MX394692B - Proceso para una purificación eficaz de oligosacáridos de leche humana (olh) neutros a partir de fermentación microbiana. - Google Patents

Proceso para una purificación eficaz de oligosacáridos de leche humana (olh) neutros a partir de fermentación microbiana.

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Publication number
MX394692B
MX394692B MX2019013267A MX2019013267A MX394692B MX 394692 B MX394692 B MX 394692B MX 2019013267 A MX2019013267 A MX 2019013267A MX 2019013267 A MX2019013267 A MX 2019013267A MX 394692 B MX394692 B MX 394692B
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MX
Mexico
Prior art keywords
hmos
neutral
purification
human milk
microbial fermentation
Prior art date
Application number
MX2019013267A
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English (en)
Other versions
MX2019013267A (es
Inventor
Stefan Jennewein
Original Assignee
Chr Hansen Hmo Gmbh
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49949589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX394692(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chr Hansen Hmo Gmbh filed Critical Chr Hansen Hmo Gmbh
Publication of MX2019013267A publication Critical patent/MX2019013267A/es
Publication of MX394692B publication Critical patent/MX394692B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Pediatric Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fodder In General (AREA)
  • Saccharide Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dairy Products (AREA)
  • Feed For Specific Animals (AREA)

Abstract

La presente invención se refiere a un proceso sencillo para la purificación de oligosacáridos de leche humana (OLH) neutros producidos por fermentación microbiana. El proceso utiliza una combinación de una etapa de tratamiento intercambiador iónico catiónico, tratamiento intercambiador iónico aniónico una etapa de nanofiltración y/o electrodiálisis, que permite la purificación eficaz de grandes cantidades de OLH neutros, a elevada pureza. Contrariamente a la purificación utilizada actualmente en la producción fermentativa de OLH neutros, el proceso expuesto permite proporcionar OLH sin la necesidad de una separación cromatográfica. De esta manera, los OLH purificados pueden obtenerse en forma sólida mediante secado por pulverización, como material cristalino o como concentrado filtrado estéril. Los OLH proporcionados están libres de proteínas y de material recombinante procedente de las cepas microbianas recombinantes utilizadas y por consiguiente resultan muy apropiados para su uso en alimentos, fórmulas médicas y aplicaciones alimentarias (p. ej., alimento para mascotas).
MX2019013267A 2014-01-20 2014-12-23 Proceso para una purificación eficaz de oligosacáridos de leche humana (olh) neutros a partir de fermentación microbiana. MX394692B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14151737.5A EP2896628B1 (en) 2014-01-20 2014-01-20 Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation
PCT/EP2014/079212 WO2015106943A1 (en) 2014-01-20 2014-12-23 PROCESS FOR EFFICIENT PURIFICATION OF NEUTRAL HUMAN MILK OLIGOSACCHARIDES (HMOs) FROM MICROBIAL FERMENTATION

Publications (2)

Publication Number Publication Date
MX2019013267A MX2019013267A (es) 2020-01-13
MX394692B true MX394692B (es) 2025-03-24

Family

ID=49949589

Family Applications (2)

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MX2016009394A MX369375B (es) 2014-01-20 2014-12-23 Proceso para una purificacion eficaz de oligosacaridos de leche humana (olh) neutros a partir de fermentacion microbiana.
MX2019013267A MX394692B (es) 2014-01-20 2014-12-23 Proceso para una purificación eficaz de oligosacáridos de leche humana (olh) neutros a partir de fermentación microbiana.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016009394A MX369375B (es) 2014-01-20 2014-12-23 Proceso para una purificacion eficaz de oligosacaridos de leche humana (olh) neutros a partir de fermentacion microbiana.

Country Status (18)

Country Link
US (4) US10377787B2 (es)
EP (5) EP2896628B1 (es)
JP (2) JP6901857B2 (es)
KR (1) KR102137027B1 (es)
CN (1) CN106132977B (es)
AT (2) AT17418U1 (es)
AU (1) AU2014377374B2 (es)
BR (1) BR112016016705A8 (es)
CZ (2) CZ35289U1 (es)
DE (2) DE202014011399U1 (es)
DK (6) DK2896628T3 (es)
ES (4) ES2701163T3 (es)
FI (2) FI3680249T3 (es)
MX (2) MX369375B (es)
PH (2) PH12016501421B1 (es)
PL (4) PL2896628T3 (es)
RU (1) RU2682445C2 (es)
WO (1) WO2015106943A1 (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2896628B1 (en) 2014-01-20 2018-09-19 Jennewein Biotechnologie GmbH Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation
US10500221B2 (en) 2014-12-05 2019-12-10 Glycom A/S Crystalline difucosyllactose
EP3141610A1 (en) 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
EP3390652B1 (en) 2015-12-18 2024-12-04 Glycom A/S Fermentative production of oligosaccharides
US10899782B2 (en) 2016-03-07 2021-01-26 Glycom A/S Separation of oligosaccharides from fermentation broth
EP3445770B1 (en) * 2016-04-19 2025-11-26 Glycom A/S Separation of oligosaccharides from fermentation broth
WO2019003136A1 (en) * 2017-06-30 2019-01-03 Glycom A/S SYNTHESIS OF OLIGOSACCHARIDES
CN110914284B (zh) 2017-07-12 2025-01-07 格礼卡姆股份公司 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物
EP3450443A1 (en) * 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
CN111164090A (zh) * 2017-09-29 2020-05-15 菲仕兰坎皮纳荷兰公司 用于从微生物发酵纯化中性母乳寡糖（hmo）的方法
EP3486326A1 (en) 2017-11-21 2019-05-22 Jennewein Biotechnologie GmbH Method for the purification of n-acetylneuraminic acid from a fermentation broth
EP3494804B1 (en) 2017-12-08 2025-08-13 Chr. Hansen HMO GmbH Spray-dried 3-fucosyllactose
EP3720300A1 (en) * 2017-12-08 2020-10-14 Jennewein Biotechnologie GmbH Spray-dried tetrasaccharides
EP3494805B1 (en) 2017-12-08 2025-08-13 Chr. Hansen HMO GmbH Spray-dried tetrasaccharides
ES3040419T3 (en) 2017-12-08 2025-10-30 Chr Hansen Hmo Gmbh Spray-dried lacto-n-fucopentaose
EP3494807A1 (en) 2017-12-11 2019-06-12 Jennewein Biotechnologie GmbH Spray-dried sialyllactose
DK3524067T3 (da) * 2018-02-08 2025-05-19 Chr Hansen Hmo Gmbh Spraytørret blanding af modermælksoligosaccharider
EP3546060A1 (en) * 2018-03-27 2019-10-02 DuPont Nutrition Biosciences ApS Process for spray drying fucosyllactose solutions and related product compositions
WO2019215073A1 (en) 2018-05-07 2019-11-14 Jennewein Biotechnologie Gmbh A SIMPLE METHOD FOR THE PURIFICATION OF LACTO-N-NEOTETRAOSE (LNnT) FROM CARBOHYDRATES OBTAINED BY MICROBIAL FERMENTATION
KR20210013138A (ko) * 2018-05-23 2021-02-03 디에스엠 아이피 어셋츠 비.브이. 올리고당의 제조
KR102837674B1 (ko) * 2018-06-01 2025-07-23 크리스찬 한센 에이치엠오 게엠베하 시알릴락토스의 정제를 위한 간단한 방법
CN109111043B (zh) * 2018-09-16 2021-11-09 苏州渭中科技发展有限公司 一种高盐高cod废水的处理方法
CN113195730A (zh) 2018-12-19 2021-07-30 巴斯夫欧洲公司 从包含生物质和至少一种寡糖的溶液中分离生物质的方法
EP3914602A4 (en) * 2019-01-21 2022-12-07 DuPont Nutrition Biosciences ApS PROCESS FOR MANUFACTURING L-FUCOSE
EP3686210A1 (en) * 2019-01-24 2020-07-29 DuPont Nutrition Biosciences ApS Process for purifying a human milk oligosaccharide and related compositions
BE1027078A9 (nl) * 2019-02-25 2020-09-28 Nutribam Bvba Samenstelling, voedingssupplement en werkwijze voor het ondersteunen en/of verbeteren van de darmgezondheid
US20220022515A1 (en) 2019-02-25 2022-01-27 Nutribam Bv Composition, Food Supplement and Method for Supporting and/or Improving Intestinal Health
EP3741770A1 (en) * 2019-05-21 2020-11-25 Jennewein Biotechnologie GmbH Purification of oligosaccharides from a fermentation broth by using filtration
EP4286014A3 (en) * 2019-06-04 2024-02-21 N.V. Nutricia Nutritional composition comprising 2'fucosyllactose and 3'galactosyllactose
EP3822282A1 (en) * 2019-11-18 2021-05-19 DuPont Nutrition Biosciences ApS Process for removing an antifoam agent from a solution comprising a human milk oligosaccharide and related compositions
ES3041027T3 (en) 2019-09-04 2025-11-06 Inbiose Nv Process for removing an antifoam agent from a solution comprising a human milk oligosaccharide and related compositions
BR112022005578A2 (pt) 2019-09-24 2022-09-20 Prolacta Bioscience Inc Composições e métodos para tratamento de doenças inflamatórias e imunes
WO2021155157A1 (en) * 2020-01-29 2021-08-05 Dsm Ip Assets B.V. Process for recovering & purifying human milk oligosaccharides
CN111540125B (zh) * 2020-04-20 2021-01-05 中国人民解放军火箭军工程设计研究院 一种充电桩的充电管理方法、设备及计算机可读存储介质
KR20230022867A (ko) 2020-06-12 2023-02-16 바스프 에스이 발효 브로스의 개선된 탈염 및 올리고당과 같은 정밀 화학물질의 정제
CN116322371A (zh) 2020-08-14 2023-06-23 普罗莱克塔生物科学公司 与细菌疗法一起使用的人乳寡糖组合物
CN112568439A (zh) * 2020-12-21 2021-03-30 湖北福星生物科技有限公司 一种从微生物发酵液中分离纯化母乳低聚糖的方法及其应用
MX2023008227A (es) 2021-01-12 2023-07-20 Prolacta Bioscience Inc Regimenes de tratamiento simbiotico.
CN112920234B (zh) * 2021-01-27 2022-03-29 南开大学 一种2′-岩藻糖基乳糖的富集纯化方法
WO2022229316A1 (en) * 2021-04-30 2022-11-03 Dsm Ip Assets B.V. Infant formula with low level of arsenic
DK181242B1 (en) 2021-05-17 2023-05-30 Dsm Ip Assets Bv GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME
EP4355464A1 (en) 2021-06-15 2024-04-24 DSM IP Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
BE1029436B1 (nl) 2021-06-15 2023-07-31 Dsm Ip Assets Bv Scheiding van moedermelkoligosachariden uit een fermentatiebouillon
US20240287116A1 (en) 2021-06-15 2024-08-29 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
BE1029435B1 (nl) 2021-06-15 2023-07-31 Dsm Ip Assets Bv Scheiding van moedermelkoligosachariden uit een fermentatiebouillon
WO2023066907A1 (en) 2021-10-18 2023-04-27 Dsm Ip Assets B.V. A method for providing an amorphous hmo product by drying
CN114539433B (zh) * 2021-12-29 2022-11-01 北京三元食品股份有限公司 一种乳低聚糖的制备方法及制备的低聚糖粉、食品
JPWO2023182527A1 (es) * 2022-03-25 2023-09-28
CN117003803A (zh) * 2022-05-07 2023-11-07 山东恒鲁生物科技有限公司 一种三糖的新晶型
CN115873051B (zh) * 2022-05-17 2024-06-25 山东恒鲁生物科技有限公司 三糖的新晶型
WO2023242184A1 (en) 2022-06-14 2023-12-21 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
WO2024047096A1 (en) 2022-08-30 2024-03-07 Inbiose N.V. Process for purification of an oligosaccharide
WO2024130119A2 (en) 2022-12-16 2024-06-20 Prolacta Bioscience, Inc. Synbiotic compositions for short chain fatty acid production
CN115651039A (zh) * 2022-12-27 2023-01-31 保龄宝生物股份有限公司 一种高密度2’-岩藻糖基乳糖的生产方法
CN116425810B (zh) * 2023-06-14 2023-08-11 山东合成远景生物科技有限公司 一种混合液中3-岩藻糖基乳糖的纯化方法
CN117089503B (zh) * 2023-10-17 2024-01-02 保龄宝生物股份有限公司 一种大肠杆菌k-12 mg1655 blbyzt6及其应用
WO2025114343A2 (en) * 2023-11-29 2025-06-05 Frieslandcampina Nederland B.V. Process for the production of human milk oligosaccharides

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61271296A (ja) 1985-05-28 1986-12-01 Kyogyo Kumiai N F I Ｎ−アセチルキトオリゴ糖の製造方法
JPH0614870B2 (ja) * 1986-12-15 1994-03-02 株式会社ヤクルト本社 ガラクトオリゴ糖の製造法
IL129363A (en) 1996-10-10 2003-02-12 Neose Technologies Inc Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration
US5945314A (en) 1997-03-31 1999-08-31 Abbott Laboratories Process for synthesizing oligosaccharides
US6323008B1 (en) 1997-08-14 2001-11-27 Neose Technologies, Inc. Methods for producing sialyloligosaccharides in a dairy source
US6017433A (en) 1997-11-12 2000-01-25 Archer Daniels Midland Company Desalting aqueous streams via filled cell electrodialysis
WO2000024918A1 (en) 1998-10-27 2000-05-04 Cargill, Incorporated Method for purifying a polyol product stream
DE19906865C2 (de) 1999-02-18 2003-03-13 Infineon Technologies Ag Verfahren und Einrichtung zur Entzerrung und Decodierung eines Datensignals
FR2796082B1 (fr) 1999-07-07 2003-06-27 Centre Nat Rech Scient Procede de production d'oligosaccharides
FR2799754A1 (fr) 1999-10-18 2001-04-20 Roquette Freres Procede de separation et de purification d'acide lactique a partir d'un milieu de fermentation
US6288222B1 (en) 2000-02-16 2001-09-11 Neose Technologies, Inc. Method of filtration of a dairy stream
US6618584B1 (en) 2000-08-30 2003-09-09 Telefonaktiebolaget Lm Ericsson (Publ) Terminal authentication procedure timing for data calls
JP2003047402A (ja) * 2001-08-06 2003-02-18 Meiji Milk Prod Co Ltd 中性オリゴ糖含有育児用調製乳
JP2003048901A (ja) 2001-08-09 2003-02-21 Oji Paper Co Ltd 長鎖キシロオリゴ糖組成物およびその製造方法
FR2844209B1 (fr) 2002-09-06 2007-10-19 Applexion Ste Nouvelle De Rech Procede de purification par nanofiltration d'une solution aqueuse sucree contenant des anions et cations monovalents et polyvalents
EP1625224B1 (en) 2003-05-06 2010-07-28 E.I. Du Pont De Nemours And Company Purification of biologically-produced 1,3-propanediol
BRPI0408911B1 (pt) * 2003-06-30 2016-07-26 Clasado Inc composição de galactooligossacarídeos e a preparação da mesma
EP1789570A2 (en) 2004-09-17 2007-05-30 Neose Technologies, Inc. Production of oligosaccharides by microorganisms
CN101031285A (zh) * 2004-10-01 2007-09-05 卫材R&D管理有限公司 含有微粒的组合物及其制备方法
EP2308965A1 (en) 2005-02-11 2011-04-13 DSM IP Assets B.V. Fermentative vitamin C production
US20070256936A1 (en) 2006-05-04 2007-11-08 Robert Jansen Method for Deashing Syrup by Electrodialysis
US20100143535A1 (en) 2007-07-12 2010-06-10 Hidemasa Motoshima Method for producing composition containing sialic acid compound
RU2584599C2 (ru) 2008-12-19 2016-05-20 Дженневейн Биотехнологие Гмбх Синтез фукозилированных соединений
GB0904562D0 (en) 2009-03-17 2009-04-29 Separation Technologies Invest Isolation and purification of components of whey
CA2758097A1 (en) * 2009-04-07 2010-10-14 Glycom A/S Synthesis of 2'-o-fucosyllactose
ES2660698T3 (es) * 2009-06-08 2018-03-23 Jennewein Biotechnologie Gmbh Síntesis de HMO
JP2012532195A (ja) * 2009-07-06 2012-12-13 チルドレンズ ホスピタル メディカル センター 乳オリゴ糖による炎症の阻害
IT1395068B1 (it) 2009-08-07 2012-09-05 Inalco Spa Processo per la produzione di galatto-oligosaccaridi ultrapuri
CN101691538B (zh) 2009-09-29 2012-05-09 保龄宝生物股份有限公司 一种米曲霉菌种及其制备高纯度低聚半乳糖的方法
NZ601141A (en) * 2010-01-19 2014-07-25 Abbott Lab Nutritional formulas containing synbiotics
EP2576578B1 (en) 2010-06-01 2018-09-19 Glycom A/S Polymorphs of 2'-o-fucosyllactose and producing thereof
DK2439264T3 (en) 2010-10-11 2015-08-03 Jennewein Biotechnologie Gmbh Novel fucosyltransferases and their use
EP2455387A1 (en) 2010-11-23 2012-05-23 Nestec S.A. Oligosaccharide mixture and food product comprising this mixture, especially infant formula
MX355780B (es) * 2010-12-31 2018-04-30 Abbott Lab Fórmula pediátrica sintética para estimular células nerviosas entéricas en el tracto gastrointestinal.
TW201233340A (en) * 2010-12-31 2012-08-16 Abbott Lab Human milk oligosaccharides for modulating inflammation
CA2822222C (en) 2010-12-31 2019-05-07 Abbott Laboratories Human milk oligosaccharides for modulating inflammation
CN102154163A (zh) 2010-12-31 2011-08-17 朱莉 一种3′-唾液酸乳糖的制备方法
DK2479263T3 (da) * 2011-01-20 2014-02-03 Jennewein Biotechnologie Gmbh Nye fucosyltransferaser og deres anvendelser
US9453230B2 (en) * 2011-02-16 2016-09-27 Glycosyn LLC Biosynthesis of human milk oligosaccharides in engineered bacteria
CN102095181A (zh) 2011-03-16 2011-06-15 黎昌兴 Led强光源流体巡回散热装置
EP2707379A4 (en) * 2011-05-13 2014-10-08 Glycosyn LLC USE OF PURIFIED 2'-FUCOSYLLACTOSIS, 3-FUCOSYLLACTOSIS AND LACTODIFUCOTETRAOSE AS PREBIOTICS
EP2526784A1 (en) 2011-05-24 2012-11-28 Nestec S.A. Milk oligosaccharide-galactooligosaccharide composition for infant formula containing the soluble oligosaccharide fraction present in milk, and having a low level of monosaccharides, and a process to produce the composition
PL2722394T3 (pl) * 2011-06-07 2018-09-28 Hero Ag Otrzymywanie oligosacharydów za pomocą procesu biotechnologicznego
NL2007268C2 (en) * 2011-08-16 2013-02-19 Friesland Brands Bv Nutritional compositions comprising human milk oligosaccharides and uses thereof.
JP6017133B2 (ja) * 2011-12-12 2016-10-26 Ｍｃフードスペシャリティーズ株式会社 風味改良剤
ES2787899T3 (es) 2011-12-19 2020-10-19 Purecircle Sdn Bhd Métodos para purificar glucósidos de esteviol
US20150065702A1 (en) 2012-03-20 2015-03-05 Glycom A/S Synthesis of the Trisaccharide 3-O-Fucosyllactose and Intermediates Thereof
WO2013182206A1 (en) 2012-06-08 2013-12-12 Glycom A/S Method for producing oligosaccharides and oligosaccharide glycosides by fermentation
US9896470B2 (en) 2012-06-14 2018-02-20 Glycom A/S Enhancing the stability and purity and increasing the bioavailability of human milk oligosaccharides or precursors or blends thereof
ITFI20120143A1 (it) * 2012-07-12 2014-01-13 Inalco S A S Di Giovanni Cipollett I & C Polimorfi idrati e anidri del 2'-o-fucosillattosio e loro metodi di produzione.
US9029136B2 (en) 2012-07-25 2015-05-12 Glycosyn LLC Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
WO2014086373A1 (en) 2012-12-07 2014-06-12 Glycom A/S Crystallisation of human milk oligosaccharides (hmo)
DK2845905T3 (da) * 2013-09-10 2021-06-14 Chr Hansen Hmo Gmbh Fremstilling af oligosaccharider
CN103468766B (zh) 2013-09-18 2015-07-01 恩施天天佳生物科技有限公司 一种高纯度甘露低聚糖的制备方法
EP2857410A1 (en) * 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
EP2896628B1 (en) 2014-01-20 2018-09-19 Jennewein Biotechnologie GmbH Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation
DK2927316T3 (en) 2014-03-31 2019-03-04 Jennewein Biotechnologie Gmbh Total fermentation of oligosaccharides
US20170044538A1 (en) 2014-04-17 2017-02-16 Biogen Ma Inc. Compositions and Methods for Modulation of SMN2 Splicing in a Subject
DK3154995T3 (da) 2014-06-11 2023-11-20 Glycom As Separation of 2'-o-fucosyllactose from fermentation broth
EP3141610A1 (en) 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export

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