JP2017506065A5 - - Google Patents
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- Publication number
- JP2017506065A5 JP2017506065A5 JP2016547592A JP2016547592A JP2017506065A5 JP 2017506065 A5 JP2017506065 A5 JP 2017506065A5 JP 2016547592 A JP2016547592 A JP 2016547592A JP 2016547592 A JP2016547592 A JP 2016547592A JP 2017506065 A5 JP2017506065 A5 JP 2017506065A5
- Authority
- JP
- Japan
- Prior art keywords
- coli
- fucosyl lactose
- salt medium
- integrated
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940062827 2'-fucosyllactose Drugs 0.000 description 3
- HWHQUWQCBPAQQH-UHFFFAOYSA-N 2-O-alpha-L-Fucosyl-lactose Natural products OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(CO)OC1OC(C(O)CO)C(O)C(O)C=O HWHQUWQCBPAQQH-UHFFFAOYSA-N 0.000 description 3
- HWHQUWQCBPAQQH-BWRPKUOHSA-N 2-fucosyllactose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O HWHQUWQCBPAQQH-BWRPKUOHSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- SNFSYLYCDAVZGP-UHFFFAOYSA-N UNPD26986 Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(OC(O)C(O)C2O)CO)OC(CO)C(O)C1O SNFSYLYCDAVZGP-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 101100075927 Aspergillus aculeatus mndA gene Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241001198387 Escherichia coli BL21(DE3) Species 0.000 description 1
- 101100022282 Escherichia coli O157:H7 manC2 gene Proteins 0.000 description 1
- 102000006471 Fucosyltransferases Human genes 0.000 description 1
- 108010019236 Fucosyltransferases Proteins 0.000 description 1
- 101150102398 Galt gene Proteins 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 101100168102 Yersinia pseudotuberculosis colC gene Proteins 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 101150041441 fcl gene Proteins 0.000 description 1
- 101150002054 galE gene Proteins 0.000 description 1
- 101150045500 galK gene Proteins 0.000 description 1
- 101150054547 galM gene Proteins 0.000 description 1
- 101150106565 gmd gene Proteins 0.000 description 1
- 101150001899 lacY gene Proteins 0.000 description 1
- 101150088678 manB gene Proteins 0.000 description 1
- 101150032120 manC gene Proteins 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14151737.5 | 2014-01-20 | ||
| EP14151737.5A EP2896628B1 (en) | 2014-01-20 | 2014-01-20 | Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation |
| PCT/EP2014/079212 WO2015106943A1 (en) | 2014-01-20 | 2014-12-23 | PROCESS FOR EFFICIENT PURIFICATION OF NEUTRAL HUMAN MILK OLIGOSACCHARIDES (HMOs) FROM MICROBIAL FERMENTATION |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019191254A Division JP7000396B2 (ja) | 2014-01-20 | 2019-10-18 | 微生物発酵からの中性ヒトミルクオリゴ糖（ＨＭＯｓ）の効果的な精製のためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506065A JP2017506065A (ja) | 2017-03-02 |
| JP2017506065A5 true JP2017506065A5 (https=) | 2018-02-01 |
| JP6901857B2 JP6901857B2 (ja) | 2021-07-14 |
Family
ID=49949589
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016547592A Active JP6901857B2 (ja) | 2014-01-20 | 2014-12-23 | 微生物発酵からの中性ヒトミルクオリゴ糖（ＨＭＯｓ）の効果的な精製のためのプロセス |
| JP2019191254A Active JP7000396B2 (ja) | 2014-01-20 | 2019-10-18 | 微生物発酵からの中性ヒトミルクオリゴ糖（ＨＭＯｓ）の効果的な精製のためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019191254A Active JP7000396B2 (ja) | 2014-01-20 | 2019-10-18 | 微生物発酵からの中性ヒトミルクオリゴ糖（ＨＭＯｓ）の効果的な精製のためのプロセス |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US10377787B2 (https=) |
| EP (5) | EP2896628B1 (https=) |
| JP (2) | JP6901857B2 (https=) |
| KR (1) | KR102137027B1 (https=) |
| CN (1) | CN106132977B (https=) |
| AT (2) | AT17418U1 (https=) |
| AU (1) | AU2014377374B2 (https=) |
| BR (1) | BR112016016705A8 (https=) |
| CZ (2) | CZ35288U1 (https=) |
| DE (2) | DE202014011399U1 (https=) |
| DK (6) | DK2896628T3 (https=) |
| ES (4) | ES2701163T3 (https=) |
| FI (2) | FI3680249T3 (https=) |
| MX (2) | MX394692B (https=) |
| PH (2) | PH12016501421A1 (https=) |
| PL (4) | PL2896628T3 (https=) |
| RU (1) | RU2682445C2 (https=) |
| WO (1) | WO2015106943A1 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2896628B1 (en) | 2014-01-20 | 2018-09-19 | Jennewein Biotechnologie GmbH | Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation |
| US10500221B2 (en) | 2014-12-05 | 2019-12-10 | Glycom A/S | Crystalline difucosyllactose |
| EP3141610A1 (en) | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
| ES3011213T3 (en) | 2015-12-18 | 2025-04-07 | Glycom As | Fermentative production of oligosaccharides |
| ES2991621T3 (es) * | 2016-03-07 | 2024-12-04 | Glycom As | Separación de oligosacáridos de caldo de fermentación |
| DK3445770T3 (da) | 2016-04-19 | 2026-02-23 | Glycom As | Separering af oligosaccharider fra fermenteringssuppe |
| WO2019003135A1 (en) * | 2017-06-30 | 2019-01-03 | Glycom A/S | PURIFICATION OF OLIGOSACCHARIDES |
| CN110914284B (zh) | 2017-07-12 | 2025-01-07 | 格礼卡姆股份公司 | 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物 |
| EP3450443A1 (en) * | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
| WO2019063757A1 (en) | 2017-09-29 | 2019-04-04 | Frieslandcampina Nederland B.V. | PROCESS FOR PURIFYING NEUTRAL HUMAN MILK (HMO) OLIGOSACCHARIDE FROM MICROBIAL FERMENTATION |
| EP3486326A1 (en) * | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
| EP3494804B1 (en) | 2017-12-08 | 2025-08-13 | Chr. Hansen HMO GmbH | Spray-dried 3-fucosyllactose |
| EP3494806B1 (en) | 2017-12-08 | 2025-08-06 | Chr. Hansen HMO GmbH | Spray-dried lacto-n-fucopentaose |
| SG11202004659QA (en) * | 2017-12-08 | 2020-06-29 | Jennewein Biotechnologie Gmbh | Spray-dried sialyllactose |
| EP3494807A1 (en) | 2017-12-11 | 2019-06-12 | Jennewein Biotechnologie GmbH | Spray-dried sialyllactose |
| EP3494805B1 (en) | 2017-12-08 | 2025-08-13 | Chr. Hansen HMO GmbH | Spray-dried tetrasaccharides |
| EP3524067B1 (en) * | 2018-02-08 | 2025-04-02 | Chr. Hansen HMO GmbH | Spray-dried mixture of human milk oligosaccharides |
| EP3546060A1 (en) * | 2018-03-27 | 2019-10-02 | DuPont Nutrition Biosciences ApS | Process for spray drying fucosyllactose solutions and related product compositions |
| JP7492458B2 (ja) * | 2018-05-07 | 2024-05-29 | クリスチャン・ハンセン・ハーエムオー・ゲーエムベーハー | 微生物発酵によって得られた炭水化物からラクト－Ｎ－ネオテトラオース（ＬＮｎＴ）を精製するための簡素な方法 |
| CN112154150A (zh) * | 2018-05-23 | 2020-12-29 | 帝斯曼知识产权资产管理有限公司 | 寡糖的生产 |
| PL3801037T3 (pl) * | 2018-06-01 | 2023-01-23 | Chr. Hansen HMO GmbH | Prosty sposób oczyszczania sialilolaktozy |
| CN109111043B (zh) * | 2018-09-16 | 2021-11-09 | 苏州渭中科技发展有限公司 | 一种高盐高cod废水的处理方法 |
| CA3122178A1 (en) | 2018-12-19 | 2020-06-25 | Basf Se | Method for separating biomass from a solution comprising biomass and at least one oligosaccaride |
| WO2020128945A1 (en) | 2018-12-19 | 2020-06-25 | Glycom A/S | Separation of oligosaccharides |
| WO2020154217A1 (en) * | 2019-01-21 | 2020-07-30 | Dupont Nutrition Biosciences Aps | Process for making l-fucose |
| EP3686210A1 (en) * | 2019-01-24 | 2020-07-29 | DuPont Nutrition Biosciences ApS | Process for purifying a human milk oligosaccharide and related compositions |
| BE1027078A9 (nl) * | 2019-02-25 | 2020-09-28 | Nutribam Bvba | Samenstelling, voedingssupplement en werkwijze voor het ondersteunen en/of verbeteren van de darmgezondheid |
| WO2020174386A1 (en) | 2019-02-25 | 2020-09-03 | Nutribam Bvba | Composition, food supplement and method for supporting and/or improving intestinal health |
| EP3741770A1 (en) * | 2019-05-21 | 2020-11-25 | Jennewein Biotechnologie GmbH | Purification of oligosaccharides from a fermentation broth by using filtration |
| WO2020245313A1 (en) * | 2019-06-04 | 2020-12-10 | N.V. Nutricia | Nutritional composition comprising 2'fucosyllactose and 3'galactosyllactose |
| EP3750902A1 (en) | 2019-06-14 | 2020-12-16 | Jennewein Biotechnologie GmbH | Process for the purification of lacto-n-neotetraose |
| EP3822282A1 (en) * | 2019-11-18 | 2021-05-19 | DuPont Nutrition Biosciences ApS | Process for removing an antifoam agent from a solution comprising a human milk oligosaccharide and related compositions |
| WO2021045968A1 (en) | 2019-09-04 | 2021-03-11 | Dupont Nutrition Biosciences Aps | Process for removing an antifoam agent from a solution comprising a human milk oligosaccharide and related compositions |
| JP2022548785A (ja) | 2019-09-24 | 2022-11-21 | プロラクタ バイオサイエンス，インコーポレイテッド | 炎症性疾患及び免疫疾患の治療のための組成物及び方法 |
| US20230074506A1 (en) * | 2020-01-29 | 2023-03-09 | Dsm Ip Assets B.V. | Process for recovering & purifying human milk oligosaccharides |
| CN111540125B (zh) * | 2020-04-20 | 2021-01-05 | 中国人民解放军火箭军工程设计研究院 | 一种充电桩的充电管理方法、设备及计算机可读存储介质 |
| JP2023528657A (ja) * | 2020-06-12 | 2023-07-05 | ビーエーエスエフ ソシエタス・ヨーロピア | 発酵ブロスの改善された脱塩及び例えばオリゴ糖のファインケミカルの精製 |
| KR20230088680A (ko) | 2020-08-14 | 2023-06-20 | 프롤랙타 바이오사이언스, 인코포레이티드 | 박테리아 요법에 사용하기 위한 인간 모유 올리고당 조성물 |
| CN112568439A (zh) * | 2020-12-21 | 2021-03-30 | 湖北福星生物科技有限公司 | 一种从微生物发酵液中分离纯化母乳低聚糖的方法及其应用 |
| CA3204530A1 (en) | 2021-01-12 | 2022-07-21 | Gregory Mckenzie | Synbiotic treatment regimens |
| CN112920234B (zh) * | 2021-01-27 | 2022-03-29 | 南开大学 | 一种2′-岩藻糖基乳糖的富集纯化方法 |
| US20240349770A1 (en) * | 2021-04-30 | 2024-10-24 | Dsm Ip Assets B.V. | Infant formula with low level of arsenic |
| DK181242B1 (en) | 2021-05-17 | 2023-05-30 | Dsm Ip Assets Bv | GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME |
| EP4355465A1 (en) | 2021-06-15 | 2024-04-24 | DSM IP Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| US20240286081A1 (en) | 2021-06-15 | 2024-08-29 | Dsm Ip Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| US20250128210A1 (en) | 2021-06-15 | 2025-04-24 | Dsm Ip Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| WO2022263425A1 (en) | 2021-06-15 | 2022-12-22 | Dsm Ip Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| EP4418878A1 (en) | 2021-10-18 | 2024-08-28 | DSM IP Assets B.V. | A method for providing an amorphous hmo product by drying |
| CN114539433B (zh) * | 2021-12-29 | 2022-11-01 | 北京三元食品股份有限公司 | 一种乳低聚糖的制备方法及制备的低聚糖粉、食品 |
| WO2023182527A1 (ja) * | 2022-03-25 | 2023-09-28 | キリンホールディングス株式会社 | ラクトジフコテトラオース（ｌｄｆｔ）の製造法 |
| CN117003803A (zh) * | 2022-05-07 | 2023-11-07 | 山东恒鲁生物科技有限公司 | 一种三糖的新晶型 |
| CN115873051B (zh) * | 2022-05-17 | 2024-06-25 | 山东恒鲁生物科技有限公司 | 三糖的新晶型 |
| US20250361256A1 (en) | 2022-06-14 | 2025-11-27 | Dsm Ip Assets B.V. | Separation of human milk oligosaccharides from a fermentation broth |
| WO2024047096A1 (en) | 2022-08-30 | 2024-03-07 | Inbiose N.V. | Process for purification of an oligosaccharide |
| WO2024130119A2 (en) | 2022-12-16 | 2024-06-20 | Prolacta Bioscience, Inc. | Synbiotic compositions for short chain fatty acid production |
| CN115651039A (zh) * | 2022-12-27 | 2023-01-31 | 保龄宝生物股份有限公司 | 一种高密度2’-岩藻糖基乳糖的生产方法 |
| CN116425810B (zh) * | 2023-06-14 | 2023-08-11 | 山东合成远景生物科技有限公司 | 一种混合液中3-岩藻糖基乳糖的纯化方法 |
| CN117089503B (zh) | 2023-10-17 | 2024-01-02 | 保龄宝生物股份有限公司 | 一种大肠杆菌k-12 mg1655 blbyzt6及其应用 |
| WO2025114343A2 (en) * | 2023-11-29 | 2025-06-05 | Frieslandcampina Nederland B.V. | Process for the production of human milk oligosaccharides |
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-
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