MX2016016923A - Produccion de xilitol a partir de glucosa mediante una cepa recombinante. - Google Patents

Produccion de xilitol a partir de glucosa mediante una cepa recombinante.

Info

Publication number
MX2016016923A
MX2016016923A MX2016016923A MX2016016923A MX2016016923A MX 2016016923 A MX2016016923 A MX 2016016923A MX 2016016923 A MX2016016923 A MX 2016016923A MX 2016016923 A MX2016016923 A MX 2016016923A MX 2016016923 A MX2016016923 A MX 2016016923A
Authority
MX
Mexico
Prior art keywords
xylitol
production
glucose
recombinant strain
xylulose
Prior art date
Application number
MX2016016923A
Other languages
English (en)
Inventor
Schwab Markus
Defretin Sophie
Diefenbacher Melanie
Chang Yiming
HONDA MALCA Sumire
Gerard Tania
Heysen Arnaud
THOR Friederike
schaefer Astrid
Original Assignee
Roquette Freres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roquette Freres filed Critical Roquette Freres
Publication of MX2016016923A publication Critical patent/MX2016016923A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/0101—L-Xylulose reductase (1.1.1.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01011—D-Arabinitol 4-dehydrogenase (1.1.1.11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un hospedador microbiano recombinante para la producción de xilitol, conteniendo el hospedador microbiano recombinante una secuencia de ácido nucleico que codifica una D-arabitol 4-oxidorreductasa específica de NAD+ (EC 1.1.1.11) que utiliza d-arabitol como sustrato y que produce D-xilulosa como producto, y una secuencia de ácido nucleico que codifica una xilitol deshidrogenasa específica de NADPH utilizando D-xilulosa como sustrato y produciendo xilitol como producto.
MX2016016923A 2014-06-18 2015-06-17 Produccion de xilitol a partir de glucosa mediante una cepa recombinante. MX2016016923A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14305934.3A EP2957640B1 (en) 2014-06-18 2014-06-18 Production of xylitol from glucose by a recombinant strain
PCT/EP2015/063549 WO2015193350A1 (en) 2014-06-18 2015-06-17 Production of xylitol from glucose by a recombinant strain

Publications (1)

Publication Number Publication Date
MX2016016923A true MX2016016923A (es) 2017-04-27

Family

ID=50981446

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016016923A MX2016016923A (es) 2014-06-18 2015-06-17 Produccion de xilitol a partir de glucosa mediante una cepa recombinante.
MX2020002674A MX2020002674A (es) 2014-06-18 2016-12-16 Produccion de xilitol a partir de glucosa mediante una cepa recombinante.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020002674A MX2020002674A (es) 2014-06-18 2016-12-16 Produccion de xilitol a partir de glucosa mediante una cepa recombinante.

Country Status (14)

Country Link
US (2) US10494614B2 (es)
EP (2) EP2957640B1 (es)
JP (1) JP6537534B2 (es)
KR (1) KR102496301B1 (es)
CN (1) CN106661540B (es)
CA (1) CA2952709C (es)
DK (2) DK2957640T3 (es)
ES (2) ES2673865T3 (es)
MX (2) MX2016016923A (es)
PL (2) PL2957640T3 (es)
RU (1) RU2693593C2 (es)
SG (1) SG11201610417XA (es)
TR (2) TR201808404T4 (es)
WO (1) WO2015193350A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11419903B2 (en) 2015-11-30 2022-08-23 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
ES2673865T3 (es) * 2014-06-18 2018-06-26 Roquette Frères Producción de xilitol a partir de glucosa mediante una cepa recombinante
CN108977432B (zh) * 2018-07-27 2021-04-06 浙江工业大学 重组大肠杆菌固定化细胞及在利用木糖母液生产木糖醇中的应用
CN114929870B (zh) * 2019-12-18 2024-04-30 埃沃尔瓦公司 宿主细胞及其用于产生核糖醇和其他单糖的用途
CN113025516A (zh) 2020-12-28 2021-06-25 浙江华康药业股份有限公司 一种利用木糖二次母液发酵制备木糖醇的方法
CN113151367A (zh) * 2021-05-10 2021-07-23 湖北工业大学 一种自我保护的鲁氏结合酵母从头合成木糖醇的发酵方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008285A (en) 1974-04-22 1977-02-15 Melaja Asko J Process for making xylitol
US4075406A (en) 1974-04-22 1978-02-21 Suomen Sokeri Osakeyhtio Process for making xylose
ES2088425T3 (es) 1989-01-17 1996-08-16 Xyrofin Oy Metodo de produccion de xilitol a partir de mezclas que contienen xilosa.
FR2652589B1 (fr) * 1989-10-04 1995-02-17 Roquette Freres Procede de fabrication de xylitol et de produits riches en xylitol.
NZ257561A (en) 1992-11-05 1996-09-25 Xyrofin Oy Recombinant method for preparing xylitol
FR2765589B1 (fr) 1997-07-03 1999-09-17 Roquette Freres Fragment d'adn comprenant le promoteur de la ribulose reductase nadph specifique de yamadazyma ohmeri, vecteur le contenant et procede de preparation de proteines utilisant ce vecteur
JPH11266888A (ja) * 1997-10-17 1999-10-05 Ajinomoto Co Inc キシリトールの製造法
FR2772788B1 (fr) 1997-12-19 2000-11-17 Roquette Freres Procede pour accroitre la production de certains polyols par une souche osmotolerante
JP2000295994A (ja) * 1999-02-09 2000-10-24 Ajinomoto Co Inc キシリトールの製造法
JP2001008682A (ja) 1999-06-24 2001-01-16 Ajinomoto Co Inc Ｄ−アラビトール、ｄ−キシルロース及びキシリトールの製造法
DE60002020T2 (de) * 1999-08-10 2004-02-12 Ajinomoto Co., Inc. Verfahren zur Herstellen von hochreinem Xylitol
ATE464387T1 (de) * 2000-01-21 2010-04-15 Danisco Herstellung von durch 5 kohlenstoffatome charakterisierte zucker und zuckeralkohole
JP4453869B2 (ja) * 2004-06-25 2010-04-21 信和化工株式会社 変異型キシリトールデヒドロゲナーゼ酵素、これを産生する微生物、該酵素または微生物を用いたキシリトールをキシルロースに変換する方法
JP5219074B2 (ja) * 2008-01-24 2013-06-26 独立行政法人産業技術総合研究所 キシロース発酵能が優れた六炭糖・五炭糖同時発酵酵母およびそれを用いたエタノールの高効率生産方法
KR101175418B1 (ko) * 2009-11-30 2012-08-20 전남대학교산학협력단 신규한 자일리톨 탈수소효소 및 이를 이용한 자일리톨 생산방법
CN101880643B (zh) * 2010-06-03 2012-04-25 南京工业大学 氧化葡萄糖酸杆菌基因工程菌及其构建方法
CN102796797B (zh) * 2012-08-09 2014-07-09 山东天力药业有限公司 微生物转化葡萄糖制备木糖醇及其中间体d-木酮糖的方法及所用的菌种
ES2673865T3 (es) * 2014-06-18 2018-06-26 Roquette Frères Producción de xilitol a partir de glucosa mediante una cepa recombinante

Also Published As

Publication number Publication date
US20170130209A1 (en) 2017-05-11
KR20170020362A (ko) 2017-02-22
DK2957640T3 (en) 2018-06-25
US10829742B2 (en) 2020-11-10
CN106661540B (zh) 2021-02-09
RU2017101446A3 (es) 2018-10-26
EP3158074A1 (en) 2017-04-26
EP2957640A1 (en) 2015-12-23
CN106661540A (zh) 2017-05-10
WO2015193350A1 (en) 2015-12-23
BR112016029704A2 (pt) 2017-10-24
CA2952709C (en) 2022-11-08
MX2020002674A (es) 2020-07-22
JP6537534B2 (ja) 2019-07-03
EP3158074B1 (en) 2019-04-24
PL3158074T3 (pl) 2019-10-31
EP2957640B1 (en) 2018-03-14
ES2673865T3 (es) 2018-06-26
TR201909794T4 (tr) 2019-07-22
JP2017518066A (ja) 2017-07-06
DK3158074T3 (da) 2019-07-22
RU2693593C2 (ru) 2019-07-03
ES2733650T3 (es) 2019-12-02
TR201808404T4 (tr) 2018-07-23
CA2952709A1 (en) 2015-12-23
PL2957640T3 (pl) 2018-09-28
US20200032224A1 (en) 2020-01-30
SG11201610417XA (en) 2017-01-27
RU2017101446A (ru) 2018-07-18
US10494614B2 (en) 2019-12-03
KR102496301B1 (ko) 2023-02-07

Similar Documents

Publication Publication Date Title
MX2020002674A (es) Produccion de xilitol a partir de glucosa mediante una cepa recombinante.
AU2020201465A1 (en) Using truncated guide rnas (tru-grnas) to increase specificity for rna-guided genome editing
WO2017083858A3 (en) Microbial production of nicotinamide riboside
JOP20210065A1 (ar) عملية لتحضير 5- فلورو-1h- بيرازولوبيريدينات مستبدلة
MX2017010459A (es) Produccion catalizada por deshidrogenasa de acido 2,5-furan-dicarboxilico.
EP3741849A3 (en) Protease variants and polynucleotides encoding same
WO2012173659A3 (en) Lignocellulosic hydrolysates as feedstocks for isobutanol fermentation
MY192824A (en) Compound targeting il-23a and tnf-alpha and uses thereof
EP3272860A4 (en) Pyruvate dehydrogenase mutant, microorganism comprising mutant, and method for producing l-amino acid by using microorganism
WO2016101960A3 (en) Yeast for preparing alcoholic beverages
MY193587A (en) Genetically modified microorganism for improved production of fine chemicals on sucrose
MY183061A (en) Polypeptides having xylanase activity with a high conversion rate of xylose-containing polysaccharides
WO2015161468A8 (en) Methods and systems for producing isosorbide from biomass
WO2016068656A3 (ko) 사이코스 에퍼머화 효소의 발현 시스템 및 이를 이용한 사이코스의 생산
MY186400A (en) Eukaryotic cell with increased production of fermentation product
WO2012102552A3 (ko) 3,6-안하이드로-ｌ-갈락토오스에 작용하는 신규한 3,6-안하이드로-ｌ-갈락토오스 데히드로게나제와 이 효소를 이용한 3,6-안하이드로 갈락토닉산의 생산
MY188407A (en) Novel lactobacillus sp. microorganisms, and composition for animal feed comprising same
MY193588A (en) Improved microorganisms for succinic acid production
AU2015344324A8 (en) Endoxylanase mutant, enzyme composition for biomass decomposition, and method for producing sugar solution
MX2019010890A (es) Compuestos antineoplasicos.
BR112016027884A2 (pt) variante de xilanase da família 11 de gh, polinucleotídeo, construção de ácido nucleico, vetor de expressão, célula hospedeira, e, métodos de produção de uma variante de xilanase da família 11 de gh e de degradação de um material
MX2016007340A (es) Formulacion de biomasa.
BR112016016397A2 (pt) método para preparar 1-alquil-3-difluorometil-5-fluoro-1h-pirazol-4-carbaldeídos e 1-alquil-3-difluorometil-5-fluoro-1h-pirazol-4-carboxilatos.
MX2016000929A (es) Manipulacion genetica de pseudomonas putida kt2440 para la produccion rapida y de alto rendimiento de vainillina de acido ferulico.
WO2014036140A3 (en) Methods for production of a terpene and a co-product

Legal Events

Date Code Title Description
FG Grant or registration