JP2018522018A5 - - Google Patents
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- JP2018522018A5 JP2018522018A5 JP2018502800A JP2018502800A JP2018522018A5 JP 2018522018 A5 JP2018522018 A5 JP 2018522018A5 JP 2018502800 A JP2018502800 A JP 2018502800A JP 2018502800 A JP2018502800 A JP 2018502800A JP 2018522018 A5 JP2018522018 A5 JP 2018522018A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- reacted
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195023P | 2015-07-21 | 2015-07-21 | |
| US62/195,023 | 2015-07-21 | ||
| US201662327973P | 2016-04-26 | 2016-04-26 | |
| US62/327,973 | 2016-04-26 | ||
| PCT/US2016/043402 WO2017015495A1 (en) | 2015-07-21 | 2016-07-21 | Methods of preparing cytotoxic benzodiazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018522018A JP2018522018A (ja) | 2018-08-09 |
| JP2018522018A5 true JP2018522018A5 (OSRAM) | 2019-08-29 |
Family
ID=56557925
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502785A Expired - Fee Related JP6858745B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502800A Withdrawn JP2018522018A (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502791A Expired - Fee Related JP6787995B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2020180147A Expired - Fee Related JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021049502A Active JP7337114B2 (ja) | 2015-07-21 | 2021-03-24 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021202215A Active JP7334228B2 (ja) | 2015-07-21 | 2021-12-14 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023132536A Withdrawn JP2023162264A (ja) | 2015-07-21 | 2023-08-16 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023134420A Withdrawn JP2023166434A (ja) | 2015-07-21 | 2023-08-22 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502785A Expired - Fee Related JP6858745B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502791A Expired - Fee Related JP6787995B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2020180147A Expired - Fee Related JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021049502A Active JP7337114B2 (ja) | 2015-07-21 | 2021-03-24 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021202215A Active JP7334228B2 (ja) | 2015-07-21 | 2021-12-14 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023132536A Withdrawn JP2023162264A (ja) | 2015-07-21 | 2023-08-16 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023134420A Withdrawn JP2023166434A (ja) | 2015-07-21 | 2023-08-22 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (11) | US9873708B2 (OSRAM) |
| EP (7) | EP3653628B1 (OSRAM) |
| JP (8) | JP6858745B2 (OSRAM) |
| KR (5) | KR20240055903A (OSRAM) |
| CN (5) | CN108026103B (OSRAM) |
| AU (7) | AU2016297608B2 (OSRAM) |
| CA (4) | CA2992082A1 (OSRAM) |
| CY (2) | CY1122553T1 (OSRAM) |
| DK (2) | DK3325483T3 (OSRAM) |
| ES (4) | ES2959741T3 (OSRAM) |
| HK (1) | HK1252322A1 (OSRAM) |
| HR (1) | HRP20201479T1 (OSRAM) |
| HU (1) | HUE051541T2 (OSRAM) |
| IL (10) | IL286788B2 (OSRAM) |
| LT (2) | LT3325483T (OSRAM) |
| PL (2) | PL3325482T3 (OSRAM) |
| PT (2) | PT3325482T (OSRAM) |
| RS (2) | RS59806B1 (OSRAM) |
| RU (3) | RU2018105752A (OSRAM) |
| SG (2) | SG10202009354SA (OSRAM) |
| SI (2) | SI3325482T1 (OSRAM) |
| SM (2) | SMT202000004T1 (OSRAM) |
| WO (3) | WO2017015502A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3653628B1 (en) | 2015-07-21 | 2022-09-14 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| KR102609698B1 (ko) | 2016-03-22 | 2023-12-04 | 에베 그룹 에. 탈너 게엠베하 | 기판을 결합하기 위한 방법 및 장치 |
| CA3041254A1 (en) | 2016-10-19 | 2018-04-26 | Invenra Inc. | Antibody constructs |
| BR112019013107A2 (pt) | 2016-12-22 | 2019-12-17 | Univ Degli Studi Magna Graecia Catanzaro | anticorpos, molécula de ligação, receptor de antígeno quimérico, vetor de expressão, composição farmacêutica, linfócito, ácido nucleico, célula de hibridoma, método para a produção do anticorpo monoclonal e usos |
| IL287405B (en) * | 2017-01-25 | 2022-07-01 | Immunogen Inc | Methods of preparing cytotoxic benzodiazepine derivatives |
| WO2019234136A1 (en) | 2018-06-05 | 2019-12-12 | King's College London | Btnl3/8 targeting constructs for delivery of payloads to the gastrointestinal system |
| MA54225A (fr) * | 2018-11-12 | 2021-09-22 | Immunogen Inc | Procédés de préparation de dérivés de benzodiazépine cytotoxiques |
| WO2020102051A1 (en) | 2018-11-12 | 2020-05-22 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| CN113661172A (zh) * | 2019-03-29 | 2021-11-16 | 伊缪诺金公司 | 用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物 |
| EP4548932A1 (en) | 2022-06-30 | 2025-05-07 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
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| US3860600A (en) | 1972-07-10 | 1975-01-14 | Sterling Drug Inc | Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines |
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2016
- 2016-07-21 EP EP19200626.0A patent/EP3653628B1/en active Active
- 2016-07-21 AU AU2016297608A patent/AU2016297608B2/en not_active Ceased
- 2016-07-21 KR KR1020247012991A patent/KR20240055903A/ko not_active Withdrawn
- 2016-07-21 JP JP2018502785A patent/JP6858745B2/ja not_active Expired - Fee Related
- 2016-07-21 IL IL286788A patent/IL286788B2/en unknown
- 2016-07-21 RU RU2018105752A patent/RU2018105752A/ru not_active Application Discontinuation
- 2016-07-21 DK DK16745961.9T patent/DK3325483T3/da active
- 2016-07-21 IL IL305989A patent/IL305989A/en unknown
- 2016-07-21 IL IL294651A patent/IL294651B2/en unknown
- 2016-07-21 WO PCT/US2016/043414 patent/WO2017015502A1/en not_active Ceased
- 2016-07-21 HU HUE16745598A patent/HUE051541T2/hu unknown
- 2016-07-21 WO PCT/US2016/043406 patent/WO2017015496A1/en not_active Ceased
- 2016-07-21 KR KR1020247012816A patent/KR20240055894A/ko not_active Withdrawn
- 2016-07-21 EP EP20181645.1A patent/EP3778602B1/en active Active
- 2016-07-21 EP EP16745598.9A patent/EP3325482B1/en active Active
- 2016-07-21 US US15/216,512 patent/US9873708B2/en active Active
- 2016-07-21 JP JP2018502800A patent/JP2018522018A/ja not_active Withdrawn
- 2016-07-21 AU AU2016297607A patent/AU2016297607A1/en not_active Abandoned
- 2016-07-21 HK HK18111602.7A patent/HK1252322A1/zh unknown
- 2016-07-21 LT LTEP16745961.9T patent/LT3325483T/lt unknown
- 2016-07-21 KR KR1020187003181A patent/KR102659706B1/ko active Active
- 2016-07-21 EP EP22195446.4A patent/EP4163284A1/en not_active Withdrawn
- 2016-07-21 SI SI201630923T patent/SI3325482T1/sl unknown
- 2016-07-21 RS RS20191647A patent/RS59806B1/sr unknown
- 2016-07-21 SM SM20200004T patent/SMT202000004T1/it unknown
- 2016-07-21 ES ES20181645T patent/ES2959741T3/es active Active
- 2016-07-21 AU AU2016297087A patent/AU2016297087B2/en not_active Ceased
- 2016-07-21 CN CN201680053093.1A patent/CN108026103B/zh not_active Expired - Fee Related
- 2016-07-21 SM SM20200506T patent/SMT202000506T1/it unknown
- 2016-07-21 JP JP2018502791A patent/JP6787995B2/ja not_active Expired - Fee Related
- 2016-07-21 EP EP16745961.9A patent/EP3325483B1/en active Active
- 2016-07-21 RS RS20201132A patent/RS60840B1/sr unknown
- 2016-07-21 RU RU2018105756A patent/RU2727151C2/ru active
- 2016-07-21 PT PT167455989T patent/PT3325482T/pt unknown
- 2016-07-21 US US15/216,517 patent/US9890179B2/en not_active Expired - Fee Related
- 2016-07-21 LT LTEP16745598.9T patent/LT3325482T/lt unknown
- 2016-07-21 CA CA2992082A patent/CA2992082A1/en active Pending
- 2016-07-21 CN CN201680053120.5A patent/CN108055844A/zh active Pending
- 2016-07-21 US US15/216,548 patent/US10081640B2/en active Active
- 2016-07-21 KR KR1020187005040A patent/KR20180038460A/ko not_active Withdrawn
- 2016-07-21 EP EP23183947.3A patent/EP4286387A3/en not_active Withdrawn
- 2016-07-21 SG SG10202009354SA patent/SG10202009354SA/en unknown
- 2016-07-21 WO PCT/US2016/043402 patent/WO2017015495A1/en not_active Ceased
- 2016-07-21 CA CA2991326A patent/CA2991326A1/en not_active Abandoned
- 2016-07-21 PT PT167459619T patent/PT3325483T/pt unknown
- 2016-07-21 ES ES19200626T patent/ES2933376T3/es active Active
- 2016-07-21 IL IL305279A patent/IL305279A/en unknown
- 2016-07-21 ES ES16745598T patent/ES2820358T3/es active Active
- 2016-07-21 IL IL283355A patent/IL283355B/en unknown
- 2016-07-21 SG SG10202106529XA patent/SG10202106529XA/en unknown
- 2016-07-21 CA CA2991305A patent/CA2991305C/en active Active
- 2016-07-21 EP EP16748205.8A patent/EP3325485B1/en active Active
- 2016-07-21 PL PL16745598T patent/PL3325482T3/pl unknown
- 2016-07-21 PL PL16745961T patent/PL3325483T3/pl unknown
- 2016-07-21 DK DK16745598.9T patent/DK3325482T3/da active
- 2016-07-21 HR HRP20201479TT patent/HRP20201479T1/hr unknown
- 2016-07-21 RU RU2018105609A patent/RU2746322C2/ru active
- 2016-07-21 CA CA3227588A patent/CA3227588A1/en active Pending
- 2016-07-21 ES ES16745961T patent/ES2764548T3/es active Active
- 2016-07-21 SI SI201630578T patent/SI3325483T1/sl unknown
- 2016-07-21 CN CN202110219412.4A patent/CN113004288A/zh active Pending
- 2016-07-21 KR KR1020187005041A patent/KR102660070B1/ko active Active
- 2016-07-21 CN CN202110366892.7A patent/CN113087763A/zh active Pending
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2017
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