BR112016029704A2 - célula hospedeira recombinante com capacidade de produzir xilitol, método para produzir xilitol, e uso de uma célula hospedeira recombinante - Google Patents

célula hospedeira recombinante com capacidade de produzir xilitol, método para produzir xilitol, e uso de uma célula hospedeira recombinante

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Publication number
BR112016029704A2
BR112016029704A2 BR112016029704A BR112016029704A BR112016029704A2 BR 112016029704 A2 BR112016029704 A2 BR 112016029704A2 BR 112016029704 A BR112016029704 A BR 112016029704A BR 112016029704 A BR112016029704 A BR 112016029704A BR 112016029704 A2 BR112016029704 A2 BR 112016029704A2
Authority
BR
Brazil
Prior art keywords
host cell
recombinant host
producing xylitol
xylitol
producing
Prior art date
Application number
BR112016029704A
Other languages
English (en)
Other versions
BR112016029704B1 (pt
Inventor
Heysen Arnaud
schaefer Astrid
THOR Friederike
Schwab Markus
Diefenbacher Melanie
Defretin Sophie
HONDA MALCA Sumire
Gerard Tania
Chang Yiming
Original Assignee
Roquette Freres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roquette Freres filed Critical Roquette Freres
Publication of BR112016029704A2 publication Critical patent/BR112016029704A2/pt
Publication of BR112016029704B1 publication Critical patent/BR112016029704B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/0101—L-Xylulose reductase (1.1.1.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01011—D-Arabinitol 4-dehydrogenase (1.1.1.11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

a presente invenção se refere a um hospedeiro microbiano recombinante para a produção de xilitol, em que o hospedeiro microbiano recombinante contém uma sequência de ácidos nucleicos que codifica uma d-arabitol 4-oxidorredutase específica de nad+ (ec 1.1.1.11) que usa d-arabitol como substrato e que produz d-xilulose como produto, e uma sequência de ácido nucleico que codifica uma xilitol desidrogenase específica de nadph que usa d-xilulose como substrato e que produz xilitol como produto.
BR112016029704-0A 2014-06-18 2015-06-17 Produção de xilitol a partir de glicose por uma cepa recombinante BR112016029704B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14305934.3A EP2957640B1 (en) 2014-06-18 2014-06-18 Production of xylitol from glucose by a recombinant strain
EP14305934.3 2014-06-18
PCT/EP2015/063549 WO2015193350A1 (en) 2014-06-18 2015-06-17 Production of xylitol from glucose by a recombinant strain

Publications (2)

Publication Number Publication Date
BR112016029704A2 true BR112016029704A2 (pt) 2017-10-24
BR112016029704B1 BR112016029704B1 (pt) 2023-06-06

Family

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Also Published As

Publication number Publication date
RU2693593C2 (ru) 2019-07-03
JP6537534B2 (ja) 2019-07-03
PL2957640T3 (pl) 2018-09-28
US20170130209A1 (en) 2017-05-11
KR102496301B1 (ko) 2023-02-07
CA2952709C (en) 2022-11-08
US10829742B2 (en) 2020-11-10
RU2017101446A3 (pt) 2018-10-26
US20200032224A1 (en) 2020-01-30
PL3158074T3 (pl) 2019-10-31
CA2952709A1 (en) 2015-12-23
TR201808404T4 (tr) 2018-07-23
CN106661540A (zh) 2017-05-10
RU2017101446A (ru) 2018-07-18
WO2015193350A1 (en) 2015-12-23
TR201909794T4 (tr) 2019-07-22
EP2957640B1 (en) 2018-03-14
DK3158074T3 (da) 2019-07-22
EP2957640A1 (en) 2015-12-23
MX2016016923A (es) 2017-04-27
MX2020002674A (es) 2020-07-22
CN106661540B (zh) 2021-02-09
KR20170020362A (ko) 2017-02-22
ES2733650T3 (es) 2019-12-02
SG11201610417XA (en) 2017-01-27
DK2957640T3 (en) 2018-06-25
JP2017518066A (ja) 2017-07-06
EP3158074A1 (en) 2017-04-26
US10494614B2 (en) 2019-12-03
EP3158074B1 (en) 2019-04-24
ES2673865T3 (es) 2018-06-26

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/06/2015, OBSERVADAS AS CONDICOES LEGAIS