BR112016029704A2 - célula hospedeira recombinante com capacidade de produzir xilitol, método para produzir xilitol, e uso de uma célula hospedeira recombinante - Google Patents
célula hospedeira recombinante com capacidade de produzir xilitol, método para produzir xilitol, e uso de uma célula hospedeira recombinanteInfo
- Publication number
- BR112016029704A2 BR112016029704A2 BR112016029704A BR112016029704A BR112016029704A2 BR 112016029704 A2 BR112016029704 A2 BR 112016029704A2 BR 112016029704 A BR112016029704 A BR 112016029704A BR 112016029704 A BR112016029704 A BR 112016029704A BR 112016029704 A2 BR112016029704 A2 BR 112016029704A2
- Authority
- BR
- Brazil
- Prior art keywords
- host cell
- recombinant host
- producing xylitol
- xylitol
- producing
- Prior art date
Links
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 title abstract 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 title abstract 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 title abstract 4
- 229960002675 xylitol Drugs 0.000 title abstract 4
- 235000010447 xylitol Nutrition 0.000 title abstract 4
- 239000000811 xylitol Substances 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- ZAQJHHRNXZUBTE-WUJLRWPWSA-N D-xylulose Chemical compound OC[C@@H](O)[C@H](O)C(=O)CO ZAQJHHRNXZUBTE-WUJLRWPWSA-N 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 230000000813 microbial effect Effects 0.000 abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 108010058076 D-xylulose reductase Proteins 0.000 abstract 1
- 102100026974 Sorbitol dehydrogenase Human genes 0.000 abstract 1
- ACFIXJIJDZMPPO-NCHANQSKSA-N nadph Chemical compound C1=CCC(C(=O)N)=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2[C@@H]([C@H](OP(O)(O)=O)[C@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NCHANQSKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/0101—L-Xylulose reductase (1.1.1.10)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01011—D-Arabinitol 4-dehydrogenase (1.1.1.11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
a presente invenção se refere a um hospedeiro microbiano recombinante para a produção de xilitol, em que o hospedeiro microbiano recombinante contém uma sequência de ácidos nucleicos que codifica uma d-arabitol 4-oxidorredutase específica de nad+ (ec 1.1.1.11) que usa d-arabitol como substrato e que produz d-xilulose como produto, e uma sequência de ácido nucleico que codifica uma xilitol desidrogenase específica de nadph que usa d-xilulose como substrato e que produz xilitol como produto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14305934.3 | 2014-06-18 | ||
EP14305934.3A EP2957640B1 (en) | 2014-06-18 | 2014-06-18 | Production of xylitol from glucose by a recombinant strain |
PCT/EP2015/063549 WO2015193350A1 (en) | 2014-06-18 | 2015-06-17 | Production of xylitol from glucose by a recombinant strain |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112016029704A2 true BR112016029704A2 (pt) | 2017-10-24 |
BR112016029704B1 BR112016029704B1 (pt) | 2023-06-06 |
Family
ID=
Also Published As
Publication number | Publication date |
---|---|
EP2957640A1 (en) | 2015-12-23 |
CN106661540A (zh) | 2017-05-10 |
SG11201610417XA (en) | 2017-01-27 |
TR201909794T4 (tr) | 2019-07-22 |
KR102496301B1 (ko) | 2023-02-07 |
US10829742B2 (en) | 2020-11-10 |
EP2957640B1 (en) | 2018-03-14 |
DK3158074T3 (da) | 2019-07-22 |
DK2957640T3 (en) | 2018-06-25 |
MX2016016923A (es) | 2017-04-27 |
CA2952709A1 (en) | 2015-12-23 |
CA2952709C (en) | 2022-11-08 |
RU2017101446A3 (pt) | 2018-10-26 |
ES2673865T3 (es) | 2018-06-26 |
KR20170020362A (ko) | 2017-02-22 |
CN106661540B (zh) | 2021-02-09 |
US20170130209A1 (en) | 2017-05-11 |
RU2017101446A (ru) | 2018-07-18 |
PL3158074T3 (pl) | 2019-10-31 |
US10494614B2 (en) | 2019-12-03 |
PL2957640T3 (pl) | 2018-09-28 |
US20200032224A1 (en) | 2020-01-30 |
EP3158074A1 (en) | 2017-04-26 |
TR201808404T4 (tr) | 2018-07-23 |
WO2015193350A1 (en) | 2015-12-23 |
ES2733650T3 (es) | 2019-12-02 |
JP6537534B2 (ja) | 2019-07-03 |
RU2693593C2 (ru) | 2019-07-03 |
EP3158074B1 (en) | 2019-04-24 |
JP2017518066A (ja) | 2017-07-06 |
MX2020002674A (es) | 2020-07-22 |
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B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
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B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/06/2015, OBSERVADAS AS CONDICOES LEGAIS |