JP2017532045A5 - - Google Patents

Info

Publication number

JP2017532045A5

JP2017532045A5 JP2017519862A JP2017519862A JP2017532045A5 JP 2017532045 A5 JP2017532045 A5 JP 2017532045A5 JP 2017519862 A JP2017519862 A JP 2017519862A JP 2017519862 A JP2017519862 A JP 2017519862A JP 2017532045 A5 JP2017532045 A5 JP 2017532045A5

Authority

JP

Japan

Prior art keywords

catalytically active

ada2

mutant

t147del

active portion

Prior art date

2015-10-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 101710142940 Adenosine deaminase 2 Proteins 0.000 claims 72
• 150000001413 amino acids Chemical class 0.000 claims 13
• 102220479490 NAD(+) hydrolase SARM1_K11A_mutation Human genes 0.000 claims 12
• 102220530054 Testis-expressed protein 10_E179V_mutation Human genes 0.000 claims 12
• 210000004027 cell Anatomy 0.000 claims 12
• 125000003275 alpha amino acid group Chemical group 0.000 claims 11
• 102220640720 ALK tyrosine kinase receptor_R20A_mutation Human genes 0.000 claims 10
• 206010028980 Neoplasm Diseases 0.000 claims 9
• 239000000539 dimer Substances 0.000 claims 7
• XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims 7
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• 125000000539 amino acid group Chemical group 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 102000004169 proteins and genes Human genes 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 5
• QWTLUPDHBKBULE-UHFFFAOYSA-N 2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetic acid Chemical compound NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(O)=O QWTLUPDHBKBULE-UHFFFAOYSA-N 0.000 claims 4
• 102100036664 Adenosine deaminase Human genes 0.000 claims 4
• 102220530094 Linker for activation of T-cells family member 2_R20E_mutation Human genes 0.000 claims 4
• 108010025198 decaglycine Proteins 0.000 claims 4
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
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• 102220580541 Non-receptor tyrosine-protein kinase TYK2_K26E_mutation Human genes 0.000 claims 2
• 102220479663 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN_K13E_mutation Human genes 0.000 claims 2
• 102220612902 Small EDRK-rich factor 1_K13A_mutation Human genes 0.000 claims 2
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• 102220532812 Villin-1_D86L_mutation Human genes 0.000 claims 2
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
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• 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
• 229930010555 Inosine Natural products 0.000 claims 1
• UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 1
• 102220578763 Mapk-regulated corepressor-interacting protein 1_R20D_mutation Human genes 0.000 claims 1
• 102220584011 Non-receptor tyrosine-protein kinase TYK2_K26D_mutation Human genes 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 102100040396 Transcobalamin-1 Human genes 0.000 claims 1
• 101710124861 Transcobalamin-1 Proteins 0.000 claims 1
• 229960005305 adenosine Drugs 0.000 claims 1
• 150000003838 adenosines Chemical class 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
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• 102200143877 c.257A>G Human genes 0.000 claims 1
• 230000003197 catalytic effect Effects 0.000 claims 1
• 238000012217 deletion Methods 0.000 claims 1
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• 229960002897 heparin Drugs 0.000 claims 1
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