MX2016009394A - Proceso para una purificacion eficaz de oligosacaridos de leche humana (olh) neutros a partir de fermentacion microbiana. - Google Patents
Proceso para una purificacion eficaz de oligosacaridos de leche humana (olh) neutros a partir de fermentacion microbiana.Info
- Publication number
- MX2016009394A MX2016009394A MX2016009394A MX2016009394A MX2016009394A MX 2016009394 A MX2016009394 A MX 2016009394A MX 2016009394 A MX2016009394 A MX 2016009394A MX 2016009394 A MX2016009394 A MX 2016009394A MX 2016009394 A MX2016009394 A MX 2016009394A
- Authority
- MX
- Mexico
- Prior art keywords
- hmos
- neutral
- purification
- human milk
- microbial fermentation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000007935 neutral effect Effects 0.000 title abstract 4
- 238000000746 purification Methods 0.000 title abstract 4
- 230000000813 microbial effect Effects 0.000 title abstract 3
- 238000000855 fermentation Methods 0.000 title abstract 2
- 230000004151 fermentation Effects 0.000 title abstract 2
- 210000004251 human milk Anatomy 0.000 title abstract 2
- 235000020256 human milk Nutrition 0.000 title abstract 2
- 229920001542 oligosaccharide Polymers 0.000 title abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 title abstract 2
- 235000013305 food Nutrition 0.000 abstract 3
- 238000013375 chromatographic separation Methods 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 239000002178 crystalline material Substances 0.000 abstract 1
- 238000000909 electrodialysis Methods 0.000 abstract 1
- 238000012262 fermentative production Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000001728 nano-filtration Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente solicitud desvela un proceso sencillo para la purificación de oligosacáridos de leche humana (OLH) neutros producidos por fermentación microbiana. El proceso utiliza una combinación de una etapa de tratamiento intercambiador iónico catiónico, tratamiento intercambiador iónico aniónico una etapa de nanofiltración y/o electrodiálisis, que permite la purificación eficaz de grandes cantidades de OLH neutros, a elevada pureza. Contrariamente a la purificación utilizada actualmente en la producción fermentativa de OLH neutros, el proceso expuesto permite proporcionar OLH sin la necesidad de una separación cromatográfica. De esta manera, los OLH purificados pueden obtenerse en forma sólida mediante secado por pulverización, como material cristalino o como concentrado filtrado estéril. Los OLH proporcionados están libres de proteínas y de material recombinante procedente de las cepas microbianas recombinantes utilizadas y por consiguiente resultan muy apropiados para su uso en alimentos, fórmulas médicas y aplicaciones alimentarias (p. ej., alimento para mascotas).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14151737.5A EP2896628B1 (en) | 2014-01-20 | 2014-01-20 | Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation |
PCT/EP2014/079212 WO2015106943A1 (en) | 2014-01-20 | 2014-12-23 | PROCESS FOR EFFICIENT PURIFICATION OF NEUTRAL HUMAN MILK OLIGOSACCHARIDES (HMOs) FROM MICROBIAL FERMENTATION |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016009394A true MX2016009394A (es) | 2017-02-08 |
MX369375B MX369375B (es) | 2019-11-07 |
Family
ID=49949589
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016009394A MX369375B (es) | 2014-01-20 | 2014-12-23 | Proceso para una purificacion eficaz de oligosacaridos de leche humana (olh) neutros a partir de fermentacion microbiana. |
MX2019013267A MX2019013267A (es) | 2014-01-20 | 2016-07-19 | Proceso para una purificacion eficaz de oligosacaridos de leche humana (olh) neutros a partir de fermentacion microbiana. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019013267A MX2019013267A (es) | 2014-01-20 | 2016-07-19 | Proceso para una purificacion eficaz de oligosacaridos de leche humana (olh) neutros a partir de fermentacion microbiana. |
Country Status (18)
Country | Link |
---|---|
US (4) | US10377787B2 (es) |
EP (5) | EP2896628B1 (es) |
JP (2) | JP6901857B2 (es) |
KR (1) | KR102137027B1 (es) |
CN (1) | CN106132977B (es) |
AT (2) | AT17418U1 (es) |
AU (1) | AU2014377374B2 (es) |
BR (1) | BR112016016705A8 (es) |
CZ (2) | CZ35289U1 (es) |
DE (2) | DE202014011358U1 (es) |
DK (6) | DK2896628T3 (es) |
ES (4) | ES2701163T3 (es) |
FI (2) | FI3686211T3 (es) |
MX (2) | MX369375B (es) |
PH (2) | PH12016501421A1 (es) |
PL (4) | PL2896628T3 (es) |
RU (1) | RU2682445C2 (es) |
WO (1) | WO2015106943A1 (es) |
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DK2896628T3 (en) | 2014-01-20 | 2019-01-14 | Jennewein Biotechnologie Gmbh | Process for Effective Purification of Neutral Milk Oligosaccharides (HMOs) from Microbial Fermentation |
EP3227309A4 (en) * | 2014-12-05 | 2019-01-16 | Glycom A/S | CRYSTALLINE DIFUCOSYLLACTOSIS |
EP3390652A4 (en) | 2015-12-18 | 2019-06-12 | Glycom A/S | Fermentative preparation of oligosaccharides |
EP3426670A4 (en) * | 2016-03-07 | 2019-11-13 | Glycom A/S | SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH |
US11312741B2 (en) | 2016-04-19 | 2022-04-26 | Glycom A/S | Separation of oligosaccharides from fermentation broth |
US20200123184A1 (en) | 2017-06-30 | 2020-04-23 | Glycom A/S | Purification of oligosaccharides |
CN110914284A (zh) | 2017-07-12 | 2020-03-24 | 格礼卡姆股份公司 | 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物 |
EP3450443A1 (en) | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
CN111164090A (zh) * | 2017-09-29 | 2020-05-15 | 菲仕兰坎皮纳荷兰公司 | 用于从微生物发酵纯化中性母乳寡糖(hmo)的方法 |
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CN113195730A (zh) | 2018-12-19 | 2021-07-30 | 巴斯夫欧洲公司 | 从包含生物质和至少一种寡糖的溶液中分离生物质的方法 |
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