|
US2859239A
(en)
|
1956-08-17 |
1958-11-04 |
Dow Chemical Co |
Acrylic acid compounds
|
|
CH549339A
(de)
|
1971-05-12 |
1974-05-31 |
Ciba Geigy Ag |
Herbizides mittel.
|
|
US5763647A
(en)
*
|
1990-03-30 |
1998-06-09 |
Shionogi & Co., Ltd. |
Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives
|
|
EP0520419A3
(en)
*
|
1991-06-26 |
1993-06-16 |
Union Carbide Chemicals & Plastics Technology Corporation |
Production of unsaturated cycloaliphatic esters and derivatives thereof
|
|
ATE401312T1
(de)
|
1997-12-15 |
2008-08-15 |
Astellas Pharma Inc |
Pyrimidin-5-carboxamid-derivate
|
|
ATE342892T1
(de)
|
1998-08-29 |
2006-11-15 |
Astrazeneca Ab |
Pyrimidine verbindungen
|
|
WO2000075113A1
(en)
|
1999-06-09 |
2000-12-14 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel heterocyclic carboxamide derivatives
|
|
WO2000076980A1
(en)
|
1999-06-10 |
2000-12-21 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel nitrogen-contaiing heterocyclic derivatives or salts thereof
|
|
JP2003523942A
(ja)
|
1999-06-30 |
2003-08-12 |
メルク エンド カムパニー インコーポレーテッド |
Ｓｒｃキナーゼ阻害剤化合物
|
|
PL366110A1
(en)
|
1999-08-13 |
2005-01-24 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
AU2003220968A1
(en)
|
2002-03-28 |
2003-10-13 |
Kyowa Hakko Kogyo Co., Ltd. |
Anti-inflammatory agent
|
|
JP4529685B2
(ja)
|
2002-06-28 |
2010-08-25 |
アステラス製薬株式会社 |
ジアミノピリミジンカルボキサミド誘導体
|
|
JP2006514989A
(ja)
|
2002-07-29 |
2006-05-18 |
ライジェル ファーマシューティカルズ |
２，４−ピリミジンジアミン化合物による自己免疫疾患の治療および予防方法
|
|
JPWO2004054617A1
(ja)
|
2002-12-13 |
2006-04-20 |
協和醗酵工業株式会社 |
中枢疾患の予防および／または治療剤
|
|
AU2003289487A1
(en)
*
|
2003-01-16 |
2004-08-10 |
Toray Fine Chemicals Co, . Ltd. |
Processes for the recovery of optically active diacyltartatic acids
|
|
MXPA05007503A
(es)
|
2003-01-17 |
2005-09-21 |
Warner Lambert Co |
Heterociclicos 2-aminopiridina sustituidos como inhibidores de proliferacion celular.
|
|
EP1590334B1
(en)
|
2003-01-30 |
2009-08-19 |
Boehringer Ingelheim Pharmaceuticals Inc. |
2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta
|
|
PL2287156T3
(pl)
|
2003-08-15 |
2013-11-29 |
Novartis Ag |
2,4-Di(fenyloamino)-pirymidyny stosowane w leczeniu chorób nowotworowych, chorób zapalnych i zaburzeń układu immunologicznego
|
|
ATE432077T1
(de)
|
2003-09-24 |
2009-06-15 |
Wyeth Corp |
5-arylpyrimidine als anti-krebs-mittel
|
|
EP1749827A4
(en)
|
2004-03-30 |
2010-04-21 |
Kyowa Hakko Kirin Co Ltd |
ANTITUMOR AGENTS
|
|
CA2571937A1
(en)
|
2004-07-08 |
2006-02-09 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Pyrimidine derivatives useful as inhibitors of pkc-theta
|
|
EP1791538A1
(en)
|
2004-09-10 |
2007-06-06 |
Altana Pharma AG |
Roflumilast and syk inhibitor combination and methods of use thereof
|
|
JP2008512428A
(ja)
|
2004-09-10 |
2008-04-24 |
ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング |
シクレソニドとＳｙｋインヒビターとの組合せ物並びにその使用方法
|
|
JP2006124387A
(ja)
|
2004-09-30 |
2006-05-18 |
Taisho Pharmaceut Co Ltd |
新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法
|
|
TW200626561A
(en)
|
2004-09-30 |
2006-08-01 |
Tibotec Pharm Ltd |
HIV inhibiting 5-substituted pyrimidines
|
|
WO2006091737A1
(en)
|
2005-02-24 |
2006-08-31 |
Kemia, Inc. |
Modulators of gsk-3 activity
|
|
US20110098301A1
(en)
|
2005-03-10 |
2011-04-28 |
Bayer Healthcare Llc |
Pyrimidine Derivatives for Treatment of Hyperproliferative Disorders
|
|
WO2007032445A1
(ja)
|
2005-09-16 |
2007-03-22 |
Kyowa Hakko Kogyo Co., Ltd. |
タンパク質キナーゼ阻害剤
|
|
RU2009105826A
(ru)
|
2006-07-21 |
2010-08-27 |
Новартис АГ (CH) |
2,4-ди(ариламино)питимидин-5-карбоксамидные соединения в качестве ингибиторов jak-киназ
|
|
US8188113B2
(en)
|
2006-09-14 |
2012-05-29 |
Deciphera Pharmaceuticals, Inc. |
Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
|
US20080139531A1
(en)
|
2006-12-04 |
2008-06-12 |
Alcon Manufacturing Ltd. |
Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
|
|
CL2007003693A1
(es)
|
2006-12-22 |
2008-06-27 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas.
|
|
NZ580372A
(en)
|
2007-04-18 |
2012-01-12 |
Pfizer Prod Inc |
Pyrimidine and triazine derivatives including a sulfonamide group for the treatment of abnormal cell growth such as cancer
|
|
WO2008132505A1
(en)
|
2007-04-27 |
2008-11-06 |
Astrazeneca Ab |
N' - (phenyl) -n- (morpholin-4-yl-pyridin-2-yl) -pyrimidine-2, 4-diamine derivatives as ephb4 kinase inhibitors for the treatment of proliferative conditions
|
|
CA2693880A1
(en)
|
2007-07-16 |
2009-01-22 |
Astrazeneca Ab |
Pyrimidine derivatives 934
|
|
NZ582485A
(en)
|
2007-07-17 |
2012-05-25 |
Rigel Pharmaceuticals Inc |
Cyclic amine substituted pyrimidinediamines as pkc inhibitors
|
|
JP5269444B2
(ja)
*
|
2008-03-11 |
2013-08-21 |
東ソー・ファインケム株式会社 |
固体ルイス酸触媒、それを用いたディールスアルダー付加物の製造方法
|
|
EP2323993B1
(en)
|
2008-04-16 |
2015-06-03 |
Portola Pharmaceuticals, Inc. |
2,6-diamino- pyrimidin- 5-yl-carboxamides as syk or jak kinases inhibitors
|
|
MY155639A
(en)
|
2008-04-16 |
2015-11-13 |
Portola Pharm Inc |
2, 6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinases inhibitors
|
|
BRPI0910668A2
(pt)
|
2008-04-22 |
2019-09-24 |
Portola Pharmaceutiacals Inc |
inibidores de proteína quinases
|
|
EP2280969A1
(en)
|
2008-04-29 |
2011-02-09 |
F. Hoffmann-La Roche AG |
Pyrimidinyl pyridone inhibitors of jnk.
|
|
KR101860057B1
(ko)
|
2008-05-21 |
2018-05-21 |
어리어드 파마슈티칼스, 인코포레이티드 |
키나아제 억제제로서 포스포러스 유도체
|
|
UY31929A
(es)
|
2008-06-25 |
2010-01-05 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
|
EP2361248B1
(en)
|
2008-06-27 |
2018-09-19 |
Celgene CAR LLC |
Heteroaryl compounds and uses thereof
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
MX2011002306A
(es)
|
2008-09-01 |
2011-05-25 |
Astellas Pharma Inc |
Compuesto de 2,4-diaminopirimidina.
|
|
EP2159220A1
(en)
|
2008-09-02 |
2010-03-03 |
Nabriva Therapeutics AG |
Organic compounds
|
|
TWI453207B
(zh)
*
|
2008-09-08 |
2014-09-21 |
Signal Pharm Llc |
胺基三唑并吡啶，其組合物及使用其之治療方法
|
|
MX2011002825A
(es)
|
2008-09-18 |
2011-04-05 |
Astellas Pharma Inc |
Compuestos heterociclicos de carboxamida.
|
|
TW201016676A
(en)
|
2008-10-03 |
2010-05-01 |
Astrazeneca Ab |
Heterocyclic derivatives and methods of use thereof
|
|
CN102272291B
(zh)
|
2008-10-31 |
2018-01-16 |
詹森生物科技公司 |
人胚胎干细胞向胰腺内分泌谱系的分化
|
|
WO2010068863A2
(en)
|
2008-12-12 |
2010-06-17 |
Cystic Fibrosis Foundation Therapeutics, Inc. |
Pyrimidine compounds and methods of making and using same
|
|
JP5683489B2
(ja)
|
2009-01-12 |
2015-03-11 |
アレイ バイオファーマ、インコーポレイテッド |
ピペリジン含有化合物およびその用途
|
|
BRPI1006162A2
(pt)
|
2009-01-13 |
2019-09-24 |
Glaxo Group Ltd |
"composto,processo para preparar um composto,formulação farmacêutica,e uso de um composto".
|
|
JP5781943B2
(ja)
|
2009-01-21 |
2015-09-24 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体
|
|
AR076550A1
(es)
|
2009-05-06 |
2011-06-22 |
Portola Pharm Inc |
Inhibidores de la janus tirosina kinasa (jak)
|
|
HUE026647T2
(en)
|
2009-05-08 |
2016-07-28 |
Astellas Pharma Inc |
Diamino heterocyclic carboxamide compound
|
|
JP2012148977A
(ja)
|
2009-05-20 |
2012-08-09 |
Astellas Pharma Inc |
アミノシクロヘキシルアルキル基を有する２，４−ジアミノピリミジン化合物
|
|
MX2011013325A
(es)
|
2009-06-10 |
2012-04-30 |
Abbott Lab |
2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa.
|
|
JP2012197231A
(ja)
|
2009-08-06 |
2012-10-18 |
Oncotherapy Science Ltd |
Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体
|
|
WO2011065800A2
(ko)
|
2009-11-30 |
2011-06-03 |
주식회사 오스코텍 |
피리미딘 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물
|
|
WO2011068898A1
(en)
|
2009-12-01 |
2011-06-09 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
JP2013533866A
(ja)
*
|
2010-06-17 |
2013-08-29 |
ドクター レディズ ラボラトリーズ リミテッド |
３−アミノピペリジンジヒドロクロリドの単一の鏡像異性体を調製するための方法
|
|
WO2012012619A1
(en)
|
2010-07-21 |
2012-01-26 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
US8580805B2
(en)
|
2010-08-31 |
2013-11-12 |
Hubert Maehr |
Pyrimidine carboxamide derivatives
|
|
US20130252917A1
(en)
|
2010-09-30 |
2013-09-26 |
Portola Pharmaceuticals, Inc. |
Combination therapy of 4-(3-(2h-1,2,3-triazo-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino)pyrimidine-5-carboxamide and fludarabine
|
|
WO2012044936A1
(en)
|
2010-09-30 |
2012-04-05 |
Portola Pharmaceuticals, Inc. |
Combination therapy with 4-(3-(2h-1,2,3-triazol-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino)pyrimidine-5-carboxamide
|
|
KR101962488B1
(ko)
*
|
2011-04-22 |
2019-03-26 |
시그날 파마소티칼 엘엘씨 |
치환된 디아미노카르복스아미드 및 디아미노카르보니트릴 피리미딘, 그의 조성물, 및 그를 사용하는 치료 방법
|
|
WO2014019166A1
(zh)
*
|
2012-08-01 |
2014-02-06 |
上海威智医药科技有限公司 |
高活性硼烷类化合物的工业化生产方法
|
|
JP2014031327A
(ja)
*
|
2012-08-02 |
2014-02-20 |
Kaneka Corp |
光学活性シス−２−アミノ−シクロヘキサンカルボン酸誘導体およびその前駆体の製造法
|
|
WO2015095679A1
(en)
|
2013-12-20 |
2015-06-25 |
Signal Pharmaceuticals, Llc |
Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
|
|
NZ715903A
(en)
*
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
TWI523838B
(zh)
*
|
2014-03-21 |
2016-03-01 |
Far Eastern New Century Corp |
Terephthalic acid and 4-methyl-3-cyclohexene-1-carboxylic acid Ester preparation method
|
|
TW201629063A
(zh)
|
2014-10-06 |
2016-08-16 |
標誌製藥公司 |
經取代胺基嘌呤化合物、其組合物及用其之治療方法
|
|
ES2882954T3
(es)
|
2014-12-16 |
2021-12-03 |
Signal Pharm Llc |
Usos médicos que comprenden métodos para la medición de la inhibición de la quinasa c-Jun N-terminal en la piel
|
|
ES2877642T3
(es)
|
2014-12-16 |
2021-11-17 |
Signal Pharm Llc |
Formulaciones de 2-(terc-butilamino)-4-((1R,3R,4R)-3-hidroxi-4-metilciclohexilamino)-pirimidin-5-carboxamida
|
|
US20180022710A1
(en)
|
2015-01-29 |
2018-01-25 |
Signal Pharmaceuticals, Llc |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
WO2017019487A1
(en)
*
|
2015-07-24 |
2017-02-02 |
Celgene Corporation |
Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
|