|
US2859239A
(en)
|
1956-08-17 |
1958-11-04 |
Dow Chemical Co |
Acrylic acid compounds
|
|
CH549339A
(de)
|
1971-05-12 |
1974-05-31 |
Ciba Geigy Ag |
Herbizides mittel.
|
|
US5763647A
(en)
*
|
1990-03-30 |
1998-06-09 |
Shionogi & Co., Ltd. |
Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives
|
|
CA2072270A1
(en)
|
1991-06-26 |
1992-12-27 |
Joseph V. Koleske |
Production of unsaturated cycloaliphatic esters and derivatives thereof
|
|
EP1054004B1
(en)
|
1997-12-15 |
2008-07-16 |
Astellas Pharma Inc. |
Novel pyrimidine-5-carboxamide derivatives
|
|
ATE342892T1
(de)
|
1998-08-29 |
2006-11-15 |
Astrazeneca Ab |
Pyrimidine verbindungen
|
|
ATE288420T1
(de)
|
1999-06-09 |
2005-02-15 |
Yamanouchi Pharma Co Ltd |
Neuartige heterocyclische carboxamid-derivate
|
|
WO2000076980A1
(en)
|
1999-06-10 |
2000-12-21 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel nitrogen-contaiing heterocyclic derivatives or salts thereof
|
|
WO2001000213A1
(en)
|
1999-06-30 |
2001-01-04 |
Merck & Co., Inc. |
Src kinase inhibitor compounds
|
|
BR0013551A
(pt)
|
1999-08-13 |
2003-06-17 |
Vertex Pharma |
Inibidores de cinases n-terminal cjun (jnk) e outras cinases de proteìnas
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
WO2003082855A1
(en)
|
2002-03-28 |
2003-10-09 |
Kyowa Hakko Kogyo Co., Ltd. |
Anti-inflammatory agent
|
|
EP1518855B1
(en)
|
2002-06-28 |
2011-10-26 |
Astellas Pharma Inc. |
Diaminopyrimidinecarboxa mide derivative
|
|
HRP20050089B1
(hr)
|
2002-07-29 |
2015-06-19 |
Rigel Pharmaceuticals |
Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
|
|
JPWO2004054617A1
(ja)
|
2002-12-13 |
2006-04-20 |
協和醗酵工業株式会社 |
中枢疾患の予防および／または治療剤
|
|
EP1586551A4
(en)
*
|
2003-01-16 |
2006-07-26 |
Toray Finechemicals Co Ltd |
METHOD FOR OBTAINING OPTICALLY ACTIVE DIACYLTARTIC ACIDS
|
|
MXPA05007503A
(es)
|
2003-01-17 |
2005-09-21 |
Warner Lambert Co |
Heterociclicos 2-aminopiridina sustituidos como inhibidores de proliferacion celular.
|
|
US20040242613A1
(en)
|
2003-01-30 |
2004-12-02 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Pyrimidine derivatives useful as inhibitors of PKC-theta
|
|
PT1660458E
(pt)
|
2003-08-15 |
2012-04-27 |
Novartis Ag |
2,4-pirimidinodiaminas úteis no tratamento de doenças neoplásicas, desordens inflamatórias e do sistema imunitário
|
|
RU2006107578A
(ru)
|
2003-09-24 |
2007-10-27 |
Вайет Холдингз Корпорейшн (Us) |
6-арилпиримидин, применяемый в качестве противоракового агента
|
|
WO2005095382A1
(ja)
|
2004-03-30 |
2005-10-13 |
Kyowa Hakko Kogyo Co., Ltd. |
抗腫瘍剤
|
|
JP2008505910A
(ja)
|
2004-07-08 |
2008-02-28 |
ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド |
Ｐｋｃ−シータのインヒビターとして有用なピリミジン誘導体
|
|
JP2008512429A
(ja)
|
2004-09-10 |
2008-04-24 |
ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング |
ロフルミラストとｓｙｋインヒビターとの組合せ物並びにその使用方法
|
|
CA2579007A1
(en)
|
2004-09-10 |
2006-03-16 |
Altana Pharma Ag |
Ciclesonide and syk inhibitor combination and methods of use thereof
|
|
JP2006124387A
(ja)
|
2004-09-30 |
2006-05-18 |
Taisho Pharmaceut Co Ltd |
新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法
|
|
JP5046943B2
(ja)
|
2004-09-30 |
2012-10-10 |
テイボテク・フアーマシユーチカルズ |
Ｈｉｖ阻害性５−置換ピリミジン
|
|
WO2006091737A1
(en)
|
2005-02-24 |
2006-08-31 |
Kemia, Inc. |
Modulators of gsk-3 activity
|
|
US20110098301A1
(en)
|
2005-03-10 |
2011-04-28 |
Bayer Healthcare Llc |
Pyrimidine Derivatives for Treatment of Hyperproliferative Disorders
|
|
WO2007032445A1
(ja)
|
2005-09-16 |
2007-03-22 |
Kyowa Hakko Kogyo Co., Ltd. |
タンパク質キナーゼ阻害剤
|
|
WO2008009458A1
(en)
|
2006-07-21 |
2008-01-24 |
Novartis Ag |
2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors
|
|
US8188113B2
(en)
|
2006-09-14 |
2012-05-29 |
Deciphera Pharmaceuticals, Inc. |
Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
|
US20080139531A1
(en)
|
2006-12-04 |
2008-06-12 |
Alcon Manufacturing Ltd. |
Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
|
|
CL2007003693A1
(es)
|
2006-12-22 |
2008-06-27 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas.
|
|
CN101678215B
(zh)
|
2007-04-18 |
2014-10-01 |
辉瑞产品公司 |
用于治疗异常细胞生长的磺酰胺衍生物
|
|
WO2008132505A1
(en)
|
2007-04-27 |
2008-11-06 |
Astrazeneca Ab |
N' - (phenyl) -n- (morpholin-4-yl-pyridin-2-yl) -pyrimidine-2, 4-diamine derivatives as ephb4 kinase inhibitors for the treatment of proliferative conditions
|
|
EA201000101A1
(ru)
|
2007-07-16 |
2010-08-30 |
Астразенека Аб |
Производные пиримидина 934
|
|
CN101903357A
(zh)
|
2007-07-17 |
2010-12-01 |
里格尔药品股份有限公司 |
作为pkc抑制剂的环状胺取代的嘧啶二胺
|
|
JP5269444B2
(ja)
*
|
2008-03-11 |
2013-08-21 |
東ソー・ファインケム株式会社 |
固体ルイス酸触媒、それを用いたディールスアルダー付加物の製造方法
|
|
SG165655A1
(en)
|
2008-04-16 |
2010-11-29 |
Portola Pharm Inc |
2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors
|
|
HRP20161310T1
(hr)
|
2008-04-16 |
2016-12-02 |
Portola Pharmaceuticals, Inc. |
2,6-diamino-pirimidin-5-il-karboksamidi kao inhibitori syk ili jak kinaza
|
|
AU2009238590A1
(en)
|
2008-04-22 |
2009-10-29 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
CA2719868A1
(en)
|
2008-04-29 |
2009-11-05 |
F. Hoffmann-La Roche Ag |
Pyrimidinyl pyridone inhibitors of jnk.
|
|
MX353308B
(es)
|
2008-05-21 |
2018-01-08 |
Ariad Pharma Inc |
Derivados fosforosos como inhibidores de cinasa.
|
|
PE20100087A1
(es)
|
2008-06-25 |
2010-02-08 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
|
NZ603525A
(en)
|
2008-06-27 |
2015-02-27 |
Celgene Avilomics Res Inc |
Pyrimidine based compound and uses thereof
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
JP5644499B2
(ja)
|
2008-09-01 |
2014-12-24 |
アステラス製薬株式会社 |
２，４−ジアミノピリミジン化合物
|
|
EP2159220A1
(en)
|
2008-09-02 |
2010-03-03 |
Nabriva Therapeutics AG |
Organic compounds
|
|
TWI453207B
(zh)
*
|
2008-09-08 |
2014-09-21 |
Signal Pharm Llc |
胺基三唑并吡啶，其組合物及使用其之治療方法
|
|
US20110166161A1
(en)
|
2008-09-18 |
2011-07-07 |
Astellas Pharma Inc. |
Heterocyclic carboxamide compounds
|
|
TW201016676A
(en)
|
2008-10-03 |
2010-05-01 |
Astrazeneca Ab |
Heterocyclic derivatives and methods of use thereof
|
|
US9234178B2
(en)
|
2008-10-31 |
2016-01-12 |
Janssen Biotech, Inc. |
Differentiation of human pluripotent stem cells
|
|
US8513242B2
(en)
|
2008-12-12 |
2013-08-20 |
Cystic Fibrosis Foundation Therapeutics, Inc. |
Pyrimidine compounds and methods of making and using same
|
|
EP2375899B1
(en)
|
2009-01-12 |
2015-02-25 |
Array Biopharma Inc. |
Piperidine-containing compounds and use thereof in the treatment of diabetes
|
|
US8470835B2
(en)
|
2009-01-13 |
2013-06-25 |
Glaxo Group Limited |
Pyrimidinecarboxamide derivatives as inhibitors of Syk kinase
|
|
JP5781943B2
(ja)
|
2009-01-21 |
2015-09-24 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体
|
|
US8367689B2
(en)
|
2009-05-06 |
2013-02-05 |
Portola Pharmaceuticals, Inc. |
Inhibitors of JAK
|
|
LT3009428T
(lt)
|
2009-05-08 |
2018-04-10 |
Astellas Pharma Inc. |
Diamino heterociklinis karboksamido junginys
|
|
JP2012148977A
(ja)
|
2009-05-20 |
2012-08-09 |
Astellas Pharma Inc |
アミノシクロヘキシルアルキル基を有する２，４−ジアミノピリミジン化合物
|
|
EP2440548A1
(en)
|
2009-06-10 |
2012-04-18 |
Abbott Laboratories |
2- ( lh-pyrazol-4 -ylamino ) -pyrimidine as kinase inhibitors
|
|
JP2012197231A
(ja)
|
2009-08-06 |
2012-10-18 |
Oncotherapy Science Ltd |
Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体
|
|
WO2011065800A2
(ko)
|
2009-11-30 |
2011-06-03 |
주식회사 오스코텍 |
피리미딘 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물
|
|
EP2507227B1
(en)
|
2009-12-01 |
2014-10-08 |
Rigel Pharmaceuticals, Inc. |
Tetrazolones as protein kinase c inhibitors and uses thereof
|
|
EP2582671A4
(en)
*
|
2010-06-17 |
2014-02-26 |
Reddys Lab Ltd Dr |
PROCESS FOR PREPARING A SINGLE ENANTIOMER FROM 3-AMINOPIPERIDIN DIHYDROCHLORIDE
|
|
JP6035238B2
(ja)
|
2010-07-21 |
2016-11-30 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
プロテインキナーゼｃ阻害剤およびその使用
|
|
US8580805B2
(en)
|
2010-08-31 |
2013-11-12 |
Hubert Maehr |
Pyrimidine carboxamide derivatives
|
|
WO2012044936A1
(en)
|
2010-09-30 |
2012-04-05 |
Portola Pharmaceuticals, Inc. |
Combination therapy with 4-(3-(2h-1,2,3-triazol-2-yl)phenylamino)-2-((1r,2s)-2-aminocyclohexylamino)pyrimidine-5-carboxamide
|
|
EP2621489A1
(en)
|
2010-09-30 |
2013-08-07 |
Portola Pharmaceuticals, Inc. |
Combinations of 4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide and fludarabine
|
|
US9139534B2
(en)
|
2011-04-22 |
2015-09-22 |
Signal Pharmaceuticals, Llc |
Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
|
|
WO2014019166A1
(zh)
*
|
2012-08-01 |
2014-02-06 |
上海威智医药科技有限公司 |
高活性硼烷类化合物的工业化生产方法
|
|
JP2014031327A
(ja)
*
|
2012-08-02 |
2014-02-20 |
Kaneka Corp |
光学活性シス−２−アミノ−シクロヘキサンカルボン酸誘導体およびその前駆体の製造法
|
|
US9556126B2
(en)
|
2013-12-20 |
2017-01-31 |
Signal Pharmaceuticals, Llc |
Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
|
|
NZ715903A
(en)
|
2014-01-30 |
2017-06-30 |
Signal Pharm Llc |
Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
|
|
TWI523838B
(zh)
*
|
2014-03-21 |
2016-03-01 |
Far Eastern New Century Corp |
Terephthalic acid and 4-methyl-3-cyclohexene-1-carboxylic acid Ester preparation method
|
|
US9512124B2
(en)
|
2014-10-06 |
2016-12-06 |
Signal Pharmaceuticals, Llc |
Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
|
|
US9513297B2
(en)
|
2014-12-16 |
2016-12-06 |
Signal Pharmaceuticals, Llc |
Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
|
|
CN107108524A
(zh)
|
2014-12-16 |
2017-08-29 |
西格诺药品有限公司 |
2‑(叔丁基氨基)‑4‑((1r,3r,4r)‑3‑羟基‑4‑甲基环己基氨基)‑嘧啶‑5‑甲酰胺的配制物
|
|
EP3250557B1
(en)
|
2015-01-29 |
2024-11-20 |
Signal Pharmaceuticals, LLC |
Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
|
|
CN107922287B
(zh)
*
|
2015-07-24 |
2021-04-09 |
细胞基因公司 |
合成(1r,2r,5r)-5-氨基-2-甲基环己醇盐酸盐的方法和其中可用的中间体
|