LT3612553T - Patobulintas didelio produktyvumo crm gamybos būdas - Google Patents

Patobulintas didelio produktyvumo crm gamybos būdas

Info

Publication number
LT3612553T
LT3612553T LTEPPCT/IN2018/050235T LT18050235T LT3612553T LT 3612553 T LT3612553 T LT 3612553T LT 18050235 T LT18050235 T LT 18050235T LT 3612553 T LT3612553 T LT 3612553T
Authority
LT
Lithuania
Prior art keywords
crm
high level
improved method
level production
production
Prior art date
Application number
LTEPPCT/IN2018/050235T
Other languages
English (en)
Inventor
Balamurali MASILAMANI
Rajan Sriraman
Mandar Shirish Dixit
Deviprasanna CHAKKA
Satyam Naidu Sureddi
Ramesh Venkat Matur
Narender Dev MANTENA
Mahima DATLA
Original Assignee
Biological E Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biological E Limited filed Critical Biological E Limited
Publication of LT3612553T publication Critical patent/LT3612553T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
LTEPPCT/IN2018/050235T 2017-04-22 2018-04-19 Patobulintas didelio produktyvumo crm gamybos būdas LT3612553T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741014335 2017-04-22
PCT/IN2018/050235 WO2018193475A2 (en) 2017-04-22 2018-04-19 An improved method for high level production of crm

Publications (1)

Publication Number Publication Date
LT3612553T true LT3612553T (lt) 2022-09-26

Family

ID=63678648

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/IN2018/050235T LT3612553T (lt) 2017-04-22 2018-04-19 Patobulintas didelio produktyvumo crm gamybos būdas

Country Status (30)

Country Link
US (1) US11098089B2 (lt)
EP (1) EP3612553B1 (lt)
JP (1) JP7161493B2 (lt)
KR (1) KR102637436B1 (lt)
CN (1) CN110741013B (lt)
AU (1) AU2018255959B2 (lt)
BR (1) BR112019022093A2 (lt)
CA (1) CA3060723A1 (lt)
CL (1) CL2019003003A1 (lt)
CO (1) CO2019011643A2 (lt)
CU (1) CU24668B1 (lt)
DK (1) DK3612553T3 (lt)
EA (1) EA201992527A1 (lt)
ES (1) ES2926535T3 (lt)
HR (1) HRP20221060T1 (lt)
HU (1) HUE059629T2 (lt)
IL (1) IL270075B1 (lt)
LT (1) LT3612553T (lt)
MX (1) MX2019012563A (lt)
MY (1) MY194242A (lt)
PH (1) PH12019550214A1 (lt)
PL (1) PL3612553T3 (lt)
PT (1) PT3612553T (lt)
RS (1) RS63551B1 (lt)
SA (1) SA519410306B1 (lt)
SG (1) SG11201909765XA (lt)
SI (1) SI3612553T1 (lt)
UA (1) UA127497C2 (lt)
WO (1) WO2018193475A2 (lt)
ZA (1) ZA201906270B (lt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113755380A (zh) * 2021-09-23 2021-12-07 艾美卫信生物药业（浙江）有限公司 一种发酵生产白喉毒素crm197蛋白的菌种培养基、配制方法以及菌种复苏培养方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69434079T2 (de) 1993-03-05 2005-02-24 Wyeth Holdings Corp. Plasmid zur Herstellung von CRM-Protein und Diphtherie-Toxin
US20040087020A1 (en) 1997-05-28 2004-05-06 Chiron S.P.A. Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin
EP1849860B1 (en) 1997-05-28 2010-11-17 Novartis Vaccines and Diagnostics S.r.l. Process for preparing an immunogenic factor of Corynebacterium diphtheriae using a culture medium with yeast extract as aminoacid source and no protein complexes of animal origin
GB9904582D0 (en) 1999-02-26 1999-04-21 Nycomed Imaging As Process
WO2005056773A1 (en) * 2003-12-12 2005-06-23 Sanofi Pasteur Limited Production of diphtheria toxin
GB0505996D0 (en) 2005-03-23 2005-04-27 Glaxosmithkline Biolog Sa Fermentation process
AU2010201410B2 (en) 2010-03-30 2015-04-30 Pelican Technology Holdings, Inc. High level expression of recombinant CRM197
GB2495341B (en) 2011-11-11 2013-09-18 Novartis Ag Fermentation methods and their products
FR2992656B1 (fr) * 2012-07-02 2016-10-07 Sanofi Pasteur Procede de production d'antigenes haemophilus influenzae type b
ITMI20130142A1 (it) * 2013-01-31 2014-08-01 Biosynth Srl Vaccini glicoconiugati comprendenti unita' di base di un costrutto molecolare esprimente epitopi multipli incorporati
US10479820B2 (en) * 2014-03-03 2019-11-19 Scarab Genomics, Llc Enhanced production of recombinant CRM197 in E. coli

Also Published As

Publication number Publication date
MX2019012563A (es) 2019-12-02
PH12019550214A1 (en) 2020-09-14
SA519410306B1 (ar) 2022-02-02
SI3612553T1 (sl) 2022-11-30
CU24668B1 (es) 2023-07-12
JP2020517274A (ja) 2020-06-18
AU2018255959A1 (en) 2019-11-14
KR102637436B1 (ko) 2024-02-15
US11098089B2 (en) 2021-08-24
ES2926535T3 (es) 2022-10-26
AU2018255959A8 (en) 2022-02-17
BR112019022093A2 (pt) 2020-05-05
WO2018193475A2 (en) 2018-10-25
CN110741013B (zh) 2023-08-08
CO2019011643A2 (es) 2020-01-17
DK3612553T3 (da) 2022-08-29
RS63551B1 (sr) 2022-09-30
CA3060723A1 (en) 2018-10-25
IL270075A (lt) 2019-12-31
WO2018193475A3 (en) 2018-12-27
JP7161493B2 (ja) 2022-10-26
EP3612553B1 (en) 2022-06-08
CN110741013A (zh) 2020-01-31
UA127497C2 (uk) 2023-09-13
ZA201906270B (en) 2020-07-29
CL2019003003A1 (es) 2020-02-14
EA201992527A1 (ru) 2020-02-28
MY194242A (en) 2022-11-24
US20200277341A1 (en) 2020-09-03
SG11201909765XA (en) 2019-11-28
EP3612553A2 (en) 2020-02-26
HUE059629T2 (hu) 2022-12-28
HRP20221060T1 (hr) 2022-11-11
AU2018255959B2 (en) 2022-02-17
CU20190083A7 (es) 2020-10-20
PL3612553T3 (pl) 2022-11-07
KR20200010218A (ko) 2020-01-30
IL270075B1 (en) 2024-02-01
PT3612553T (pt) 2022-09-08

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