US2488564A
(en)
|
1947-06-03 |
1949-11-22 |
Orthe Pharmaecutlcal Corp |
Preparation of hyaluronidase
|
US2488565A
(en)
|
1947-06-04 |
1949-11-22 |
Ortho Pharma Corp |
Preparation of hyaluronidase
|
US2676139A
(en)
|
1950-09-01 |
1954-04-20 |
American Home Prod |
Hyaluronidase
|
US2808362A
(en)
|
1952-05-02 |
1957-10-01 |
Armour & Co |
Preparation of hyaluronidase
|
US2795529A
(en)
|
1954-06-17 |
1957-06-11 |
American Home Prod |
Stabilized hyaluronidase solution containing calcium chloride
|
US2806815A
(en)
|
1955-04-12 |
1957-09-17 |
Ortho Pharma Corp |
Stabilized hyaluronidase
|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
US3630200A
(en)
|
1969-06-09 |
1971-12-28 |
Alza Corp |
Ocular insert
|
US3710795A
(en)
|
1970-09-29 |
1973-01-16 |
Alza Corp |
Drug-delivery device with stretched, rate-controlling membrane
|
US3847770A
(en)
|
1972-04-10 |
1974-11-12 |
Continental Can Co |
Photopolymerizable compositions prepared from beta hydroxy esters and polyitaconates
|
GB1429184A
(en)
|
1972-04-20 |
1976-03-24 |
Allen & Hanburys Ltd |
Physically anti-inflammatory steroids for use in aerosols
|
US4044126A
(en)
|
1972-04-20 |
1977-08-23 |
Allen & Hanburys Limited |
Steroidal aerosol compositions and process for the preparation thereof
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
GB8322007D0
(en)
|
1983-08-16 |
1983-09-21 |
Wellcome Found |
Pharmaceutical delivery system
|
US4952496A
(en)
|
1984-03-30 |
1990-08-28 |
Associated Universities, Inc. |
Cloning and expression of the gene for bacteriophage T7 RNA polymerase
|
US4769027A
(en)
|
1984-08-15 |
1988-09-06 |
Burroughs Wellcome Co. |
Delivery system
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
US4751180A
(en)
|
1985-03-28 |
1988-06-14 |
Chiron Corporation |
Expression using fused genes providing for protein product
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
US5716826A
(en)
|
1988-03-21 |
1998-02-10 |
Chiron Viagene, Inc. |
Recombinant retroviruses
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
WO1990009800A1
(en)
|
1989-02-21 |
1990-09-07 |
Washington University |
Modified forms of reproductive hormones
|
IT1229203B
(en)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS.
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
US5846951A
(en)
|
1991-06-06 |
1998-12-08 |
The School Of Pharmacy, University Of London |
Pharmaceutical compositions
|
US5262522A
(en)
|
1991-11-22 |
1993-11-16 |
Immunex Corporation |
Receptor for oncostatin M and leukemia inhibitory factor
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
US5349001A
(en)
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
AU7097094A
(en)
|
1993-06-01 |
1994-12-20 |
Enzon, Inc. |
Carbohydrate-modified polymer conjugates with erythropoietic activity
|
US5457035A
(en)
|
1993-07-23 |
1995-10-10 |
Immunex Corporation |
Cytokine which is a ligand for OX40
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
US5605976A
(en)
|
1995-05-15 |
1997-02-25 |
Enzon, Inc. |
Method of preparing polyalkylene oxide carboxylic acids
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
DK0690127T3
(en)
|
1994-03-31 |
1999-05-03 |
Amgen Inc |
Compositions and Methods for Stimulating Megakaryocyte Growth and Differentiation
|
US5795569A
(en)
|
1994-03-31 |
1998-08-18 |
Amgen Inc. |
Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
|
US20020159979A1
(en)
|
1994-06-06 |
2002-10-31 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
IT1270594B
(en)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
GB9422383D0
(en)
|
1994-11-05 |
1995-01-04 |
Wellcome Found |
Antibodies
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
US6030613A
(en)
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
US6086875A
(en)
|
1995-01-17 |
2000-07-11 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
US6485726B1
(en)
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
US5747027A
(en)
|
1995-04-07 |
1998-05-05 |
The Regents Of The University Of California |
BH55 hyaluronidase
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
US7153510B1
(en)
|
1995-05-04 |
2006-12-26 |
Yale University |
Recombinant vesiculoviruses and their uses
|
US5756593A
(en)
|
1995-05-15 |
1998-05-26 |
Enzon, Inc. |
Method of preparing polyalkyene oxide carboxylic acids
|
FR2735789B1
(en)
|
1995-06-23 |
1997-07-25 |
Centre Nat Rech Scient |
RECOMBINANT ADENOVIRUSES, THEIR USE FOR PREPARING AVA, COMPLEMENTARY CELL LINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
EP0850313B8
(en)
|
1995-09-08 |
2009-07-29 |
Genzyme Corporation |
Improved aav vectors for gene therapy
|
US7001765B2
(en)
|
1996-03-06 |
2006-02-21 |
Medigene Ag |
Adeno-associated virus vector for boosting immunogenicity of cells
|
US5747322A
(en)
|
1996-05-09 |
1998-05-05 |
The Regents Of The University Of California |
Recombinant crab collagenase
|
ES2300113T3
(en)
|
1996-08-02 |
2008-06-01 |
Bristol-Myers Squibb Company |
A PROCEDURE FOR INHIBITING TOXICITY INDUCED BY IMMUNOGLOBULINS RESULTING FROM THE USE OF IMMUNOGLOBULINS IN THERAPY AND IN VIVO DIAGNOSIS.
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
US6258351B1
(en)
|
1996-11-06 |
2001-07-10 |
Shearwater Corporation |
Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
WO1998035039A1
(en)
*
|
1997-02-06 |
1998-08-13 |
Human Genome Sciences, Inc. |
Dendritic cell-derived growth factor
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
ES2246069T3
(en)
|
1997-05-02 |
2006-02-01 |
Genentech, Inc. |
PROCEDURE FOR THE PREPARATION OF MULTI-SPECIFIC ANTIBODIES THAT HAVE COMMON AND MULTIMERIC COMPONENTS.
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
WO2001087925A2
(en)
|
2000-05-16 |
2001-11-22 |
Bolder Biotechnology, Inc. |
Methods for refolding proteins containing free cysteine residues
|
WO1999009139A1
(en)
|
1997-08-15 |
1999-02-25 |
Rubicon Laboratory, Inc. |
Retrovirus and viral vectors
|
AU9397098A
(en)
|
1997-09-19 |
1999-04-12 |
Trustees Of The University Of Pennsylvania, The |
Methods and cell line useful for production of recombinant adeno-associated viruses
|
US20050158273A1
(en)
|
1997-09-25 |
2005-07-21 |
Harris J. M. |
Soluble, degradable polyethylene glycol) derivatives for controllable release of bound molecules into solution
|
GB9722131D0
(en)
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
US6448369B1
(en)
|
1997-11-06 |
2002-09-10 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
US6180095B1
(en)
|
1997-12-17 |
2001-01-30 |
Enzon, Inc. |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
|
AU1825299A
(en)
|
1997-12-17 |
1999-07-05 |
Enzon, Inc. |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
US5965119A
(en)
|
1997-12-30 |
1999-10-12 |
Enzon, Inc. |
Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
|
US6624142B2
(en)
|
1997-12-30 |
2003-09-23 |
Enzon, Inc. |
Trimethyl lock based tetrapartate prodrugs
|
EP1061954B1
(en)
|
1998-03-12 |
2004-06-09 |
Nektar Therapeutics Al, Corporation |
Poly(ethylene glycol) derivatives with proximal reactive groups
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
IL138608A0
(en)
|
1998-04-02 |
2001-10-31 |
Genentech Inc |
Antibody variants and fragments thereof
|
US6824766B2
(en)
|
1998-04-17 |
2004-11-30 |
Enzon, Inc. |
Biodegradable high molecular weight polymeric linkers and their conjugates
|
US6251382B1
(en)
|
1998-04-17 |
2001-06-26 |
Enzon, Inc. |
Biodegradable high molecular weight polymeric linkers and their conjugates
|
US6153655A
(en)
|
1998-04-17 |
2000-11-28 |
Enzon, Inc. |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
US6436392B1
(en)
|
1998-05-20 |
2002-08-20 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors
|
CN1314992A
(en)
|
1998-07-03 |
2001-09-26 |
奈勒斯菲尔德控制有限公司 |
Method and arrangement for measuring fluid
|
CA2341029A1
(en)
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
US6420339B1
(en)
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
US6491907B1
(en)
|
1998-11-10 |
2002-12-10 |
The University Of North Carolina At Chapel Hill |
Recombinant parvovirus vectors and method of making
|
EP1006183A1
(en)
|
1998-12-03 |
2000-06-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Recombinant soluble Fc receptors
|
EP2112166B1
(en)
|
1998-12-23 |
2018-11-21 |
Pfizer Inc. |
Human monoclonal antibodies to ctla-4
|
US6682736B1
(en)
|
1998-12-23 |
2004-01-27 |
Abgenix, Inc. |
Human monoclonal antibodies to CTLA-4
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
PL209786B1
(en)
|
1999-01-15 |
2011-10-31 |
Genentech Inc |
Variant of mother polypeptide containing Fc region, polypeptide containing variant of Fc region with altered affinity of Fc gamma receptor binding (Fc R), polypeptide containing variant of Fc region with altered affinity of Fc gamma neonatal receptor binding (Fc Rn), composition, isolated nucleic acid, vector, host cell, method for obtaining polypeptide variant, the use thereof and method for obtaining region Fc variant
|
GB9904582D0
(en)
|
1999-02-26 |
1999-04-21 |
Nycomed Imaging As |
Process
|
US6428968B1
(en)
|
1999-03-15 |
2002-08-06 |
The Trustees Of The University Of Pennsylvania |
Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject
|
CZ299516B6
(en)
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Erythropoietin glycoprotein conjugate, process for its preparation and use and pharmaceutical composition containing thereof
|
PE20010288A1
(en)
|
1999-07-02 |
2001-03-07 |
Hoffmann La Roche |
ERYTHROPOYETIN DERIVATIVES
|
DE19933288A1
(en)
|
1999-07-15 |
2001-01-18 |
Medigene Ag |
Structural protein of adeno-associated virus with altered antigenicity, its production and use
|
US6461802B1
(en)
|
1999-08-02 |
2002-10-08 |
Agfa-Gevaert |
Adhesive layer for polyester film
|
DE60033530T2
(en)
|
1999-08-24 |
2007-10-31 |
Medarex Inc. |
HUMAN ANTIBODIES TO CTLA-4 AND THEIR USES
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
US7241447B1
(en)
|
1999-10-07 |
2007-07-10 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors and uses thereof
|
WO2001045737A2
(en)
|
1999-12-22 |
2001-06-28 |
Onyx Pharmaceuticals, Inc. |
Herpes simplex virus-1 glycoprotein c mutants for treating unwanted hyperproliferative cell growth
|
WO2001046291A1
(en)
|
1999-12-22 |
2001-06-28 |
Shearwater Corporation |
Sterically hindered derivatives of water soluble polymers
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
WO2001053505A2
(en)
|
2000-01-21 |
2001-07-26 |
Biovex Limited |
Herpes virus strains for gene therapy
|
WO2001062827A2
(en)
|
2000-02-22 |
2001-08-30 |
Shearwater Corporation |
N-maleimidyl polymer derivatives
|
US6586398B1
(en)
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
JP2003530838A
(en)
|
2000-04-12 |
2003-10-21 |
ヒューマン ゲノム サイエンシズ インコーポレイテッド |
Albumin fusion protein
|
US7306902B2
(en)
|
2002-06-28 |
2007-12-11 |
Oncolyties Biotech Inc. |
Oncolytic viruses as phenotyping agents for neoplasms
|
ATE313554T1
(en)
|
2000-05-16 |
2006-01-15 |
Lipoxen Technologies Ltd |
DERIVATIZATION OF PROTEINS IN AQUEOUS SOLVENT
|
GB0029407D0
(en)
|
2000-12-01 |
2001-01-17 |
Affitech As |
Product
|
EP1355919B1
(en)
|
2000-12-12 |
2010-11-24 |
MedImmune, LLC |
Molecules with extended half-lives, compositions and uses thereof
|
ATE505204T1
(en)
|
2000-12-20 |
2011-04-15 |
Hoffmann La Roche |
CONJUGATES OF ERYTHROPOIETIN (EPO) WITH POLYETHYLENE GLYCOL (PEG)
|
TWI246524B
(en)
|
2001-01-19 |
2006-01-01 |
Shearwater Corp |
Multi-arm block copolymers as drug delivery vehicles
|
US20020096037A1
(en)
|
2001-01-25 |
2002-07-25 |
Richard Muller |
Color-coded melody text and method of teaching
|
US6888319B2
(en)
|
2001-03-01 |
2005-05-03 |
Palomar Medical Technologies, Inc. |
Flashlamp drive circuit
|
JP4336771B2
(en)
|
2001-03-09 |
2009-09-30 |
モルフォシス アーゲー |
Serum albumin binding moiety
|
US6653103B2
(en)
|
2001-03-30 |
2003-11-25 |
Wisconsin Alumni Research Foundation |
Inhibition of nucleocytoplasmic transport by vesicular stomatitis virus M protein-like polypeptides
|
US20040106794A1
(en)
|
2001-04-16 |
2004-06-03 |
Schering Corporation |
3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
|
CA2442648C
(en)
|
2001-05-11 |
2012-10-16 |
Pro-Virus, Inc. |
Oncolytic virus therapy
|
IL149701A0
(en)
|
2001-05-23 |
2002-11-10 |
Pfizer Prod Inc |
Use of anti-ctla-4 antibodies
|
US20030044386A1
(en)
|
2001-07-11 |
2003-03-06 |
Barber Glen N. |
Recombinant VSV for the treatment of tumor cells
|
US6908963B2
(en)
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
CA2466027C
(en)
|
2001-11-07 |
2013-01-08 |
Nektar Therapeutics Al, Corporation |
Branched polymers and their conjugates
|
US20080194481A1
(en)
|
2001-12-21 |
2008-08-14 |
Human Genome Sciences, Inc. |
Albumin Fusion Proteins
|
KR101271635B1
(en)
|
2001-12-21 |
2013-06-12 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
Albumin fusion proteins
|
CA2471363C
(en)
|
2001-12-21 |
2014-02-11 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
AU2003209446B2
(en)
|
2002-03-01 |
2008-09-25 |
Immunomedics, Inc. |
Bispecific antibody point mutations for enhancing rate of clearance
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
CN100343393C
(en)
|
2002-03-15 |
2007-10-17 |
布赖汉姆妇女医院 |
Central airway administration for systemic delivery of therapeutics
|
AU2003258060B2
(en)
|
2002-03-27 |
2007-07-12 |
Baylor College Of Medicine |
Potent oncolytic herpes simplex virus for cancer therapy
|
US20030225260A1
(en)
|
2002-04-30 |
2003-12-04 |
Snyder Richard O. |
Production of recombinant AAV virions
|
IL149820A0
(en)
|
2002-05-23 |
2002-11-10 |
Curetech Ltd |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
|
US20050220818A1
(en)
|
2002-06-21 |
2005-10-06 |
Wellstat Biologics Corporation |
Administration of therapeutic viruses
|
US7087229B2
(en)
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
US7122189B2
(en)
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
US7425619B2
(en)
|
2002-08-14 |
2008-09-16 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
CA2498297A1
(en)
|
2002-09-09 |
2004-03-18 |
University Of Tennessee Research Foundation |
Recombinatant mutants of rhabdovirus and methods of use thereof
|
AU2003270555B2
(en)
|
2002-09-09 |
2009-01-29 |
Nektar Therapeutics |
Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid
|
EP1553975B8
(en)
|
2002-09-27 |
2023-04-12 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
NZ521851A
(en)
|
2002-10-08 |
2005-02-25 |
Auckland Uniservices Ltd |
Nitroaniline-based unsymmetrical mustard alkylating agents for gene dependent enzyme prodrug therapy
|
EP1562972B1
(en)
|
2002-10-15 |
2010-09-08 |
Facet Biotech Corporation |
ALTERATION OF FcRn BINDING AFFINITIES OR SERUM HALF-LIVES OF ANTIBODIES BY MUTAGENESIS
|
KR20040040782A
(en)
|
2002-11-08 |
2004-05-13 |
선바이오(주) |
Novel hexa-arm polyethylene glycol and its derivatives and the methods of preparation thereof
|
GB2395337B
(en)
|
2002-11-14 |
2005-12-28 |
Gary Michael Wilson |
Warning Unit
|
AU2004204494B2
(en)
|
2003-01-09 |
2011-09-29 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
CN102139114A
(en)
|
2003-02-26 |
2011-08-03 |
尼克塔治疗公司 |
Polymer factor VIII moiety conjugates
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
EP1599598A4
(en)
|
2003-03-04 |
2007-08-08 |
Yeda Res & Dev |
Pon polypeptides, polynucleotides encoding same and compositions and methods utilizing same
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
DE602004024041D1
(en)
|
2003-03-05 |
2009-12-24 |
Halozyme Inc |
SOLUBLE HYALURONIDASE GLYCOPROTEIN (SHASEGP), METHOD OF ITS PREPARATION, USES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
MXPA05010260A
(en)
|
2003-03-27 |
2006-03-17 |
Ottawa Health Research Inst |
Mutant vesicular stomatitis viruses and use thereof.
|
US7731974B2
(en)
|
2003-03-27 |
2010-06-08 |
Ottawa Hospital Research Institute |
Mutant vesicular stomatitis viruses and uses thereof
|
US7610156B2
(en)
|
2003-03-31 |
2009-10-27 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
KR100512483B1
(en)
|
2003-05-07 |
2005-09-05 |
선바이오(주) |
Novel Preparation method of PEG-maleimide PEG derivatives
|
JP5048332B2
(en)
|
2003-05-23 |
2012-10-17 |
ネクター セラピューティクス |
Polymer derivatives having a specific atomic arrangement
|
WO2005000099A2
(en)
*
|
2003-06-09 |
2005-01-06 |
Genzyme Corporation |
BLOOD FACTOR DOMAINS (BFDs)
|
ES2735809T3
(en)
|
2003-08-12 |
2019-12-20 |
Lipoxen Tech Limited |
Derivatives of sialic acid for protein derivatization and conjugation
|
AU2004278684B2
(en)
|
2003-09-30 |
2011-05-12 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor
|
GB0324368D0
(en)
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
GB0326798D0
(en)
|
2003-11-17 |
2003-12-24 |
Crusade Lab Ltd |
Methods for generating mutant virus
|
JP2007511216A
(en)
|
2003-11-17 |
2007-05-10 |
クルセイド ラボラトリーズ リミテッド |
Mutant virus
|
US7897146B2
(en)
|
2003-11-17 |
2011-03-01 |
Crusade Laboratories Limited |
Treatment using herpes simplex virus
|
EP2221315A1
(en)
|
2003-12-04 |
2010-08-25 |
Xencor, Inc. |
Methods of generating variant proteins with increased host string content and compositions thereof
|
EP1718677B1
(en)
|
2003-12-19 |
2012-04-18 |
Genentech, Inc. |
Monovalent antibody fragments useful as therapeutics
|
US20050249723A1
(en)
|
2003-12-22 |
2005-11-10 |
Xencor, Inc. |
Fc polypeptides with novel Fc ligand binding sites
|
US20080089892A1
(en)
|
2004-01-12 |
2008-04-17 |
Eli Lilly And Co. |
Fc Region Variants
|
US7375078B2
(en)
|
2004-02-23 |
2008-05-20 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
WO2005092925A2
(en)
|
2004-03-24 |
2005-10-06 |
Xencor, Inc. |
Immunoglobulin variants outside the fc region
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
WO2005118799A1
(en)
|
2004-04-15 |
2005-12-15 |
Ista Pharmaceuticals, Inc. |
Ovine hyaluronidase
|
WO2005116224A2
(en)
|
2004-05-18 |
2005-12-08 |
Children's Memorial Hospital |
Tetracycline-regulated adeno-associated viral (aav) vectors for gene delivery to the nervous system
|
US7427396B2
(en)
|
2004-06-03 |
2008-09-23 |
Genzyme Corporation |
AAV vectors for gene delivery to the lung
|
WO2006002394A2
(en)
|
2004-06-24 |
2006-01-05 |
New York University |
Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
SI2471813T1
(en)
|
2004-07-15 |
2015-03-31 |
Xencor, Inc. |
Optimized Fc variants
|
US20070166281A1
(en)
|
2004-08-21 |
2007-07-19 |
Kosak Kenneth M |
Chloroquine coupled antibodies and other proteins with methods for their synthesis
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
EP1819823A2
(en)
|
2004-12-01 |
2007-08-22 |
Bayer Schering Pharma Aktiengesellschaft |
Generation of replication competent viruses for therapeutic use
|
MX2007011767A
(en)
|
2005-03-23 |
2007-10-18 |
Pfizer Prod Inc |
Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer.
|
SI2161336T1
(en)
|
2005-05-09 |
2013-11-29 |
Ono Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
|
EP2963118B1
(en)
|
2005-06-01 |
2017-08-09 |
California Institute of Technology |
Method of targeted gene delivery using viral vectors
|
CN105483093A
(en)
|
2005-06-23 |
2016-04-13 |
休斯顿大学 |
Use of mutant herpes simplex virus-2 for cancer therapy
|
BRPI0613361A2
(en)
|
2005-07-01 |
2011-01-04 |
Medarex Inc |
isolated human monoclonal antibody, composition, immunoconjugate, bispecific molecule, isolated nucleic acid molecule, expression vector, host cell, transgenic mouse, method for modulating an immune response in an individual, method for inhibiting tumor cell growth in an individual, method for treating an infectious disease in a subject, a method for enhancing an immune response to an antigen in a subject, a method for treating or preventing an inflammatory disease in a subject, and a method for preparing the anti-pd-11 antibody
|
MX2008001865A
(en)
|
2005-08-12 |
2008-04-15 |
Human Genome Sciences Inc |
Albumin fusion proteins.
|
US7943374B2
(en)
|
2005-08-21 |
2011-05-17 |
Markus Hildinger |
Super-size adeno-associated viral vector harboring a recombinant genome larger than 5.7 kb
|
US7301003B2
(en)
|
2005-08-26 |
2007-11-27 |
Enzon Pharmaceuticals, Inc. |
Method of preparing polymers having terminal amine groups
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
US7846445B2
(en)
|
2005-09-27 |
2010-12-07 |
Amunix Operating, Inc. |
Methods for production of unstructured recombinant polymers and uses thereof
|
US7601798B2
(en)
|
2005-10-04 |
2009-10-13 |
Enzon Pharmaceuticals, Inc. |
Methods of preparing polymers having terminal amine groups using protected amine salts
|
US7989554B2
(en)
|
2006-01-10 |
2011-08-02 |
Enzon Pharmaceuticals, Inc. |
Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
|
US8048848B2
(en)
|
2006-02-03 |
2011-11-01 |
Prolor Biotech Ltd. |
Long-acting interferons and derivatives thereof and methods thereof
|
CA2643182C
(en)
|
2006-03-13 |
2014-09-02 |
Tir Technology Lp |
Adaptive control apparatus and method for a solid-state lighting system
|
EP2038424A2
(en)
|
2006-06-21 |
2009-03-25 |
Enzon Pharmaceuticals, Inc. |
Stabilized proteins
|
US20100254944A1
(en)
|
2006-09-14 |
2010-10-07 |
Mani Subramanian |
Albumin Fusion Proteins
|
AU2007296189A1
(en)
|
2006-09-15 |
2008-03-20 |
Enzon Pharmaceuticals, Inc. |
Polyalkylene oxides having hindered ester-based biodegradable linkers
|
US20100178684A1
(en)
|
2006-12-21 |
2010-07-15 |
Woo Savio L C |
Transgenic oncolytic viruses and uses thereof
|
EP2114420B1
(en)
|
2007-02-16 |
2016-01-27 |
Virttu Biologics Limited |
Herpes simplex viruses and methods of viral replication
|
NZ580980A
(en)
|
2007-04-20 |
2012-04-27 |
Sigma Tau Rare Diseases S A |
Enzymatic anticancer therapy
|
US8071741B2
(en)
*
|
2007-04-20 |
2011-12-06 |
Defiante Farmaceutica, S.A. |
Stable recombinant adenosine deaminase
|
EP2535354B1
(en)
|
2007-06-18 |
2017-01-11 |
Merck Sharp & Dohme B.V. |
Antibodies to human programmed death receptor pd-1
|
EP2369005B1
(en)
|
2007-06-21 |
2013-04-03 |
Technische Universität München |
Biological active proteins having increased in vivo and/or in vitro stability
|
KR20100058541A
(en)
|
2007-08-15 |
2010-06-03 |
아뮤닉스 인코포레이티드 |
Compositions and methods for modifying properties of biologically active polypeptides
|
US8187855B2
(en)
|
2008-03-06 |
2012-05-29 |
Halozyme, Inc. |
Large-scale production of soluble hyaluronidase
|
US8313896B2
(en)
|
2008-04-04 |
2012-11-20 |
The General Hospital Corporation |
Oncolytic herpes simplex virus immunotherapy in the treatment of brain cancer
|
EP2307033A4
(en)
|
2008-05-29 |
2012-06-13 |
Gen Hospital Corp |
Use of oncolytic herpes viruses for killing cancer stem cells
|
US20110223188A1
(en)
|
2008-08-25 |
2011-09-15 |
Solomon Langermann |
Targeted costimulatory polypeptides and methods of use to treat cancer
|
EP2335221B8
(en)
|
2008-09-16 |
2016-05-25 |
Novartis AG |
Reproducible quantification of biomarker expression
|
KR20210060670A
(en)
|
2008-12-09 |
2021-05-26 |
제넨테크, 인크. |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
CA2746181C
(en)
|
2008-12-09 |
2016-03-15 |
Halozyme, Inc. |
Extended soluble ph20 polypeptides and uses thereof
|
US8481297B2
(en)
|
2009-01-08 |
2013-07-09 |
Yale University |
Compositions and methods of use of an oncolytic vesicular stomatitis virus
|
ES2730800T3
(en)
|
2009-02-03 |
2019-11-12 |
Amunix Pharmaceuticals Inc |
Extended recombinant polypeptides and compositions comprising the same
|
US8703717B2
(en)
|
2009-02-03 |
2014-04-22 |
Amunix Operating Inc. |
Growth hormone polypeptides and methods of making and using same
|
US8680050B2
(en)
|
2009-02-03 |
2014-03-25 |
Amunix Operating Inc. |
Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
|
ES2385251B1
(en)
|
2009-05-06 |
2013-05-06 |
Fundació Privada Institut D'investigació Biomèdica De Bellvitge |
ONCOLYTIC ADENOVIRUSES FOR THE TREATMENT OF CANCER.
|
US20120134977A1
(en)
|
2009-06-01 |
2012-05-31 |
Yeda Research And Development Co. Ltd. |
Prodrugs containing albumin binding probe
|
CN106916229A
(en)
|
2009-06-08 |
2017-07-04 |
阿穆尼克斯运营公司 |
Growth hormone polypeptides and its preparation and application
|
DK2440228T3
(en)
|
2009-06-08 |
2018-12-17 |
Amunix Operating Inc |
Glucose regulating polypeptides and methods for their preparation and use
|
AU2010290131C1
(en)
|
2009-08-24 |
2015-12-03 |
Amunix Operating Inc. |
Coagulation factor VII compositions and methods of making and using same
|
WO2011028344A2
(en)
|
2009-08-25 |
2011-03-10 |
Amunix Operating Inc. |
Interleukin-1 receptor antagonist compositions and methods of making and using same
|
WO2011041093A1
(en)
|
2009-10-01 |
2011-04-07 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer
|
BR122021025338B1
(en)
|
2009-11-24 |
2023-03-14 |
Medimmune Limited |
ISOLATED ANTIBODY OR BINDING FRAGMENT THEREOF AGAINST B7-H1, PHARMACEUTICAL COMPOSITION AND ITS USES
|
US20130017199A1
(en)
|
2009-11-24 |
2013-01-17 |
AMPLIMMUNE ,Inc. a corporation |
Simultaneous inhibition of pd-l1/pd-l2
|
CA2782424C
(en)
|
2009-12-06 |
2021-07-27 |
Biogen Idec Hemophilia Inc. |
Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof
|
US9611310B2
(en)
|
2010-07-09 |
2017-04-04 |
Bioverativ Therapeutics Inc. |
Systems for factor VIII processing and methods thereof
|
EA201291482A1
(en)
|
2010-07-09 |
2013-10-30 |
Байоджен Айдек Хемофилия Инк. |
CHEMERIC COAGULATION FACTORS
|
US20130017997A1
(en)
|
2010-08-19 |
2013-01-17 |
Amunix Operating Inc. |
Factor VIII Compositions and Methods of Making and Using Same
|
KR20130096731A
(en)
|
2010-09-08 |
2013-08-30 |
할로자임, 아이엔씨 |
Methods for assessing and identifying or evolving conditionally active therapeutic proteins
|
ES2754394T3
(en)
|
2010-09-08 |
2020-04-17 |
Chemotherapeutisches Forschungsinstitut Georg Speyer Haus |
Chimeric antigen receptors with an optimized hinge region
|
EP3305798A1
(en)
|
2010-12-09 |
2018-04-11 |
The Trustees of The University of Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
EP2907504B1
(en)
|
2011-02-08 |
2017-06-28 |
Halozyme, Inc. |
Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
|
JP5987053B2
(en)
|
2011-05-12 |
2016-09-06 |
ジェネンテック, インコーポレイテッド |
Multiple reaction monitoring LC-MS / MS method for detecting therapeutic antibodies in animal samples using framework signature peptides
|
WO2013019906A1
(en)
|
2011-08-01 |
2013-02-07 |
Genentech, Inc. |
Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
|
WO2013059593A1
(en)
|
2011-10-20 |
2013-04-25 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Anti-cd22 chimeric antigen receptors
|
IN2014CN04961A
(en)
|
2011-12-05 |
2015-09-18 |
Igenica Biotherapeutics Inc |
|
ES2749620T3
(en)
|
2011-12-30 |
2020-03-23 |
Halozyme Inc |
PH20 polypeptide variants, formulations, and uses thereof
|
US20140170159A9
(en)
|
2012-03-08 |
2014-06-19 |
Ge Wei |
Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof
|
ES2786263T3
(en)
|
2012-07-13 |
2020-10-09 |
Univ Pennsylvania |
Enhancement of T-lymphocyte CAR activity by co-introduction of a bispecific antibody
|
EP3783098A1
(en)
|
2013-05-14 |
2021-02-24 |
Board Of Regents, The University Of Texas System |
Human application of engineered chimeric antigen receptor (car) t-cells
|
WO2015031771A2
(en)
|
2013-08-30 |
2015-03-05 |
Board Of Regents, The University Of Texas System |
Administration of kynurenine depleting enzymes for tumor therapy
|
CN107011441B
(en)
|
2013-09-13 |
2020-12-01 |
百济神州(广州)生物科技有限公司 |
anti-PD 1 antibodies and their use as therapeutic and diagnostic agents
|
EP4303229A3
(en)
|
2014-01-21 |
2024-04-17 |
Novartis AG |
Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
|
PL3207130T3
(en)
|
2014-10-14 |
2020-02-28 |
Halozyme, Inc. |
Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
|