS63157B1 publication Critical patent/RS63157B1/sr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
RS20220353A 2015-06-01 2016-06-01 Metode in vitro diferencijacije dopaminskih (mda) neurona srednjeg mozga RS63157B1 (sr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562169379P 2015-06-01 2015-06-01
US201562169444P 2015-06-01 2015-06-01
EP16804350.3A EP3303564B1 (en) 2015-06-01 2016-06-01 Methods of in vitro differentiation of midbrain dopamine (mda) neurons
PCT/US2016/035312 WO2016196661A1 (en) 2015-06-01 2016-06-01 Methods of in vitro differentiation of midbrain dopamine (mda) neurons

Publications (1)

Publication Number Publication Date
RS63157B1 true RS63157B1 (sr) 2022-05-31

Family

ID=57441792

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20220353A RS63157B1 (sr) 2015-06-01 2016-06-01 Metode in vitro diferencijacije dopaminskih (mda) neurona srednjeg mozga

Country Status (17)

Country Link
US (2) US10858625B2 (sr)
EP (3) EP3303564B1 (sr)
JP (4) JP6974180B2 (sr)
KR (2) KR20220020416A (sr)
AU (2) AU2016270793B2 (sr)
CA (1) CA2987617A1 (sr)
DK (1) DK3303564T3 (sr)
ES (1) ES2910032T3 (sr)
HR (1) HRP20220482T1 (sr)
HU (1) HUE058258T2 (sr)
IL (2) IL255992B (sr)
LT (1) LT3303564T (sr)
PL (1) PL3303564T3 (sr)
PT (1) PT3303564T (sr)
RS (1) RS63157B1 (sr)
SI (1) SI3303564T1 (sr)
WO (1) WO2016196661A1 (sr)

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EP3411048A4 (en) 2016-02-05 2019-07-31 Memorial Sloan-Kettering Cancer Center METHOD FOR THE DISTINCTION OF PRECURSORS OF STEM CELLS FROM THE ECOTODERMAL DESCALING LINE
EP4001403A1 (en) * 2016-08-16 2022-05-25 FUJIFILM Cellular Dynamics, Inc. Methods for differentiating pluripotent cells
KR20190141218A (ko) * 2017-04-26 2019-12-23 메모리얼 슬로안 케터링 캔서 센터 사용 준비된 냉동보존 세포
EP3655774A1 (en) * 2017-07-17 2020-05-27 Miltenyi Biotec B.V. & Co. KG A method for single cell protein expression profiling of floorplate mesencephalic dopaminergic progenitor cells
WO2019032680A1 (en) * 2017-08-08 2019-02-14 Regents Of The University Of Minnesota METHODS OF GENERATING AND USING ORGANOIDS AND ASSOCIATED CELLS
JP2022534693A (ja) * 2019-05-23 2022-08-03 ザ マクリーン ホスピタル コーポレーション パーキンソン病のための自家細胞置換療法
AU2020315932A1 (en) 2019-07-25 2022-03-10 Aspen Neuroscience, Inc. Methods of identifying dopaminergic neurons and progenitor cells
CA3152522A1 (en) * 2019-08-29 2021-03-04 Memorial Sloan-Kettering Cancer Center Methods of generating and isolating midbrain dopamine neurons
KR102288424B1 (ko) * 2019-09-20 2021-08-11 한국생명공학연구원 직접 리프로그래밍을 통한 유도 도파민성 신경세포 전구체의 제조방법
MX2022011831A (es) 2020-03-25 2023-01-04 Sana Biotechnology Inc Células neurales hipoinmunogénicas para el tratamiento de trastornos y afecciones neurológicas.
US20230165909A1 (en) 2020-04-21 2023-06-01 Aspen Neuroscience, Inc. Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
WO2021216622A1 (en) 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
CN116635047A (zh) * 2020-06-26 2023-08-22 米纳瓦生物技术公司 用于从多能干细胞衍生多巴胺能神经元的方法
AU2021297464A1 (en) * 2020-06-26 2023-02-23 Minerva Biotechnologies Corporation Methods for deriving dopaminergic neurons from pluripotent stem cells
JP2024513912A (ja) * 2021-04-07 2024-03-27 フジフィルム セルラー ダイナミクス，インコーポレイテッド ドーパミン作動性前駆細胞（ｐｒｅｃｕｒｓｏｒ ｃｅｌｌ）及び使用方法
WO2023004370A1 (en) 2021-07-21 2023-01-26 Aspen Neuroscience, Inc. Aav-based modulation of gba1 and related compositions and uses thereof
US20230081881A1 (en) 2021-07-21 2023-03-16 Aspen Neuroscience, Inc. Transposon-based modulation of gba1 and related compositions and uses thereof
WO2023086894A1 (en) 2021-11-12 2023-05-19 Axent Biosciences Inc. Methods for production of functional neurons
US20230377685A1 (en) 2022-04-15 2023-11-23 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells

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KR100903755B1 (ko) * 2000-05-17 2009-06-18 제론 코포레이션 신경 선조세포 집단
JP2008511304A (ja) * 2004-09-02 2008-04-17 ニューロ セラピューティクス エービー ドーパミンニューロンの増強産生に関する方法と材料
SI1835924T1 (sl) 2004-12-23 2013-12-31 Ethicon, Incorporated Zdravljenje Parkinsonove bolezni in sorodnih obolenj z uporabo celic, pridobljenih post partum
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Also Published As

Publication number Publication date
ES2910032T3 (es) 2022-05-11
HUE058258T2 (hu) 2022-07-28
JP2018522538A (ja) 2018-08-16
IL291532A (en) 2022-05-01
EP4079314A1 (en) 2022-10-26
PL3303564T3 (pl) 2022-05-09
JP2020146060A (ja) 2020-09-17
HRP20220482T1 (hr) 2022-07-08
LT3303564T (lt) 2022-05-10
US20180094242A1 (en) 2018-04-05
JP6974180B2 (ja) 2021-12-01
US10858625B2 (en) 2020-12-08
WO2016196661A1 (en) 2016-12-08
EP3303564B1 (en) 2022-02-23
AU2022228216A1 (en) 2022-10-06
SI3303564T1 (sl) 2022-07-29
EP4070803A1 (en) 2022-10-12
KR20220020416A (ko) 2022-02-18
KR102358878B1 (ko) 2022-02-08
JP2023181494A (ja) 2023-12-21
AU2016270793B2 (en) 2022-06-09
AU2016270793A1 (en) 2017-12-14
EP3303564A4 (en) 2018-10-31
CA2987617A1 (en) 2016-12-08
US20210123018A1 (en) 2021-04-29
EP3303564A1 (en) 2018-04-11
IL255992B (en) 2022-04-01
PT3303564T (pt) 2022-06-02
KR20180014743A (ko) 2018-02-09
DK3303564T3 (da) 2022-04-04
IL255992A (en) 2018-01-31
JP2022031961A (ja) 2022-02-22

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