MX2020001720A - Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilci clohexanol e intermedios utiles en este. - Google Patents

Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilci clohexanol e intermedios utiles en este.

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Publication number
MX2020001720A
MX2020001720A MX2020001720A MX2020001720A MX2020001720A MX 2020001720 A MX2020001720 A MX 2020001720A MX 2020001720 A MX2020001720 A MX 2020001720A MX 2020001720 A MX2020001720 A MX 2020001720A MX 2020001720 A MX2020001720 A MX 2020001720A
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Mexico
Prior art keywords
garment
amino
methods
region
useful
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Application number
MX2020001720A
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English (en)
Inventor
Hon-Wah Man
Chinnapillai Rajendiran
Periyandi Nagarajan
Terrence Joseph Connolly
Jasti Venkateswarlu
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Celgene Corp
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Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2020001720A publication Critical patent/MX2020001720A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/58—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from or via amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

En la presente, se proporcionan métodos e intermedios para producir clorhidrato de (1R,2R,5R)-5-amino-2-metilciclohexanol, que son útiles para la preparación de compuestos útiles para el tratamiento de una enfermedad, y trastorno o afección asociada con la vía JNK.
MX2020001720A 2015-07-24 2016-07-22 Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilci clohexanol e intermedios utiles en este. MX2020001720A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562196363P 2015-07-24 2015-07-24
PCT/US2016/043511 WO2017019487A1 (en) 2015-07-24 2016-07-22 Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein

Publications (1)

Publication Number Publication Date
MX2020001720A true MX2020001720A (es) 2021-08-13

Family

ID=57885143

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020001720A MX2020001720A (es) 2015-07-24 2016-07-22 Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilci clohexanol e intermedios utiles en este.
MX2018001004A MX2018001004A (es) 2015-07-24 2016-07-22 Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilci clohexanol e intermedios utiles en este.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018001004A MX2018001004A (es) 2015-07-24 2016-07-22 Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilci clohexanol e intermedios utiles en este.

Country Status (10)

Country Link
US (4) US10252981B2 (es)
EP (2) EP3795553B1 (es)
JP (2) JP6805232B2 (es)
CN (1) CN107922287B (es)
AU (2) AU2016297784B2 (es)
CA (2) CA3208587A1 (es)
ES (1) ES2819374T3 (es)
HK (1) HK1255553A1 (es)
MX (2) MX2020001720A (es)
WO (1) WO2017019487A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
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CN111848423B (zh) * 2019-04-30 2022-10-14 尚科生物医药（上海）有限公司 3-氧代环丁基氨基甲酸叔丁酯的制备方法

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US11192847B2 (en) 2021-12-07
CN107922287A (zh) 2018-04-17
US20190152893A1 (en) 2019-05-23
US10774033B2 (en) 2020-09-15
EP3795553A1 (en) 2021-03-24
JP7165178B2 (ja) 2022-11-02
HK1255553A1 (zh) 2019-08-23
EP3325432B1 (en) 2020-09-02
AU2016297784B2 (en) 2020-12-24
JP2021046426A (ja) 2021-03-25
US20220234990A1 (en) 2022-07-28
EP3325432A4 (en) 2019-04-24
CA2993173C (en) 2023-10-03
US20200369600A1 (en) 2020-11-26
CN107922287B (zh) 2021-04-09
AU2016297784A1 (en) 2018-02-08
MX2018001004A (es) 2018-06-07
ES2819374T3 (es) 2021-04-15
US20180215700A1 (en) 2018-08-02
AU2021201493A1 (en) 2021-03-25
EP3795553B1 (en) 2024-05-15
EP3325432A1 (en) 2018-05-30
CA3208587A1 (en) 2017-02-02
AU2021201493B2 (en) 2022-07-14
JP2018521085A (ja) 2018-08-02
US11780801B2 (en) 2023-10-10
WO2017019487A1 (en) 2017-02-02
CA2993173A1 (en) 2017-02-02
JP6805232B2 (ja) 2020-12-23
US10252981B2 (en) 2019-04-09

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