|
US2859239A
(en)
*
|
1956-08-17 |
1958-11-04 |
Dow Chemical Co |
Acrylic acid compounds
|
|
CH549339A
(de)
|
1971-05-12 |
1974-05-31 |
Ciba Geigy Ag |
Herbizides mittel.
|
|
US5763647A
(en)
*
|
1990-03-30 |
1998-06-09 |
Shionogi & Co., Ltd. |
Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives
|
|
EP0520419A3
(en)
*
|
1991-06-26 |
1993-06-16 |
Union Carbide Chemicals & Plastics Technology Corporation |
Production of unsaturated cycloaliphatic esters and derivatives thereof
|
|
ATE401312T1
(de)
|
1997-12-15 |
2008-08-15 |
Astellas Pharma Inc |
Pyrimidin-5-carboxamid-derivate
|
|
AU5438299A
(en)
|
1998-08-29 |
2000-03-21 |
Astrazeneca Ab |
Pyrimidine compounds
|
|
EP1184376B1
(en)
|
1999-06-09 |
2005-02-02 |
Yamanouchi Pharmaceutical Co. Ltd. |
Novel heterocyclic carboxamide derivatives
|
|
AU5108000A
(en)
|
1999-06-10 |
2001-01-02 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel nitrogen-contaiing heterocyclic derivatives or salts thereof
|
|
EP1206265B1
(en)
|
1999-06-30 |
2003-11-12 |
Merck & Co., Inc. |
Src kinase inhibitor compounds
|
|
DE60039616D1
(de)
|
1999-08-13 |
2008-09-04 |
Vertex Pharma |
INHIBITOREN DER c-JUN N-TERMINALEN KINASE (JNK) UND ANDERE PROTEIN-KINASEN
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
WO2003082855A1
(en)
|
2002-03-28 |
2003-10-09 |
Kyowa Hakko Kogyo Co., Ltd. |
Anti-inflammatory agent
|
|
ES2373226T3
(es)
|
2002-06-28 |
2012-02-01 |
Astellas Pharma Inc. |
Derivado de diaminopirimidincarboxamida.
|
|
IL166241A0
(en)
|
2002-07-29 |
2006-01-15 |
Rigel Pharmaceuticals Inc |
Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds
|
|
JPWO2004054617A1
(ja)
|
2002-12-13 |
2006-04-20 |
協和醗酵工業株式会社 |
中枢疾患の予防および／または治療剤
|
|
CN1315777C
(zh)
*
|
2003-01-16 |
2007-05-16 |
东丽泛应化学(股) |
旋光二酰基酒石酸的回收方法
|
|
EP1590341B1
(en)
|
2003-01-17 |
2009-06-17 |
Warner-Lambert Company LLC |
2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation
|
|
EP1590334B1
(en)
|
2003-01-30 |
2009-08-19 |
Boehringer Ingelheim Pharmaceuticals Inc. |
2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta
|
|
ATE542801T1
(de)
|
2003-08-15 |
2012-02-15 |
Novartis Ag |
Zur behandlung von neoplastischen krankheiten, entzündlichen erkrankungen und erkrankungen des immunsystems geeignete 2,4-pyrimidindiamine
|
|
JP2007506746A
(ja)
|
2003-09-24 |
2007-03-22 |
ワイス・ホールディングズ・コーポレイション |
抗癌剤としての５−アリールピリミジン類
|
|
WO2005095382A1
(ja)
|
2004-03-30 |
2005-10-13 |
Kyowa Hakko Kogyo Co., Ltd. |
抗腫瘍剤
|
|
US7601714B2
(en)
|
2004-07-08 |
2009-10-13 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Pyrimidine derivatives useful as inhibitors of PKC-theta
|
|
CA2579007A1
(en)
|
2004-09-10 |
2006-03-16 |
Altana Pharma Ag |
Ciclesonide and syk inhibitor combination and methods of use thereof
|
|
JP2008512429A
(ja)
|
2004-09-10 |
2008-04-24 |
ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング |
ロフルミラストとｓｙｋインヒビターとの組合せ物並びにその使用方法
|
|
ATE542802T1
(de)
|
2004-09-30 |
2012-02-15 |
Tibotec Pharm Ltd |
Hiv-inhibierende 5-substituierte pyrimidine
|
|
JP2006124387A
(ja)
|
2004-09-30 |
2006-05-18 |
Taisho Pharmaceut Co Ltd |
新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法
|
|
WO2006091737A1
(en)
|
2005-02-24 |
2006-08-31 |
Kemia, Inc. |
Modulators of gsk-3 activity
|
|
EP1858882A1
(en)
|
2005-03-10 |
2007-11-28 |
Bayer Pharmaceuticals Corporation |
Pyrimidine derivatives for treatment of hyperproliferative disorders
|
|
WO2007032445A1
(ja)
|
2005-09-16 |
2007-03-22 |
Kyowa Hakko Kogyo Co., Ltd. |
タンパク質キナーゼ阻害剤
|
|
WO2008009458A1
(en)
|
2006-07-21 |
2008-01-24 |
Novartis Ag |
2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors
|
|
US8188113B2
(en)
|
2006-09-14 |
2012-05-29 |
Deciphera Pharmaceuticals, Inc. |
Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
|
US20080139531A1
(en)
|
2006-12-04 |
2008-06-12 |
Alcon Manufacturing Ltd. |
Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
|
|
CL2007003693A1
(es)
|
2006-12-22 |
2008-06-27 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas.
|
|
DK2146779T3
(en)
|
2007-04-18 |
2016-11-28 |
Pfizer Prod Inc |
Sulfonylamid derivatives to treat abnormal cell growth.
|
|
JP2010525047A
(ja)
|
2007-04-27 |
2010-07-22 |
アストラゼネカ アクチボラグ |
増殖状態の処置のためのＥｐｈＢ４キナーゼ阻害剤としてのＮ’−（フェニル）−Ｎ−（モルホリン−４−イル−ピリジン−２−イル）−ピリミジン−２，４−ジアミン誘導体
|
|
CN101796046A
(zh)
|
2007-07-16 |
2010-08-04 |
阿斯利康(瑞典)有限公司 |
嘧啶衍生物934
|
|
CN101903357A
(zh)
|
2007-07-17 |
2010-12-01 |
里格尔药品股份有限公司 |
作为pkc抑制剂的环状胺取代的嘧啶二胺
|
|
JP5269444B2
(ja)
*
|
2008-03-11 |
2013-08-21 |
東ソー・ファインケム株式会社 |
固体ルイス酸触媒、それを用いたディールスアルダー付加物の製造方法
|
|
KR20100132550A
(ko)
|
2008-04-16 |
2010-12-17 |
포톨라 파마슈티컬스, 인코포레이티드 |
ｓｙｋ 또는 ＪＡＫ 키나제 억제제로서의 ２,６－디아미노-피리미딘－５－일－카르복스아미드
|
|
CA2723205C
(en)
|
2008-04-16 |
2017-03-14 |
Portola Pharmaceuticals, Inc. |
2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinase inhibitors
|
|
BRPI0910668A2
(pt)
|
2008-04-22 |
2019-09-24 |
Portola Pharmaceutiacals Inc |
inibidores de proteína quinases
|
|
WO2009132980A1
(en)
|
2008-04-29 |
2009-11-05 |
F. Hoffmann-La Roche Ag |
Pyrimidinyl pyridone inhibitors of jnk.
|
|
JP2011523646A
(ja)
|
2008-05-21 |
2011-08-18 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
キナーゼ阻害剤としてのリン誘導体
|
|
PE20100087A1
(es)
|
2008-06-25 |
2010-02-08 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
AU2009262068C1
(en)
|
2008-06-27 |
2015-07-02 |
Celgene Car Llc |
Heteroaryl compounds and uses thereof
|
|
EP2325175A4
(en)
|
2008-09-01 |
2012-03-21 |
Astellas Pharma Inc |
2,4-DIAMINOPYRIMIDINVERBINDUNG
|
|
EP2159220A1
(en)
|
2008-09-02 |
2010-03-03 |
Nabriva Therapeutics AG |
Organic compounds
|
|
TWI453207B
(zh)
*
|
2008-09-08 |
2014-09-21 |
Signal Pharm Llc |
胺基三唑并吡啶，其組合物及使用其之治療方法
|
|
BRPI0918045A2
(pt)
|
2008-09-18 |
2015-12-01 |
Astellas Pharma Inc |
compostos de carboxamida heterocíclicos
|
|
TW201016676A
(en)
|
2008-10-03 |
2010-05-01 |
Astrazeneca Ab |
Heterocyclic derivatives and methods of use thereof
|
|
EP2346988B1
(en)
|
2008-10-31 |
2017-05-31 |
Janssen Biotech, Inc. |
Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
|
|
WO2010068863A2
(en)
|
2008-12-12 |
2010-06-17 |
Cystic Fibrosis Foundation Therapeutics, Inc. |
Pyrimidine compounds and methods of making and using same
|
|
JP5683489B2
(ja)
|
2009-01-12 |
2015-03-11 |
アレイ バイオファーマ、インコーポレイテッド |
ピペリジン含有化合物およびその用途
|
|
CA2749403A1
(en)
|
2009-01-13 |
2010-09-02 |
Glaxo Group Limited |
Pyrimidinecarboxamide derivatives as inhibitors of syk kinase
|
|
WO2010090875A1
(en)
|
2009-01-21 |
2010-08-12 |
Rigel Pharmaceuticals, Inc. |
Derivatives of n2-(3-pyridil or phenyl)-n4-(4-piperidyl)-2,4-pyrimidinediamine useful in the treatment of inflammatory, autoimmune or proliferative diseases
|
|
WO2010129802A1
(en)
|
2009-05-06 |
2010-11-11 |
Portola Pharmaceuticals, Inc. |
Inhibitors of jak
|
|
MX2011011875A
(es)
|
2009-05-08 |
2011-12-08 |
Astellas Pharma Inc |
Compuesto de carboxamida heterociclica diamino.
|
|
JP2012148977A
(ja)
|
2009-05-20 |
2012-08-09 |
Astellas Pharma Inc |
アミノシクロヘキシルアルキル基を有する２，４−ジアミノピリミジン化合物
|
|
MX2011013325A
(es)
|
2009-06-10 |
2012-04-30 |
Abbott Lab |
2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa.
|
|
JP2012197231A
(ja)
|
2009-08-06 |
2012-10-18 |
Oncotherapy Science Ltd |
Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体
|
|
WO2011065800A2
(ko)
|
2009-11-30 |
2011-06-03 |
주식회사 오스코텍 |
피리미딘 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물
|
|
US20110130415A1
(en)
|
2009-12-01 |
2011-06-02 |
Rajinder Singh |
Protein kinase c inhibitors and uses thereof
|
|
JP2013533866A
(ja)
*
|
2010-06-17 |
2013-08-29 |
ドクター レディズ ラボラトリーズ リミテッド |
３−アミノピペリジンジヒドロクロリドの単一の鏡像異性体を調製するための方法
|
|
CA2801781C
(en)
|
2010-07-21 |
2018-02-27 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
US8580805B2
(en)
|
2010-08-31 |
2013-11-12 |
Hubert Maehr |
Pyrimidine carboxamide derivatives
|
|
WO2012045020A1
(en)
|
2010-09-30 |
2012-04-05 |
Portola Pharmaceuticals, Inc. |
Combinations of 4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide and fludarabine
|
|
WO2012044936A1
(en)
|
2010-09-30 |
2012-04-05 |
Portola Pharmaceuticals, Inc. |
Combination therapy with 4-(3-(2h-1,2,3-triazol-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino)pyrimidine-5-carboxamide
|
|
TWI548621B
(zh)
|
2011-04-22 |
2016-09-11 |
標誌製藥公司 |
經取代之二胺基甲醯胺及二胺基甲腈嘧啶、其組合物、及以該等治療之方法
|
|
WO2014019166A1
(zh)
*
|
2012-08-01 |
2014-02-06 |
上海威智医药科技有限公司 |
高活性硼烷类化合物的工业化生产方法
|
|
JP2014031327A
(ja)
*
|
2012-08-02 |
2014-02-20 |
Kaneka Corp |
光学活性シス−２−アミノ−シクロヘキサンカルボン酸誘導体およびその前駆体の製造法
|
|
RU2016129380A
(ru)
|
2013-12-20 |
2018-01-25 |
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
Замещенные диаминопиримидильные соединения, их композиции и способы лечения с их участием
|
|
NZ715903A
(en)
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
TWI523838B
(zh)
*
|
2014-03-21 |
2016-03-01 |
Far Eastern New Century Corp |
Terephthalic acid and 4-methyl-3-cyclohexene-1-carboxylic acid Ester preparation method
|
|
DK3204386T3
(da)
|
2014-10-06 |
2021-05-25 |
Signal Pharm Llc |
Substituerede aminopurinforbindelser, sammensætninger deraf og fremgangsmåder til behandling dermed
|
|
US9513297B2
(en)
|
2014-12-16 |
2016-12-06 |
Signal Pharmaceuticals, Llc |
Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
|
|
EP3712134B1
(en)
|
2014-12-16 |
2023-11-29 |
Signal Pharmaceuticals, LLC |
Salts of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide
|
|
EP3250557B1
(en)
|
2015-01-29 |
2024-11-20 |
Signal Pharmaceuticals, LLC |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
EP3325432B1
(en)
*
|
2015-07-24 |
2020-09-02 |
Celgene Corporation |
Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
|