MX385379B - Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilciclohexanol e intermedios utiles en este. - Google Patents
Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilciclohexanol e intermedios utiles en este.Info
- Publication number
- MX385379B MX385379B MX2020001720A MX2020001720A MX385379B MX 385379 B MX385379 B MX 385379B MX 2020001720 A MX2020001720 A MX 2020001720A MX 2020001720 A MX2020001720 A MX 2020001720A MX 385379 B MX385379 B MX 385379B
- Authority
- MX
- Mexico
- Prior art keywords
- garment
- amino
- methods
- region
- useful
- Prior art date
Links
- HKWIETGWMFZMPJ-RYLOHDEPSA-N (1r,2r,5r)-5-amino-2-methylcyclohexan-1-ol;hydrochloride Chemical compound Cl.C[C@@H]1CC[C@@H](N)C[C@H]1O HKWIETGWMFZMPJ-RYLOHDEPSA-N 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 230000006835 compression Effects 0.000 abstract 4
- 238000007906 compression Methods 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 210000001624 hip Anatomy 0.000 abstract 2
- 230000037361 pathway Effects 0.000 abstract 2
- 230000000399 orthopedic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
- C07C209/58—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from or via amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/86—Separation
- C07C209/88—Separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562196363P | 2015-07-24 | 2015-07-24 | |
| PCT/US2016/043511 WO2017019487A1 (en) | 2015-07-24 | 2016-07-22 | Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2020001720A MX2020001720A (es) | 2021-08-13 |
| MX385379B true MX385379B (es) | 2025-03-18 |
Family
ID=57885143
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020001720A MX385379B (es) | 2015-07-24 | 2016-07-22 | Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilciclohexanol e intermedios utiles en este. |
| MX2018001004A MX2018001004A (es) | 2015-07-24 | 2016-07-22 | Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilci clohexanol e intermedios utiles en este. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018001004A MX2018001004A (es) | 2015-07-24 | 2016-07-22 | Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilci clohexanol e intermedios utiles en este. |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10252981B2 (enExample) |
| EP (2) | EP3325432B1 (enExample) |
| JP (2) | JP6805232B2 (enExample) |
| CN (1) | CN107922287B (enExample) |
| AU (2) | AU2016297784B2 (enExample) |
| CA (2) | CA3208587A1 (enExample) |
| ES (2) | ES2994877T3 (enExample) |
| MX (2) | MX385379B (enExample) |
| WO (1) | WO2017019487A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3250557B1 (en) | 2015-01-29 | 2024-11-20 | Signal Pharmaceuticals, LLC | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| EP3325432B1 (en) | 2015-07-24 | 2020-09-02 | Celgene Corporation | Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein |
| CN111848423B (zh) * | 2019-04-30 | 2022-10-14 | 尚科生物医药（上海）有限公司 | 3-氧代环丁基氨基甲酸叔丁酯的制备方法 |
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| EP3712134B1 (en) | 2014-12-16 | 2023-11-29 | Signal Pharmaceuticals, LLC | Salts of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide |
| EP3250557B1 (en) | 2015-01-29 | 2024-11-20 | Signal Pharmaceuticals, LLC | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| EP3325432B1 (en) * | 2015-07-24 | 2020-09-02 | Celgene Corporation | Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein |
-
2016
- 2016-07-22 EP EP16831114.0A patent/EP3325432B1/en active Active
- 2016-07-22 CN CN201680043308.1A patent/CN107922287B/zh active Active
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- 2016-07-22 CA CA3208587A patent/CA3208587A1/en active Pending
- 2016-07-22 US US15/746,853 patent/US10252981B2/en active Active
- 2016-07-22 MX MX2020001720A patent/MX385379B/es unknown
- 2016-07-22 AU AU2016297784A patent/AU2016297784B2/en active Active
- 2016-07-22 WO PCT/US2016/043511 patent/WO2017019487A1/en not_active Ceased
- 2016-07-22 JP JP2018503482A patent/JP6805232B2/ja active Active
- 2016-07-22 ES ES16831114T patent/ES2819374T3/es active Active
- 2016-07-22 MX MX2018001004A patent/MX2018001004A/es active IP Right Grant
- 2016-07-22 EP EP20193348.8A patent/EP3795553B1/en active Active
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2019
- 2019-01-28 US US16/258,802 patent/US10774033B2/en active Active
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2020
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2021
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|---|---|
| EP3795553B1 (en) | 2024-05-15 |
| WO2017019487A1 (en) | 2017-02-02 |
| JP7165178B2 (ja) | 2022-11-02 |
| MX2020001720A (es) | 2021-08-13 |
| US20180215700A1 (en) | 2018-08-02 |
| EP3325432A4 (en) | 2019-04-24 |
| MX2018001004A (es) | 2018-06-07 |
| EP3325432B1 (en) | 2020-09-02 |
| AU2016297784A1 (en) | 2018-02-08 |
| JP2018521085A (ja) | 2018-08-02 |
| CN107922287B (zh) | 2021-04-09 |
| JP6805232B2 (ja) | 2020-12-23 |
| CA2993173C (en) | 2023-10-03 |
| CN107922287A (zh) | 2018-04-17 |
| AU2016297784B2 (en) | 2020-12-24 |
| EP3325432A1 (en) | 2018-05-30 |
| US10774033B2 (en) | 2020-09-15 |
| US11780801B2 (en) | 2023-10-10 |
| US20220234990A1 (en) | 2022-07-28 |
| JP2021046426A (ja) | 2021-03-25 |
| HK1255553A1 (en) | 2019-08-23 |
| US11192847B2 (en) | 2021-12-07 |
| US20200369600A1 (en) | 2020-11-26 |
| US20190152893A1 (en) | 2019-05-23 |
| EP3795553A1 (en) | 2021-03-24 |
| AU2021201493B2 (en) | 2022-07-14 |
| AU2021201493A1 (en) | 2021-03-25 |
| CA2993173A1 (en) | 2017-02-02 |
| CA3208587A1 (en) | 2017-02-02 |
| ES2819374T3 (es) | 2021-04-15 |
| US10252981B2 (en) | 2019-04-09 |
| ES2994877T3 (en) | 2025-02-03 |
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