|
US2859239A
(en)
*
|
1956-08-17 |
1958-11-04 |
Dow Chemical Co |
Acrylic acid compounds
|
|
CH549339A
(de)
|
1971-05-12 |
1974-05-31 |
Ciba Geigy Ag |
Herbizides mittel.
|
|
US5763647A
(en)
*
|
1990-03-30 |
1998-06-09 |
Shionogi & Co., Ltd. |
Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives
|
|
EP0520419A3
(en)
*
|
1991-06-26 |
1993-06-16 |
Union Carbide Chemicals & Plastics Technology Corporation |
Production of unsaturated cycloaliphatic esters and derivatives thereof
|
|
WO1999031073A1
(en)
|
1997-12-15 |
1999-06-24 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel pyrimidine-5-carboxamide derivatives
|
|
EP1107957B1
(en)
|
1998-08-29 |
2006-10-18 |
AstraZeneca AB |
Pyrimidine compounds
|
|
EP1184376B1
(en)
|
1999-06-09 |
2005-02-02 |
Yamanouchi Pharmaceutical Co. Ltd. |
Novel heterocyclic carboxamide derivatives
|
|
WO2000076980A1
(en)
|
1999-06-10 |
2000-12-21 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel nitrogen-contaiing heterocyclic derivatives or salts thereof
|
|
CA2383546A1
(en)
|
1999-06-30 |
2001-01-04 |
William H. Parsons |
Src kinase inhibitor compounds
|
|
NZ517694A
(en)
|
1999-08-13 |
2005-03-24 |
Vertex Pharma |
Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
JPWO2003082855A1
(ja)
|
2002-03-28 |
2005-08-04 |
協和醗酵工業株式会社 |
抗炎症剤
|
|
CN1665789A
(zh)
|
2002-06-28 |
2005-09-07 |
山之内制药株式会社 |
二氨基嘧啶酰胺衍生物
|
|
ATE451104T1
(de)
|
2002-07-29 |
2009-12-15 |
Rigel Pharmaceuticals Inc |
Verfahren zur behandlung oder pruvention von autoimmunkrankheiten mit 2,4-pyrimidindiamin- verbindungen
|
|
WO2004054617A1
(ja)
|
2002-12-13 |
2004-07-01 |
Kyowa Hakko Kogyo Co., Ltd. |
中枢疾患の予防および／または治療剤
|
|
EP1586551A4
(en)
*
|
2003-01-16 |
2006-07-26 |
Toray Finechemicals Co Ltd |
METHOD FOR OBTAINING OPTICALLY ACTIVE DIACYLTARTIC ACIDS
|
|
JP2006516561A
(ja)
|
2003-01-17 |
2006-07-06 |
ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー |
細胞増殖の阻害剤としての２−アミノピリジン置換ヘテロ環類
|
|
EP1590334B1
(en)
|
2003-01-30 |
2009-08-19 |
Boehringer Ingelheim Pharmaceuticals Inc. |
2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta
|
|
DK2287156T3
(da)
|
2003-08-15 |
2013-08-26 |
Novartis Ag |
2,4-Di(phenylamino)-pyrimidiner egnede i behandling af neoplastiske sygdomme, inflammatoriske lidelser og lidelser i immunsystemet
|
|
EP1663241B1
(en)
|
2003-09-24 |
2009-05-27 |
Wyeth Holdings Corporation |
5-arylpyrimidines as anticancer agents
|
|
EP1749827A4
(en)
|
2004-03-30 |
2010-04-21 |
Kyowa Hakko Kirin Co Ltd |
ANTITUMOR AGENTS
|
|
JP2008505910A
(ja)
|
2004-07-08 |
2008-02-28 |
ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド |
Ｐｋｃ−シータのインヒビターとして有用なピリミジン誘導体
|
|
JP2008512429A
(ja)
|
2004-09-10 |
2008-04-24 |
ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング |
ロフルミラストとｓｙｋインヒビターとの組合せ物並びにその使用方法
|
|
CA2579007A1
(en)
|
2004-09-10 |
2006-03-16 |
Altana Pharma Ag |
Ciclesonide and syk inhibitor combination and methods of use thereof
|
|
JP2006124387A
(ja)
|
2004-09-30 |
2006-05-18 |
Taisho Pharmaceut Co Ltd |
新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法
|
|
EP1797047B1
(en)
|
2004-09-30 |
2012-01-25 |
Tibotec Pharmaceuticals |
Hiv inhibiting 5-substituted pyrimidines
|
|
WO2006091737A1
(en)
|
2005-02-24 |
2006-08-31 |
Kemia, Inc. |
Modulators of gsk-3 activity
|
|
GT200600105A
(es)
|
2005-03-10 |
2007-02-14 |
|
Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos.
|
|
WO2007032445A1
(ja)
|
2005-09-16 |
2007-03-22 |
Kyowa Hakko Kogyo Co., Ltd. |
タンパク質キナーゼ阻害剤
|
|
WO2008009458A1
(en)
|
2006-07-21 |
2008-01-24 |
Novartis Ag |
2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors
|
|
US8188113B2
(en)
|
2006-09-14 |
2012-05-29 |
Deciphera Pharmaceuticals, Inc. |
Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
|
US20080139531A1
(en)
|
2006-12-04 |
2008-06-12 |
Alcon Manufacturing Ltd. |
Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
|
|
CL2007003693A1
(es)
*
|
2006-12-22 |
2008-06-27 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas.
|
|
WO2008129380A1
(en)
|
2007-04-18 |
2008-10-30 |
Pfizer Products Inc. |
Sulfonyl amide derivatives for the treatment of abnormal cell growth
|
|
NZ581397A
(en)
|
2007-04-27 |
2012-02-24 |
Astrazeneca Ab |
Pyrimidine compounds for the inhibition of Eph receptors and for the treatment of cancer
|
|
CN101796046A
(zh)
|
2007-07-16 |
2010-08-04 |
阿斯利康(瑞典)有限公司 |
嘧啶衍生物934
|
|
WO2009012421A1
(en)
|
2007-07-17 |
2009-01-22 |
Rigel Pharmaceuticals, Inc. |
Cyclic amine substituted pyrimidinediamines as pkc inhibitors
|
|
JP5269444B2
(ja)
*
|
2008-03-11 |
2013-08-21 |
東ソー・ファインケム株式会社 |
固体ルイス酸触媒、それを用いたディールスアルダー付加物の製造方法
|
|
CN102066339B
(zh)
|
2008-04-16 |
2014-09-24 |
波托拉医药品公司 |
作为syk或jak蛋白激酶抑制剂的2，6-二氨基-嘧啶-5-基甲酰胺类化合物
|
|
CA2960692C
(en)
|
2008-04-16 |
2019-09-24 |
Portola Pharmaceuticals, Inc. |
2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinase inhibitors
|
|
NZ588830A
(en)
|
2008-04-22 |
2012-11-30 |
Portola Pharm Inc |
Inhibitors of protein kinases
|
|
CA2719868A1
(en)
|
2008-04-29 |
2009-11-05 |
F. Hoffmann-La Roche Ag |
Pyrimidinyl pyridone inhibitors of jnk.
|
|
PL2300013T5
(pl)
|
2008-05-21 |
2025-04-28 |
Takeda Pharmaceutical Company Limited |
Pochodne fosforu jako inhibitor kinazy
|
|
UY31929A
(es)
|
2008-06-25 |
2010-01-05 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
TWI458721B
(zh)
|
2008-06-27 |
2014-11-01 |
Celgene Avilomics Res Inc |
雜芳基化合物及其用途
|
|
CN102137848A
(zh)
|
2008-09-01 |
2011-07-27 |
安斯泰来制药株式会社 |
2,4-二氨基嘧啶化合物
|
|
EP2159220A1
(en)
*
|
2008-09-02 |
2010-03-03 |
Nabriva Therapeutics AG |
Organic compounds
|
|
TWI453207B
(zh)
*
|
2008-09-08 |
2014-09-21 |
Signal Pharm Llc |
胺基三唑并吡啶，其組合物及使用其之治療方法
|
|
EP2331507A2
(en)
|
2008-09-18 |
2011-06-15 |
Astellas Pharma Inc. |
Heterocyclic carboxamide compounds
|
|
TW201016676A
(en)
|
2008-10-03 |
2010-05-01 |
Astrazeneca Ab |
Heterocyclic derivatives and methods of use thereof
|
|
RU2522001C2
(ru)
|
2008-10-31 |
2014-07-10 |
Сентокор Орто Байотек Инк. |
Дифференцирование человеческих эмбриональных стволовых клеток в линию панкреатических эндокринных клеток
|
|
WO2010068863A2
(en)
|
2008-12-12 |
2010-06-17 |
Cystic Fibrosis Foundation Therapeutics, Inc. |
Pyrimidine compounds and methods of making and using same
|
|
WO2010080864A1
(en)
|
2009-01-12 |
2010-07-15 |
Array Biopharma Inc. |
Piperidine-containing compounds and use thereof
|
|
CA2749403A1
(en)
|
2009-01-13 |
2010-09-02 |
Glaxo Group Limited |
Pyrimidinecarboxamide derivatives as inhibitors of syk kinase
|
|
US8377924B2
(en)
|
2009-01-21 |
2013-02-19 |
Rigel Pharmaceuticals Inc. |
Protein kinase C inhibitors and uses thereof
|
|
US8367689B2
(en)
|
2009-05-06 |
2013-02-05 |
Portola Pharmaceuticals, Inc. |
Inhibitors of JAK
|
|
DK2428508T3
(en)
|
2009-05-08 |
2016-02-01 |
Astellas Pharma Inc |
Diamino heterocyclic carboxamide COMPOUND
|
|
JP2012148977A
(ja)
|
2009-05-20 |
2012-08-09 |
Astellas Pharma Inc |
アミノシクロヘキシルアルキル基を有する２，４−ジアミノピリミジン化合物
|
|
MX2011013325A
(es)
|
2009-06-10 |
2012-04-30 |
Abbott Lab |
2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa.
|
|
JP2012197231A
(ja)
|
2009-08-06 |
2012-10-18 |
Oncotherapy Science Ltd |
Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体
|
|
WO2011065800A2
(ko)
|
2009-11-30 |
2011-06-03 |
주식회사 오스코텍 |
피리미딘 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물
|
|
CA2780759A1
(en)
|
2009-12-01 |
2011-06-09 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
JP2013533866A
(ja)
*
|
2010-06-17 |
2013-08-29 |
ドクター レディズ ラボラトリーズ リミテッド |
３−アミノピペリジンジヒドロクロリドの単一の鏡像異性体を調製するための方法
|
|
CA2801781C
(en)
|
2010-07-21 |
2018-02-27 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
US8580805B2
(en)
|
2010-08-31 |
2013-11-12 |
Hubert Maehr |
Pyrimidine carboxamide derivatives
|
|
US20130244963A1
(en)
|
2010-09-30 |
2013-09-19 |
Portola Pharmaceuticals, Inc. |
Combination therapy with 4-(3-(2h-1,2,3-triazol-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino)pyrimidine-5-carboxamide
|
|
WO2012045010A1
(en)
|
2010-09-30 |
2012-04-05 |
Portola Pharmaceuticals, Inc. |
Combinations of 4-(3-(2h-1,2,3-triazo-2-yl) phenylamino)-2-((1r,2s)-2-aminocyclohexylamino) pyrimidine-5-carboxamide and fludarabine
|
|
SG194086A1
(en)
|
2011-04-22 |
2013-11-29 |
Signal Pharm Llc |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
|
|
WO2014019166A1
(zh)
*
|
2012-08-01 |
2014-02-06 |
上海威智医药科技有限公司 |
高活性硼烷类化合物的工业化生产方法
|
|
JP2014031327A
(ja)
*
|
2012-08-02 |
2014-02-20 |
Kaneka Corp |
光学活性シス−２−アミノ−シクロヘキサンカルボン酸誘導体およびその前駆体の製造法
|
|
MX2016007898A
(es)
|
2013-12-20 |
2016-10-07 |
Signal Pharm Llc |
Compuestos diaminopirimidilo sustituidos, las composiciones de estos y los metodos de tratamiento con estos.
|
|
NZ715903A
(en)
*
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
TWI523838B
(zh)
*
|
2014-03-21 |
2016-03-01 |
Far Eastern New Century Corp |
Terephthalic acid and 4-methyl-3-cyclohexene-1-carboxylic acid Ester preparation method
|
|
CN113248506A
(zh)
|
2014-10-06 |
2021-08-13 |
西格诺药品有限公司 |
取代的氨基嘌呤化合物、其组合物及其治疗方法
|
|
SG11201704827UA
(en)
|
2014-12-16 |
2017-07-28 |
Signal Pharm Llc |
Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide
|
|
WO2016100308A1
(en)
|
2014-12-16 |
2016-06-23 |
Signal Pharmaceuticals, Llc |
Methods for measurement of inhibition of c-jun n-terminal kinase in skin
|
|
EP3250557B1
(en)
|
2015-01-29 |
2024-11-20 |
Signal Pharmaceuticals, LLC |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
CN107922287B
(zh)
*
|
2015-07-24 |
2021-04-09 |
细胞基因公司 |
合成(1r,2r,5r)-5-氨基-2-甲基环己醇盐酸盐的方法和其中可用的中间体
|