MX2020002674A - Produccion de xilitol a partir de glucosa mediante una cepa recombinante. - Google Patents

Produccion de xilitol a partir de glucosa mediante una cepa recombinante.

Info

Publication number
MX2020002674A
MX2020002674A MX2020002674A MX2020002674A MX2020002674A MX 2020002674 A MX2020002674 A MX 2020002674A MX 2020002674 A MX2020002674 A MX 2020002674A MX 2020002674 A MX2020002674 A MX 2020002674A MX 2020002674 A MX2020002674 A MX 2020002674A
Authority
MX
Mexico
Prior art keywords
xylitol
production
glucose
recombinant strain
xylulose
Prior art date
Application number
MX2020002674A
Other languages
English (en)
Inventor
Markus Schwab
Sophie Defretin
Melanie Diefenbacher
Yiming Chang
Malca Sumire Honda
Tania Gerard
Arnaud Heysen
Friederike Thor
Astrid Schaefer
Original Assignee
Roquette Freres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roquette Freres filed Critical Roquette Freres
Publication of MX2020002674A publication Critical patent/MX2020002674A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/0101—L-Xylulose reductase (1.1.1.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01011—D-Arabinitol 4-dehydrogenase (1.1.1.11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un hospedador microbiano recombinante para la producción de xilitol, conteniendo el hospedador microbiano recombinante una secuencia de ácido nucleico que codifica una D-arabitol 4-oxidorreductasa específica de NAD+ (EC 1.1.1.11) que utiliza d-arabitol como sustrato y que produce D-xilulosa como producto, y una secuencia de ácido nucleico que codifica una xilitol deshidrogenasa específica de NADPH utilizando D-xilulosa como sustrato y produciendo xilitol como producto.
MX2020002674A 2014-06-18 2016-12-16 Produccion de xilitol a partir de glucosa mediante una cepa recombinante. MX2020002674A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14305934.3A EP2957640B1 (en) 2014-06-18 2014-06-18 Production of xylitol from glucose by a recombinant strain

Publications (1)

Publication Number Publication Date
MX2020002674A true MX2020002674A (es) 2020-07-22

Family

ID=50981446

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016016923A MX2016016923A (es) 2014-06-18 2015-06-17 Produccion de xilitol a partir de glucosa mediante una cepa recombinante.
MX2020002674A MX2020002674A (es) 2014-06-18 2016-12-16 Produccion de xilitol a partir de glucosa mediante una cepa recombinante.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016016923A MX2016016923A (es) 2014-06-18 2015-06-17 Produccion de xilitol a partir de glucosa mediante una cepa recombinante.

Country Status (14)

Country Link
US (2) US10494614B2 (es)
EP (2) EP2957640B1 (es)
JP (1) JP6537534B2 (es)
KR (1) KR102496301B1 (es)
CN (1) CN106661540B (es)
CA (1) CA2952709C (es)
DK (2) DK2957640T3 (es)
ES (2) ES2673865T3 (es)
MX (2) MX2016016923A (es)
PL (2) PL2957640T3 (es)
RU (1) RU2693593C2 (es)
SG (1) SG11201610417XA (es)
TR (2) TR201808404T4 (es)
WO (1) WO2015193350A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US11419903B2 (en) 2015-11-30 2022-08-23 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
DK2957640T3 (en) * 2014-06-18 2018-06-25 Roquette Freres Preparation of xylitol from glucose by a recombinant strain
CN108977432B (zh) * 2018-07-27 2021-04-06 浙江工业大学 重组大肠杆菌固定化细胞及在利用木糖母液生产木糖醇中的应用
US20230068713A1 (en) * 2019-12-18 2023-03-02 Evolva Sa Host cells and their use for producing ribitol and further monosaccharides
CN113025516A (zh) 2020-12-28 2021-06-25 浙江华康药业股份有限公司 一种利用木糖二次母液发酵制备木糖醇的方法
CN113151367A (zh) * 2021-05-10 2021-07-23 湖北工业大学 一种自我保护的鲁氏结合酵母从头合成木糖醇的发酵方法

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US4075406A (en) 1974-04-22 1978-02-21 Suomen Sokeri Osakeyhtio Process for making xylose
EP0454702B1 (en) 1989-01-17 1996-04-10 Xyrofin Oy Method for the production of xylitol from mixtures containing xylose
FR2652589B1 (fr) 1989-10-04 1995-02-17 Roquette Freres Procede de fabrication de xylitol et de produits riches en xylitol.
DE69326559T2 (de) * 1992-11-05 2000-02-10 Xyrofin Oy Espoo Rekombinante methode und wirt zur herstellung von xylitol
FR2765589B1 (fr) 1997-07-03 1999-09-17 Roquette Freres Fragment d'adn comprenant le promoteur de la ribulose reductase nadph specifique de yamadazyma ohmeri, vecteur le contenant et procede de preparation de proteines utilisant ce vecteur
JPH11266888A (ja) 1997-10-17 1999-10-05 Ajinomoto Co Inc キシリトールの製造法
FR2772788B1 (fr) 1997-12-19 2000-11-17 Roquette Freres Procede pour accroitre la production de certains polyols par une souche osmotolerante
JP2000295994A (ja) * 1999-02-09 2000-10-24 Ajinomoto Co Inc キシリトールの製造法
JP2001008682A (ja) 1999-06-24 2001-01-16 Ajinomoto Co Inc Ｄ−アラビトール、ｄ−キシルロース及びキシリトールの製造法
DE60002020T2 (de) * 1999-08-10 2004-02-12 Ajinomoto Co., Inc. Verfahren zur Herstellen von hochreinem Xylitol
JP2003520583A (ja) * 2000-01-21 2003-07-08 ダニスコ スイートナーズ オイ 五炭糖及び糖アルコールの製造
JP4453869B2 (ja) * 2004-06-25 2010-04-21 信和化工株式会社 変異型キシリトールデヒドロゲナーゼ酵素、これを産生する微生物、該酵素または微生物を用いたキシリトールをキシルロースに変換する方法
JP5219074B2 (ja) * 2008-01-24 2013-06-26 独立行政法人産業技術総合研究所 キシロース発酵能が優れた六炭糖・五炭糖同時発酵酵母およびそれを用いたエタノールの高効率生産方法
KR101175418B1 (ko) * 2009-11-30 2012-08-20 전남대학교산학협력단 신규한 자일리톨 탈수소효소 및 이를 이용한 자일리톨 생산방법
CN101880643B (zh) * 2010-06-03 2012-04-25 南京工业大学 氧化葡萄糖酸杆菌基因工程菌及其构建方法
CN102796797B (zh) * 2012-08-09 2014-07-09 山东天力药业有限公司 微生物转化葡萄糖制备木糖醇及其中间体d-木酮糖的方法及所用的菌种
DK2957640T3 (en) * 2014-06-18 2018-06-25 Roquette Freres Preparation of xylitol from glucose by a recombinant strain

Also Published As

Publication number Publication date
PL2957640T3 (pl) 2018-09-28
ES2673865T3 (es) 2018-06-26
BR112016029704A2 (pt) 2017-10-24
ES2733650T3 (es) 2019-12-02
KR20170020362A (ko) 2017-02-22
US20170130209A1 (en) 2017-05-11
EP2957640B1 (en) 2018-03-14
MX2016016923A (es) 2017-04-27
WO2015193350A1 (en) 2015-12-23
DK3158074T3 (da) 2019-07-22
JP2017518066A (ja) 2017-07-06
JP6537534B2 (ja) 2019-07-03
TR201909794T4 (tr) 2019-07-22
PL3158074T3 (pl) 2019-10-31
EP3158074A1 (en) 2017-04-26
CA2952709A1 (en) 2015-12-23
US10829742B2 (en) 2020-11-10
DK2957640T3 (en) 2018-06-25
CN106661540B (zh) 2021-02-09
CN106661540A (zh) 2017-05-10
RU2017101446A (ru) 2018-07-18
EP2957640A1 (en) 2015-12-23
EP3158074B1 (en) 2019-04-24
US10494614B2 (en) 2019-12-03
CA2952709C (en) 2022-11-08
RU2693593C2 (ru) 2019-07-03
US20200032224A1 (en) 2020-01-30
SG11201610417XA (en) 2017-01-27
TR201808404T4 (tr) 2018-07-23
KR102496301B1 (ko) 2023-02-07
RU2017101446A3 (es) 2018-10-26

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