MX2019012563A - Un metodo mejorado para la alta produccion de crm. - Google Patents

Un metodo mejorado para la alta produccion de crm.

Info

Publication number
MX2019012563A
MX2019012563A MX2019012563A MX2019012563A MX2019012563A MX 2019012563 A MX2019012563 A MX 2019012563A MX 2019012563 A MX2019012563 A MX 2019012563A MX 2019012563 A MX2019012563 A MX 2019012563A MX 2019012563 A MX2019012563 A MX 2019012563A
Authority
MX
Mexico
Prior art keywords
improved method
crm
high level
level production
crm197
Prior art date
Application number
MX2019012563A
Other languages
English (en)
Inventor
Venkat Matur Ramesh
Dev Mantena Narender
Datla Mahima
Sriraman Rajan
Chakka Deviprasanna
Naidu Sureddi Satyam
Masilamani Balamurali
Shirish Dixit Mandar
Original Assignee
Biological E Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biological E Ltd filed Critical Biological E Ltd
Publication of MX2019012563A publication Critical patent/MX2019012563A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Manufacture Of Electron Tubes, Discharge Lamp Vessels, Lead-In Wires, And The Like (AREA)
  • Forging (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención provee un método mejorado para la producción de CRM197 con alto rendimiento utilizando la cepa diseñada de Corynebacterium diphtheria que tiene número de copias incrementado del gen CRM197, en el cual el método comprende cultivar la cepa en medios libres de componentes derivados de animales con uno o más aminoácidos.
MX2019012563A 2017-04-22 2018-04-19 Un metodo mejorado para la alta produccion de crm. MX2019012563A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741014335 2017-04-22
PCT/IN2018/050235 WO2018193475A2 (en) 2017-04-22 2018-04-19 An improved method for high level production of crm

Publications (1)

Publication Number Publication Date
MX2019012563A true MX2019012563A (es) 2019-12-02

Family

ID=63678648

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012563A MX2019012563A (es) 2017-04-22 2018-04-19 Un metodo mejorado para la alta produccion de crm.

Country Status (30)

Country Link
US (1) US11098089B2 (es)
EP (1) EP3612553B1 (es)
JP (1) JP7161493B2 (es)
KR (1) KR102637436B1 (es)
CN (1) CN110741013B (es)
AU (1) AU2018255959B2 (es)
BR (1) BR112019022093A2 (es)
CA (1) CA3060723A1 (es)
CL (1) CL2019003003A1 (es)
CO (1) CO2019011643A2 (es)
CU (1) CU24668B1 (es)
DK (1) DK3612553T3 (es)
EA (1) EA201992527A1 (es)
ES (1) ES2926535T3 (es)
HR (1) HRP20221060T1 (es)
HU (1) HUE059629T2 (es)
IL (1) IL270075B2 (es)
LT (1) LT3612553T (es)
MX (1) MX2019012563A (es)
MY (1) MY194242A (es)
PH (1) PH12019550214A1 (es)
PL (1) PL3612553T3 (es)
PT (1) PT3612553T (es)
RS (1) RS63551B1 (es)
SA (1) SA519410306B1 (es)
SG (1) SG11201909765XA (es)
SI (1) SI3612553T1 (es)
UA (1) UA127497C2 (es)
WO (1) WO2018193475A2 (es)
ZA (1) ZA201906270B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113164581A (zh) 2018-09-23 2021-07-23 生物E有限公司 纯化的肺炎链球菌荚膜多糖
CN113755380A (zh) * 2021-09-23 2021-12-07 艾美卫信生物药业（浙江）有限公司 一种发酵生产白喉毒素crm197蛋白的菌种培养基、配制方法以及菌种复苏培养方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0616034B1 (en) * 1993-03-05 2004-10-20 Wyeth Holdings Corporation Plasmid for production of CRM protein and diphtheria toxin
JP4173560B2 (ja) 1997-05-28 2008-10-29 カイロン ソチエタ ア レスポンサビリタ リミタータ アミノ酸源として酵母または大豆抽出物を含み、動物起源のタンパク質複合体を含まない培養培地
US20040087020A1 (en) 1997-05-28 2004-05-06 Chiron S.P.A. Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin
GB9904582D0 (en) 1999-02-26 1999-04-21 Nycomed Imaging As Process
US20110097359A1 (en) 2003-12-12 2011-04-28 Tim Lee Production of diphtheria toxin
GB0505996D0 (en) 2005-03-23 2005-04-27 Glaxosmithkline Biolog Sa Fermentation process
AU2010201410B2 (en) * 2010-03-30 2015-04-30 Pelican Technology Holdings, Inc. High level expression of recombinant CRM197
GB2495341B (en) * 2011-11-11 2013-09-18 Novartis Ag Fermentation methods and their products
FR2992656B1 (fr) * 2012-07-02 2016-10-07 Sanofi Pasteur Procede de production d'antigenes haemophilus influenzae type b
ITMI20130142A1 (it) * 2013-01-31 2014-08-01 Biosynth Srl Vaccini glicoconiugati comprendenti unita' di base di un costrutto molecolare esprimente epitopi multipli incorporati
WO2015134402A1 (en) 2014-03-03 2015-09-11 Scarab Genomics, Llc Enhanced production of recombinant crm197 in e. coli

Also Published As

Publication number Publication date
SI3612553T1 (sl) 2022-11-30
EP3612553A2 (en) 2020-02-26
BR112019022093A2 (pt) 2020-05-05
UA127497C2 (uk) 2023-09-13
JP7161493B2 (ja) 2022-10-26
US20200277341A1 (en) 2020-09-03
HRP20221060T1 (hr) 2022-11-11
CL2019003003A1 (es) 2020-02-14
EA201992527A1 (ru) 2020-02-28
PL3612553T3 (pl) 2022-11-07
LT3612553T (lt) 2022-09-26
CO2019011643A2 (es) 2020-01-17
AU2018255959A8 (en) 2022-02-17
WO2018193475A3 (en) 2018-12-27
JP2020517274A (ja) 2020-06-18
AU2018255959A1 (en) 2019-11-14
IL270075A (es) 2019-12-31
DK3612553T3 (da) 2022-08-29
IL270075B2 (en) 2024-06-01
PH12019550214A1 (en) 2020-09-14
US11098089B2 (en) 2021-08-24
AU2018255959B2 (en) 2022-02-17
ZA201906270B (en) 2020-07-29
HUE059629T2 (hu) 2022-12-28
PT3612553T (pt) 2022-09-08
CU24668B1 (es) 2023-07-12
CA3060723A1 (en) 2018-10-25
RS63551B1 (sr) 2022-09-30
CN110741013B (zh) 2023-08-08
KR102637436B1 (ko) 2024-02-15
SG11201909765XA (en) 2019-11-28
EP3612553B1 (en) 2022-06-08
MY194242A (en) 2022-11-24
ES2926535T3 (es) 2022-10-26
SA519410306B1 (ar) 2022-02-02
CN110741013A (zh) 2020-01-31
IL270075B1 (en) 2024-02-01
CU20190083A7 (es) 2020-10-20
KR20200010218A (ko) 2020-01-30
WO2018193475A2 (en) 2018-10-25

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