JP2017527284A5 - - Google Patents
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- JP2017527284A5 JP2017527284A5 JP2017512039A JP2017512039A JP2017527284A5 JP 2017527284 A5 JP2017527284 A5 JP 2017527284A5 JP 2017512039 A JP2017512039 A JP 2017512039A JP 2017512039 A JP2017512039 A JP 2017512039A JP 2017527284 A5 JP2017527284 A5 JP 2017527284A5
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- JP
- Japan
- Prior art keywords
- deletion
- variant
- csgg
- substitution
- pore
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022133867A JP2022177005A (ja) | 2014-09-01 | 2022-08-25 | 変異体ポア |
| JP2024085524A JP2024122996A (ja) | 2014-09-01 | 2024-05-27 | 変異体ポア |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1415455.3 | 2014-09-01 | ||
| GB201415455A GB201415455D0 (en) | 2014-09-01 | 2014-09-01 | Protein pores and sensing applications |
| GB201422079 | 2014-12-11 | ||
| GB1422079.2 | 2014-12-11 | ||
| GB1506489.2 | 2015-04-16 | ||
| GBGB1506489.2A GB201506489D0 (en) | 2014-09-01 | 2015-04-16 | Protein pores for sensing applications |
| GB1506754.9 | 2015-04-21 | ||
| GBGB1506754.9A GB201506754D0 (en) | 2015-04-21 | 2015-04-21 | Mutant pore |
| GB1508287.8 | 2015-05-14 | ||
| GBGB1508287.8A GB201508287D0 (en) | 2015-05-14 | 2015-05-14 | Mutant pores |
| GB1511203.0 | 2015-06-25 | ||
| GBGB1511203.0A GB201511203D0 (en) | 2015-06-25 | 2015-06-25 | Mutant pore |
| GBGB1515240.8A GB201515240D0 (en) | 2015-08-27 | 2015-08-27 | Mutant pore |
| GB1515240.8 | 2015-08-27 | ||
| PCT/EP2015/069965 WO2016034591A2 (en) | 2014-09-01 | 2015-09-01 | Mutant pores |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020204136A Division JP2021078500A (ja) | 2014-09-01 | 2020-12-09 | 変異体ポア |
| JP2022133867A Division JP2022177005A (ja) | 2014-09-01 | 2022-08-25 | 変異体ポア |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527284A JP2017527284A (ja) | 2017-09-21 |
| JP2017527284A5 true JP2017527284A5 (enExample) | 2018-10-11 |
| JP7161291B2 JP7161291B2 (ja) | 2022-10-26 |
Family
ID=55440449
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512039A Active JP7161291B2 (ja) | 2014-09-01 | 2015-09-01 | 変異体ポア |
| JP2020204136A Pending JP2021078500A (ja) | 2014-09-01 | 2020-12-09 | 変異体ポア |
| JP2022133867A Pending JP2022177005A (ja) | 2014-09-01 | 2022-08-25 | 変異体ポア |
| JP2024085524A Pending JP2024122996A (ja) | 2014-09-01 | 2024-05-27 | 変異体ポア |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020204136A Pending JP2021078500A (ja) | 2014-09-01 | 2020-12-09 | 変異体ポア |
| JP2022133867A Pending JP2022177005A (ja) | 2014-09-01 | 2022-08-25 | 変異体ポア |
| JP2024085524A Pending JP2024122996A (ja) | 2014-09-01 | 2024-05-27 | 変異体ポア |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10400014B2 (enExample) |
| EP (2) | EP3224274B1 (enExample) |
| JP (4) | JP7161291B2 (enExample) |
| KR (3) | KR20250130441A (enExample) |
| CN (7) | CN117164682A (enExample) |
| AU (1) | AU2015310913B2 (enExample) |
| CA (1) | CA2959220A1 (enExample) |
| WO (1) | WO2016034591A2 (enExample) |
Families Citing this family (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| AU2012264497B2 (en) | 2011-05-27 | 2017-06-15 | Oxford Nanopore Technologies Limited | Coupling method |
| JP6298404B2 (ja) | 2011-07-25 | 2018-03-20 | オックスフォード ナノポール テクノロジーズ リミテッド | 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法 |
| JP6226869B2 (ja) | 2011-10-21 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| CN112646019B (zh) | 2012-04-10 | 2022-08-16 | 牛津纳米孔科技公开有限公司 | 突变胞溶素孔 |
| EP2875154B1 (en) | 2012-07-19 | 2017-08-23 | Oxford Nanopore Technologies Limited | SSB method for characterising a nucleic acid |
| AU2013291763B2 (en) | 2012-07-19 | 2019-06-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| GB201222928D0 (en) | 2012-12-19 | 2013-01-30 | Oxford Nanopore Tech Ltd | Analysis of a polynucleotide |
| AU2014224432B2 (en) | 2013-03-08 | 2019-10-24 | Oxford Nanopore Technologies Limited | Enzyme stalling method |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| CA2927726A1 (en) | 2013-10-18 | 2015-04-23 | Oxford Nanopore Technologies Limited | Modified helicases for use in nucleic acid sequencing |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| EP3097210B2 (en) | 2014-01-22 | 2022-04-20 | Oxford Nanopore Technologies Limited | Method for attaching one or more polynucleotide binding proteins to a target polynucleotide |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| EP3137490B1 (en) | 2014-05-02 | 2021-01-27 | Oxford Nanopore Technologies Limited | Mutant pores |
| US10400014B2 (en) | 2014-09-01 | 2019-09-03 | Oxford Nanopore Technologies Ltd. | Mutant CsgG pores |
| US10266885B2 (en) | 2014-10-07 | 2019-04-23 | Oxford Nanopore Technologies Ltd. | Mutant pores |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| EP3283887B1 (en) | 2015-04-14 | 2021-07-21 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| GB201508669D0 (en) | 2015-05-20 | 2015-07-01 | Oxford Nanopore Tech Ltd | Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown |
| WO2017004504A1 (en) | 2015-07-02 | 2017-01-05 | The University Of Massachusetts | Membrane and droplet-interface bilayer systems and methods |
| AU2016369071B2 (en) | 2015-12-08 | 2022-05-19 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Modified nanopores, compositions comprising the same, and uses thereof |
| KR102222192B1 (ko) | 2016-03-02 | 2021-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 기공 |
| JP7364333B2 (ja) | 2016-04-06 | 2023-10-18 | オックスフォード ナノポール テクノロジーズ ピーエルシー | 変異体ポア |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| WO2017203268A1 (en) | 2016-05-25 | 2017-11-30 | Oxford Nanopore Technologies Limited | Method |
| GB201611770D0 (en) | 2016-07-06 | 2016-08-17 | Oxford Nanopore Tech | Microfluidic device |
| GB201616590D0 (en) | 2016-09-29 | 2016-11-16 | Oxford Nanopore Technologies Limited | Method |
| GB201617886D0 (en) | 2016-10-21 | 2016-12-07 | Oxford Nanopore Technologies Limited | Method |
| GB201619930D0 (en) | 2016-11-24 | 2017-01-11 | Oxford Nanopore Tech | Apparatus and methods for controlling insertion of a membrane channel into a membrane |
| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| AU2018218531B2 (en) | 2017-02-10 | 2021-01-28 | Oxford Nanopore Technologies Limited | Modified nanopores, compositions comprising the same, and uses thereof |
| WO2018170362A2 (en) * | 2017-03-16 | 2018-09-20 | The Penn State Research Foundation | Versatile display scaffolds for proteins |
| GB201707122D0 (en) * | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB201707138D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Machine learning analysis of nanopore measurements |
| KR102593484B1 (ko) | 2017-06-29 | 2023-10-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 나노포어를 통한 폴리머의 결정적 스텝핑 |
| CN117106037B (zh) * | 2017-06-30 | 2025-07-25 | 弗拉芒区生物技术研究所 | 新颖蛋白孔 |
| WO2019081442A1 (en) * | 2017-10-23 | 2019-05-02 | F. Hoffmann-La Roche Ag | REMOVAL AND REINTEGRATION OF PROTEIN NANOPORES IN A MEMBRANE USING AN OSMOTIC IMBALANCE |
| GB2568895B (en) | 2017-11-29 | 2021-10-27 | Oxford Nanopore Tech Ltd | Microfluidic device |
| GB2569630B (en) | 2017-12-21 | 2022-10-12 | Sharp Life Science Eu Ltd | Droplet Interfaces in Electro-wetting Devices |
| GB201801768D0 (en) | 2018-02-02 | 2018-03-21 | Oxford Nanopore Tech Ltd | Synthesis method |
| GB201808556D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| GB2574048B (en) | 2018-05-24 | 2021-06-16 | Oxford Nanopore Tech Ltd | Nanopore sensor component with electrostatic discharge protection |
| CN112203767B (zh) | 2018-05-24 | 2023-04-11 | 牛津纳米孔科技公司 | 电润湿装置中的液滴界面 |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| MX2020013158A (es) * | 2018-06-08 | 2021-04-29 | Modalis Therapeutics Corp | Proteina cas9 modificada y uso de la misma. |
| GB201812615D0 (en) | 2018-08-02 | 2018-09-19 | Ucl Business Plc | Membrane bound nucleic acid nanopores |
| GB201814369D0 (en) | 2018-09-04 | 2018-10-17 | Oxford Nanopore Tech Ltd | Method for determining a polymersequence |
| CN112823392B (zh) * | 2018-10-12 | 2024-09-03 | 生命科技股份有限公司 | 用于评估微卫星不稳定性状态的方法和系统 |
| JP7499761B2 (ja) * | 2018-11-08 | 2024-06-14 | オックスフォード ナノポール テクノロジーズ ピーエルシー | 細孔 |
| GB201818216D0 (en) | 2018-11-08 | 2018-12-26 | Oxford Nanopore Tech Ltd | Pore |
| GB201819378D0 (en) | 2018-11-28 | 2019-01-09 | Oxford Nanopore Tech Ltd | Analysis of nanopore signal using a machine-learning technique |
| WO2020109800A1 (en) | 2018-11-28 | 2020-06-04 | Oxford Nanopore Technologies Ltd. | Sensing system and method of operation |
| GB201821155D0 (en) | 2018-12-21 | 2019-02-06 | Oxford Nanopore Tech Ltd | Method |
| CN111499705B (zh) * | 2019-01-30 | 2023-08-08 | 深圳市梅丽纳米孔科技有限公司 | 一种突变NfpAB纳米孔、测试系统及制作方法与应用 |
| KR20210138594A (ko) | 2019-03-12 | 2021-11-19 | 옥스포드 나노포어 테크놀로지즈 피엘씨 | 나노포어 감지 디바이스 및 이를 작동하는 방법 및 형성하는 방법 |
| GB2580988B (en) | 2019-03-19 | 2022-04-13 | Oxford Nanopore Tech Ltd | Current measurement apparatus, molecular entity sensing apparatus, method of measuring a current, method of sensing a molecular entity |
| GB201907243D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Sensing interactions between molecular entities and nanapores |
| GB201907244D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| GB201907246D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| US11926819B2 (en) | 2019-05-28 | 2024-03-12 | The Regents Of The University Of California | Methods of adding polymers to ribonucleic acids |
| GB201915480D0 (en) | 2019-10-25 | 2019-12-11 | Oxford Nanopore Tech Ltd | Improved nanopore sensing device, components and method of manufacture |
| GB201917060D0 (en) | 2019-11-22 | 2020-01-08 | Oxford Nanopore Tech Ltd | Method |
| CN118011004A (zh) | 2019-12-02 | 2024-05-10 | 牛津纳米孔科技公开有限公司 | 使用纳米孔表征靶多肽的方法 |
| GB201917742D0 (en) | 2019-12-04 | 2020-01-15 | Oxford Nanopore Tech Ltd | Method |
| US20240218415A1 (en) * | 2020-03-25 | 2024-07-04 | Universal Sequencing Technology Corporation | Enzyme mutants directly attached to a nanogap device |
| GB202004944D0 (en) | 2020-04-03 | 2020-05-20 | King S College London | Method |
| GB202016874D0 (en) | 2020-10-23 | 2020-12-09 | Oxford Nanopore Tech Ltd | Nanopore support structure and manufacture thereof |
| EP4168583A2 (en) | 2020-06-18 | 2023-04-26 | Oxford Nanopore Technologies plc | Method of characterising a polynucleotide moving through a nanopore |
| GB202009349D0 (en) | 2020-06-18 | 2020-08-05 | Oxford Nanopore Tech Ltd | Method |
| CN115698331A (zh) | 2020-06-18 | 2023-02-03 | 牛津纳米孔科技公开有限公司 | 使用检测器选择性地表征多核苷酸的方法 |
| WO2022013551A1 (en) | 2020-07-17 | 2022-01-20 | Oxford Nanopore Technologies Limited | Nanopore sensing device |
| WO2022020461A1 (en) | 2020-07-22 | 2022-01-27 | Oxford Nanopore Technologies Inc. | Solid state nanopore formation |
| CN117337333A (zh) | 2021-05-19 | 2024-01-02 | 牛津纳米孔科技公开有限公司 | 用于补体链测序的方法 |
| GB202107192D0 (en) | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| GB202107354D0 (en) | 2021-05-24 | 2021-07-07 | Oxford Nanopore Tech Ltd | Method |
| US20240352516A1 (en) * | 2021-08-18 | 2024-10-24 | Qitan Technology Ltd., Chengdu | Mutant of pore protein monomer, protein pore, and use thereof |
| EP4371998A1 (en) * | 2021-08-18 | 2024-05-22 | Qitan Technology Ltd., Chengdu | Mutant of porin monomer, protein pore and application thereof |
| CN113480620B (zh) * | 2021-08-18 | 2024-02-06 | 成都齐碳科技有限公司 | 孔蛋白单体的突变体、蛋白孔及其应用 |
| CN113651876B (zh) * | 2021-08-18 | 2024-02-02 | 成都齐碳科技有限公司 | 孔蛋白单体的突变体、蛋白孔及其应用 |
| GB2610380A (en) | 2021-08-23 | 2023-03-08 | Cambridge Entpr Ltd | Nucleic acid detection |
| GB202112235D0 (en) | 2021-08-26 | 2021-10-13 | Oxford Nanopore Tech Ltd | Nanopore |
| CN113735948B (zh) * | 2021-09-28 | 2024-02-02 | 成都齐碳科技有限公司 | 孔蛋白单体的突变体、蛋白孔及其应用 |
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