TR201909794T4 - Bir rekombinant suş aracılığıyla glikozdan ksilitol üretimi. - Google Patents

Bir rekombinant suş aracılığıyla glikozdan ksilitol üretimi. Download PDF

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Publication number
TR201909794T4
TR201909794T4 TR2019/09794T TR201909794T TR201909794T4 TR 201909794 T4 TR201909794 T4 TR 201909794T4 TR 2019/09794 T TR2019/09794 T TR 2019/09794T TR 201909794 T TR201909794 T TR 201909794T TR 201909794 T4 TR201909794 T4 TR 201909794T4
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TR
Turkey
Prior art keywords
xylitol
production
glucose
recombinant strain
xylulose
Prior art date
Application number
TR2019/09794T
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English (en)
Inventor
schaefer Astrid
Diefenbacher Melanie
Chang Yiming
HONDA MALCA Sumire
Schwab Markus
Defretin Sophie
Gerard Tania
Heysen Arnaud
THOR Friederike
Original Assignee
Roquette Freres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roquette Freres filed Critical Roquette Freres
Publication of TR201909794T4 publication Critical patent/TR201909794T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/0101—L-Xylulose reductase (1.1.1.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01011—D-Arabinitol 4-dehydrogenase (1.1.1.11)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Mevcut buluş, ksilitol üretimine yönelik rekombinant bir mikrobiyal konak ile ilgilidir, rekombinant mikrobiyal konak substrat olarak D-arabitol kullanan ve ürün olarak D-ksiluloz üreten bir NAD + -spesifik D-arabitol 4-oksidoredüktaz (EC 1.1.1.11) kodlayan bir nükleik asit dizisi ve substrat olarak D-ksiluloz kullanan ve ürün olarak ksilitol üreten bir NADPH- spesifik ksilitol dehidrojenaz kodlayan bir nükleik asit dizisi içerir.
TR2019/09794T 2014-06-18 2015-06-17 Bir rekombinant suş aracılığıyla glikozdan ksilitol üretimi. TR201909794T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14305934.3A EP2957640B1 (en) 2014-06-18 2014-06-18 Production of xylitol from glucose by a recombinant strain

Publications (1)

Publication Number Publication Date
TR201909794T4 true TR201909794T4 (tr) 2019-07-22

Family

ID=50981446

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2018/08404T TR201808404T4 (tr) 2014-06-18 2014-06-18 Bir rekombinant suş aracılığıyla glikozdan ksilitol üretimi.
TR2019/09794T TR201909794T4 (tr) 2014-06-18 2015-06-17 Bir rekombinant suş aracılığıyla glikozdan ksilitol üretimi.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2018/08404T TR201808404T4 (tr) 2014-06-18 2014-06-18 Bir rekombinant suş aracılığıyla glikozdan ksilitol üretimi.

Country Status (14)

Country Link
US (2) US10494614B2 (tr)
EP (2) EP2957640B1 (tr)
JP (1) JP6537534B2 (tr)
KR (1) KR102496301B1 (tr)
CN (1) CN106661540B (tr)
CA (1) CA2952709C (tr)
DK (2) DK2957640T3 (tr)
ES (2) ES2673865T3 (tr)
MX (2) MX2016016923A (tr)
PL (2) PL2957640T3 (tr)
RU (1) RU2693593C2 (tr)
SG (1) SG11201610417XA (tr)
TR (2) TR201808404T4 (tr)
WO (1) WO2015193350A1 (tr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11419903B2 (en) 2015-11-30 2022-08-23 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
ES2673865T3 (es) * 2014-06-18 2018-06-26 Roquette Frères Producción de xilitol a partir de glucosa mediante una cepa recombinante
CN108977432B (zh) * 2018-07-27 2021-04-06 浙江工业大学 重组大肠杆菌固定化细胞及在利用木糖母液生产木糖醇中的应用
DK202070849A1 (en) * 2019-12-18 2021-07-22 Evolva Sa Host cells and their use for producing monosaccharides
CN113025516A (zh) 2020-12-28 2021-06-25 浙江华康药业股份有限公司 一种利用木糖二次母液发酵制备木糖醇的方法
CN113151367A (zh) * 2021-05-10 2021-07-23 湖北工业大学 一种自我保护的鲁氏结合酵母从头合成木糖醇的发酵方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
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US4008285A (en) 1974-04-22 1977-02-15 Melaja Asko J Process for making xylitol
US4075406A (en) 1974-04-22 1978-02-21 Suomen Sokeri Osakeyhtio Process for making xylose
JP2947609B2 (ja) 1989-01-17 1999-09-13 スオメン ザイロフィン オサケ イティオ キシロース含有混合物からのキシリトールの製造方法
FR2652589B1 (fr) * 1989-10-04 1995-02-17 Roquette Freres Procede de fabrication de xylitol et de produits riches en xylitol.
PL178040B1 (pl) * 1992-11-05 2000-02-29 Xyrofin Oy Sposób wytwarzania ksylitolu i zrekombinowany gospodarz drobnoustrojowy
FR2765589B1 (fr) 1997-07-03 1999-09-17 Roquette Freres Fragment d'adn comprenant le promoteur de la ribulose reductase nadph specifique de yamadazyma ohmeri, vecteur le contenant et procede de preparation de proteines utilisant ce vecteur
JPH11266888A (ja) * 1997-10-17 1999-10-05 Ajinomoto Co Inc キシリトールの製造法
FR2772788B1 (fr) 1997-12-19 2000-11-17 Roquette Freres Procede pour accroitre la production de certains polyols par une souche osmotolerante
JP2000295994A (ja) * 1999-02-09 2000-10-24 Ajinomoto Co Inc キシリトールの製造法
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EP1075795B1 (en) * 1999-08-10 2003-04-09 Ajinomoto Co., Inc. Process for producing xylitol of high purity
JP2003520583A (ja) * 2000-01-21 2003-07-08 ダニスコ スイートナーズ オイ 五炭糖及び糖アルコールの製造
JP4453869B2 (ja) * 2004-06-25 2010-04-21 信和化工株式会社 変異型キシリトールデヒドロゲナーゼ酵素、これを産生する微生物、該酵素または微生物を用いたキシリトールをキシルロースに変換する方法
JP5219074B2 (ja) * 2008-01-24 2013-06-26 独立行政法人産業技術総合研究所 キシロース発酵能が優れた六炭糖・五炭糖同時発酵酵母およびそれを用いたエタノールの高効率生産方法
KR101175418B1 (ko) * 2009-11-30 2012-08-20 전남대학교산학협력단 신규한 자일리톨 탈수소효소 및 이를 이용한 자일리톨 생산방법
CN101880643B (zh) * 2010-06-03 2012-04-25 南京工业大学 氧化葡萄糖酸杆菌基因工程菌及其构建方法
CN102796797B (zh) * 2012-08-09 2014-07-09 山东天力药业有限公司 微生物转化葡萄糖制备木糖醇及其中间体d-木酮糖的方法及所用的菌种
ES2673865T3 (es) * 2014-06-18 2018-06-26 Roquette Frères Producción de xilitol a partir de glucosa mediante una cepa recombinante

Also Published As

Publication number Publication date
RU2693593C2 (ru) 2019-07-03
JP6537534B2 (ja) 2019-07-03
PL2957640T3 (pl) 2018-09-28
US20170130209A1 (en) 2017-05-11
KR102496301B1 (ko) 2023-02-07
BR112016029704A2 (pt) 2017-10-24
CA2952709C (en) 2022-11-08
US10829742B2 (en) 2020-11-10
RU2017101446A3 (tr) 2018-10-26
US20200032224A1 (en) 2020-01-30
PL3158074T3 (pl) 2019-10-31
CA2952709A1 (en) 2015-12-23
TR201808404T4 (tr) 2018-07-23
CN106661540A (zh) 2017-05-10
RU2017101446A (ru) 2018-07-18
WO2015193350A1 (en) 2015-12-23
EP2957640B1 (en) 2018-03-14
DK3158074T3 (da) 2019-07-22
EP2957640A1 (en) 2015-12-23
MX2016016923A (es) 2017-04-27
MX2020002674A (es) 2020-07-22
CN106661540B (zh) 2021-02-09
KR20170020362A (ko) 2017-02-22
ES2733650T3 (es) 2019-12-02
SG11201610417XA (en) 2017-01-27
DK2957640T3 (en) 2018-06-25
JP2017518066A (ja) 2017-07-06
EP3158074A1 (en) 2017-04-26
US10494614B2 (en) 2019-12-03
EP3158074B1 (en) 2019-04-24
ES2673865T3 (es) 2018-06-26

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