CO2019011643A2 - Un método mejorado para la producción de nivel alto de crm - Google Patents
Un método mejorado para la producción de nivel alto de crmInfo
- Publication number
- CO2019011643A2 CO2019011643A2 CONC2019/0011643A CO2019011643A CO2019011643A2 CO 2019011643 A2 CO2019011643 A2 CO 2019011643A2 CO 2019011643 A CO2019011643 A CO 2019011643A CO 2019011643 A2 CO2019011643 A2 CO 2019011643A2
- Authority
- CO
- Colombia
- Prior art keywords
- production
- improved method
- crm
- level
- crm197
- Prior art date
Links
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 abstract 2
- 241000186216 Corynebacterium Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 206010013023 diphtheria Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Manufacture Of Electron Tubes, Discharge Lamp Vessels, Lead-In Wires, And The Like (AREA)
- Forging (AREA)
- Peptides Or Proteins (AREA)
Abstract
RESUMEN DE LA INVENCIÓN La presente invención provee un método mejorado para la producción de CRM197 con alto rendimiento utilizando la cepa diseñada de Corynebacterium diphtheria que tiene número de copias incrementado del gen CRM197, en el cual el método comprende cultivar la cepa en medios libres de componentes derivados de animales con uno o más aminoácidos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201741014335 | 2017-04-22 | ||
| PCT/IN2018/050235 WO2018193475A2 (en) | 2017-04-22 | 2018-04-19 | An improved method for high level production of crm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2019011643A2 true CO2019011643A2 (es) | 2020-01-17 |
Family
ID=63678648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2019/0011643A CO2019011643A2 (es) | 2017-04-22 | 2019-10-21 | Un método mejorado para la producción de nivel alto de crm |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US11098089B2 (es) |
| EP (1) | EP3612553B1 (es) |
| JP (1) | JP7161493B2 (es) |
| KR (1) | KR102637436B1 (es) |
| CN (1) | CN110741013B (es) |
| AU (1) | AU2018255959B2 (es) |
| BR (1) | BR112019022093A2 (es) |
| CA (1) | CA3060723A1 (es) |
| CL (1) | CL2019003003A1 (es) |
| CO (1) | CO2019011643A2 (es) |
| CU (1) | CU24668B1 (es) |
| DK (1) | DK3612553T3 (es) |
| EA (1) | EA201992527A1 (es) |
| ES (1) | ES2926535T3 (es) |
| HR (1) | HRP20221060T1 (es) |
| HU (1) | HUE059629T2 (es) |
| IL (1) | IL270075B1 (es) |
| LT (1) | LT3612553T (es) |
| MX (1) | MX2019012563A (es) |
| MY (1) | MY194242A (es) |
| PH (1) | PH12019550214A1 (es) |
| PL (1) | PL3612553T3 (es) |
| PT (1) | PT3612553T (es) |
| RS (1) | RS63551B1 (es) |
| SA (1) | SA519410306B1 (es) |
| SG (1) | SG11201909765XA (es) |
| SI (1) | SI3612553T1 (es) |
| UA (1) | UA127497C2 (es) |
| WO (1) | WO2018193475A2 (es) |
| ZA (1) | ZA201906270B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113755380A (zh) * | 2021-09-23 | 2021-12-07 | 艾美卫信生物药业（浙江）有限公司 | 一种发酵生产白喉毒素crm197蛋白的菌种培养基、配制方法以及菌种复苏培养方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69434079T2 (de) * | 1993-03-05 | 2005-02-24 | Wyeth Holdings Corp. | Plasmid zur Herstellung von CRM-Protein und Diphtherie-Toxin |
| US20040087020A1 (en) * | 1997-05-28 | 2004-05-06 | Chiron S.P.A. | Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin |
| EP2199382A3 (en) | 1997-05-28 | 2010-09-22 | Novartis Vaccines and Diagnostics S.r.l. | Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin |
| GB9904582D0 (en) | 1999-02-26 | 1999-04-21 | Nycomed Imaging As | Process |
| EP1692269A4 (en) * | 2003-12-12 | 2007-09-26 | Sanofi Pasteur Ltd | PRODUCTION OF DIPHTHERIA TOXIN |
| GB0505996D0 (en) * | 2005-03-23 | 2005-04-27 | Glaxosmithkline Biolog Sa | Fermentation process |
| AU2010201410B2 (en) * | 2010-03-30 | 2015-04-30 | Pelican Technology Holdings, Inc. | High level expression of recombinant CRM197 |
| GB2495341B (en) * | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| FR2992656B1 (fr) * | 2012-07-02 | 2016-10-07 | Sanofi Pasteur | Procede de production d'antigenes haemophilus influenzae type b |
| ITMI20130142A1 (it) * | 2013-01-31 | 2014-08-01 | Biosynth Srl | Vaccini glicoconiugati comprendenti unita' di base di un costrutto molecolare esprimente epitopi multipli incorporati |
| JP6473460B2 (ja) * | 2014-03-03 | 2019-02-20 | スカラブ ゲノミクス， エルエルシー | 大腸菌における組換えｃｒｍ１９７の産生強化 |
-
2018
- 2018-04-19 RS RS20220813A patent/RS63551B1/sr unknown
- 2018-04-19 MX MX2019012563A patent/MX2019012563A/es unknown
- 2018-04-19 KR KR1020197033074A patent/KR102637436B1/ko active IP Right Grant
- 2018-04-19 AU AU2018255959A patent/AU2018255959B2/en active Active
- 2018-04-19 HR HRP20221060TT patent/HRP20221060T1/hr unknown
- 2018-04-19 LT LTEPPCT/IN2018/050235T patent/LT3612553T/lt unknown
- 2018-04-19 SI SI201830744T patent/SI3612553T1/sl unknown
- 2018-04-19 WO PCT/IN2018/050235 patent/WO2018193475A2/en active Application Filing
- 2018-04-19 HU HUE18773868A patent/HUE059629T2/hu unknown
- 2018-04-19 CU CU2019000083A patent/CU24668B1/es unknown
- 2018-04-19 JP JP2019557469A patent/JP7161493B2/ja active Active
- 2018-04-19 CA CA3060723A patent/CA3060723A1/en active Pending
- 2018-04-19 EP EP18773868.7A patent/EP3612553B1/en active Active
- 2018-04-19 ES ES18773868T patent/ES2926535T3/es active Active
- 2018-04-19 PL PL18773868.7T patent/PL3612553T3/pl unknown
- 2018-04-19 US US16/606,958 patent/US11098089B2/en active Active
- 2018-04-19 UA UAA201911302A patent/UA127497C2/uk unknown
- 2018-04-19 DK DK18773868.7T patent/DK3612553T3/da active
- 2018-04-19 IL IL270075A patent/IL270075B1/en unknown
- 2018-04-19 SG SG11201909765X patent/SG11201909765XA/en unknown
- 2018-04-19 BR BR112019022093A patent/BR112019022093A2/pt unknown
- 2018-04-19 EA EA201992527A patent/EA201992527A1/ru unknown
- 2018-04-19 CN CN201880026461.2A patent/CN110741013B/zh active Active
- 2018-04-19 PT PT187738687T patent/PT3612553T/pt unknown
- 2018-04-19 MY MYPI2019006169A patent/MY194242A/en unknown
-
2019
- 2019-09-23 ZA ZA2019/06270A patent/ZA201906270B/en unknown
- 2019-10-16 PH PH12019550214A patent/PH12019550214A1/en unknown
- 2019-10-16 SA SA519410306A patent/SA519410306B1/ar unknown
- 2019-10-21 CL CL2019003003A patent/CL2019003003A1/es unknown
- 2019-10-21 CO CONC2019/0011643A patent/CO2019011643A2/es unknown
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