JP2018526340A5 - - Google Patents
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- JP2018526340A5 JP2018526340A5 JP2018502791A JP2018502791A JP2018526340A5 JP 2018526340 A5 JP2018526340 A5 JP 2018526340A5 JP 2018502791 A JP2018502791 A JP 2018502791A JP 2018502791 A JP2018502791 A JP 2018502791A JP 2018526340 A5 JP2018526340 A5 JP 2018526340A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
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- reacted
- monomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C[C@@](C(N[C@@](C)C(Nc1cc(C*)cc(CO)c1)=O)=O)NC(CCCCC(*)=O)=O Chemical compound C[C@@](C(N[C@@](C)C(Nc1cc(C*)cc(CO)c1)=O)=O)NC(CCCCC(*)=O)=O 0.000 description 2
- ROVBYDCETXMZLN-UHFFFAOYSA-N COc(cc(c(N=CC1N2c3ccccc3C1)c1)C2=O)c1O Chemical compound COc(cc(c(N=CC1N2c3ccccc3C1)c1)C2=O)c1O ROVBYDCETXMZLN-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195023P | 2015-07-21 | 2015-07-21 | |
| US62/195,023 | 2015-07-21 | ||
| US201662327973P | 2016-04-26 | 2016-04-26 | |
| US62/327,973 | 2016-04-26 | ||
| PCT/US2016/043406 WO2017015496A1 (en) | 2015-07-21 | 2016-07-21 | Methods of preparing cytotoxic benzodiazepine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020180147A Division JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018526340A JP2018526340A (ja) | 2018-09-13 |
| JP2018526340A5 true JP2018526340A5 (OSRAM) | 2019-08-29 |
| JP6787995B2 JP6787995B2 (ja) | 2020-11-18 |
Family
ID=56557925
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502791A Expired - Fee Related JP6787995B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502800A Withdrawn JP2018522018A (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502785A Active JP6858745B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2020180147A Expired - Fee Related JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021049502A Active JP7337114B2 (ja) | 2015-07-21 | 2021-03-24 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021202215A Active JP7334228B2 (ja) | 2015-07-21 | 2021-12-14 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023132536A Withdrawn JP2023162264A (ja) | 2015-07-21 | 2023-08-16 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023134420A Withdrawn JP2023166434A (ja) | 2015-07-21 | 2023-08-22 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502800A Withdrawn JP2018522018A (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502785A Active JP6858745B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2020180147A Expired - Fee Related JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021049502A Active JP7337114B2 (ja) | 2015-07-21 | 2021-03-24 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021202215A Active JP7334228B2 (ja) | 2015-07-21 | 2021-12-14 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023132536A Withdrawn JP2023162264A (ja) | 2015-07-21 | 2023-08-16 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023134420A Withdrawn JP2023166434A (ja) | 2015-07-21 | 2023-08-22 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (11) | US9890179B2 (OSRAM) |
| EP (7) | EP3325483B1 (OSRAM) |
| JP (8) | JP6787995B2 (OSRAM) |
| KR (5) | KR20180038460A (OSRAM) |
| CN (5) | CN113087763A (OSRAM) |
| AU (7) | AU2016297608B2 (OSRAM) |
| CA (4) | CA3227588A1 (OSRAM) |
| CY (2) | CY1122553T1 (OSRAM) |
| DK (2) | DK3325483T3 (OSRAM) |
| ES (4) | ES2933376T3 (OSRAM) |
| HK (1) | HK1252322A1 (OSRAM) |
| HR (1) | HRP20201479T1 (OSRAM) |
| HU (1) | HUE051541T2 (OSRAM) |
| IL (10) | IL286788B2 (OSRAM) |
| LT (2) | LT3325482T (OSRAM) |
| PL (2) | PL3325483T3 (OSRAM) |
| PT (2) | PT3325482T (OSRAM) |
| RS (2) | RS60840B1 (OSRAM) |
| RU (3) | RU2727151C2 (OSRAM) |
| SG (2) | SG10202009354SA (OSRAM) |
| SI (2) | SI3325482T1 (OSRAM) |
| SM (2) | SMT202000004T1 (OSRAM) |
| WO (3) | WO2017015495A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180038460A (ko) | 2015-07-21 | 2018-04-16 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체의 제조 방법 |
| EP3433875B1 (de) | 2016-03-22 | 2022-05-04 | EV Group E. Thallner GmbH | Verfahren zum bonden von substraten |
| CN118359704A (zh) | 2016-10-19 | 2024-07-19 | 英温拉公司 | 抗体构建体 |
| EA201991204A1 (ru) | 2016-12-22 | 2019-12-30 | Университа Дельи Студи Манья Греча Катандзаро | Моноклональное антитело против уникального сиалогликозилированного опухолеассоциированного эпитопа cd43 |
| AU2018213202B2 (en) | 2017-01-25 | 2022-03-24 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| WO2019234136A1 (en) | 2018-06-05 | 2019-12-12 | King's College London | Btnl3/8 targeting constructs for delivery of payloads to the gastrointestinal system |
| SG11202104423XA (en) * | 2018-11-12 | 2021-05-28 | Immunogen Inc | Methods of preparing cytotoxic benzodiazepine derivatives |
| CN112996792B (zh) * | 2018-11-12 | 2024-04-26 | 伊缪诺金公司 | 制备细胞毒性苯并二氮杂卓衍生物的方法 |
| CN113661172A (zh) * | 2019-03-29 | 2021-11-16 | 伊缪诺金公司 | 用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物 |
| AU2023298568A1 (en) | 2022-06-30 | 2025-01-09 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
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2016
- 2016-07-21 KR KR1020187005040A patent/KR20180038460A/ko not_active Withdrawn
- 2016-07-21 SI SI201630923T patent/SI3325482T1/sl unknown
- 2016-07-21 ES ES19200626T patent/ES2933376T3/es active Active
- 2016-07-21 IL IL286788A patent/IL286788B2/en unknown
- 2016-07-21 PL PL16745961T patent/PL3325483T3/pl unknown
- 2016-07-21 HU HUE16745598A patent/HUE051541T2/hu unknown
- 2016-07-21 PL PL16745598T patent/PL3325482T3/pl unknown
- 2016-07-21 SM SM20200004T patent/SMT202000004T1/it unknown
- 2016-07-21 US US15/216,517 patent/US9890179B2/en not_active Expired - Fee Related
- 2016-07-21 JP JP2018502791A patent/JP6787995B2/ja not_active Expired - Fee Related
- 2016-07-21 LT LTEP16745598.9T patent/LT3325482T/lt unknown
- 2016-07-21 WO PCT/US2016/043402 patent/WO2017015495A1/en not_active Ceased
- 2016-07-21 CN CN202110366892.7A patent/CN113087763A/zh active Pending
- 2016-07-21 AU AU2016297608A patent/AU2016297608B2/en not_active Ceased
- 2016-07-21 RS RS20201132A patent/RS60840B1/sr unknown
- 2016-07-21 KR KR1020247012816A patent/KR20240055894A/ko not_active Withdrawn
- 2016-07-21 EP EP16745961.9A patent/EP3325483B1/en active Active
- 2016-07-21 RU RU2018105756A patent/RU2727151C2/ru active
- 2016-07-21 CN CN201680053120.5A patent/CN108055844A/zh active Pending
- 2016-07-21 DK DK16745961.9T patent/DK3325483T3/da active
- 2016-07-21 IL IL305989A patent/IL305989A/en unknown
- 2016-07-21 EP EP22195446.4A patent/EP4163284A1/en not_active Withdrawn
- 2016-07-21 KR KR1020187005041A patent/KR102660070B1/ko active Active
- 2016-07-21 WO PCT/US2016/043406 patent/WO2017015496A1/en not_active Ceased
- 2016-07-21 CN CN201680053093.1A patent/CN108026103B/zh not_active Expired - Fee Related
- 2016-07-21 LT LTEP16745961.9T patent/LT3325483T/lt unknown
- 2016-07-21 KR KR1020187003181A patent/KR102659706B1/ko active Active
- 2016-07-21 SM SM20200506T patent/SMT202000506T1/it unknown
- 2016-07-21 HK HK18111602.7A patent/HK1252322A1/zh unknown
- 2016-07-21 US US15/216,548 patent/US10081640B2/en active Active
- 2016-07-21 HR HRP20201479TT patent/HRP20201479T1/hr unknown
- 2016-07-21 CA CA3227588A patent/CA3227588A1/en active Pending
- 2016-07-21 CN CN202110219412.4A patent/CN113004288A/zh active Pending
- 2016-07-21 PT PT167455989T patent/PT3325482T/pt unknown
- 2016-07-21 ES ES20181645T patent/ES2959741T3/es active Active
- 2016-07-21 EP EP19200626.0A patent/EP3653628B1/en active Active
- 2016-07-21 CN CN201680051138.1A patent/CN108290895B/zh not_active Expired - Fee Related
- 2016-07-21 AU AU2016297087A patent/AU2016297087B2/en not_active Ceased
- 2016-07-21 RU RU2018105752A patent/RU2018105752A/ru not_active Application Discontinuation
- 2016-07-21 PT PT167459619T patent/PT3325483T/pt unknown
- 2016-07-21 IL IL294651A patent/IL294651B2/en unknown
- 2016-07-21 IL IL305279A patent/IL305279A/en unknown
- 2016-07-21 JP JP2018502800A patent/JP2018522018A/ja not_active Withdrawn
- 2016-07-21 AU AU2016297607A patent/AU2016297607A1/en not_active Abandoned
- 2016-07-21 EP EP23183947.3A patent/EP4286387A3/en not_active Withdrawn
- 2016-07-21 SG SG10202009354SA patent/SG10202009354SA/en unknown
- 2016-07-21 SG SG10202106529XA patent/SG10202106529XA/en unknown
- 2016-07-21 US US15/216,512 patent/US9873708B2/en active Active
- 2016-07-21 EP EP16745598.9A patent/EP3325482B1/en active Active
- 2016-07-21 JP JP2018502785A patent/JP6858745B2/ja active Active
- 2016-07-21 ES ES16745598T patent/ES2820358T3/es active Active
- 2016-07-21 DK DK16745598.9T patent/DK3325482T3/da active
- 2016-07-21 EP EP16748205.8A patent/EP3325485B1/en active Active
- 2016-07-21 EP EP20181645.1A patent/EP3778602B1/en active Active
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