SA519410306B1 - Crm197 طريقة محسنة لإنتاج مستوى عالي من - Google Patents
Crm197 طريقة محسنة لإنتاج مستوى عالي منInfo
- Publication number
- SA519410306B1 SA519410306B1 SA519410306A SA519410306A SA519410306B1 SA 519410306 B1 SA519410306 B1 SA 519410306B1 SA 519410306 A SA519410306 A SA 519410306A SA 519410306 A SA519410306 A SA 519410306A SA 519410306 B1 SA519410306 B1 SA 519410306B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- crm197
- improved method
- high level
- level production
- production
- Prior art date
Links
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 241000186216 Corynebacterium Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 206010013023 diphtheria Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Manufacture Of Electron Tubes, Discharge Lamp Vessels, Lead-In Wires, And The Like (AREA)
- Forging (AREA)
Abstract
طريقة محسنة لإنتاج مستوى عالي من CRM197 AN IMPROVED METHOD FOR HIGH LEVEL PRODUCTION OF CRM197 الملخـــص يوفر الاختراع الحالي طريقة محسّنة لإنتاج CRM197 بانتاجية عالية باستخدام سلالة Corynebacterium diphtheria هندسية والتي تحتوي على عدد أكبر من نسخ جين CRM197، حيث تشتمل الطريقة على نمو السلالة في وسائط خالية من المكونات المشتقة من الحيوانات مع واحد أو أكثر من الأحماض الأمينية amino acids. شكل. 1
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201741014335 | 2017-04-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
SA519410306B1 true SA519410306B1 (ar) | 2022-02-02 |
Family
ID=63678648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA519410306A SA519410306B1 (ar) | 2017-04-22 | 2019-10-16 | Crm197 طريقة محسنة لإنتاج مستوى عالي من |
Country Status (30)
Country | Link |
---|---|
US (1) | US11098089B2 (ar) |
EP (1) | EP3612553B1 (ar) |
JP (1) | JP7161493B2 (ar) |
KR (1) | KR102637436B1 (ar) |
CN (1) | CN110741013B (ar) |
AU (1) | AU2018255959B2 (ar) |
BR (1) | BR112019022093A2 (ar) |
CA (1) | CA3060723A1 (ar) |
CL (1) | CL2019003003A1 (ar) |
CO (1) | CO2019011643A2 (ar) |
CU (1) | CU24668B1 (ar) |
DK (1) | DK3612553T3 (ar) |
EA (1) | EA201992527A1 (ar) |
ES (1) | ES2926535T3 (ar) |
HR (1) | HRP20221060T1 (ar) |
HU (1) | HUE059629T2 (ar) |
IL (1) | IL270075B1 (ar) |
LT (1) | LT3612553T (ar) |
MX (1) | MX2019012563A (ar) |
MY (1) | MY194242A (ar) |
PH (1) | PH12019550214A1 (ar) |
PL (1) | PL3612553T3 (ar) |
PT (1) | PT3612553T (ar) |
RS (1) | RS63551B1 (ar) |
SA (1) | SA519410306B1 (ar) |
SG (1) | SG11201909765XA (ar) |
SI (1) | SI3612553T1 (ar) |
UA (1) | UA127497C2 (ar) |
WO (1) | WO2018193475A2 (ar) |
ZA (1) | ZA201906270B (ar) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113755380A (zh) * | 2021-09-23 | 2021-12-07 | 艾美卫信生物药业(浙江)有限公司 | 一种发酵生产白喉毒素crm197蛋白的菌种培养基、配制方法以及菌种复苏培养方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69434079T2 (de) * | 1993-03-05 | 2005-02-24 | Wyeth Holdings Corp. | Plasmid zur Herstellung von CRM-Protein und Diphtherie-Toxin |
US20040087020A1 (en) * | 1997-05-28 | 2004-05-06 | Chiron S.P.A. | Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin |
EP2199382A3 (en) | 1997-05-28 | 2010-09-22 | Novartis Vaccines and Diagnostics S.r.l. | Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin |
GB9904582D0 (en) | 1999-02-26 | 1999-04-21 | Nycomed Imaging As | Process |
EP1692269A4 (en) * | 2003-12-12 | 2007-09-26 | Sanofi Pasteur Ltd | PRODUCTION OF DIPHTHERIA TOXIN |
GB0505996D0 (en) * | 2005-03-23 | 2005-04-27 | Glaxosmithkline Biolog Sa | Fermentation process |
AU2010201410B2 (en) * | 2010-03-30 | 2015-04-30 | Pelican Technology Holdings, Inc. | High level expression of recombinant CRM197 |
GB2495341B (en) * | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
FR2992656B1 (fr) * | 2012-07-02 | 2016-10-07 | Sanofi Pasteur | Procede de production d'antigenes haemophilus influenzae type b |
ITMI20130142A1 (it) * | 2013-01-31 | 2014-08-01 | Biosynth Srl | Vaccini glicoconiugati comprendenti unita' di base di un costrutto molecolare esprimente epitopi multipli incorporati |
JP6473460B2 (ja) * | 2014-03-03 | 2019-02-20 | スカラブ ゲノミクス, エルエルシー | 大腸菌における組換えcrm197の産生強化 |
-
2018
- 2018-04-19 RS RS20220813A patent/RS63551B1/sr unknown
- 2018-04-19 MX MX2019012563A patent/MX2019012563A/es unknown
- 2018-04-19 KR KR1020197033074A patent/KR102637436B1/ko active IP Right Grant
- 2018-04-19 AU AU2018255959A patent/AU2018255959B2/en active Active
- 2018-04-19 HR HRP20221060TT patent/HRP20221060T1/hr unknown
- 2018-04-19 LT LTEPPCT/IN2018/050235T patent/LT3612553T/lt unknown
- 2018-04-19 SI SI201830744T patent/SI3612553T1/sl unknown
- 2018-04-19 WO PCT/IN2018/050235 patent/WO2018193475A2/en active Application Filing
- 2018-04-19 HU HUE18773868A patent/HUE059629T2/hu unknown
- 2018-04-19 CU CU2019000083A patent/CU24668B1/es unknown
- 2018-04-19 JP JP2019557469A patent/JP7161493B2/ja active Active
- 2018-04-19 CA CA3060723A patent/CA3060723A1/en active Pending
- 2018-04-19 EP EP18773868.7A patent/EP3612553B1/en active Active
- 2018-04-19 ES ES18773868T patent/ES2926535T3/es active Active
- 2018-04-19 PL PL18773868.7T patent/PL3612553T3/pl unknown
- 2018-04-19 US US16/606,958 patent/US11098089B2/en active Active
- 2018-04-19 UA UAA201911302A patent/UA127497C2/uk unknown
- 2018-04-19 DK DK18773868.7T patent/DK3612553T3/da active
- 2018-04-19 IL IL270075A patent/IL270075B1/en unknown
- 2018-04-19 SG SG11201909765X patent/SG11201909765XA/en unknown
- 2018-04-19 BR BR112019022093A patent/BR112019022093A2/pt unknown
- 2018-04-19 EA EA201992527A patent/EA201992527A1/ru unknown
- 2018-04-19 CN CN201880026461.2A patent/CN110741013B/zh active Active
- 2018-04-19 PT PT187738687T patent/PT3612553T/pt unknown
- 2018-04-19 MY MYPI2019006169A patent/MY194242A/en unknown
-
2019
- 2019-09-23 ZA ZA2019/06270A patent/ZA201906270B/en unknown
- 2019-10-16 PH PH12019550214A patent/PH12019550214A1/en unknown
- 2019-10-16 SA SA519410306A patent/SA519410306B1/ar unknown
- 2019-10-21 CL CL2019003003A patent/CL2019003003A1/es unknown
- 2019-10-21 CO CONC2019/0011643A patent/CO2019011643A2/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY195408A (en) | Novel Aspartokinase Variant and Method for Producing L- Amino Acid Using the Same | |
EP3904521A4 (en) | L-AMINO ACID-PRODUCING VARIANT STRAIN OF E. COLI OR CORYNEBACTERIUM GLUTAMICUM, AND METHODS OF PREPARATION OF L-AMINO ACIDS USING THE SAME | |
MX2021004214A (es) | Composiciones y metodos de inmunoterapia. | |
MY181461A (en) | Method for producing l-amino acids in corynebacteria using a glycine cleavage system | |
MX2019005420A (es) | Preparacion de acido (r)-3-hidroxibutirico o sus sales mediante fermentacion de una etapa. | |
PH12018500426A1 (en) | Microorganism producing l-leucine and method of producing l-leucinie using the same | |
DK2102337T3 (da) | Microorganisme af slægten Corynebacterium med forhøjet L-lysinproduktionsevne samt fremgangsmåde til fremstilling af L-lysin under anvendelse af denne | |
MY191029A (en) | Novel polypeptide and method of producing imp using the same | |
EA036334B9 (ru) | Генетически модифицированная бактерия clostridium для получения салицилата из хоризмата | |
MY195583A (en) | Modified Homoserine Dehydrogenase and Method for Producing Homoserine Or L-Amino Acid Derived from Homoserine using the same | |
PH12020551031A1 (en) | Modified homoserine dehydrogenase and method for producing homoserine or l-amino acid derived from homoserine using the same | |
ATE503004T1 (de) | Glutaminsäure in hoher ausbeute produzierender mikroorganismus und verfahren zur produktion von glutaminsäure damit | |
MY169049A (en) | Microorganisms for producing putrescine and process for producing putrescine using them | |
PH12018500150A1 (en) | Microorganisms for producing putrescine or ornithine and process for producing putrescine or ornithine using them | |
MY189896A (en) | Microorganisms of the genus corynebacterium having l-isoleucine producing ability and methods for producing l-isoleucine using the same | |
MY181203A (en) | Microorganism of corynebacterium sp. having enhanced l-lysine producibility and method for producing l-lysine using same | |
MX2019004405A (es) | Metodo y aparato de union de canula-cateter con aguja. | |
PH12020551274A1 (en) | Mycosporine-like amino acid-producing microorganism and method for production of mycosporine-like amino acids by using same | |
MY190149A (en) | Corynebacterium sp. microorganisms having l-lysine-producing ability and l-lysine producing method using same | |
SA519410306B1 (ar) | Crm197 طريقة محسنة لإنتاج مستوى عالي من | |
MY197889A (en) | Microorganism producing l-amino acid and method for producing l-amino acid using the same | |
MY182443A (en) | Method of producing lipid | |
MX2019015056A (es) | Variante de acetohidroxiacido sintasa, microorganismo que comprende la misma, y procedimiento de produccion de aminoacidos de cadena l-ramificada mediante el uso del mismo. | |
MY181143A (en) | Microorganisms producing l-amino acids and process for producing l-amino acids using the same | |
MY189749A (en) | A microorganism of the genus corynebacterium producing l-lysine and a method for producing l-lysine using the same |